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The Earth's ionosphere undergoes regular intra‐annual variations (IAVs) characterized by two peaks and troughs around the equinoxes and solstices. This phenomenon is crucial for analyzing the ionospheric response to geomagnetic storms. This study presents a comprehensive analysis of the IAVs contributed by diurnal and semidiurnal migrating tides (DW1 and SW2) using Global Ionospheric Maps (GIMs) data from 2017 to 2021. Through data stacking techniques, the seasonal variability and splitting phenomenon of DW1 and SW2 across different latitudes are examined. The findings indicate that the splitting of these tides can be attributed to their quasi‐periodic variations, predominantly composed of annual oscillation (AO) and semiannual oscillation (SAO). The combination of DW1, SW2, and their side‐band harmonics results in beats with annual and semiannual periodicities, enabling the restoration of the seasonal variations in DW1 and SW2. The ionospheric day‐to‐day variations were reconstructed by superimposing DW1 and SW2, and their IAVs were evaluated using the envelope method. Comparison with IAVs driven by Earth's orbital geometry reveals that tide‐driven IAVs are more significant, and both exhibit solar activity dependence. The results advance the understanding of ionospheric variability, emphasizing the critical role of tidal contributions. Plain Language Summary: The ionosphere, an essential layer of Earth's atmosphere, significantly impacts high‐frequency communication and global satellite navigation systems. It exhibits seasonal variations, characterized by peaks during equinoxes and troughs around solstices. While the underlying physics of these variations still requires further exploration, this study uses global ionosphere maps from 2017 to 2021 to investigate the intra‐annual variations (IAVs) attributed to ionospheric migrating tides. Our findings reveal the "splitting" behavior of DW1 and SW2, where these waves separate into multiple frequency components due to their quasi‐periodic nature. This splitting phenomenon primarily arises from the annual and semiannual variations in the amplitudes of DW1 and SW2, enabling the reconstruction of ionospheric day‐to‐day variations. Interestingly, the IAVs driven by the migrating tides have a more significant impact on seasonal changes than the direct effects of Earth's orbit. The atmospheric tides in the lower atmosphere may influence the composition of the upper atmosphere, subsequently affecting the ionosphere. Overall, this research highlights the intricate interplay of mechanisms shaping the seasonal patterns of the ionosphere. Key Points: Under high‐frequency resolution spectra, the ionospheric diurnal and semidiurnal migrating tides will splitIonospheric intra‐annual variations (IAVs) can be reconstructed by combining migrating tides and their side‐band harmonicsThe IAVs in the ionospheric day‐to‐day variations are more significant than those induced by the geometry of Earth's orbit [ABSTRACT FROM AUTHOR]

Background: Pneumonia has a high incidence in traumatic brain injury (TBI) patients and lacks effective treatments. Early mobilization (EM) may be a potentially effective treatment. Aim: To explore the impact of EM on TBI‐related pneumonia in the neurosurgical intensive care unit (NICU). Study Design: This study was a historical control study. 100 TBI patients who received EM intervention were prospectively included as the experimental group (EM cohort), and 250 TBI patients were retrospectively included as the control group. The propensity score matching (PSM) method was employed to balance baseline and minimize potential bias. The relationship between EM and TBI‐related pneumonia was investigated by univariate and multivariate logistic regression, then further determined by subgroup analysis. The influence of other variables was excluded by interaction analyses. Finally, the effect of EM on the prognosis of TBI patients was analysed by comparing the Glasgow Coma Scale (GCS) and the hospital stay. Results: After screening, 86 patients were included in the EM cohort and 199 patients were included in the control cohort. There were obvious differences between the two cohorts at baseline, and these differences were eliminated after PSM, when the incidence of pneumonia was significantly lower in the EM cohort than in the control cohort (35.0% vs. 61.9%, p <.001). Multivariate logistic regression showed that EM was an independent risk factor for TBI‐related pneumonia and was significantly associated with a decreased incidence of pneumonia. This correlation was present in most subgroups and was not affected by other variables (p for interaction >.05). Patients in the EM cohort had shorter length of ICU stay (6 vs. 7 days, p =.017) and higher GCS at discharge (12 vs. 11, p =.010). Conclusion: EM is a safe and effective treatment for TBI patients in NICU, which can reduce the incidence of pneumonia, help to improve prognosis and shorten the length of ICU stay. Relevance to Clinical Practice: Although the utilization rate of EM is low in TBI patients for various reasons, EM is still an effective method to prevent complications. Our study confirms that a scientific and detailed EM strategy can effectively reduce the incidence of pneumonia while ensuring the safety of TBI patients, which is worthy of further research and clinical application. [ABSTRACT FROM AUTHOR]

The presence of a high density of defects at the perovskite/electron transport layer (ETL) interface results in significant nonradiative recombination losses, thus impeding the efficiency enhancement of perovskite/silicon tandem solar cells (TSCs). In this investigation, a metallocene‐based molecule, cobalt (III) dichlorophene hexafluorophosphate (CcPF6), is employed for perovskite surface passivation. To maximize its efficacy, the molecule is dissolved in a mixed solvent of acetonitrile and chlorobenzene, leading to the reconstruction of the perovskite surface and effective passivation of surface defects. This modification strategy substantially enhances the overall efficiency of perovskite/silicon tandem solar cells by mitigating the issue of low fill factor resulting from non‐uniform coating of the top perovskite layer on the textured silicon bottom cell. Leveraging a double‐sided textured silicon heterojunction (HJT) bottom cell, a certified power conversion efficiency (PCE) of 30.43% for a monolithic perovskite/silicon TSC (1.00 cm2) is achieved, featuring an open‐circuit voltage (Voc) of 1.93 V and a fill factor (FF) of 78.43%. After storage in the drying cabinet (5% humidity at 20 °C) for 1000 h, the device retains 94.27% of its initial performance. [ABSTRACT FROM AUTHOR]

Aiming at the rich bifurcation and chaotic characteristics in the inverter with proportion integral derivative (PID) controller, the discrete iterative model of such an inverter was derived based on the stroboscopic mapping theory; the nonlinear evolution and the cause of instability in this inverter are analyzed. It was observed that the low‐frequency oscillation following instability was due to the Hopf bifurcation, which will decrease the power supplied quality by the inverter. To address the potential issue of the system instability caused by nonlinear behaviors, an improved exponential time‐delay feedback control scheme was proposed. The controlled object's output current first subtracted its own delay a period of time to form a difference term, which was subsequently fed into an exponential link to make difference with the constant 1. The resulting value was then fed into a proportional link to obtain the control term, which was applied to the PID controlled inverter in a feedback manner. Moreover, the range of the feedback proportional coefficient was solved via the Jury criterion. Finally, the effectiveness of this scheme was verified through the comparative simulations, demonstrating that this scheme can not only increase the stability domain for each parameter by more than 50% in the PID controlled inverter but also stabilize the quasi‐periodic behavior due to the low scale oscillation caused by the Hopf bifurcation at the switching frequency. [ABSTRACT FROM AUTHOR]

Treponema pallidum is the causative factor of syphilis, a sexually transmitted disease (STD) characterized by perivascular infiltration of inflammatory cells, vascular leakage, swelling and proliferation of endothelial cells (ECs). The endothelium lining blood and lymphatic vessels is a key barrier separating body fluids from host tissues and is a major target of T. pallidum. In this review, we focus on how T. pallidum establish intimate interactions with ECs, triggering endothelial dysfunction such as endothelial inflammation, abnormal repairment and damage of ECs. In addition, we summarize that migration and invasion of T. pallidum across vascular ECs may occur through two pathways. These two mechanisms of transendothelial migration are paracellular and cholesterol‐dependent, respectively. Herein, clarifying the relationship between T. pallidum and endothelial dysfunction is of great significance to provide novel strategies for diagnosis and prevention of syphilis, and has a great potential prospect of clinical application. [ABSTRACT FROM AUTHOR]

