1. Exendin-4 shows no effects on the prostatic index in high-fat-diet-fed rat with benign prostatic hyperplasia by improving insulin resistance.
- Author
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Zheng, J.‐X., Xiao, Y.‐C., Hu, Y.‐R., Hao, M., and Kuang, H.‐Y.
- Subjects
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EXENDINS , *BENIGN prostatic hyperplasia , *RATS -- Food , *HIGH-fat diet , *INSULIN resistance - Abstract
Benign prostatic hyperplasia ( BPH) is a prevalent disease globally, and accumulating evidence has indicated an association between BPH, insulin resistance ( IR) and diabetes. Exendin-4 is widely used in clinics, which could enhance the proliferation of pancreatic β cells. The ability of exendin-4 to promote tumorigenesis has been of concern, and whether exendin-4 would enhance the propagation of BPH is not fully understood. We aimed to determine whether glucagon-like peptide-1 receptors ( GLP-1 Rs) were expressed in rat prostate and to determine the effect of exendin-4 on prostate of BPH. Male Wistar rats were used and assigned to six groups: normal diet ( ND), high-fat diet ( HFD), HFD + exendin-4, HFD + BPH, HFD + BPH + exendin-4 and HFD + BPH + rosiglitazone group. After castration, steroids were injected subcutaneously for 4 weeks to induce BPH. Rats were kept on high-fat diet to induce IR. Treatment groups were treated with exendin-4 and rosiglitazone. Prostatic index and HOMA- IR index were used to evaluate the prostatic hyperplasia status and the degree of IR respectively. The expression of GLP-1 R was indicated not only by immunohistochemistry, but also by Western blot analysis. The expression of GLP-1 R was significantly higher, and HOMA-I R index and body weight significantly decreased after administration of exendin-4. However, no significant differences in the prostatic index were observed between exendin-4 treatment groups and non-exendin-4 treatment groups. Prostatic index was not influenced by exendin-4 maybe by improving IR and weight loss. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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