1. MicroRNA-26b is underexpressed in human breast cancer and induces cell apoptosis by targeting SLC7A11
- Author
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Liu, Xiao-Xiao, Li, Xiao-Jun, Zhang, Bo, Liang, Yong-Jun, Zhou, Ci-Xiang, Cao, Dan-Xia, He, Ming, Chen, Guo-Qiang, He, Jian-Rong, and Zhao, Qian
- Subjects
GENE expression ,NON-coding RNA ,BREAST cancer ,APOPTOSIS ,GENE targeting ,TUMOR suppressor genes ,CANCER cells ,CELL lines - Abstract
Abstract: MicroRNAs are widely dysregulated in various cancers and integrated into tumorigenic programs as either oncogenes or tumor suppressor genes. Here, we show that miR-26b, which is down-regulated in human breast cancer specimens and cell lines, impairs viability and triggers apoptosis of human breast cancer MCF7 cells. SLC7A11 is identified as a direct target of miR-26b and its expression is remarkably increased in both breast cancer cell lines and clinical samples. Furthermore, SLC7A11 silence mimics miR-26b-aroused viability impairment and apoptosis in MCF7 cells. Our studies reveal a protective role of miR-26b in the molecular etiology of human breast cancer by promoting apoptosis. [Copyright &y& Elsevier]
- Published
- 2011
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