The paper is concerned with the region tracking control problem of multiple nonholonomic mobile robot systems with collision avoidance. The peculiar characteristic of the proposed scheme is that a class of potential energy functions is chosen to form the desired target region constraining the robots for aggregation, and some local potential energy functions are selected to maintain collision avoidance among robots. Such that each mobile robot only needs to interact with their neighbors to realize the region tracking control task. Moreover, this paper provides a new analytical framework of region tracking control for a network of wheeled mobile robots, in which the integration of the system decomposition and sliding mode control method enables to convert the nonholonomic constraint problem of the controlled mobile robot system into a holonomic constraint problem. This provides a new approach to solving the mobile robot control problem. Theoretical analysis and numerical simulation results are given to validate the effectiveness of the proposed control scheme. [ABSTRACT FROM AUTHOR]

It is significant to modulate the bandgap of crystalline silicon (c‐Si) by applying large strains on it through controlled stretch. However, investigations on the stretchability of c‐Si are still insufficient, especially for samples with feature sizes in the submicron to micron scale. In this work, the large stretchability of silicon wires with submicron to micron diameters (SiMWs) is reported for the first time by using vapor–liquid–solid grown ultralong SiMWs. The diameters of the SiMW specimens range from 400 nm to 1.8 μm. The loading speed for stretching SiMWs is 100 nm s−1. It is found that the SiMWs with micron diameter have a stretch limit over 10%, while the stretch limit for samples with submicron diameter can reach 12%. The results fill the gaps in the knowledge of micron‐scale silicon materials' stretchability. The average Young's modulus of SiMWs is measured as 115 GPa. Cyclic loading tests indicate that the tensile deformation of SiMWs is elastic and reversible with no plastic deformation observed. In this work, it is shown that large stretch of SiMWs can be achieved without the need of harsh experimental conditions, which will greatly facilitate the study of large strain engineering on c‐Si to modulate their properties and broaden their applications. [ABSTRACT FROM AUTHOR]

Quantitative understanding of the land water loading is a prerequisite to the construction of reliable tectonic deformation velocity field in the Tibetan Plateau (TP). Here, for the first time, we image the three‐dimensional crustal loading deformation velocity field of each land water component in the TP. Our results reveal that the loading signal strength of the six land water components ranks from largest to smallest as groundwater, glacier, lake, soil water, permafrost, and snow, with the maximum vertical velocity close to ±1.60 mm/yr and the maximum horizontal velocity exceeding 0.40 mm/yr. All land water components can achieve a strong enough vertical loading velocity exceeding the present‐day Global Positioning System (GPS) velocity at some sites. But for horizontal loading, apparent impacts are only from glacier, lake and groundwater, however, are very limited, with the absolute ratio of loading velocity to GPS velocity being smaller than 5% at almost all the sites. Plain Language Summary: The crustal kinematic characteristics and uplift mechanism of the Tibetan Plateau (TP) have been widely studied based on the three‐dimensional deformation velocity field from Global Positioning System (GPS) measurements. However, except for tectonic signal, the land water loading effect is also involved in GPS observation and may lead to the biased tectonic interpretation of GPS deformation velocity field. In this study, we construct a set of three‐dimensional crustal loading deformation velocity fields for the TP based on the state‐of‐the‐art multi‐component land water mass change fields constrained by multi‐source data spanning ∼20 years. Results reveal that the loading signal strength of the six land water components ranks from largest to smallest as groundwater, glacier, lake, soil water, permafrost, and snow. We find that all land water components can achieve a strong enough vertical loading velocity exceeding the present‐day GPS vertical velocity at some sites, but show very limited horizontal loading. Our results could provide loading correction reference for the construction of high‐accuracy TP tectonic deformation velocity field. Key Points: We image the three‐dimensional crustal deformation velocity fields of the Tibetan Plateau due to multi‐component land water loadingEvident loading is from groundwater, glacier, and lake, with the maximum vertical and horizontal velocities exceeding ±1.0 mm/yr and 0.2 mm/yr, respectivelyAll land water components can achieve a vertical loading velocity exceeding the Global Positioning System velocity at some sites, but show very limited horizontal loading [ABSTRACT FROM AUTHOR]

Enhancing sensitivity to sorafenib can significantly extend the duration of resistance to it, offering substantial benefits for treating patients with hepatocellular carcinoma (HCC). However, the role of ferroptosis in influencing sorafenib sensitivity within HCC remains pivotal. The enhancer of zeste homolog 2 (EZH2) plays a significant role in promoting malignant progression in HCC, yet the relationship between ferroptosis, sorafenib sensitivity, and EZH2 is not entirely clear. Bioinformatic analysis indicates elevated EZH2 expression in HCC, predicting an unfavorable prognosis. Overexpressing EZH2 can drive HCC cell proliferation while simultaneously reducing ferroptosis. Further analysis reveals that EZH2 amplifies the modification of H3K27 me3, thereby influencing TFR2 expression. This results in decreased RNA polymerase II binding within the TFR2 promoter region, leading to reduced TFR2 expression. Knocking down EZH2 amplifies sorafenib sensitivity in HCC cells. In sorafenib‐resistant HepG2(HepG2‐SR) cells, the expression of EZH2 is increased. Moreover, combining tazemetostat—an EZH2 inhibitor—with sorafenib demonstrates significant synergistic ferroptosis‐promoting effects in HepG2‐SR cells. In conclusion, our study illustrates how EZH2 epigenetically regulates TFR2 expression through H3K27 me3, thereby suppressing ferroptosis. The combination of the tazemetostat with sorafenib exhibits superior synergistic effects in anticancer therapy and sensitizes the HepG2‐SR cells to sorafenib, shedding new light on delaying and ameliorating sorafenib resistance. [ABSTRACT FROM AUTHOR]

Medium‐scale traveling ionospheric disturbances (MSTIDs) can significantly alter a region's ionosphere features, severely impacting the performance and stability of services such as shortwave communication and navigation positioning. By utilizing the total electron content (TEC) data from BeiDou geostationary satellites for 2022–2023, this study investigated the characteristics of MSTIDs over Hong Kong concerning local time and seasons. A total of 622 MSTID events were observed, classified into three types: daytime (10:00–17:00 LT), twilight (17:00–22:00 LT), and nighttime (22:00–02:00 LT). The occurrence rates and excitation mechanisms of the three types of MSTIDs were analyzed. Daytime and twilight MSTIDs had higher occurrence rates during winter, while nighttime MSTIDs had higher occurrence rates in summer and were even absent during winter. Overall, daytime MSTIDs were the most common, followed by twilight MSTIDs, while nighttime MSTIDs were less frequent. The propagation directions of MSTIDs exhibited anisotropy but showed some clustering patterns. Daytime MSTIDs exhibited high directional diversity during summer, but more concentrated in winter. Nighttime MSTIDs, on the other hand, were more focused during summer. It is worth noting that twilight MSTIDs exhibit similar climatological characteristics to daytime MSTIDs, which have not been observed in previous studies. It is suggested that daytime MSTIDs in the Hong Kong region are likely primarily generated by atmospheric gravity waves (AGWs) from low‐latitude regions, while nighttime MSTIDs are likely caused by Perkins instability. Twilight MSTIDs may originate from AGWs at the solar terminator, as well as daytime MSTIDs propagated from mid‐latitude areas. Key Points: MSTIDs during daytime, twilight, and nighttime over Hong Kong are statistically analyzed for the first time using BeiDou GEO satellitesThe occurrence of MSTIDs shows significant seasonality and local time dependence, with propagation directions exhibiting anisotropyTwilight MSTIDs display propagation characteristics similar to daytime MSTIDs, possibly related to AWGs generated at the solar terminator [ABSTRACT FROM AUTHOR]

