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While the terrestrial base stations (TBSs) in the fifth‐generation (5G) network provide high throughput for the conventional terrestrial users (TUs), it is still challenging for the network to support massive TUs and unmanned aerial vehicles (UAVs) simultaneously due to the complicated air–ground channel and severe interference. In this paper, the deployment of a high‐altitude platform (HAP) as a supplement for the terrestrial networks, in which the HAP and TBSs serve TUs and UAVs simultaneously in a joint manner, is studied. The novel network has two challenges. First, the deployment of the HAP, which is a new degree of freedom, should be optimized considering the terrestrial network. Second, the channel of the joint HAP and TBS network that serves multiple TUs and UAVs concurrently is complicated, and the resource allocation of the network should be designed. To tackle the above two challenges, a joint resource allocation and HAP deployment problem are formulated, and a gradient‐and‐matching‐based algorithm is proposed to solve it efficiently. Simulation results show that the HAP and the proposed algorithm enhance the sum‐rate of the network by over 30%, and the average data rate of both the TUs and the UAVs can be effectively improved. [ABSTRACT FROM AUTHOR]

Nowadays, driving safety has become an important topic in the field of intelligent driving. The key step in the intelligent transportation system (ITS) is to detect and track the vehicles on the road through various sensors equipped on the vehicle. While putting the sensors aside the road can have benefits in the vehicle‐road collaborative scenario. In this paper, an efficient and applicable multi‐sensor fusion protocol for a vehicle‐road collaborative system is proposed where roadside units (RSUs) are equipped with cameras and radars. To fully use the history information and the multi‐source heterogeneous sensing data to improve the reliability of multi‐sensor fusion, a Bayesian‐based two‐layer fusion scheme is further proposed. Moreover, the efficiency and robustness of the proposed scheme are evaluated in a real highway environment in Changsha, China. [ABSTRACT FROM AUTHOR]

The electromagnetic situation, which can promote the abilities of understanding and decision‐making for the battlefield, has attracted significant interest recently in information‐based warfare. This paper investigates the deep learning‐based electromagnetic situation analysis and judgment in a complicated battlefield environment. To comprehensively simulate the two‐sided battling process, a turn‐based confrontation strategy is proposed, and an electromagnetic situation analysis and judgment model are then designed based on the AlphaGo Zero algorithm to achieve efficient situation analysis and decision‐making. In addition, an electromagnetic situation‐based attack‐defense platform is developed to realize and evaluate this designed model. Simulation results demonstrate that this designed model achieves significant performance in electromagnetic situation analysis and judgment compared with the Monte Carlo Tree Search based baseline. [ABSTRACT FROM AUTHOR]

With the explosive growth of data communications, existing infrastructure networks are under ever‐increasing pressure. Due to the advantages of fully controllable mobility, rapid deployment, and low cost, the unmanned aerial vehicles (UAVs) have attracted much attentions from both industry and academia in recent years, and it has become an inevitable trend to employ UAVs to enhance the network performance in different environments. As an important paradigm of UAV‐assisted communications, UAV relaying communications has been regarded as a promising solution in enhancing connectivity and improving transmission rate. This paper for the first time comprehensively summarizes UAV relaying communications and its application scenarios, including single UAV relaying networks, multi‐user UAV relaying networks, multi‐hop UAV relaying networks, as well as Internet of UAVs, and deeply analyzes the key technologies and challenges to be solved under this topic. Furthermore, the state‐of‐the‐art researches and opportunities of UAV relaying communications are discussed in detail. [ABSTRACT FROM AUTHOR]

The article discusses the research on the uranium-lead dating of cassiterite for geochronology of the mineralization process of Yangbin Porphyry tin deposits in Zhejiang, China. Topics include the relationship between granitic magmatism and tin mineralization, the potential for prospecting in the metallogenic belts in South China, and the use of laser ablation inductively coupled plasma mass spectrometry to analyse cassiterite.

