1. Cytotoxic 7‐Methoxylated Caged Xanthones from the Twigs of Garcinia oligantha.
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Yang, Jin‐Ling Please verify that the linked ORCID identifiers are correct for each author. The ORCID ID for 'Changwu Zheng' seems to be invalid. Please check and supply the correct ORCID ID. --> Please confirm that given names and surnames/family names h, Fu, Wen‐Wei, Xiang, Qian, Wu, Rong, Tang, Yue‐Xun, Zheng, Chang‐Wu, Lu, Yue, Zhou, Hua, and Xu, Hong‐Xi
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GARCINIA , *TWIGS , *CELL analysis , *NUCLEAR magnetic resonance spectroscopy , *DOUBLE bonds , *CANCER cells - Abstract
Main observation and conclusion: Nineteen unprecedented 7‐methoxylated caged xanthones (1—19) were isolated from the twigs of Garcinia oligantha under the guidance of NMR spectroscopy. Their structures and absolute configurations were demonstrated by extensive spectroscopic data, single‐crystal X‐ray diffraction, electronic circular dichroism (ECD) calculations, and the modified Mosher's method. Compound 1 is a rare scalemic 7‐methoxylated neo‐caged xanthone, which was resolved using HPLC with CD detection on a chiral‐phase AD column, and compounds 2—3 are rare 7‐methoxylated caged xanthones with the hydrogenated Δ8(8a) double bond. Fourteen compounds exhibited promising inhibitory activities against four human cancer cell lines with IC50 values ranging from 1.9 to 14.3 μmol/L. A cell apoptosis analysis using flow cytometry showed that compound 11 could induce apoptosis in a dose dependent manner. Moreover, PARP, caspase‐9, and Bcl‐2 western blotting suggested that compound 11‐induced apoptosis may be involved in caspase‐dependent pathway. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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