Background: Acute lymphoblastic leukemia (ALL) is the most common cancer in children. IKZF3 (IKAROS family zinc finger 3) is a hematopoietic‐specific transcription factor, and it has been validated that it is involved in leukemia. However, the role of IKZF3 single‐nucleotide polymorphisms (SNPs) remains unclear. In this case–control study, the authors investigated the association of IKZF3 SNPs with ALL in children. Methods: Six IKZF3 reference SNPs (rs9635726, rs2060941, rs907092, rs12946510, rs1453559, and rs62066988) were genotyped in 692 patients who had ALL (cases) and in 926 controls. The associations between IKZF3 polymorphisms and ALL risk were determined using odds ratios (ORs) and 95% confidence intervals (CIs). The associations of rs9635726 and rs2060941 with the risk of ALL were further estimated by using false‐positive report probability (FPRP) analysis. Functional analysis in silico was performed to evaluate the probability that rs9635726 and rs2060941 might influence the regulation of IKZF3. Results: The authors observed that rs9635726C>T (adjusted OR, 1.49; 95% CI, 1.06–2.11; p =.023) and rs2060941G>T (adjusted OR, 1.51; 95% CI, 1.24–1.84; p =.001) were related to and increased risk of ALL in the recessive and dominant models, respectively. Furthermore, the associations of both rs9635726 (FPRP =.177) and rs2060941 (FPRP <.001) with ALL were noteworthy in the FPRP analysis. Functional analysis indicated that rs9635726 and rs2060941 might repress the transcription of IKZF3 by disrupting its binding to MLLT1, TAF1, POLR2A, and/or RAD21. Conclusions: This study revealed that IKZF3 polymorphisms were associated with increased ALL susceptibility in children and might influence the expression of IKZF3 by disrupting its binding to MLLT1, TAF1, POLR2A, and/or RAD21. IKZF3 polymorphisms were suggested as a biomarker for childhood ALL. [ABSTRACT FROM AUTHOR]

Aim: To explore the mediating role of psychological capital between authentic leadership and innovative behaviour among Chinese nurses. Design: A cross‐sectional study. Methods: In December 2021, online surveys were delivered among nurses from 37 hospitals in Anhui Province by convenience sampling approach. The data was collected using the Chinese version of the Authentic Leadership Questionnaire, Nurse Psychological Capital Questionnaire and Nurse Innovative Behaviour Scale. The structural equation model and bootstrap test examined the mediating role of psychological capital between authentic leadership and innovative behaviour. Results: 3495 Chinese nurses from 37 Anhui Province hospitals participated in this study. The mean item score of authentic leadership was 3.25 (SD 0.83), psychological capital was 4.85 (SD 0.89), and innovative behaviour was 2.82 (SD 0.84). Authentic leadership perceived by nurses, psychological capital, and innovative behaviour were statistically significant and positively correlated with each other (r = 0.524 ~ 0.806, p < 0.01). Psychological capital significantly mediated the association between authentic leadership and innovative behaviour (β = 0.449, p < 0.001), and its mediating effect accounted for 76.75% of the total effect. Conclusion: Results suggest the importance of developing nurse managers' authentic leadership to foster nurses' psychological capital and innovation behaviour. [ABSTRACT FROM AUTHOR]

The main objective of this paper is to advance the concept of region reaching control for a single robot to the study of region reaching consistency for uncertain fully‐actuated multi‐robot systems formulated by Lagrange dynamics. By introducing a directed network communication topology and utilizing the pinning‐like control methods, a distributed region reaching consensus control strategy is proposed. The desired region shape can be specified by selecting an appropriate potential objective function. A feature of the developed region reaching consensus algorithm is fully distributed, which is also an important generalization of pinning‐like set point tracking scheme based on the typical proportion‐integration‐differentiation control scheme. More importantly, the scope of consistency in this paper can be explicitly defined, which is different from traditional consistency control algorithms. Subsequently, numerical examples are presented to illustrate the performance of the designed controllers. [ABSTRACT FROM AUTHOR]

Wide‐bandgap metal compound‐based dopant‐free passivating contacts have been explored to fabricate crystalline silicon (Si) solar cells to mitigate the high carrier recombination rate of metal‐Si contact directly. Here, an over 4‐nm‐thick single‐layer strontium fluoride (SrFx) and a double‐layer SrFx/lithium fluoride (LiF) films deposited by a facile vacuum thermal evaporation are developed to act as high‐performance electron‐selective contacts. SrFx with ultra‐low work function (2.8 eV) induces a strong downward band bending at the n‐type Si (n‐Si)/SrFx interface, and a dipole active layer exists at the SrFx/aluminum (Al) interface, enabling a low contact resistivity (ρc) of 34.1 mΩ cm2 and thus yielding an impressive fill factor (FF) of 82.8%. Eventually, a power conversion efficiency (PCE) of 20.1% is achieved in the SrFx‐based solar cell. Moreover, in the n‐Si/SrFx/LiF/Al contact, the diffusion of Li in the SrFx film favors facilitating electron transport as well as relaxing its thickness restriction, inhibiting carrier recombination. And an impressive FF of 83.7% with a low ρc of 25.9 mΩ cm2, an improved open‐circuit voltage of 631 mV, and a short‐circuit current density of 39.9 mA/cm2 are attained, resulting in a champion PCE of 21.1%. Double‐layer SrFx/LiF deposited by a simple process provides a grand opportunity to fabricate low‐cost and high‐PCE photovoltaic devices. [ABSTRACT FROM AUTHOR]

Controlling a robot manipulator system with both uncertain kinematics and dynamics is a challenging problem since the traditional control schemes that relying on the robot system models are no longer applicable. Developing a neural network‐based adaptive tracking control for such uncertain robot manipulator systems with region constraints is especially changing. In this paper, region tracking controllers are designed for a robot manipulator systems with uncertain kinematics and dynamics. The developed region tracking controllers ensures that the uncertain robot manipulator can track a moving region other than the traditional fixed point, which has better redundancy characteristics. The results are obtained through the development of the sliding‐mode and a novel proportion‐integration‐differentiation (PID)‐like method to address the region tracking control problem. Numerical simulations are presented to verify the proposed controller's performance. [ABSTRACT FROM AUTHOR]

ATPase family AAA domain‐containing protein 1 (ATAD1) maintains mitochondrial homeostasis by removing mislocalized tail‐anchored (TA) proteins from the mitochondrial outer membrane (MOM). Hepatitis C virus (HCV) infection induces mitochondrial fragmentation, and viral NS5B protein is a TA protein. Here, we investigate whether ATAD1 plays a role in regulating HCV infection. We find that HCV infection has no effect on ATAD1 expression, but knockout of ATAD1 significantly enhances HCV infection; this enhancement is suppressed by ATAD1 complementation. NS5B partially localizes to mitochondria, dependent on its transmembrane domain (TMD), and induces mitochondrial fragmentation, which is further enhanced by ATAD1 knockout. ATAD1 interacts with NS5B, dependent on its three internal domains (TMD, pore‐loop 1, and pore‐loop 2), and induces the proteasomal degradation of NS5B. In addition, we provide evidence that ATAD1 augments the antiviral function of MAVS upon HCV infection. Taken together, we show that the mitochondrial quality control exerted by ATAD1 can be extended to a novel antiviral function through the extraction of the viral TA‐protein NS5B from the mitochondrial outer membrane. Synopsis: ATAD1 removes the HCV tail‐anchored protein NS5B from mitochondria and mediates its proteasomal degradation, revealing an antiviral function associated with mitochondrial quality control. ATAD1 exhibits a novel antiviral function beyond its established function in mitochondrial quality control.ATAD1 negatively regulates HCV infection by removing the mislocalized viral NS5B protein from the mitochondria and mediating its proteasomal degradation.ATAD1 augments the antiviral function of MAVS upon HCV infection. [ABSTRACT FROM AUTHOR]