Matrix proteins play key roles in shell formation in the pearl oyster, but little is known about how these proteins are regulated. Here, two POU domain family members, Pf- POU2F1 and Pf- POU3F4, were cloned and characterized. Functional domain analysis revealed that both them have conserved POUS and POUH domains; these domains are important for transcription factor function. The tissue distributions of Pf- POU2F1 and Pf- POU3F4 mRNAs in pearl oyster revealed different expression patterns, and the expression of Pf- POU3F4 m RNA was relatively high in the mantle. The promoters of the matrix protein genes Aspein and Prismalin-14 were cloned using genome-walking PCR. Relatively high transcriptional activities of these promoters were detected in HEK-293T cells. In transient co-transfection assays, Pf- POU3F4 greatly up-regulated the promoter activities of the Aspein and Prismalin-14 genes in a dose-dependent manner. Structural integrity of Pf- POU3F4 was essential for its activation function. One region of the Aspein gene promoter, −181 to −77 bp, and two binding sites in the Prismalin-14 gene promoter, −359 to −337 bp and −100 to −73 bp, were required for activation of Pf- POU3F4. An electrophoresis mobility shift assay demonstrated that Pf- POU3F4 directly bound these sites. Pf- POU3F4 knockdown led to a decrease in Aspein and Prismalin-14 gene expression. Furthermore, expression levels for the Pf- POU3F4 gene were similar to those of the Aspein and Prismalin-14 genes during five development stages. Taken together, these results suggest that the transcription factor Pf- POU3F4 regulates expression of the matrix protein genes Aspein and Prismalin-14 in pearl oyster. Database The nucleotide sequence data of Pf-POU2F1 is available in the GenBank databases under the accession number . The nucleotide sequence data of Pf-POU3F4 is available in the GenBank databases under the accession number . The nucleotide sequence data of Aspein gene promoter is available in the GenBank databases under the accession number . The nucleotide sequence data of Prismalin-14 gene promoter is available in the GenBank databases under the accession number . [ABSTRACT FROM AUTHOR]

Myocardial infarction (MI), which is characterized by chamber dilation and LV dysfunction, is associated with substantially higher mortality. We investigated the effects and underlying mechanisms of Luteolin on post-infarction cardiac dysfunction. Myocardial infarction was constructed by left anterior descending coronary artery ligation. In vitro, cultured neonatal cardiomyocytes subjected to simulated MI were used to probe mechanism. Luteolin significantly improved cardiac function, decreased cardiac enzyme and inflammatory cytokines release after MI. Enhanced autophagic flux as indicated by more autophagosomes puncta, less accumulation of aggresomes and P62 in the neonatal cardiomyocytes after hypoxia was observed in the Luteolin pre-treatment group. Western blot analysis also demonstrated that Luteolin up-regulated autophagy in the cardiomyocytes subjected to simulated MI injury. Furthermore, Luteolin increased mitochondrial membrane potential, adenosine triphosphate content, citrate synthase activity and complexes I/II/III/IV/V activities in the cardiomyocytes subjected to simulated MI injury. Interestingly, mammalian sterile 20-like kinase 1 (Mst1) knockout abolished the protective effects of Luteolin administration. Luteolin enhances cardiac function, reduces cardiac enzyme and inflammatory markers release after MI. The protective effects of Luteolin are associated with up-regulation of autophagy and improvement of mitochondrial biogenesis through Mst1 inhibition. [ABSTRACT FROM AUTHOR]

The insulin-PI3K-m TOR pathway exhibits a variety of cardiovascular activities including protection against I/R injury. Lin28a enhanced glucose uptake and insulin-sensitivity via insulin-PI3K-m TOR signalling pathway. However, the role of lin28a on experimental cardiac I/R injury in diabetic mice are not well understood. Diabetic mice underwent 30 min. of ischaemia followed by 3 hrs of reperfusion. Animals were randomized to be treated with lentivirus carrying lin28a si RNA (siLin28a) or lin28a c DNA (Lin28a) 72 hrs before coronary artery ligation. Myocardial infarct size ( IS), cardiac function, cardiomyocyte apoptosis and mitochondria morphology in diabetic mice who underwent cardiac I/R injury were compared between groups. The target proteins of lin28a were examined by western blot analysis. Lin28a overexpression significantly reduced myocardial IS, improved LV ejection fraction ( LVEF), decreased myocardial apoptotic index and alleviated mitochondria cristae destruction in diabetic mice underwent cardiac I/R injury. Lin28a knockdown exacerbated cardiac I/R injury as demonstrated by increased IS, decreased LVEF, increased apoptotic index and aggravated mitochondria cristae destruction. Interestingly, pre-treatment with rapamycin abolished the beneficial effects of lin28a overexpression. Lin28a overexpression increased, while Lin28a knockdown decreased the expression of IGF1R, p-Akt, p-m TOR and p-p70s6k after cardiac I/R injury in diabetic mice. Rapamycin pre-treatment abolished the effects of increased p-m TOR and p-p70s6k expression exerted by lin28a overexpression. This study indicates that lin28a overexpression reduces IS, improves cardiac function, decreases cardiomyocyte apoptosis index and alleviates cardiomyocyte mitochondria impairment after cardiac I/R injury in diabetic mice. The mechanism responsible for the effects of lin28a is associated with the insulin-PI3K-m TOR dependent pathway. [ABSTRACT FROM AUTHOR]

