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2. Evolution of nutritional management in children with cystic fibrosis – a narrative review.

Author

Smith, Chris, Lowdon, Jacqueline, Noordhoek, Jacqueline, and Wilschanski, Michael

Subjects
NUTRITION disorders, MALNUTRITION, BODY mass index, DISEASE management, NUTRITIONAL assessment, FOOD security, LIFE expectancy, DISEASES, FAMILY attitudes, NUTRITIONAL status, QUALITY of life, NUTRITION services, CYSTIC fibrosis, DIET therapy, DEMOGRAPHY, OBESITY, COMORBIDITY, DISEASE complications, CHILDREN
Abstract

Nutrition has played a central role in the management and outcomes of people with cystic fibrosis (pwCF) since the 1970s. Advances in therapies and practices in recent decades have led to a significant change in the patient landscape with dramatic improvements in life expectancy, as well as quality of life, bringing with it new issues. Historically, cystic fibrosis was a condition associated with childhood and malnutrition; however, changes in patient demographics, nutritional assessment and fundamental nutritional management have evolved, and it has become an increasingly prevalent adult disease with new nutritional challenges, including obesity. This paper aims to describe these changes and the impact and challenges they bring for those working in this field. Nutritional professionals will need to evolve, adapt and remain agile to the wider range of situations and support required for a new generation of pwCF. Specialised nutrition support will continue to be required, and it will be additionally important to improve and optimise quality of life and long‐term health. Key points: Traditional cystic fibrosis dietary advice focused on a default high‐fat/high‐calorie intake with limited consideration for other important nutrients. The emerging new era approach should be individualised, flexible and with an emphasis on diversity and longevity.Historically, this population was predominantly undernourished or at risk of undernutrition, but with the success and impact of nutritional guidelines, multidisciplinary teams, screening and new therapies, overnutrition is becoming an increasing concern that requires attention.Significant improvements in life expectancy mean more people with cystic fibrosis are living into old age, bringing with it age‐related complications and new opportunities that require nutritional consideration from childhood. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Training in Paediatric Clinical Nutrition Across Europe: A Survey of the National Societies Network (2016-2019) of the European Society for Paediatric Gastroenterology, Hepatology and Nutrition.

Author

Papadopoulou, Alexandra, Ribes-Koninckx, Carmen, Baker, Alastair, Noni, Maria, Koutri, Eleni, Karagianni, Maria-Vasiliki, Protheroe, Sue, Guarino, Alfredo, Mas, Emmanuel, Wilschanski, Michael, Roman, Enriqueta, Escher, Johanna, Furlano, Raoul I., Posovszky, Carsten, Hoffman, Ilse, Veres, Gabor, Bronsky, Jiri, Hauer, Almuthe Christine, Tjesic-Drinkovic, Duska, and Fotoulaki, Maria

Published
2022
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5. Tumor necrosis factor‐α inhibitor‐induced follicular psoriasiform eruption.

Author

Goldberger, Tal, Benshushan, Stephanie, Davidovics, Zev, Wilschanski, Michael, and Molho‐Pessach, Vered

Subjects
CROHN'S disease, INFLAMMATORY bowel diseases, NECROSIS, SKIN diseases
Abstract

Tumor necrosis factor‐α inhibitor‐associated adverse cutaneous reactions are common in patients with inflammatory bowel disease. Infection‐related dermatoses and psoriasiform eruptions are seen most frequently. We describe a follicular psoriasiform eruption that appeared during treatment with infliximab in two adolescents with Crohn's disease. [ABSTRACT FROM AUTHOR]

Published
2022
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9. Clinical and Practice Variations in Pediatric Acute Recurrent or Chronic Pancreatitis: Report From the INSPPIRE Study.

Author

Dike, Chinenye R., Zimmerman, Bridget, Yuhua Zheng, Wilschanski, Michael, Werlin, Steven L., Troendle, David, Shah, Uzma, Schwarzenberg, Sarah Jane, Pohl, John, Perito, Emily R., Ooi, Chee Y., Nathan, Jaimie D., Morinville, Veronique D., McFerron, Brian, Mascarenhas, Maria, Maqbool, Asim, Quin Liu, Lin, Tom K., Husain, Sohail Z., and Heyman, Melvin B.

Published
2020
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10. Diabetes Mellitus in Children with Acute Recurrent and Chronic Pancreatitis: Data From the INternational Study Group of Pediatric Pancreatitis: In Search for a CuRE Cohort.