Background: Pesticides are irreplaceable inputs for protecting crops from pests and improving crop yield and quality. Self‐assembly nanotechnology is a promising strategy by which to develop novel nano‐formulations for pesticides. Nano‐formulations improve the effective utilization of pesticides and reduce risks to the environment because of their eco‐friendly preparation, high drug loading, and desirable physicochemical properties. Here, to enhance the utilization efficiency of myclobutanil (MYC) and develop a novel nano‐formulation, carrier‐free co‐assembled nanoparticles (MT NPs) based on MYC and tannic acid (TA) were prepared by noncovalent molecular interactions using a green preparation process without any additives. Results: The results showed that the prepared spherical nanoparticles had good stability in neutral and acidic aqueous solutions, low surface tension (40.53 mN m−1), high rainfastness, and good maximum retention values on plant leaves. Release of active ingredients from MT NPs could be regulated by altering the molar ratio of subassemblies in the co‐assembly and the pH of the environment. Antifungal experiments demonstrated that MT NPs had better activities against Alternaria alternata and Fusarium graminearum [half‐maximal effective concentration (EC50) = 6.40 and 77.08 mg/L] compared with free MYC (EC50 = 11.46 and 124.82 mg/L), TA (EC50 = 251.19 and 503.81 mg/L), and an MYC + TA mixture (EC50 = 9.62 and 136.21 mg/L). These results suggested that MYC and TA incorporated in the co‐assembled nanoparticles had a synergistic antifungal activity. The results of a genotoxicity assessment indicated that MT NPs could reduce the genotoxicity of MYC to plant cells. Conclusion: Co‐assembled MT NPs with synergistic antifungal activity have outstanding potential for the management of plant diseases. © 2023 Society of Chemical Industry. [ABSTRACT FROM AUTHOR]

With the surging demand for ultra‐high‐resolution displays, the International Telecommunication Union (ITU) announce the next‐generation color gamut standard, named ITU‐R Recommendation BT.2020, which not only sets a seductive but challenging milestone for display technologies but also urges researchers to recognize the importance of color coordinates. Organic light‐emitting diodes (OLEDs) are an important display technology in current daily life, but they face challenges in approaching the BT.2020 standard. Thermally activated delayed fluorescence (TADF) emitters have bright prospects in OLEDs because they possess 100% theoretical exciton utilization. Thus, the development of TADF emitters emitting primary red (R), green (R), and blue (B) emission is of great significance. Here, a comprehensive overview of the latest advancements in TADF emitters that exhibit Commission Internationale de l'Éclairage (CIE) coordinates surpassing the National Television System Committee (NTSC) and approaching BT.2020 standards is presented. Rational strategies for molecular designs, as well as the resulting photophysical properties and OLED performances, are discussed to elucidate the underlying mechanisms for shifting the CIE coordinates of both donor‐acceptor and multiple resonance (MR) typed TADF emitters toward the BT.2020 standard. Finally, the challenges in realization of the wide‐color‐gamut BT.2020 standard and the prospects for this research area are provided. [ABSTRACT FROM AUTHOR]

The accuracy of ionospheric models estimated by ground‐based multiple global navigation satellite system ionospheric data over regions with sparse tracking stations is not ideal. To improve the accuracy of the estimated ionospheric model, different types of ionospheric data with different combinations were employed for previous studies. However, the ionospheric observational ranges for different types of ionospheric data are not the same. In this study, the accuracy of ionospheric maps generated by ground‐based ionospheric data (ground‐based strategy) and ground‐based ionospheric data combined with data provided by other geodetic measurements normalized by the single‐layer normalization method (multi‐source strategy) were studied. The results showed that the main differences between the ionospheric models estimated by the two strategies occur for data taken over the ocean, which mainly range from −1 to 0 total electron content unit (TECU). When assessed using Jason‐3 vertical total electron content data, the mean root mean square (RMS) value of the ionospheric model estimated by the multi‐source strategy was 5.03 TECU, which is approximately 15% smaller than that estimated by the ground‐based strategy. The maximum reduction in results using the multisource strategy was approximately 25% over different latitudes compared with that of the ground‐based strategy. Furthermore, the self‐consistency evaluation method was employed for evaluation. The results showed that the RMS of the ionospheric model estimated by the multi‐source strategy was 2.41 TECU, which is 3.60% better than that of the ground‐based strategy. The maximum reduction was 15% on different days. Key Points: The single‐layer normalization method is employed to make multi‐source data have the same observational range compared with those of ground‐based global navigation satellite system dataThe distribution of multi‐source data has better coverage, especially over the oceanic regionThe main differences between the ionospheric models estimated by the ground‐based strategy and the multi‐source strategy occur over the ocean [ABSTRACT FROM AUTHOR]

Aim: This study aimed to characterize the pathological types, diagnosis, chromosomal abnormalities, and postnatal clinical manifestations of right and double aortic arch malformations in fetuses. Methods: In this retrospective study, all fetuses diagnosed with right or double aortic arch anomalies for whom conventional two‐dimensional echocardiography combined with spatio‐temporal image correlation was performed at our tertiary referral center between December 2012 and December 2021 were included. Results: In total, 234 fetuses with aortic arch abnormalities were identified. Forty‐one cases lost to follow‐up. One hundred ninety‐three cases were included in this study. One hundred eighty‐seven cases with right aortic arch. Six cases with double aortic arch. Most cases of right aortic arch with aberrant left subclavian artery (77/101, 76.2%) were isolated lesions, whereas most of those with mirror‐image branching (45/75, 60%) were associated with intracardiac or extracardiac anomalies. Chromosomal abnormalities were screened prenatally in 113 fetuses with right aortic arch, among whom three with aberrant left subclavian artery (3/63, 4.8%) and eight with mirror‐image branching (8/50, 16%) had chromosome anomalies (p < 0.05). Furthermore, three cases had microdeletion 22q11.2 and these were significantly associated with intracardiac malformations. Conclusions: Most cases of isolated right aortic arch do not present with clinical symptoms except isolated left subclavian artery and isolated left brachiocephalic trunk. In addition, the risk of chromosomal abnormalities in patients with isolated right aortic arch is very low. We recommend that pregnant women should be informed of the risks and benefits of undergoing invasive prenatal chromosomal detection. [ABSTRACT FROM AUTHOR]

Aim: This study developed a set of competency evaluation indicators for shift work nurses in China. Background: Nurses on night shifts must deal with the treatment, nursing, and management work, which requires excellent competency of night shift nurses in their knowledge, skills, and ability. However, the competency evaluation index system for shift work nurses has not been established yet in China. Methods: This study performed a literature review and semi‐structured interviews to draft the preliminary competency evaluation indicators for nursing shift work. The Delphi technique was adopted to administer two rounds of questionnaires on 21 nursing experts. Results: The positive coefficients of experts in the two rounds were 100% and 90.48%, respectively, whereas the authority coefficients were 0.974 and 0.971, respectively. The coefficients of variation were 0.00–0.26 and 0.00–0.16, respectively. The competency evaluation index system for shift work nurses consisted of 2 first‐level indicators, 16 second‐level indicators, and 67 third‐level indicators. Conclusion: The competency index system of shift work nurses is scientific and applicable. Implications for Nursing Management: The competency evaluation index system of shift work nurses would provide an effective practical framework for shift nursing administration to evaluate, train, and assess the competency of shift work nurses. [ABSTRACT FROM AUTHOR]