Abstract: Calmodulin (CaM) plays a very important role in many physiological processes and is highly conserved in different species. In a previous study, we successfully cloned CaM and a novel calmodulin-like protein (CaLP) with an extra C-terminal sequence from the pearl oyster Pinctada fucata and then expressed in Escherichia coli. In this research, we used fluorescence confocal microscopy to analyze the protein–protein interaction between CaM/CaLP and p21Cip1, which is cloned from mammalian cells, to show the different characteristics of these two proteins in vivo. The fluorescence confocal microscopy showed that the C-terminal globular domain together with the extra tail of CaLP is very important in CaLP''s sequestration in cytoplasm. The most interesting phenomenon is that transfection of p21Cip1 can stimulate translocation of CaLP from the cytoplasm to the nucleus, but this is not the case for CaM. Fluorescence confocal microscopy and co-immunoprecipitation on different mutants of CaLP with p21Cip1 indicated that the C-terminal globular domain of CaLP is responsible for the trafficking of CaLP from cytoplasm to nucleus. [Copyright &y& Elsevier]

The article focuses on a research paper evaluating the redox state of the granitic rocks in the Xintianling Deposit in Nanling Range, South China. Topics discussed include the formation of the Scheelite Skarn in Xintianling Deposit, petrogenesis of the granitic rocks. It also suggests that lead isotopes indicated the origin of skarn ore bodies from crustal materials and sulfur of the ores from magmatic and sedimentary sulfur.

The article discusses a study that was conducted to determine whether the composition of apatite, a phosphate minerals in granitic rock associated with ore deposit can represent the petrogenesis and mineralization types to indicate the metallogeny and tectonic evolution in southeast Hunan province, China. Topics discussed include chlorine and fluorine content of apatites, role of hydrothermal recycling in providing sufficient chlorine and europium and cerium anomaly of the apatite.

The article offers information on boron isotopic and chemical composition of Tourmaline in Baotan Tin Deposit, Northern Guangxi, South China. Topics discussed include Tourmaline as a common deposit in hydrothermal ore deposits, four types of tourmaline such as tourmaline nodules in granite (NT type), pre-ore quartz-tourmaline veins (PT type) and cassiterite quartz-tourmaline veins (CT type), and electron microprobe analyses of four types of tourmaline.

The article discusses geochronological framework of penggongmiao granite batholith in China. Topics discussed include division of Pengongmiao granite batholith into four intrusion phases including early stage granite, the main stage granite and additional stage of granite dikes, zircons containing uranium and thorium-rich mineral inclusions, and development of the magma with higher degree of differentiation.

The insulin-PI3K-mTOR pathway exhibits a variety of cardiovascular activities including protection against I/R injury. Lin28a enhanced glucose uptake and insulin-sensitivity via insulin-PI3K-mTOR signalling pathway. However, the role of lin28a on experimental cardiac I/R injury in diabetic mice are not well understood. Diabetic mice underwent 30 min. of ischaemia followed by 3 hrs of reperfusion. Animals were randomized to be treated with lentivirus carrying lin28a siRNA (siLin28a) or lin28a cDNA (Lin28a) 72 hrs before coronary artery ligation. Myocardial infarct size (IS), cardiac function, cardiomyocyte apoptosis and mitochondria morphology in diabetic mice who underwent cardiac I/R injury were compared between groups. The target proteins of lin28a were examined by western blot analysis. Lin28a overexpression significantly reduced myocardial IS, improved LV ejection fraction (LVEF), decreased myocardial apoptotic index and alleviated mitochondria cristae destruction in diabetic mice underwent cardiac I/R injury. Lin28a knockdown exacerbated cardiac I/R injury as demonstrated by increased IS, decreased LVEF, increased apoptotic index and aggravated mitochondria cristae destruction. Interestingly, pre-treatment with rapamycin abolished the beneficial effects of lin28a overexpression. Lin28a overexpression increased, while Lin28a knockdown decreased the expression of IGF1R, p-Akt, p-mTOR and p-p70s6k after cardiac I/R injury in diabetic mice. Rapamycin pre-treatment abolished the effects of increased p-mTOR and p-p70s6k expression exerted by lin28a overexpression. This study indicates that lin28a overexpression reduces IS, improves cardiac function, decreases cardiomyocyte apoptosis index and alleviates cardiomyocyte mitochondria impairment after cardiac I/R injury in diabetic mice. The mechanism responsible for the effects of lin28a is associated with the insulin-PI3K-mTOR dependent pathway., (© 2015 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.)