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Designable molecular structures, unique ion‐coordination charge storage mechanisms, and resource sustainability enable organic electrode materials to become potential candidates for alkali metal‐ion batteries (AMIBs). Herein, integrating the excellent π–π stacking ability of Hexaazatriphenylene units and strong electron‐withdrawing properties of cyano (C≡N) groups into one moleuce, a π‐conjugated organic compound 1,4,5,8,9,11‐Hexaazatriphenylenehexacarbonitrile (HAT‐CN) is synthesized and systematically investigated as electrodes in Li/Na/K‐ion batteries. Explored by mechanism characterizations and density functional theory calculations, HAT‐CN can provide nine redox‐active sites for Na/K‐ions to intercalate/de‐intercalate, among which six Na/K‐ions are distributed evenly to both sides of conjugated skeletons through intermolecular intercalation and three Na/K‐ions are stored with the synergistic effect of C≡N groups. Employing HAT‐CN as electrodes, AMIBs are found to exhibit high reversible capacities, excellent rate capabilities, and stable cycle performances. After 100 cycles at the current density of 100 mA g−1, Na‐ion batteries present 415.6 mAh g−1 with a capacity fading rate of 1.2% per cycle. Meanwhile, K‐ion batteries maintain 345 mAh g−1 with a coulombic efficiency ≈100%. Li‐ion batteries display superlithiation performances with ultra‐high reversible capacity. This work emphasizes the necessity of comprehensively studying the electrochemical performance of organic electrodes in different secondary battery systems and is conducive to maximizing electrode functionality. [ABSTRACT FROM AUTHOR]

Unlike prior researches focusing on interannual or interdecadal changes of the Northwest Pacific subtropical high (NWPSH), this paper emphasizes the interdecadal changes in the relationship between May‐June and July‐August NWPSH. The correlation coefficients between them are 0.66 (passing the 99.9% confidence level) and 0.12 during 1979–2002 and 2003–2023. Therefore, the May‐June NWPSH has a strong connection with July‐August East Asian precipitation during 1979–2002, but not during 2003–2023. The interdecadal variations in the relationship of NWPSH are due to interdecadal changes of ENSO. During 1979–2002, the eastern‐type ENSO in prior winter, having longer durations, can influence May‐June and July‐August NWPSH and the North Indian Ocean. However, the central‐type ENSO in prior winter only persists it's influence until May‐June, and changes into a Pacific Dipole pattern in July‐August during 2003–2023. Despite the North Indian Ocean continually warms during 2003–2023, the tropical Pacific Dipole offsets its impacts on the NWPSH. Plain Language Summary: The Northwest Pacific Subtropical High (NWPSH) has always been valued by meteorologists due to its important role in the East Asian climate. This paper found that the relationship between the NWPSH in May‐June and July‐August has weakened significantly since 2002. The eastern‐type ENSO, characterized by longer durations, can influence the NWPSH and the North Indian Ocean in May‐June and July‐August before 2002. However, from 2003 to 2023, the influence of the central‐type ENSO only persists until May‐June, transitioning to a Pacific Dipole pattern in July‐August. Therefore, both May‐June and July‐August NWPSH are affected by the North Indian Ocean before 2002. However, the NWPSH in May‐June is affected by the North Indian Ocean and prior winter ENSO after 2002, while the July‐August NWPSH is impacted by the tropical Pacific Dipole. And the tropical Pacific Dipole also offsets the influence of the North Indian Ocean on the NWPSH. This leads to a weakening of the relationship between the NWPSH in May‐June and July‐August. Key Points: The relationship between the Northwest Pacific subtropical high (NWPSH) in May‐June and July‐August has significantly weakened after 2002The reason for weakening relationship of NWPSH is that the persistent eastern ENSO has become a short‐period central ENSO after 2002Central ENSO will become Pacific Dipole mode in summer, which will weaken the influence of North Indian Ocean on NWPSH [ABSTRACT FROM AUTHOR]

