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Improved durability, enhanced interfacial stability, and room temperature applicability are desirable properties for all‐solid‐state lithium metal batteries (ASSLMBs), yet these desired properties are rarely achieved simultaneously. Here, in this work, it is noticed that the huge resistance at Li metal/electrolyte interface dominantly impeded the normal cycling of ASSLMBs especially at around room temperature (<30 °C). Accordingly, a supramolecular polymer ion conductor (SPC) with "weak solvation" of Li+ was prepared. Benefiting from the halogen‐bonding interaction between the electron‐deficient iodine atom (on 1,4‐diiodotetrafluorobenzene) and electron‐rich oxygen atoms (on ethylene oxide), the O‐Li+ coordination was significantly weakened. Therefore, the SPC achieves rapid Li+ transport with high Li+ transference number, and importantly, derives a unique Li2O‐rich SEI with low interfacial resistance on lithium metal surface, therefore enabling stable cycling of ASSLMBs even down to 10 °C. This work is a new exploration of halogen‐bonding chemistry in solid polymer electrolyte and highlights the importance of "weak solvation" of Li+ in the solid‐state electrolyte for room temperature ASSLMBs. [ABSTRACT FROM AUTHOR]

Improved durability, enhanced interfacial stability, and room temperature applicability are desirable properties for all‐solid‐state lithium metal batteries (ASSLMBs), yet these desired properties are rarely achieved simultaneously. Here, in this work, it is noticed that the huge resistance at Li metal/electrolyte interface dominantly impeded the normal cycling of ASSLMBs especially at around room temperature (<30 °C). Accordingly, a supramolecular polymer ion conductor (SPC) with "weak solvation" of Li+ was prepared. Benefiting from the halogen‐bonding interaction between the electron‐deficient iodine atom (on 1,4‐diiodotetrafluorobenzene) and electron‐rich oxygen atoms (on ethylene oxide), the O‐Li+ coordination was significantly weakened. Therefore, the SPC achieves rapid Li+ transport with high Li+ transference number, and importantly, derives a unique Li2O‐rich SEI with low interfacial resistance on lithium metal surface, therefore enabling stable cycling of ASSLMBs even down to 10 °C. This work is a new exploration of halogen‐bonding chemistry in solid polymer electrolyte and highlights the importance of "weak solvation" of Li+ in the solid‐state electrolyte for room temperature ASSLMBs. [ABSTRACT FROM AUTHOR]

This work describes a simple and reliable colorimetric method based on the gold nanoparticles without any modification, which can realize the rapid, sensitive, and quantitative detection of lead (Pb2+) and copper (Cu2+) ions, providing a reference for monitoring metal ions in the environmental water. When Pb2+ was added to the gold nanoparticles solution containing a low concentration of L‐Cysteine, the combination of Pb2+ and L‐Cysteine can induce the aggregation of gold nanoparticles. On the contrary, Cu2+ can catalyze the oxidation of L‐Cysteine and destroy the formation of the Au‐S bond between L‐Cysteine and gold nanoparticles, thereby preventing the aggregation of gold nanoparticles. As the ultraviolet‐visible spectrum of gold nanoparticle solution is closely related to their aggregation status, the Cu2+ and Pb2+ can be determined. The calibration curves, which are constructed based on ratios of the absorbance at 650 nm and 520 nm of gold nanoparticles, display good linearity in the range of 50.0−2.5 × 103 nM for Pb2+ and 25.0−300.0 nM for Cu2+, respectively. The limits of quantitation of Pb2+ and Cu2+ are determined to be 50.0 and 25.0 nM, respectively. In addition, the spiked recoveries of Pb2+ and Cu2+ in real water samples are 94.6−112.5 and 87.3−114.7% with a relative standard deviation of less than 6.3%, respectively. [ABSTRACT FROM AUTHOR]

