1. Metabolic programming in chronically stimulated T cells: Lessons from cancer and viral infections.
- Author
-
Bettonville M, D'Aria S, and Braun MY
- Subjects
- Adaptation, Biological genetics, Adaptation, Biological immunology, Animals, Antigens immunology, Cellular Reprogramming genetics, Energy Metabolism genetics, Gene Expression Regulation, Host-Pathogen Interactions genetics, Host-Pathogen Interactions immunology, Humans, Immunologic Memory, Lymphocyte Activation genetics, Neoplasms immunology, Neoplasms metabolism, Signal Transduction, T-Lymphocyte Subsets cytology, Virus Diseases immunology, Virus Diseases metabolism, Cellular Reprogramming immunology, Energy Metabolism immunology, Lymphocyte Activation immunology, T-Lymphocyte Subsets immunology, T-Lymphocyte Subsets metabolism
- Abstract
T-cell metabolism is central to the shaping of a successful immune response. However, there are pathological situations where T cells are rendered dysfunctional and incapable of eliminating infected or transformed cells. Here, we review the current knowledge on T-cell metabolism and how persistent antigenic stimulation, in the form of cancer and chronic viral infection, modifies both metabolic and functional pathways in T cells., (© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
- Published
- 2016
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