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The muscle contractions in human epidermis carry abundant information for medical diagnostics and health monitoring. Traditional crack‐based strain sensors possess high mechanosensitivity, but have limited stretchability for human epidermis monitoring. Herein, by coupling the complementary effects of two parallel connected cracked gold (Au) film electrodes and an engineered ordered layer of Ag nanowire micromeshes (Ag NMs), a strain sensor with enhanced extensibility as well as high sensitivity is provided. The Au and Ag NMs sensory layers separated by poly(dimethylsiloxane) (PDMS) matrix can be equal to two resistors in parallel, and the Ag NMs would provide stable alternative current pathways to ensure the efficient electronic transport even at high strains when Au layer totally ruptures. The resultant sensor possesses wide detection range of up to ≈22%, great sensitivity (a gauge factor of 2658.9 within 16% strain, and 11026.7 with strain of 16–20%), quick response and relaxation time (≈180 ms/≈200 ms), and excellent durability (≈1000 stretching–releasing cycles). Various human epidermal signals can be recognized by the sensor, which demonstrate great potential applications in wearable healthcare monitors, electronic skins, and intelligent devices. [ABSTRACT FROM AUTHOR]

A 3D Co‐based metal–organic framework (Co‐MOF) with two kinds of large pores filled by free Co2+ ions and ligands was synthesized and characterized. To expand the MOF structure and conductivity, the free Co2+ ions and ligands were exchanged by conductive ionic liquid EtpyBr and photosensitive AgNO3 through single crystal‐to‐single crystal transformation, which produced structure‐changed 3D MOFs Co‐MOF‐Br and Co‐Ag‐MOF, which were characterized by single‐crystal X‐ray diffraction. Incorporating small quantities of doped polyaniline (PANI) with redox activity into the pores could further tune the stability and conductivity of the three MOFs. The PANI/MOFs all show outstanding electrical conductivity (≈10−2 S cm−1), and PANI/Co‐MOF‐Br has the largest p‐type Seebeck coefficient of 66.6 μV K−1. PANI/Co‐MOF‐Br and PANI/Co‐Ag‐MOF have 4 and 15 times higher photocurrent density compared with PANI/Co‐MOF, respectively. This work sheds light on the design of advanced electrically conductive 3D MOFs. [ABSTRACT FROM AUTHOR]

Transparent nonvolatile memory fabricated on flexible substrates is expected to meet the requirement of integrated flexible transparent circuits. Here, a simple route to prepare flexible transparent memristors is presented. Flexible transparent conducting Ag grids with low sheet resistance are self‐assembled on polyethylene terephthalate (PET) substrate, and the WO3 dielectric layer is selectively deposited on the Ag grids via a low‐cost cathodic electrodeposition method under ambient condition. Finally, the Au/WO3/Ag grids/PET device exhibits fair good optical transmittance in the visible region, low operating voltages, fast switching speed, and long retention time against electric and mechanical stimulus. Therefore, a universal approach is demonstrated for flexible transparent memristors application by combining Ag grids electrode with cathodic electrodeposition technology. [ABSTRACT FROM AUTHOR]

A series of thiazole-based inhibitors selectively targeting DNA-binding domain of the androgen receptor (AR) were synthesized and evaluated, and the SAR data were summarized. We identified a novel compound SKLB-C2807 that effectively inhibited the human prostate cancer cell line LNCaP/AR with the IC50 value of 0.38 μ m without significant antiproliferative effects on other cell lines PC-3 (AR-negative), SW620, MCF-7 (ER-positive), and L-O2 (non-cancerous). This compound also considerably decreased the expression of prostate-specific antigen. Its binding mode to the AR-DBD was studied. These efforts lay the foundation for developing the next generation of anti-androgens. [ABSTRACT FROM AUTHOR]

Nintedanib is a novel triple angiokinase inhibitor that inhibits three growth factors simultaneously. Deuterated derivatives of nintedanib at certain metabolically active sites were prepared and evaluated in vitro and in vivo. In particular, deuterated compound SKLB-C2202 had significantly improved pharmacokinetic properties compared with nintedanib. These efforts lay the foundation for further investigating the druggability of SKLB-C2202. [ABSTRACT FROM AUTHOR]

A highly effective and operationally simple method for the deuteration of phenols using NaOH as a catalyst and D2O as the deuterium source is presented. A high regioselectivity for the ortho and/or para hydrogens relative to the oxygen atom was achieved, as well as a high degree of deuterium incorporation. The method also has a high functional-group tolerance, and allowed the deuteration of complex pharmaceutically interesting substrates. [ABSTRACT FROM AUTHOR]

Highlights: [•] Isolation of two double bond reductase (DBR) genes from liverworts. [•] These two DBRs showed different substrate preference and catalytic efficiency. [•] A single amino acid enhances the catalytic efficiency of DBR2 versus DBR1. [ABSTRACT FROM AUTHOR]

Cutaneous dirt-adherent disease (CDAD) is a rare psychogenic dermatosis mainly occurring in young Japanese and Chinese women. It mainly occurs on cheeks, forehead, nipple, mammary areola and around mammary areola. To our knowledge, this is the first case of CDAD with the skin lesion of psoriasis rupioides to be reported. In our case, the patient, a 43-year-old Chinese man presented with thick, yellowish-brown adherent crusts on his face with severe painful 6-days duration. Histopathologic image: Parakeratosis, the epidermis demonstrates regular acanthosis with some thinning of the suprapapillary plates, neutrophils exocytosis are noted. As for the histopathologic diagnosis in his right crus, combined with the clinical manifestation of rupioides-shaped crusts, film phenomenon and Auspitz's sign, we considered Psoriasis rupioide., (© 2019 Wiley Periodicals, Inc.)