The electrolytes for lithium metal batteries (LMBs) are plagued by a low Li+ transference number (T+) of conventional lithium salts and inability to form a stable solid electrolyte interphase (SEI). Here, we synthesized a self‐folded lithium salt, lithium 2‐[2‐(2‐methoxy ethoxy)ethoxy]ethanesulfonyl(trifluoromethanesulfonyl) imide (LiETFSI), and comparatively studied with its structure analogue, lithium 1,1,1‐trifluoro‐N‐[2‐[2‐(2‐methoxyethoxy)ethoxy)]ethyl]methanesulfonamide (LiFEA). The special anion chemistry imparts the following new characteristics: i) In both LiFEA and LiETFSI, the ethylene oxide moiety efficiently captures Li+, resulting in a self‐folded structure and high T+ around 0.8. ii) For LiFEA, a Li−N bond (2.069 Å) is revealed by single crystal X‐ray diffraction, indicating that the FEA anion possesses a high donor number (DN) and thus an intensive interphase "self‐cleaning" function for an ultra‐thin and compact SEI. iii) Starting from LiFEA, an electron‐withdrawing sulfone group is introduced near the N atom. The distance of Li−N is tuned from 2.069 Å in LiFEA to 4.367 Å in LiETFSI. This alteration enhances ionic separation, achieves a more balanced DN, and tunes the self‐cleaning intensity for a reinforced SEI. Consequently, the fast charging/discharging capability of LMBs is progressively improved. This rationally tuned anion chemistry reshapes the interactions among Li+, anions, and solvents, presenting new prospects for advanced LMBs. [ABSTRACT FROM AUTHOR]

The electrolytes for lithium metal batteries (LMBs) are plagued by a low Li+ transference number (T+) of conventional lithium salts and inability to form a stable solid electrolyte interphase (SEI). Here, we synthesized a self‐folded lithium salt, lithium 2‐[2‐(2‐methoxy ethoxy)ethoxy]ethanesulfonyl(trifluoromethanesulfonyl) imide (LiETFSI), and comparatively studied with its structure analogue, lithium 1,1,1‐trifluoro‐N‐[2‐[2‐(2‐methoxyethoxy)ethoxy)]ethyl]methanesulfonamide (LiFEA). The special anion chemistry imparts the following new characteristics: i) In both LiFEA and LiETFSI, the ethylene oxide moiety efficiently captures Li+, resulting in a self‐folded structure and high T+ around 0.8. ii) For LiFEA, a Li−N bond (2.069 Å) is revealed by single crystal X‐ray diffraction, indicating that the FEA anion possesses a high donor number (DN) and thus an intensive interphase "self‐cleaning" function for an ultra‐thin and compact SEI. iii) Starting from LiFEA, an electron‐withdrawing sulfone group is introduced near the N atom. The distance of Li−N is tuned from 2.069 Å in LiFEA to 4.367 Å in LiETFSI. This alteration enhances ionic separation, achieves a more balanced DN, and tunes the self‐cleaning intensity for a reinforced SEI. Consequently, the fast charging/discharging capability of LMBs is progressively improved. This rationally tuned anion chemistry reshapes the interactions among Li+, anions, and solvents, presenting new prospects for advanced LMBs. [ABSTRACT FROM AUTHOR]

The chemo‐regulation abilities of chemotherapeutic medications are appealing to address the low immunogenicity, immunosuppressive lactate microenvironment, and adaptive immune resistance of colorectal cancer. In this work, the proteolysis targeting chimera (PROTAC) of BRD4 (dBET57) is found to downregulate colorectal cancer glycolysis through the transcription inhibition of c‐Myc, which also inhibits the expression of programmed death ligand 1 (PD‐L1) to reverse immune evasion and avoid adaptive immune resistance. Based on this, self‐delivery nano‐PROTACs (designated as DdLD NPs) are further fabricated by the self‐assembly of doxorubicin (DOX) and dBET57 with the assistance of DSPE‐PEG2000. DdLD NPs can improve the stability, intracellular delivery, and tumor targeting accumulation of DOX and dBET57. Meanwhile, the chemotherapeutic effect of DdLD NPs can efficiently destroy colorectal cancer cells to trigger a robust immunogenic cell death (ICD). More importantly, the chemo‐regulation effects of DdLD NPs can inhibit colorectal cancer glycolysis to reduce the lactate production, and downregulate the PD‐L1 expression through BRD4 degradation. Taking advantages of the chemotherapy and chemo‐regulation ability, DdLD NPs systemically activated the antitumor immunity to suppress the primary and metastatic colorectal cancer progression without inducing any systemic side effects. Such self‐delivery nano‐PROTACs may provide a new insight for chemotherapy‐enabled tumor immunotherapy. [ABSTRACT FROM AUTHOR]

The formation of Pb-O bond between Pb SP 2+ sp and L-Cysteine can induce significant aggregation of Au NPs (blue color), conversely, Cu can catalyze the oxidation of Cysteine and prevent the aggregation of Au NPs (pink color). DOI: 10.1002/sscp.202200019 The cover picture shows that the lead ion (Pb SP 2+ sp ) and copper ion (Cu SP 2+ sp ) in lake water are detected by UV-Vis analysis using gold nanoparticles (Au NPs) as the colorimetric probe. [Extracted from the article]