Perovskite single crystals (SCs) have been emerging as promising materials for electroluminescence (EL) device applications owing to their superior optoelectronic properties. However, the device performance of single‐crystal perovskite light‐emitting diodes (SC‐PeLEDs) is limited by the lack of effective defect management and energy level modulation. Here, a nonstoichiometric composition tuning (NCT) strategy for the construction of high‐performance SC‐PeLEDs is reported. The NCT strategy, finely tuning the MABr (MA+ = CH3NH3+) excess in the nonstoichiometric MAPbBr3 SCs to enhance the crystal quality, reduce the trap density, and elevate the energy level of the resultant perovskite SC, enables markedly decreased nonradiative recombination and more efficient carrier injection for the devices. In consequence, the optimized SC‐PeLEDs exhibit an ultrahigh peak luminance of 161 900 cd m−2 and a large external quantum efficiency (EQE) of up to 8.1%, representing the most efficient SC‐PeLED reported thus far. This strategy also shows a high universality in enhancing the EL performance of other lead bromide perovskite SC‐PeLEDs, endowing them with luminances and EQEs three times larger than those of the pristine devices. This work opens an avenue for the development of high‐performance EL devices based on perovskite SCs. [ABSTRACT FROM AUTHOR]

Coal gangue (CG), which is mainly generated during coal excavation, mining, and coal washing, is an industrial solid waste that is recognized as an environmental pollutant. The ever‐increasing amount of CG produced is a serious threat to the ecological environment and property safety, especially in China, which is the largest coal producer and consumer in the world. Considerable studies have investigated means for utilizing CG worldwide. This review summarizes and discusses various porous inorganic materials made from CG, including cement‐based porous materials, porous bricks, porous ceramics (cordierite and mullite) and glasses, porous geopolymers, zeolites, aerogels, and porous carbon materials. Different preparation processes and performances of each type of porous inorganic materials were reviewed. Porous CG‐based materials can be used as promising adsorbents for the removal of various pollutants and have good potential for use in construction industry as well as catalyst material applications. Besides, porous materials obtained from CG have also been tested as slow‐release fertilizers after the absorption of phosphate, as electrode materials, and as oil‐in‐water separation agents. The systematic summary of porous materials based on CG aims at promoting high‐value‐added applications for this waste. Future research directions for the use of CG as a raw material are also presented. [ABSTRACT FROM AUTHOR]

Herein, a solid strategy to prepare bifunctional SiO2 coatings (BSCs) with both antireflection and luminescence downshifting properties by in situ generating YVO4:Eu3+,Bi3+ phosphors in SiO2 antireflection coatings (ARCs) is reported. Namely, a self‐prepared precursor solution of the downshifting phosphors is added to a mixture of commercial SiO2 sol solution and ethanol to uniformly coat the surface of quartz glass; therefore, a novel composite porous SiO2 coating containing in situ generated YVO4:Eu3+,Bi3+ phosphors (labeled SiO2@YVO4:Eu3+,Bi3+ coating) is formed on the glass surface after annealing. The SiO2@YVO4:Eu3+,Bi3+ BSCs can effectively convert ultraviolet (UV) region photons to visible photons that are well absorbed by silicon solar cells and have better transmittance than pure SiO2 ARC. As proof‐of‐concept applications, the as‐prepared optimal SiO2@YVO4:Eu3+,Bi3+ coating can effectively improve the photoelectric conversion efficiency (PCE) of tunnel oxide passivated contact solar cells by 0.18%abs and decrease the UV‐induced degradation value of the PCE of silicon heterojunction solar cells by 0.62%abs compared to the pure SiO2 ARC. The results demonstrate that in situ generating luminescence downshifting phosphors in the SiO2 ARC of photovoltaic glass is a promising way to improve the PCE and UV stability of silicon solar cells. [ABSTRACT FROM AUTHOR]

Ionospheric scintillation could seriously disrupt the signal tracking of the global navigation satellite systems (GNSS), further causing positioning accuracy degradation or unavailability. BeiDou navigation satellite system (BDS), a newly developed GNSS by China, has begun to provide global positioning, navigation, and timing service. The objective of the present study is to investigate the effects of ionospheric scintillation on BDS‐2 and BDS‐3 multi‐frequency signals. Ionospheric scintillation monitor receiver data from four monitors in Brazil were collected from October 2021 to May 2022. The results illustrate that S4(B2) and S4(B3) linearly increase with S4(B1) for S4(B1) ≤ 0.6, which is consistent with weak scattering theories, and average experimental ratios of S4(B2)/S4(B1), S4(B3)/S4(B1), and S4(B2)/S4(B3) are less than corresponding theoretical ones by 6.1%, 4.4%, and 1.9%, respectively. Meanwhile, as S4 values increase, lower‐frequency scintillation saturates earlier than higher ones, and the probability of ionospheric scintillation events on B2 and B3 signals is approximately twice (S4 ≥ 0.7) as B1 signals in the equatorial ionization anomaly (EIA) regions. To alleviate the undesirable effects of missing data on GNSS positioning, we first investigate the inter‐frequency relationship and distribution probability of two significant spectral parameters, that is, T (the spectral strength of the phase noise at 1 Hz) and p (the spectral slope of the phase power spectral density) in the tracking jitter model among three BDS frequencies. Results show that the performances among B1, B2, and B3 frequencies have a higher correlation respectively, and their values for B2 and B3 signals are more susceptible to be impacted by ionospheric scintillation. Plain Language Summary: Ionospheric scintillation seriously affects the precision and continuity of the global navigation satellite systems (GNSS) signals and causes positioning accuracy degradation or unavailability. Therefore, it is essential to study the impacts of ionospheric scintillation on the GNSS receiver performance. This study first investigates the inter‐frequency relation of the amplitude scintillation index S4 for B1, B2, and B3 signals from BDS‐2 and BDS‐3 satellites based on the Ionospheric scintillation monitor receiver data at four geomagnetic latitudes in the Brazilian territory. Furthermore, the distribution probability and inter‐frequency relationship of two significant phase spectral parameters of the tracking jitter model, which are widely applied in GNSS positioning solutions, are also presented among three BDS frequencies. All investigations conducted within this contribution show agreement with earlier work in ionospheric scintillation and provide supportive and detailed numerical statements and comparisons. Key Points: The inter‐frequency relation of the amplitude scintillation index for multi‐frequency signals from BDS‐2 and BDS‐3 satellites is displayedThe probability of the ionospheric scintillation events on B2 and B3 signals is approximately twice (S4 ≥ 0.6) as B1 signals in EIA regionsThe spectral parameters p and T of B2 and B3 signals are more susceptible to be affected by ionospheric scintillation [ABSTRACT FROM AUTHOR]