Author

Bellin, Melena D., Lowe, Mark, Bridget Zimmerman, M., Wilschanski, Michael, Werlin, Steven, Troendle, David M., Shah, Uzma, Schwarzenberg, Sarah J., Pohl, John F., Perito, Emily, Ooi, Chee Yee, Nathan, Jaimie D., Morinville, Veronique D., McFerron, Brian A., Mascarenhas, Maria R., Maqbool, Asim, Liu, Quin, Lin, Tom K., Husain, Sohail Z., and Himes, Ryan

Published
2019
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11. The Use of Jejunal Tube Feeding in Children: A Position Paper by the Gastroenterology and Nutrition Committees of the European Society for Paediatric Gastroenterology, Hepatology, and Nutrition 2019.

Author

Broekaert, Ilse J., Falconer, Jackie, Bronsky, Jiri, Gottrand, Frederic, Dall'Oglio, Luigi, Goto, Eunice, Hojsak, Iva, Hulst, Jessie, Kochavi, Brigitte, Papadopoulou, Alexandra, Ribes-Koninckx, Carmen, Schaeppi, Michela, Werlin, Steven, Wilschanski, Michael, and Thapar, Nikhil

Published
2019
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12. Chronic Pancreatitis: Pediatric and Adult Cohorts Show Similarities in Disease Progress Despite Different Risk Factors.

Author

Schwarzenberg, Sarah J., Uc, Aliye, Zimmerman, Bridget, Wilschanski, Michael, Wilcox, C. Mel, Whitcomb, David C., Werlin, Steven L., Troendle, David, Tang, Gong, Slivka, Adam, Singh, Vikesh K., Sherman, Stuart, Shah, Uzma, Sandhu, Bimaljit S., Romagnuolo, Joseph, Rhee, Sue, Pohl, John F., Perito, Emily R., Ooi, Chee Y., and Nathan, Jaimie D.

Published
2019
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14. Recommendations for Diagnosis and Management of Autoimmune Pancreatitis in Childhood: Consensus From INSPPIRE.

Author

Scheers, Isabelle, Palermo, Joseph J., Freedman, Steven, Wilschanski, Michael, Shah, Uzma, Abu-El-Haija, Maisam, Barth, Bradley, Fishman, Douglas S., Gariepy, Cheryl, Giefer, Matthew J., Heyman, Melvin B., Himes, Ryan W., Husain, Sohail Z., Lin, Tom K., Quin Liu, Lowe, Mark, Mascarenhas, Maria, Morinville, Veronique, Chee Y. Ooi, and Perito, Emily R.

Published
2018
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17. ESPGHAN- Guidelines for the Evaluation and Treatment of Gastrointestinal and Nutritional Complications in Children with Neurological Impairment.

Author

Romano, Claudio, van Wynckel, Myriam, Hulst, Jessie, Broekaert, Ilse, Bronsky, Jiri, Dall’Oglio, Luigi, Mis, Nataša F., Hojsak, Iva, Orel, Rok, Papadopoulou, Alexandra, Schaeppi, Michela, Thapar, Nikhil, Wilschanski, Michael, Sullivan, Peter, Gottrand, Frédéric, Dall'Oglio, Luigi, and Mis, Nataša Fidler

Published
2017
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18. Causal Evaluation of Acute Recurrent and Chronic Pancreatitis in Children: Consensus From the INSPPIRE Group.

Author

Gariepy, Cheryl E., Heyman, Melvin B., Lowe, Mark E., Pohl, John F., Werlin, Steven L., Wilschanski, Michael, Barth, Bradley, Fishman, Douglas S., Freedman, Steven D., Giefer, Matthew J., Gonska, Tanja, Himes, Ryan, Husain, Sohail Z., Morinville, Veronique D., Ooi, Chee Y., Schwarzenberg, Sarah J., Troendle, David M., Yen, Elizabeth, and Uc, Aliye

Published
2017
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21. An international consensus report on a new algorithm for the management of infant diarrhoea.

Author

Lo Vecchio, Andrea, Vandenplas, Yvan, Benninga, Marc, Broekaert, Ilse, Falconer, Jackie, Gottrand, Frederic, Lifschitz, Carlos, Lionetti, Paolo, Orel, Rok, Papadopoulou, Alexandra, Ribes‐Koninckx, Carmen, Salvatore, Silvia, Shamir, Raanan, Schäppi, Michela, Staiano, Annamaria, Szajewska, Hania, Thapar, Nikhil, Wilschanski, Michael, and Guarino, Alfredo

Subjects
INFANT diseases, DIARRHEA in infants, ALGORITHMS, GASTROENTERITIS in children, PEDIATRICS, THERAPEUTICS
Abstract