Rational design of molecular structures is one of the effective strategies to obtain high‐performance organic cathode materials. However, besides the optimization of single‐molecule structures, the influence of the “weak” interaction forces (e.g. hydrogen bonds) in organic cathode materials on the performance of batteries should be fully considered. Herein, three organic small molecules with different numbers of hydroxyl groups (namely nitrogen heterocyclic tetraketone (DAB), monohydroxyl nitrogen heterocyclic dione (HDA), dihydroxyl nitrogen heterocyclic dione (DHT)) were selected as the cathodes of aqueous zinc ion batteries (AZIBs), and the effect of the intermolecular hydrogen bonds on their electrochemical performance was studied for the first time. Clearly, the stable hydrogen‐bond networks built through the hydroxyl groups significantly enhance the cycle stability of organic small‐molecule cathodes and facilitate rapid proton conduction between the hydrogen‐bond networks through the Grotthuss mechanism, thereby endowing them with excellent rate performance. In addition, a larger and more dense two‐dimensional hydrogen‐bond network can be constructed through multiple hydroxyl groups, further enhancing the structural stability of organic small‐molecule cathodes, giving them better cycle tolerance, excellent rate performance, and extreme environmental tolerance. [ABSTRACT FROM AUTHOR]

This study investigates the connection between significant sea surface temperature (SST) anomalies in the North Pacific during boreal spring (February–April, FMA) and the subsequent South China Sea (SCS) summer monsoon (SCSSM) onset. The SST anomalies, similar to the Pacific meridional mode (PMM), referred to as the PMM+ mode, are defined to examine the new influencing factor on the SCSSM onset. Our findings reveal that the (February–March–April, FMA) PMM+ has a noteworthy positive correlation with the subsequent May SCSSM onset date, with this correlation being minimally affected by the El Niño–Southern Oscillation (ENSO) during preceding winter. A robust positive PMM+ in boreal spring can be persist until May via atmosphere–ocean interaction. The cooling area over Western North Pacific would reduce precipitation heating, thereby generating Rossby waves that reinforce the formation of the anomalous anticyclone over the SCS. As a result, easterly winds and suppressed convection prevail over the SCS, making the SCSSM break out later than normal. Furthermore, the amplification of anticyclonic vorticity anomalies also strengthens the western North Pacific subtropical high (WNPSH) stronger and shifts its position further westward compared to normal years, thereby blocking active convection to the west of the SCS. Given the weakened relationship between El Niño–Southern Oscillation (ENSO) and the SCSSM onset in recent years, the PMM+ could be considered as a promising preceding signal for the SCSSM onset, thus holding significant implications for the SCSSM prediction efforts. [ABSTRACT FROM AUTHOR]

Water evaporation–induced electricity generators (WEGs) are regarded as one of the most promising solutions for addressing the increasingly severe environmental pollution and energy crisis. Owing to the potential carbon emission in the preparation process of WEGs, whether WEG represents a clean electricity generation technology is open to question. Here, a brand‐new strategy is proposed for manufacturing negative carbon emission WEG (CWEG). In this strategy, the microalgae film is used as the electricity generation interface of WEG, which achieves a stable open‐circuit voltage (Voc) of 0.25 V and a short‐circuit current (Isc) of 3.3 µA. Since microalgae can capture carbon dioxide during its growing process, CWEG holds great promise to generate electricity without carbon emissions in the full life cycle compared with other WEGs. To the best of the author's knowledge, this is the first work using microalgae films to fabricate WEG. Therefore, it is believed that this work not only provides a new direction for designing high‐efficiency and eco‐friendly WEG but also offers an innovative approach to the resource utilization of microalgae. [ABSTRACT FROM AUTHOR]

Background and Aims: Sex‐specific associations of sex hormone‐binding globulin (SHBG) and bioavailable testosterone (BAT) with NAFLD remain indeterminate. We aimed to explore observational and genetically determined relationships between each hormone and NAFLD. Methods: We included 187 395 men and 170 193 women from the UK Biobank. Linear and nonlinear Cox regression models and Mendelian randomization (MR) analysis were used to test the associations. Results: During 12.49 years of follow‐up, 2209 male and 1886 female NAFLD cases were documented. Elevated SHBG levels were linearly associated with a lower risk of NAFLD in women (HR (95% CI),.71 (.63,.79)), but not in men (a "U" shape, pnon‐linear <.001). Higher BAT levels were associated with a lower NAFLD risk in men (HR (95% CI),.81 (.71,.93)) but a higher risk in women (HR (95% CI): 1.25 (1.15, 1.36)). Genetically determined SHBG and BAT levels were linearly associated with NAFLD risk in women (OR (95% CI):.57 (.38,.87) and 2.21 (1.41, 3.26) respectively); in men, an "L‐shaped" MR association between SHBG levels and NAFLD risk was found (pnon‐linear =.016). The bidirectional MR analysis further revealed the effect of NAFLD on SHBG and BAT levels in both sexes. Conclusions: Consistently, linear associations of lower SHBG and higher BAT levels with increased NAFLD risk were both conventionally and genetically found in women, while in men, SHBG acts in a nonlinear manner. In addition, NAFLD may affect SHBG and BAT levels. [ABSTRACT FROM AUTHOR]