Application‐oriented growth of patterned organic semiconductor (OSC) thin films with a single domain is a nonnegotiable requirement for the manufacturing of high‐performance organic electronic devices. However, the prevalent selective‐wetting patterning method remains a challenge in controlling the density of nucleation events in microscale spaces, resulting in thin films with high grain boundary density and no preferential orientation spherulites. Herein, a simple double‐blade‐coating printing technique using a combination of wetting‐patterned substrates to produce an array of highly crystalline OSC thin films is developed. Specifically, the approach confines the OSC crystallization on a molecular‐flat water surface in specific areas, enabling a significant reduction in the number of nuclei. Consequently, patterned 2,7‐dioctyl[1]benzothieno[3,2‐b] benzothiophene (C8‐BTBT) thin films comprising single‐crystal domains are achieved with an exceptionally high yield of 62.5%. The organic field‐effect transistor array developed from such patterns of C8‐BTBT single‐crystalline films exhibits an excellent average mobility of 11.5 cm2 V−1 s−1 which is 12.5‐fold higher compared to that of the reference sample fabricated via conventional single‐blade coating. It is believed that this approach can be widely applied to other soluble organic materials, thereby opening up opportunities for fabricating multicomponent integrated electronics. [ABSTRACT FROM AUTHOR]

Summary: Peptide asparaginyl ligases (PALs) are useful tools for precision modifications of proteins and live‐cell surfaces by ligating peptides after Asn/Asp (Asx). They share high sequence and structural similarity to plant legumains that are generally known as asparaginyl endopeptidases (AEPs), thus making it challenging to identify PALs from AEPs. In this study, we investigate 875 plant species from algae to seed plants with available sequence data in public databases to identify new PALs.We conducted evolutionary trace analysis on 1500 plant legumains, including eight known PALs, to identify key residues that could differentiate ligases and proteases, followed by recombinant expression and functional validation of 16 novel legumains.Previously, we showed that the substrate‐binding sequences flanking the catalytic site can strongly influence the enzymatic direction of a legumain and which we named as ligase‐activity determinants (LADs). Here, we show that two conserved substrate‐binding Gly residues of LADs are critical, but negative determinants for ligase activity.Our results suggest that specific glycine residues are molecular determinants to identify PALs and AEPs as two different legumain subfamilies, accounting for c. 1% and 88%, respectively. [ABSTRACT FROM AUTHOR]

Extensive efforts have been made to develop wide‐bandgap metal compound‐based carrier‐selective contacts to improve the performance of crystalline silicon (c‐Si) solar cells, by mitigating the deleterious effects of metal–Si contact directly. Herein, thermally evaporated wide‐bandgap strontium oxide (SrOx) is exploited as an electron‐selective contact for c‐Si solar cells. Benefiting from a lower work function (3.1 eV) of SrOx, a strong downward band‐bending is achieved at the n‐type c‐Si/SrOx interface, enabling the electron‐selective transport characteristic. Thin SrOx films simultaneously provide moderate surface passivation after annealing and enable a low contact resistivity on c‐Si surfaces. By the implementation of a single‐dielectric‐layer SrOx‐based rear contact, a champion power conversion efficiency of 20.0% is realized on the n‐type c‐Si solar cell featuring an intriguing fill factor of 82.8%. Moreover, electron‐selective SrOx contact is demonstrated to show high thermal stability up to 500 °C. The SrOx layer formed by a facile thermal evaporation process presents a unique opportunity to develop highly efficient and low‐cost c‐Si solar cells. [ABSTRACT FROM AUTHOR]

Background: The role of splicing factor‐coding gene polymorphisms in pediatric acute lymphoblastic leukemia (ALL) susceptibility is still unclear. Methods: A case–control designed model was used to estimate the overall risk of pediatric ALL and five single nucleotide polymorphisms (SNPs) of splicing factor‐coding genes in 808 cases and 1,340 controls, which were genotyped using a TaqMan assay. Stratified analysis was performed to explore the association of rs2233911 genotype and pediatric ALL susceptibility. The influence of splicing factor arginine/serine‐rich 1 (SFRS1) polymorphisms on the sensitivity to different chemotherapeutic regimens based on minimal residual disease (MRD) levels was analyzed. The haplotype analysis was adopted to evaluate the association between inferred haplotypes of the splicing factor‐coding genes and pediatric ALL risk. Results: Among the five analyzed SNPs, SFRS1 rs2233911 AG/GG exhibited a significant association with increased pediatric ALL risk. The stratified analysis further identified the harmful effect of SFRS1 rs2233911 AG/GG in specific subgroups. Moreover, rs2233911 AG/GG had a protective effect on MRD in marrow of ≥0.01% 12 weeks of Chinese Children Cancer Group chemotherapeutics, but provided a harmful effect on MRD in the marrow of ≥0.01% at days 15–19 of the South China Children Leukemia Group chemotherapeutics. Haplotype analysis of these five SNPs yielded haplotypes ACGCC and ACGTC significantly correlating with increased pediatric ALL susceptibility. On the contrary, haplotypes GCATG and GTACC were linked with remarkably decreased pediatric ALL risk. Conclusion: SFRS1 gene polymorphism was associated with increased pediatric ALL risk and indicated that rs2233911 AG/GG might be a potential biomarker for choosing chemotherapeutics. [ABSTRACT FROM AUTHOR]

The inhomogeneous distribution of Global Navigation Satellite System (GNSS) data is a significant problem for global GNSS computerized ionospheric tomography (CIT). By combining ground‐based GNSS data from 460 global stations with space‐borne GNSS data onboard eleven Low‐Earth‐Orbit (LEO) satellites, we employed the EOF (empirical orthogonal function)‐based multiplicative algebraic reconstruction technique (EMART) to reconstruct the global ionospheric electron densities. In comparison with GNSS + LEO (EMART_GL) solutions, the proportion of crossed voxels for GNSS‐only (EMART_G) solutions can rise by up to 12.54%, from 56.83% to 69.37%. Validation experiments were conducted under quiet and disturbed conditions using GNSS slant total electron content (STEC) references that were not previously used in ionospheric tomography. The EMART_GL solutions outperformed the EMART_G solutions when compared to the STEC references under quiet and disturbed conditions. The root mean square values of the CIT‐derived STEC for the EMART_G solutions can be decreased by 31.3% and 30.3% on average under quiet and disturbed conditions, respectively. The vertical TEC references from the Jason‐2 satellite were also used for validation over the ocean areas. Due to insufficient data over the ocean areas, the EMART_GL solutions showed no significant improvements. The reconstructed 3D IEDs were further validated with the COSMIC electron density profiles. Generally, the tomographic results of the EMART_GL solutions were more consistent with the COSMIC profiles when compared to those of the EMART_G solutions and the NeQuick‐2 model. It demonstrates that it is beneficial for global ionospheric tomography by combining ground‐based and space‐borne data. Plain Language Summary: The computerized ionospheric tomography technique is extensively being applied to imaging ionospheric electron density (IED) distributions based on Global Navigation Satellite System (GNSS) observations. The voxel‐based model is usually utilized in ionospheric tomography, with the ionosphere being divided into many cubic voxels. However, predominant issues like unevenly distributed stations, a lack of data, and high‐elevation GNSS signals could affect the precise information about the ionosphere. The electron densities of voxels that are not crossed by GNSS rays cannot be accurately estimated. To address this problem, incorporating multisource data, such as data from Low‐Earth‐Orbit (LEO) satellites, make great sense. A growing number of LEO satellites offer new opportunities for global IED reconstruction. In this study, the EOF (empirical orthogonal function)‐based multiplicative algebraic reconstruction technique (EMART) was used to reconstruct the 3D IED by combining ground‐based GNSS data from global receivers and space‐borne GNSS data onboard eleven LEO satellites. Key Points: Space‐borne Global Navigation Satellite System (GNSS) data from 11 Low‐Earth‐Orbit satellites were combined with the ground‐based GNSS data for global 3D ionospheric tomographyThe incorporation of space‐borne data significantly increased the total number of voxels with observationsCombining ground‐based and space‐borne GNSS data improved the performances of global ionospheric tomography [ABSTRACT FROM AUTHOR]