Aim: Implementing international guidelines guarantees high standards of clinical care. A group of experts developed an algorithm to drive the management of common gastrointestinal symptoms in infancy by paediatricians and general practitioners.Methods: The algorithm started from the evidence-based recommendations of the European Society of Gastroenterology, Hepatology and Nutrition and the European Society of Pediatric Infectious Diseases and an updated review of the literature. We used the structured quantitative method of nominal group technique to reach a consensus.Results: A practical algorithm for the management of infants with acute diarrhoea was designed based on the consensus reached for each statement. The management of an infant with acute diarrhoea should include a sequence of actions: (i) a semiquantitative estimate of infant dehydration through validated clinical scores, (ii) rehydration therapy and early refeeding with breast milk or regular formula and (iii) effective agents to reduce the severity and duration of the diarrhoea. Finally, in children with prolonged diarrhoea, the search for aetiology should include persistent infections or reinfections, cows' milk protein allergy and coeliac diseases. Lactose should always be withdrawn.Conclusion: This algorithm provides an evidence-based sequence of interventions to optimise the management of infants with acute diarrhoea. [ABSTRACT FROM AUTHOR]

Published
2016
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22. Functional gastro-intestinal disorder algorithms focus on early recognition, parental reassurance and nutritional strategies.

Author

Vandenplas, Yvan, Benninga, Marc, Broekaert, Ilse, Falconer, Jackie, Gottrand, Frederic, Guarino, Alfredo, Lifschitz, Carlos, Lionetti, Paolo, Orel, Rok, Papadopoulou, Alexandra, Ribes ‐ Koninckx, Carmen, Ruemmele, Frank M., Salvatore, Silvia, Shamir, Raanan, Schäppi, Michela, Staiano, Annamaria, Szajewska, Hania, Thapar, Nikhil, and Wilschanski, Michael

Subjects
GASTROINTESTINAL disease treatment, INFANT nutrition, CONSTIPATION, THERAPEUTICS, INFANT disease treatment, PRIMARY care
Abstract

Unlabelled: Up to 50% of infants present with symptoms of regurgitation, infantile colic and/or constipation during the first 12 months of life. Although they are often classed as functional disorders, there is an overlap with cows' milk allergy. We present practical algorithms for the management of such disorders, based on existing evidence and general consensus, with a particular focus on primary health care. Management consists of early recognition of warning signs of organic disease, parental reassurance and nutritional strategies.Conclusion: The proposed algorithms aim to help healthcare providers manage frequent gastrointestinal and cows' milk-related symptoms in infants safely and effectively. [ABSTRACT FROM AUTHOR]

Published
2016
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33. Treatment regimens for Helicobacter pylori infection in children: is in vitro susceptibility testing helpful?

Author

Faber, Joseph, Bar-Meir, Maskit, Rudensky, Bernard, Schlesinger, Yechiel, Rachman, Elena, Benenson, Shmuel, Sirota, Gisela, Stankiewic, Halina, Halle, David, and Wilschanski, Michael

Abstract

Background: Treatment regimens for Helicobacter pylori have variable success rates, and data comparing effectiveness with respect to strain sensitivity are relatively scarce.Objective: To evaluate the efficacy of two treatment regimens for eradication of H. pylori and the impact of bacterial susceptibility testing.Study Design: 265 children endoscopically diagnosed with H. pylori infection were randomly assigned to receive omeprazole + amoxicillin with clarithromycin or omeprazole + amoxicillin with metronidazole. Bacterial culture and susceptibility was performed in a subgroup. Eradication was assessed by C-urea breath test.Results: Eradication was achieved in 73.4% by omeprazole + amoxicillin with metronidazole and in 62.6% by omeprazole + amoxicillin with clarithromycin (P = 0.078). H. pylori was cultured successfully in 105 patients. Resistance to metronidazole was detected in 31.4% of the isolates and resistance to clarithromycin in 15%. Eradication rate by omeprazole + amoxicillin with metronidazole for metronidazole-susceptible bacteria (N = 38) was 90%, and for resistant bacteria (N = 19) it was 42%. Only 75% of clarithromycin-sensitive strains were successfully treated by omeprazole + amoxicillin with clarithromycin, and none of the cases with clarithromycin-resistant strains responded to omeprazole + amoxicillin with clarithromycin treatment.Conclusion: There is a trend of greater efficacy of eradication with omeprazole + amoxicillin with metronidazole versus omeprazole + amoxicillin with clarithromycin therapy. Although resistance negatively influences eradication, first-line sensitivity-based treatment would be expected to improve this rate only slightly. Susceptibility testing should probably be reserved only for treatment failures. [ABSTRACT FROM AUTHOR]

Published
2005
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34. Relative expression and localization of the insulin-like growth factor system components in the fetal, child and adult intestine.