Hydrocephalus is one of the most common brain disorders and a life‐long incurable condition. An empirical "one‐size‐fits‐all" approach of cerebrospinal fluid (CSF) shunting remains the mainstay of hydrocephalus treatment and effective pharmacotherapy options are currently lacking. Macrophage‐mediated ChP inflammation and CSF hypersecretion have recently been identified as a significant discovery in the pathogenesis of hydrocephalus. In this study, a pioneering DNA nano‐drug (TSOs) is developed by modifying S2 ssDNA and S4 ssDNA with SPAK ASO and OSR1 ASO in tetrahedral framework nucleic acids (tFNAs) and synthesis via a one‐pot annealing procedure. This construct can significantly knockdown the expression of SPAK and OSR1, along with their downstream ion channel proteins in ChP epithelial cells, thereby leading to a decrease in CSF secretion. Moreover, these findings indicate that TSOs effectively inhibit the M0 to M1 phenotypic switch of ChP macrophages via the MAPK pathways, thus mitigating the cytokine storm. In in vivo post‐hemorrhagic hydrocephalus (PHH) models, TSOs significantly reduce CSF secretion rates, alleviate ChP inflammation, and prevent the onset of hydrocephalus. These compelling results highlight the potential of TSOs as a promising therapeutic option for managing hydrocephalus, with significant applications in the future. [ABSTRACT FROM AUTHOR]

The South China Sea summer monsoon (SCSSM) onset and withdrawal have critical impacts on the climate of East Asia. However, using different reanalysis data may lead to the uncertainty of the SCSSM. This study uses reanalysis datasets including JRA‐55, ERA5, NCEP‐NCAR NCEP‐1 and NCEP‐DOE NCEP‐2 to calculate onset and withdrawal dates and index of SCSSM from 1991 to 2020, analyses the uncertainty and figures out the possible reasons. Results reveal that the four reanalysis datasets have obvious uncertainty in calculating the withdrawal date of SCSSM, with the deviation being up to 3.4 pentads. Further analysis shows that large differences in thermal conditions and lead to the uncertainties. From the perspective of precipitation, Greater uncertainty exists in the relationship between monsoon retreat and September–October precipitation, NCEP1 and NCEP2 datasets show weak correlation in southern China and Indonesia. Moreover, the uncertainty can be also found in the correlations of SCSSM with global sea surface temperature (SST) anomalies. JRA‐55 and ERA5 show a strong correlation of with SST in several areas, and exhibit a distinct Pacific decadal oscillation (PDO) mode with monsoon onset, while NCEP‐1 and NCEP‐2 have a weaker correlation with SST anomalies than JRA‐55 or ERA5. Comparing multiple factors comprehensively, this paper concludes that JRA‐55 may be more representative in the monsoon study, followed by ERA data. In short, depending on the specific research questions, researchers can choose appropriate data sources to study the SCSSM based on the different aspects and the uncertainty also deserve our special attention when selecting the reanalysis datasets. [ABSTRACT FROM AUTHOR]

Extracellular vesicles (EVs) exert a significant influence not only on the pathogenesis of diseases but also on their therapeutic interventions, contingent upon the variances observed in their originating cells. Mitochondria can be transported between cells via EVs to promote pathological changes. In this study, we found that EVs derived from M1 macrophages (M1‐EVs), which encapsulate inflammatory mitochondria, can penetrate pancreatic beta cells. Inflammatory mitochondria fuse with the mitochondria of pancreatic beta cells, resulting in lipid peroxidation and mitochondrial disruption. Furthermore, fragments of mitochondrial DNA (mtDNA) are released into the cytosol, activating the STING pathway and ultimately inducing apoptosis. The potential of adipose‐derived stem cell (ADSC)‐released EVs in suppressing M1 macrophage reactions shows promise. Subsequently, ADSC‐EVs were utilized and modified with an F4/80 antibody to specifically target macrophages, aiming to treat ferroptosis of pancreatic beta cells in vivo. In summary, our data further demonstrate that EVs secreted from M1 phenotype macrophages play major roles in beta cell ferroptosis, and the modified ADSC‐EVs exhibit considerable potential for development as a vehicle for targeted delivery to macrophages. [ABSTRACT FROM AUTHOR]

