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Soil internal forces can affect aggregate breakdown, and then impact splash detachment and transport of aggregate fragments. However, currently, the processes of soil splash detachment and transport under different soil internal forces are still not fully understood. Thus, to determine the effects of soil internal forces on the splash transport process, two soils (Binxian soil and Keshan soil) in the Mollisols (black soil) of Northeast China were selected to analyse the detachment and transport characteristics of aggregate fragments under different splash distances (0–10, 10–20, 20–30, 30–40 and 40–50 cm) through simulated rainfall experiments. Different concentrations of KCl electrolyte (from 1 to 10−5 mol L−1) were employed as rainfall materials to regulate soil internal forces. The results revealed that the net pressure of soil internal forces and splash amount presented the same trend with decreasing electrolyte concentration, that is, increased initially (from 1 to 10−2 mol L−1), followed by levelling off (from 10−2 to 10−5 mol L−1). The splash amount and net pressure had an exponential relationship (p < 0.01). Under the same electrolyte concentration, Binxian soil had a higher net pressure and splash amount than Keshan soil. The splash amount for the two soils was mostly distributed at a splash distance of 0–20 cm, and it exponentially decreased with increasing splash distance (p < 0.01). An empirical expression in our study was developed to predict the splash amount (M) based on the net pressure (N) and splash distance (S). The size distribution of splashed aggregates could be affected by the net pressure of soil internal forces, the greater the net pressure, the smaller size aggregates splashed. At each splash distance, the highest mass percentage was observed for the fragments <0.053 mm and accounted for 35.5% to 82.1% of the total splash amount. This study provides valuable information to better understand the processes and mechanisms of rainfall splash erosion in the Chinese Mollisol region. Highlights: The distribution characteristics of aggregate fragments under different soil internal forces were tested.Relations between soil internal forces and soil aggregate detachment were determined.The distribution of splashed aggregates size was greatly affected by soil internal forces.Soil internal forces had important effects on splash erosion in the Mollisols of Northeast China. [ABSTRACT FROM AUTHOR]

Background: Hearing loss (HL) is a common sensory disorder in humans characterized by extreme clinical and genetic heterogeneity. In recent years, next‐generation sequencing (NGS) technologies have proven to be highly effective and powerful tools for population genetic studies of HL. Here, we analyzed clinical and molecular data from 21 Chinese deaf families who did not have hotspot mutations in the common deafness genes GJB2, SLC26A4, GJB3, and MT‐RNR1. Method: Targeted next‐generation sequencing (TGS) of 127 known deafness genes was performed in probands of 12 families, while whole‐exome sequencing (WES) or trio‐WES was used for the remaining nine families. Results: Potential pathogenic mutations in a total of 12 deafness genes were identified in 13 probands; the mutations were observed in GJB2, CDH23, EDNRB, MYO15A, OTOA, OTOF, TBC1D24, SALL1, TMC1, TWNK, USH1C, and USH1G, with eight of the identified mutations being novel. Further, a copy number variant (CNV) was detected in one proband with heterozygous deletion of chromosome 4p16.3‐4p15.32. Thus, the total diagnostic rate using NGS in our deafness patients reached 66.67% (14/21). Conclusions: These results expand the mutation spectrum of deafness‐causing genes and provide support for the use of NGS detection technologies for routine molecular diagnosis in Chinese deaf populations. [ABSTRACT FROM AUTHOR]

Purpose: To determine the postoperative effects of radiotherapy (PORT) on the local recurrence‐free survival (LRFS) and overall survival (OS) of stage III‐N2 non‐small‐cell lung cancer (NSCLC). Materials and Methods: 183 patients with resected stage III‐pN2 NSCLC from Hunan Cancer Hospital between 2013 and 2016 were divided into two groups for postoperative chemotherapy (POCT) (n = 105) or combination chemotherapy and radiotherapy (POCRT) (n = 78). The LRFS and OS were compared and the factors affecting local recurrence were illustrated in these two groups. The sites of failure based on the lobe of the primary tumor in two groups were described. Results: PORT leads to a strikingly lower risk for local recurrence and brought superior OS benefit. For different pN2 Subclassification, Patients with multiple‐station pN2 ± pN1 disease had the worst LRFS (11 months) and single‐station pN2 + multiple station pN1 disease had a relatively short LRFS (24 months) in group POCT. Short LRFS is correlated with multiple‐station pN2, older age (Y > 55), patients with a high positive LN ratio > 1/3 and a poor tumor histological differentiation degree. In group POCT, the most frequent failure site occurs at the ipsilateral hilum (21.0%), the bronchial stump (20.0%), followed by LNs4R (19.0%), LNs4L (18.1%), LNs7 (15.2%), most of left‐sided tumors more frequently involved the contralateral mediastinum, whereas the ipsilateral recurrences dominated for right‐sided tumors, especially for LNs4R. In group POCRT, the highest failure site was the bronchial stump (11.5%), followed by LNs4L (8.97%), LNs1 (7.69%), the ipsilateral hilum (6.41%) and LNs4R (6.41%). Conclusion: PORT remarkably reduced local recurrence and improved OS in stage III‐pN2 NSCLC, especially in the multiple‐station pN2 group. [ABSTRACT FROM AUTHOR]