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Background: Emerging evidence has implied the importance of long non‐coding RNAs in cancer development, including prostate cancer (PCa). Bioinformatic analyses have identified that ADAMTS9‐AS1 may play a role in cancer progression. Methods: A quantitative real‐time polymerase chain reaction was conducted to measure ADAMTS9‐AS1 expression level at messenger RNA level. In vitro functional analyses were performed to investigate cell behaviors status under different conditions. Moreover, rescue assays were conducted to explore the potential mechanisms of ADAMTS9‐AS1 in PCa progression. Results: ADAMTS9‐AS1 expression is down‐regulated in PCa. Forcing ADAMTS9‐AS1 expression impedes PCa cell proliferation via initiating cell apoptosis. Importantly, microRNA‐142‐5p (miR‐142‐5p) mimic and small‐interfering RNA targeting cyclin D1 (CCND1, si‐CCND1) could attenuate the inhibitory effects of ADAMTS9‐AS1 overexpression on PCa cell growth. Conclusions: Collectively, our results indicate that ADAMTS9‐AS1 suppresses PCa progression by regulating the miR‐142‐5p/CCND1 axis, which provides a new mechanism for the progression of PCa. [ABSTRACT FROM AUTHOR]

J Clin Hypertens (Greenwich). 2012;14:802-805. ©2012 Wiley Periodicals, Inc. Recurrent cerebral hemorrhages caused by hypertension secondary to reninoma are extremely rare in children. Because of its detrimental effects on children's health, the importance of early diagnosis of and treatment for reninoma should be emphasized. Here, the authors present a 10-year-old boy with intermittent headaches and neurologic deficiency symptoms caused by hypertension. A reninoma in the right kidney was detected and successfully treated with laparoscopic partial nephrectomy. Two cell types were revealed in the tumor tissue under electron microscopy: renin secreting tumor cells and mast cells. This rare case expands our knowledge of hypertension in children and provides direct evidence that mast cells may infiltrate reninoma. [ABSTRACT FROM AUTHOR]