Epimedium (EM) and Psoraleae Fructus (PF) are a traditional herb combination often used as a fixed form to treat osteoporosis disease in the clinic. However, the intricate interactions of this pair remain unknown. In our study, we undertook a comprehensive examination of their compatibility behaviors. Concurrently, a precise and sensitive quantitation method was successfully developed and validated using liquid chromatography‐tandem mass spectrometry for the determination of 12 components. This method was applied in analyzing herbal extracts and biological samples (both in the portal vein and systemic plasma), which was also used to study the pharmacokinetics of the herb pair. The results indicated that the combination of EM and PF enhanced the dissolution of chemical components from PF in extracts, but it had a negligible influence on the contents of the components from EM. On the contrary, the in vivo exposure of the lowly exposed EM flavonoids significantly increased following the combination of EM and PF, whereas the highly exposed psoralen and isopsoralen were greatly reduced. These interactions might be crucial for the synergy and toxicity reduction of the herbal pair in disease treatment, which pave the way for further exploration into the clinical application and pharmacological mechanisms of EM and PF. [ABSTRACT FROM AUTHOR]

Topical application of tyrosinase inhibitors, such as hydroquinone and arbutin, is the most common clinical treatment for hyperpigmentation. Glabridin (Gla) is a natural isoflavone that inhibits tyrosinase activity, free radical scavenging, and antioxidation. However, its water solubility is poor, and it cannot pass through the human skin barrier alone. Tetrahedral framework nucleic acid (tFNA), a new type of DNA biomaterial, can penetrate cells and tissues and can be used as carriers to deliver small‐molecule drugs, polypeptides, and oligonucleotides. This study aimed to develop a compound drug system using tFNA as the carrier to transport Gla and deliver it through the skin to treat pigmentation. Furthermore, we aimed to explore whether tFNA–Gla can effectively alleviate the hyperpigmentation caused by increased melanin production and determine whether tFNA–Gla exerts substantial synergistic effects during treatment. Our results showed that the developed system successfully treated pigmentation by inhibiting regulatory proteins related to melanin production. Furthermore, our findings showed that the system was effective in treating epidermal and superficial dermal diseases. The tFNA‐based transdermal drug delivery system can thus develop into novel, effective options for non‐invasive drug delivery through the skin barrier. [ABSTRACT FROM AUTHOR]

Skin photodamage, which is induced by ultraviolet (UV) radiation, is a prevalent cause of skin damage. In this study, a transdermal drug delivery system is developed for the topical treatment of skin photodamage, which is composed of tetrahedral framework nucleic acids (tFNAs) and lipoic acid (LA). The tFNAs‐LA (TLA) nanocomposite exhibits excellent biocompatibility, as well as antioxidant, anti‐apoptotic, and anti‐inflammatory capabilities. tFNA, as a carrier, facilitates TLA for cell entry and skin penetration, while the loaded LA enhances the antioxidant and anti‐inflammatory capabilities. In photodamaged human dermal fibroblast (HDF), TLA promotes proliferation and migration while inhibiting apoptosis activation and reactive oxygen species production. Moreover, TLA modulates apoptosis‐related proteins and NF‐κB signaling pathways, increasing cellular secretion while suppressing inflammatory responses in photodamaged HDF cells. In the in vivo experiment, topical application of TLA promotes tissue healing in photodamaged skin, and regulates the expression of inflammation and collagen‐related proteins. It is suggested that the transdermal ability of TLA enables non‐invasive therapy for skin photodamage, highlighting the potential of employing nucleic acid‐based transdermal drug delivery systems for skin disease. [ABSTRACT FROM AUTHOR]