Deep‐Learning‐based Fault Localisation (DLFL) leverages deep neural networks to learn the relationship between statement behaviour and program failures, showing promising results. However, since DLFL uses program failures as labels to conduct supervised learning, a labelled dataset is a requisite of applying DLFL. A failure is detected by comparing program output with a test oracle which is the standard answer for the given input. The problem is, test oracles are often difficult, or even impossible to acquire in real life, and that has severely restricted the application of DLFL since we have only unlabelled datasets in most cases. Thus, MetaFL: Metamorphic Fault Localisation Using Weakly Supervised Deep Learning is proposed, to provide a weakly supervised learning solution for DLFL. Instead of using test oracles, MetaFL uses metamorphic relations to prescribe expected behaviour of a program, and defines labels of metamorphic testing groups by verifying integrity in each group of test cases. Hence, a coarse‐grained labelled dataset can be built from the originally unlabelled one, with which DLFL can work now, utilising a weakly supervised learning paradigm. The experiments show that MetaFL yields a performance comparable to plain DLFL under ideal condition (i.e. the labels of datasets are available). MetaFL successfully extends the methodology of DLFL from supervised learning to weakly supervised learning, and a fully labelled dataset is no longer mandatory for applying DLFL. [ABSTRACT FROM AUTHOR]

Elastomeric nanoparticles (ENPs) are rubber nanoparticles that have different effects than carbon black (CB) when added to rubber composites. To further understand the effects of ENPs on rubber composites, the morphologies, viscoelasticity, mechanical properties, and interactions with rubber were carefully studied. The results revealed that ENPs and CB differed in terms of their dispersion states and reinforcing effects on rubber. The addition of ENPs can reduce the free chain ends of rubber composites, which helps reduce the rolling resistance, making it a possible way to develop energy‐saving tires. Compared with current techniques for lowering the free chain ends of vulcanisates, it is easier and simpler to add ENPs to rubber composites. The results also show that ENPs and CB had a synergistic effect on rubber reinforcement. The optimal ENP content, considering the vulcanisate characteristics, was approximately 10 phr. [ABSTRACT FROM AUTHOR]

Fricke gel dosimeters have great potential for three‐dimensional (3D) dose verification in radiation therapy; however, they suffer from time‐dependent ion diffusion after irradiation, severely affecting their stability and reliability. In this work, a pullulan‐based amphiphilic molecule was synthesized, characterized, and self‐assembled into nanogels. Nanogel structures were embedded into gel dosimeters to reduce the diffusion rates, and radiation‐sensitive nanogel‐incorporated Fricke hydrogel nanocomposites were prepared successfully. The results demonstrated that the diffusion coefficient of improved dosimeters was reduced to 0.125 ± 0.001 mm2 h−1, while maintaining the high optical dose sensitivity (0.0410 ± 0.0004 Gy−1 cm−1). It provides a powerful tool toward the practical application of 3D dosimeters. [ABSTRACT FROM AUTHOR]

The pursuit of high‐performance and integrated perovskite optoelectronic devices drives the development of efficient methods to pattern perovskite single crystals (PSCs). However, due to stochastic and multiple nucleation, PSCs obtained from traditional patterning methods still suffer from heterogeneous morphology and low crystallinity, resulting in unwanted large variation in the device performance. Herein, an effective and universal strategy is reported for the large‐scale patterned growth of high‐quality perovskite single‐crystal microplates with uniform size and thickness. By modulating the wettability of gold nanoparticles, nucleation energetic barriers are subtly regulated and thus intractably random and multiple nucleation are fundamentally suppressed, enabling the formation of homogeneous perovskite microplates with exceptional properties in terms of ultralow surface defect density (6.1 × 107 cm−2) and high carrier mobility (176 cm2 V−1 s−1). In consequence, the photodetector array based on the patterned perovskite microplates exhibits a large photoresponsivity up to 615 A W−1, along with a low photocurrent variable coefficient <5.2%, which enables the realization of ultrasensitive and high‐contrast imaging functions. This patterning technique constitutes a major step toward the deployment of PSCs in integrated optoelectronic devices. [ABSTRACT FROM AUTHOR]

Enhancing the electrochemical stability and reversibility of redox‐active organic molecules is crucial to improve the performance of non‐aqueous redox flow batteries (RFBs). Compared with the widely adopted strategy of molecular engineering, we show in this study that tuning the intermolecular interaction between the active material with the supporting electrolyte is another feasible way to address the performance of non‐aqueous organic RFBs. Combined with theoretical and experimental investigations, the influence of Lewis acidity of the supporting electrolyte cations and anions on the electrochemical stability and reversibility of bipyridine‐based anode material is revealed. As a demonstration, a redox flow cell based on 4,4′‐bipyridine anolyte and ferrocene catholyte shows greatly enhanced performance by using supporting electrolyte composed of soft Lewis acid and soft Lewis base. This study provides an alternative, yet highly effective way to addressing the cyclability of an organic compound for non‐aqueous RFBs. [ABSTRACT FROM AUTHOR]

Background: Central precocious puberty (CPP) is a precocious puberty due to premature activation of the hypothalamic–pituitary‐gonadal axis (HPG). MKRN3 defects are well‐known causes of CPP, while DLK1 mutations were recently identified in a few patients with CPP. Methods: The study was approved by the Institutional Review and the scientific committee of the hospital. The clinical data were collected. Whole‐exome sequencing (WES) was performed to detect causative variants. Key words 'DLK1', 'MKRN3', and "central precocious puberty" were used for literature search in PubMed, Google Scholar, HGMD, and OMIM databases. Results: The patient, a male, whose puberty began before age nine, had significant metabolic abnormalities including overweight, hyperlipidemia, and hyperuricemia. WES detected a recurrent frame‐shift mutation, NM_003836.5:c.479delC(p.P160fs*50) in DLK1 in the patient and his father. Conclusion: The familial DLK1‐CPP was identified in China for the first time, which supported that short stature is predicted in patients with CPP without GnRHa treatment. Therefore, we recommend that children with DLK1‐CPP should be treated as early as possible to improve adult height. The patient in this study had persistent hyperuricemia, further suggests that this antiadipogenic factor represents a link between reproduction and metabolism. [ABSTRACT FROM AUTHOR]

Human adenoviruses (HAdVs) can cause acute respiratory diseases (ARDs) worldwide, and HAdV‐55 is a reemergent pathogen in recent years. In the study, we investigated an outbreak of ARD at a school due to HAdV‐55 in Beijing, China, during the early outbreak of coronavirus disease 2019 (COVID‐19). The epidemic prevention team was dispatched to the school to collect epidemiologic data and nasopharyngeal samples. Then, real‐time reverse transcription polymerase chain reaction (PCR) and multiplex PCR assays were used to detect severe acute respiratory syndrome coronavirus 2 and other respiratory pathogens, respectively. One representative HAdV‐55 isolate was selected and submitted for whole‐genome sequencing using a MiSeq system and the whole‐genome phylogenetic tree was conducted based on the maximum likelihood method. The outbreak lasted from January 27 to February 6, 2020, and 108 students developed fever, among whom 60 (55.56%) cases were diagnosed with HAdV‐55 infection in the laboratory using real‐time PCR and 56 cases were hospitalized. All the confirmed cases had a fever and 11 cases (18.33%) presented with a fever above 39°C. Other main clinical symptoms included sore throat (43.33%) and headache (43.33%). We obtained and assembled the full genome of one isolate, BJ‐446, with 34 761 nucleotides in length. HAdV‐55 isolate BJ‐446 was 99.85% identical to strain QS‐DLL, which was the first HAdV‐55 strain in China isolated from an ARD outbreak in Shanxi in 2006. One and four amino acid mutations were observed in the hexon gene and the coding region of L2 pV 40.1 kDa protein, respectively. We identified the first HAdV‐55 infection associated with the ARD outbreak in Beijing since the emergence of COVID‐19. The study suggests that improved surveillance of HAdV is needed, although COVID‐19 is still prevalent in the world. [ABSTRACT FROM AUTHOR]