Author

Freier, Serem, Eran, Maya, Reinus, Constantin, Ariel, Ilana, Faber, Joseph, Wilschanski, Michael, and Braverman, Danny

Abstract

Background: The insulin-like growth factors (IGFs) are important in the development and maintenance of the gastrointestinal tract.Objectives: To compare the expression of IGFs and their receptors in the stomach and duodenum of the fetus, the child and the adult. To identify the cells mainly responsible for the production of the members of the IGF system.Methods: Tissue was obtained from fetus after abortion and from children and adults during diagnostic endoscopy and biopsy. The expression of the IGFs and their receptors was estimated by an RNAse protection assay and sections were stained with antisera to the components of IGF system.Results: The tissues from the stomach and the duodenum expressed the two IGFs and their receptors at all stages of life. The fetal IGF receptors I and II, were approximately ten times higher than in the child and IGF-II was five times higher. Immunohistochemical staining showed the components of the IGF system to be localized to the gastric glands and to the basotlateral border of the gastric epithelial cells. In the duodenum, they were concentrated at the apical portion of the epithelial tissue. They could also be identified in ganglion cells and nerves.Conclusions: The IGFs and their receptors in the stomach and duodenum are expressed in all age groups and mostly are highest in the fetus. The IGF system proteins were located in the gastric glands and epithelium and in the apical portion of the villous epithelium of the duodenum. [ABSTRACT FROM AUTHOR]

Published
2005
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43. An international consensus report on a new algorithm for the management of infant diarrhoea

Author

Carlos H. Lifschitz, Marc A. Benninga, Yvan Vandenplas, Frédéric Gottrand, Michael Wilschanski, Raanan Shamir, Carmen Ribes-Koninckx, Silvia Salvatore, Alexandra Papadopoulou, Ilse Broekaert, Nikhil Thapar, Rok Orel, Alfredo Guarino, Annamaria Staiano, Paolo Lionetti, Andrea Lo Vecchio, Jackie Falconer, Hania Szajewska, Michela Schäppi, Growth and Development, Clinical sciences, LO VECCHIO, Andrea, Vandenplas, Yvan, Benninga, Marc, Broekaert, Ilse, Falconer, Jackie, Gottrand, Frederic, Lifschitz, Carlo, Lionetti, Paolo, Orel, Rok, Papadopoulou, Alexandra, Ribes Koninckx, Carmen, Salvatore, Silvia, Shamir, Raanan, Schäppi, Michela, Staiano, Annamaria, Szajewska, Hania, Thapar, Nikhil, Wilschanski, Michael, Guarino, Alfredo, and Paediatric Gastroenterology

Subjects
Diarrhea, medicine.medical_specialty, Pediatrics, infant diarrhoea, Psychological intervention, Breast milk, Algorithm, Dehydration, Gastroenteritis, Infant diarrhoea, Prolonged diarrhoea, Pediatrics, Perinatology and Child Health, 03 medical and health sciences, 0302 clinical medicine, Pharmacotherapy, 030225 pediatrics, Internal medicine, Nominal group technique, Humans, Medicine, 030212 general & internal medicine, Intensive care medicine, book, Pediatric gastroenterology, Medicine(all), algorithm, business.industry, Infant, dehydration, General Medicine, Perinatology and Child Health, Hepatology, Child, Preschool, Acute Disease, Pediatric Infectious Disease, Fluid Therapy, book.journal, prolonged diarrhoea, gastroenteriti, business, Breast feeding, Algorithms
Abstract

AIM: Implementing international guidelines guarantees high standards of clinical care. A group of experts developed an algorithm to drive the management of common gastrointestinal symptoms in infancyby paediatricians and general practitioners. METHODS: The algorithm started from the evidence-based recommendations of the European Society of Gastroenterology, Hepatology and Nutrition and the European Society of Pediatric Infectious Diseases and an updated review of the literature. We used the structured quantitative method of nominal group technique to reach a consensus. RESULTS: A practical algorithm for the management of infants with acute diarrhoea was designed based on theconsensus reached for each statement. The management of an infant with acute diarrhoeashould include a sequence of actions: 1) a semi-quantitative estimate of infant dehydration through validated clinical scores, 2) rehydration therapy and early re-feedingwith breast milk or regular formula and 3) effective agents to reduce the severity and duration of the diarrhoea. Finally, in children with prolonged diarrhoea, the search for aetiology should include persistent infections or reinfections, cows' milk protein allergy and celiac diseases. Lactose should always be withdrawn. CONCLUSION: This algorithm provides an evidence-based sequence of interventions to optimisethe management of infants with acute diarrhoea. This article is protected by copyright. All rights reserved.

Published
2016

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