How to seek multiregional sustainable development within planetary boundaries depends on the scientific inquiry into urban carrying capacity from multiscale evaluation and multidimensional interaction. Using a typical region moving forward on the sustainable development demonstration belt of China, the Yangtze River Economic Belt (YREB), as a case study, a new integrated framework of multiscale evaluation and multidimensional interaction is proposed to track the urban comprehensive carrying capacity. We made a multiscale comprehensive assessment and constructed a panel vector autoregressive model for giving dissection on the drivers of urban carrying capacity and the qualitative and quantitative interaction from multidimensional variations. Results show that (1) the urban carrying capacity of China's YREB and its three reaches harbors an upward trend over time although there are uneven development patterns of inter‐regional and inter‐dimensional urban carrying capacity; (2) factor market carrying capacity (FMCC) is the critical driving force among four dimensions of urban carrying capacity, which has promotion effects on ecological environment carrying capacity (EECC) and industrial economics carrying capacity, but an inhibiting effect on transportation carrying capacity (TCC). (3) FMCC is the Granger cause of TCC, and there is a bidirectional Granger causality between the dimensions of FMCC and EECC; (4) each dimension is self‐supporting and influenced by its fluctuations. Tracking the underlying factors of urban carrying capacity can help construct an early‐warning mechanism when confronting the challenge of sustainable development and play a guiding role in both academic and practical aspects. [ABSTRACT FROM AUTHOR]

Sepsis is a highly lethal condition and is caused by the dysregulation of the body's immune response to infection. Indeed, sepsis remains the leading cause of death in severely ill patients, and currently, no effective treatment is available. Pyroptosis, which is mainly activated by cytoplasmic danger signals and eventually promote the release of the pro‐inflammatory factors, is a newly discovered programmed cell death procedure that clears infected cells while simultaneously triggering an inflammatory response. Increasing evidence indicates that pyroptosis participates in the development of sepsis. As a novel DNA nanomaterial, tetrahedral framework nucleic acids (tFNAs) characterized by its unique spatial structure, possess an excellent biosafety profile and can quickly enter the cell to impart anti‐inflammatory and anti‐oxidation effects. In this study, the roles of tFNAs in the in vitro model of macrophage cell pyroptosis and in the in vivo model of septic mice were examined, and it was found that tFNAs could mitigate organ inflammatory damage in septic mice, wherein they reduced inflammatory factor levels by inhibiting pyroptosis. These results provide possible new strategies for the future treatment of sepsis. [ABSTRACT FROM AUTHOR]

Single cell RNA‐seq (scRNA‐seq) profiles conceal temporal and spatial tissue developmental information. De novo reconstruction of single cell temporal trajectory has been fairly addressed, but reverse engineering single cell 3D spatial tissue organization is hitherto landmark based, and de novo spatial reconstruction is a compelling computational open problem. Here it is shown that a proposed algorithm for de novo coalescent embedding (D‐CE) of oligo/single cell transcriptomic networks can help to address this problem. Relying on the spatial information encoded in the expression patterns of genes, it is found that D‐CE of cell–cell association transcriptomic networks, by preserving mesoscale network organization, captures spatial domains, identifies spatially expressed genes, reconstructs cell samples' 3D spatial distribution, and uncovers spatial domains and markers necessary for understanding the design principles on spatial organization and pattern formation. Comparison to the novoSpaRC and CSOmap (the only available de novo 3D spatial reconstruction methods) on 14 datasets and 497 reconstructions, reveals a significantly superior performance of D‐CE. [ABSTRACT FROM AUTHOR]

Objectives: Titanium mesh has become a mainstream choice for guided bone regeneration (GBR) owing to its excellent space maintenance. However, the traditional fixation method using titanium screws impacts surgery efficiency and increases patient trauma. We report a novel method of fixing a titanium mesh using resorbable sutures. We assessed the feasibility of resorbable sutures for fixing a titanium mesh and whether it can serve as a stable, universal, and minimally invasive fixation method for a broader application of titanium meshes. Methods: Patients undergoing GBR with a digital titanium mesh fixed using titanium screws (TS group) and resorbable sutures (RS group) were observed at different time points. The stability of the fixation methods was evaluated on parameters such as titanium mesh spatial displacement, bone augmentation, and bone resorption. Results: A total of 36 patients were included in this study. The exposure rate of the titanium mesh in the TS group was 16.67%, while no exposure was noted in the RS group. There was no significant difference in the parameters of titanium mesh spatial displacement, bone augmentation, and bone resorption between the two groups (p > 0.05). Conclusion: The use of resorbable sutures for fixing a titanium mesh can achieve similar results to traditional fixation using titanium screws. Although this new fixation method can improve the efficiency of the surgery and reduce the risk of complications, the long‐term clinical effects require further follow‐up investigation. [ABSTRACT FROM AUTHOR]

