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Start Over Descriptor "structural simplification" Publisher wiley-blackwell
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1. Design, synthesis, biological evaluation, NMR and DFT studies of structurally simplified trimethoxy benzamides as selective P-glycoprotein inhibitors: the role of molecular flatness.

Author

Stefanachi, Angela, Mangiatordi, Giuseppe Felice, Tardia, Piero, Alberga, Domenico, Leonetti, Francesco, Niso, Mauro, Colabufo, Nicola Antonio, Adamo, Carlo, Nicolotti, Orazio, and Cellamare, Saverio

Subjects
*INTRAMOLECULAR catalysis, *HYDROGEN bonding, *BENZAMIDE, *GLYCOPROTEINS, *GLYCOCONJUGATES
Abstract

In a recent investigation carried out on a panel of trimethoxybenzanilides, we showed that the formation of an intramolecular hydrogen bond is a key element for tuning P-gp inhibitory activity. In this study, we designed new structurally simplified trimethoxy benzamides ( 5- 17, Table [ABSTRACT FROM AUTHOR]

Published
2016
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