The Global Navigation Satellite System (GNSS) has significantly facilitated the detection of ionospheric irregularities. Nevertheless, the ground‐based GNSS stations are inhomogeneously distributed around the world with large gaps, especially in the vast ocean regions. This adversely affects the interpretation of the spatio‐temporal variation characteristics of the ionospheric irregularities. In this study, ionospheric irregularities over the regions of the equatorial, and low‐latitude ocean during a G4‐class strong geomagnetic storm were investigated by utilizing the spaceborne GNSS reflectometry (GNSS‐R) technique. We derived and validated the ionospheric regularities index S4R from the signal‐to‐noise ratio measurements of the spaceborne GNSS‐R. Meanwhile, we utilized the ionospheric irregularities data from ground‐based (GNSS and ionosonde) and space‐based (Swarm and FORMOSAT‐3/COSMIC) instruments to evaluate and analyze the CYGNSS‐derived S4R. All comparisons and validations conducted within this study illustrate that the spaceborne GNSS‐R measurements provide complementary data and realize the timely observation as well as confirmation of the ionospheric irregularities at the same location over the oceans. It is expected to benefit the application of spaceborne GNSS‐R in ionospheric irregularities monitoring and applications over the ocean area. Plain Language Summary: Ionospheric irregularities adversely degrade the performance of various modern technologies. Therefore, it is significant to monitor ionospheric irregularities. Since the 1990s, detecting and monitoring ionospheric irregularities have been conducted based on various instruments, especially the ground‐based GNSS (Global Navigation Satellite System) receivers. However, the ground‐based GNSS stations are unevenly distributed globally with large gaps particularly in the vast marine areas, which affects the interpretation of the spatio‐temporal variation characteristics of the ionospheric irregularities over ocean areas. This contribution developed an approach using the Cyclone global navigation satellite system spaceborne GNSS reflectometry (GNSS‐R) observations to investigate the ionospheric irregularities over the oceans in equatorial and low‐latitude regions. Meanwhile, we compared the improved approach results with the ionospheric irregularities data from ground‐based (GNSS and ionosonde) and space‐based (Swarm and FORMOSAT‐3/COSMIC). The results reveal that the ionospheric irregularities observed by ground‐based and space‐based data are consistent with CYGNSS‐derived S4R in marine areas. Key Points: An ionospheric irregularities detection method is improved by leveraging the Cyclone global navigation satellite system spaceborne GNSS reflectometry (GNSS‐R) observationsThe ionospheric irregularities observed by spaceborne GNSS‐R are comprehensively verified by GNSS, ionosonde, F3/C, and Swarm measurementsIonospheric irregularity observations using spaceborne GNSS‐R are in good consistency with other ground‐based and space‐based data [ABSTRACT FROM AUTHOR]

The water absorption of ultra‐high molecular weight polyethylene (UHMWPE) and polyformaldehyde (POM) in different hydrostatic pressure has been investigated by means of high pressure immerse experiments and molecular dynamics simulation. Experiment results showed that water absorption of UHMWPE and POM tended to decrease with the rise of environmental pressure of water within 0 ~ 3 MPa. Water absorption of POM was far greater than UHMWPE under all kinds of hydraulic pressure. When the pressure is 3 MPa, the water absorption of POM is reduced by about 15.2% compared with that under normal pressure, while that of UHMWPE is reduced by about 41.64%. Simulation results showed that water molecules were bonded with UHMWPE molecular chain by means of Van der Waals force, and water molecules were bonded with POM molecular chain by means of Van der Waals force and hydrogen bonds, which provided potent theoretical support for the water absorption properties of UHMWPE and POM. [ABSTRACT FROM AUTHOR]

1D APbX3 (A = Cs, MA, FA, X = Cl, Br, I) nanorods (NRs) show potential for the future integrated optoelectronic devices as the ideal building blocks due to their outstanding optoelectronic performances. However, there is still a lack of high‐efficiency controllable strategies to synthesize CsPbX3 NRs. An interfacial synthesis strategy is shown here to fabricate CsPbBr3 NRs by inserting Pb2+ into postsynthetic CsBr nanocrystals in vortex method at the water‐hexane interface. The water phase can intrinsically separate from the hexane phase in such a system and take away excess Pb2+ and other side reaction salts. Additionally, without additional ligand assisted growth, the whole reaction system could result in a very clean surface of CsPbBr3 NRs, eliminating the further purification process. The new approach for interfacial synthesis paves the way for efficient synthesis of CsPbBr3 nanorods. [ABSTRACT FROM AUTHOR]

The potential of dendrimers exhibiting thermally activated delayed fluorescence (TADF) as emitters in solution‐processed organic light‐emitting diodes (OLEDs) has to date not yet been realized. This in part is due to a poor understanding of the structure–property relationship in dendrimers where reports of detailed photophysical characterization and mechanism studies are lacking. In this report, using absorption and solvatochromic photoluminescence studies in solution, the origin and character of the lowest excited electronic states in dendrimers with multiple dendritic electron‐donating moieties connected to a central electron‐withdrawing core via a para‐ or a meta‐phenylene bridge is probed. Characterization of host‐free OLEDs reveals the superiority of meta‐linked dendrimers as compared to the already reported para‐analogue. Comparative temperature‐dependent time‐resolved solid‐state photoluminescence measurements and quantum chemical studies explore the effect of the substitution mode on the TADF properties and the reverse intersystem crossing (RISC) mechanism, respectively. For TADF dendrimers with similarly small ∆EST, it is observed that RISC can be enhanced by the regiochemistry of the donor dendrons due to control of the reorganization energies, which is a heretofore unexploited strategy that is distinct from the involvement of intermediate triplet states through a nonadiabatic (vibronic) coupling with the lowest singlet charge transfer state. [ABSTRACT FROM AUTHOR]

BACKGROUND: Berberine is a plant‐derived herbicidal alkaloid. The herbicidal mechanism of berberine is still not clear. In this study, our aim is to clarify the mechanism of berberine inhibiting the root growth of Arabidopsis thaliana, aiming at providing new insight into identifying the molecular targets of berberine. RESULTS: The whole‐genome RNA sequencing had revealed that 403 genes were down‐regulated, and 422 genes were up‐regulated in Arabidopsis roots with berberine treatment. According to KEGG and GO analysis, the expression of two genes AT5G48010 (Thas) and AT5G42600 (MRN1) which are in the sesquiterpenoid and triterpenoid biosynthesis pathway were affected most. These two genes belong to thalianol and marneral gene clusters. RT‐PCR showed that Arabidopsis responds to berberine by inhibiting root growth through repressing the expression of thalianol and marneral gene clusters, which was independent of the upstream effectors ARP6 and HTA9‐1. GC–MS analysis showed that berberine could inhibit THAH in the biosynthetic network of triterpenoid gene cluster in Arabidopsis and thus cause the accumulation of thalianol. CONCLUSION: Our study indicated the repression of the thalianol and marneral gene clusters as the primary mechanism of action of berberine in Arabidopsis, which may result in plant growth defects by interrupting the thalianol metabolic pathway. This provides novel clues as to the possible molecular herbicidal mechanism of berberine. © 2022 Society of Chemical Industry. [ABSTRACT FROM AUTHOR]