This paper applies agricultural big data into agricultural economics management in order to improve agricultural economics management effects and comprehensively analyzes criterion and trending, maturity and advancement, practice and advancement, usability and extension of the platform according to the structure of agricultural economics management system by using big data. Meanwhile the paper describes the actual application condition of agricultural economics management, designs tests to analyze the agricultural economics data and digs the effects according to the agricultural economics management data through the crawler technology, and explains the application effects in the agricultural economics management. Tests and studies prove the reliability of the method put in the paper. Core Ideas: The system structure chart classifies the decision‐making system according to its functions.The main body of the data anomaly inspection model is data.Data duplication mostly occurs in general information systems. [ABSTRACT FROM AUTHOR]

Natural disasters, such as typhoons and earthquakes, pose great challenges to power system resilience and power supply reliability. It is widely acknowledged that critical transmission lines play a significant role in enhancing the resilience and reliability of power systems under severe natural disasters. In order to improve the disaster resilience of power systems with renewables, a critical line identification approach is proposed in this work based on the complex network theory. Firstly, the concept of core skeleton network (CSN) of power systems with renewables is introduced and a two-step strategy is presented to optimise the CSNs of the concerned power system considering the variable outputs of renewables. Then, a statistical salience method incorporating edge salience and the state-of-the-art null model in complex network theory is proposed to identify critical lines of each CSN and the concerned power system with renewables. Finally, the effectiveness of the proposed critical lines identification approach is verified by simulations on the modified IEEE 118-bus system with renewables, Guangdong Provincial Power System (GPPS) and Zhejiang Provincial Power System (ZPPS) in China. Simulation results show that by using the proposed approach, the critical transmission lines can be effectively identified, not requiring a predefined number of critical lines. [ABSTRACT FROM AUTHOR]

Various computational super‐resolution methods are available based on the analysis of fluorescence fluctuation behind acquired frames. However, dilemmas often exist in the balance of fluorophore characteristics, computation cost, and achievable resolution. Here we present an approach that uses a super‐resolution radial fluctuations (SRRF) image to guide the Bayesian analysis of fluorophore blinking and bleaching (3B) events, allowing greatly accelerated localization of overlapping fluorophores with high accuracy. This radial fluctuation Bayesian analysis (RFBA) approach is also extended to three dimensions for the first time and combined with light‐sheet fluorescence microscopy, to achieve super‐resolution volumetric imaging of thick samples densely labeled with common fluorophores. For example, a 700‐nm thin Bessel plane illumination is developed to optically section the Drosophila brain, providing a high‐contrast 3D image of rhythmic neurons. RFBA analyzes 30 serial volumes to reconstruct a super‐resolved 3D image at 4‐times higher resolutions (~70 and 170 nm), and precisely resolve the axon terminals. The computation is over 2‐orders faster than conventional 3B analysis microscopy. The capability of RFBA is also verified through dual‐color imaging of cell nucleus in live Drosophila brain. The spatial co‐localization patterns of the nuclear envelope and DNA in a neuron deep inside the brain can be precisely extracted by our approach. [ABSTRACT FROM AUTHOR]

A strategy for the rapid synthesis of 3‐substituted N‐sulfonyl pyrazoles via p‐TSA‐promoted cyclization reactions of sulfonyl hydrazines with N,N‐dimethyl enaminones has been developed. This method achieves both the formation of pyrazole ring and the continued retention of sulfonyl group, providing a series of 3‐substituted N‐sulfonyl pyrazoles in moderate to good yields with good functional group tolerance, easily available starting materials, and can be scaled‐up. [ABSTRACT FROM AUTHOR]

The cover image is based on the Original Article A minimally invasive method for titanium mesh fixation with resorbable sutures in guided bone regeneration: A retrospective study by Songhang Li DDS et al., https://doi.org/10.1111/cid.13147. [ABSTRACT FROM AUTHOR]