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The synthesis of open‐shell polycyclic hydrocarbons with large diradical characters is challenging because of their high reactivities. Herein, two diindeno‐fused corannulene regioisomers DIC‐1 and DIC‐2, curved fragments of fullerene C104, were synthesized that exhibit open‐shell singlet ground states. The incorporation of the curved and non‐alternant corannulene moiety within diradical systems leads to significant diradical characters as high as 0.98 for DIC‐1 and 0.89 for DIC‐2. Such high diradical characters can presumably be ascribed to the re‐aromatization of the corannulene π system. Although the DIC compounds have large diradical characters, they display excellent stability under ambient conditions. The half‐lives are 37 days for DIC‐1 and 6.6 days for DIC‐2 in solution. This work offers a new design strategy towards diradicaloids with large diradical characters yet maintain high stability. [ABSTRACT FROM AUTHOR]

The synthesis of open‐shell polycyclic hydrocarbons with large diradical characters is challenging because of their high reactivities. Herein, two diindeno‐fused corannulene regioisomers DIC‐1 and DIC‐2, curved fragments of fullerene C104, were synthesized that exhibit open‐shell singlet ground states. The incorporation of the curved and non‐alternant corannulene moiety within diradical systems leads to significant diradical characters as high as 0.98 for DIC‐1 and 0.89 for DIC‐2. Such high diradical characters can presumably be ascribed to the re‐aromatization of the corannulene π system. Although the DIC compounds have large diradical characters, they display excellent stability under ambient conditions. The half‐lives are 37 days for DIC‐1 and 6.6 days for DIC‐2 in solution. This work offers a new design strategy towards diradicaloids with large diradical characters yet maintain high stability. [ABSTRACT FROM AUTHOR]

Comprehensive Summary: Biogenic amines (BAs) are important biomarkers for monitoring food quality and assisting in the diagnosis of disease. Facial, portable, accurate and high‐throughput BAs detection is still challenging by the specific sensor compounds development or the complicated instrument operation. Deep learning (DL) algorithms are blooming for their superiority on the nonlinear and multidimensional data analysis, which endow the great advantage for the artificial intelligence assisted large sample analysis of the environmental or daily health monitoring. In this work, we developed a deep learning‐assisted visualized fluorometric array‐based sensing method. Two commercial fluorescent dyes were selected and combined into sensor arrays. Variation in the alkalinity of BAs causes significant and distinct fluorescence changes of the dyes. In conjunction with pattern recognition by the pretrained CNN models, the sensor array clearly differentiates seven BAs with 99.29% prediction accuracy and allows rapid single and multi‐component quantification with a volume fraction range from 200 cm3/m3 to 2500 cm3/m3. This method also provides a new way for meat freshness monitoring. We envision that this novel analytical method for BAs can be used as an alternative and promising tool for the detection of a wider variety of analytes. [ABSTRACT FROM AUTHOR]

A series of photoswitchable cyclopentadienone derivative dimers bearing bromo, thienyl, 4‐(dimethylamino)phenyl, 3‐pyridinyl, 4‐nitrophenyl and cyano groups was designed and facilely synthesized. Photoswitching properties such as the photoconversions in the photostationary state (PSS), the thermal kinetics and thermal half‐lives of photoisomers were systematically investigated. These photoswitches show high fatigue resistance and large photoconversions in the PSS. This work proves that the photoswitching properties of photoswitches based on cyclopentadienone dimers can be tuned by substitution groups and also pave the way to functionalize the cyclopentadienone derivative dimer‐based photoswitch, which is important for its future applications. [ABSTRACT FROM AUTHOR]

Abstract: A pair of interconvertible stereoisomers of imide‐fused corannulene derivatives was mixed with C60, which resulted in cocrystallization into a 1:1 segregated packing motif through concave–convex π–π interactions. Only one conformation was observed in the cocrystal owing to guest‐induced conformational switching. The 1D assemblies of the complex showed promising applications in organic electronics. [ABSTRACT FROM AUTHOR]

Abstract: Genetic risk factors could cause cutaneous adverse drug reactions (cADRs) in patients after treatment with clarithromycin. This study explored the association of HLA class I genes with clarithromycin‐cADRs in Han Chinese patients. A total of 12 clarithromycin‐cADR patients and 34 clarithromycin‐tolerant controls were recruited for the high‐resolution genotyping of HLA class I genes (HLA‐A, HLA‐B and HLA‐C). The population controls consisted of 283 Han Chinese retrieved from the MHC database for validated comparison. A molecular docking analysis of HLA‐A*02:07 protein and clarithromycin was conducted using glide module with Schrödinger Suite. Among all tested HLA alleles, the carrier frequencies of HLA‐A*02:07 (58% versus 5.9%, OR = 22.40, 95% CI = 3.58–139.98, p = 8.20 × 10E‐5, pc = 1.1 × 10E‐3) and HLA‐B*46:01 (50% versus 5.9%, OR = 16.00, 95% CI = 2.59–98.99, p = 0.002, pc = 0.03) were significantly higher in clarithromycin‐cADRs than in clarithromycin‐tolerant controls. However, when compared to population controls, only HLA‐A*02:07, and not HLA‐B*46:01, reached statistical significance (58% versus 15.5%, OR = 7.61, 95% CI = 2.31–25.04, p = 1.2 × 10E‐4, pc = 1.7 × 10E‐3). Furthermore, molecular docking data revealed that clarithromycin could bind to and interact with HLA‐A*02:07 in two possible binding situations. These data suggest that HLA‐A*02:07 might be a genetic risk factor for developing clarithromycin‐cADRs in Han Chinese and serve as a useful biomarker for personalized medicine to prevent clarithromycin‐cADRs. [ABSTRACT FROM AUTHOR]