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1. Development of Novel Isoindolone‐Based Compounds against Trypanosoma brucei rhodesiense

Author

Dr. Daniel G. Silva, Pim‐Bart Feijens, Rik Hendrickx, An Matheeussen, Lucie Grey, Prof. Dr. Guy Caljon, Prof. Dr. Louis Maes, Prof. Dr. Flavio S. Emery, and Dr. Anna Junker

Subjects
anti-infectives, heterocyclic, in vitro, T. b. brucei, T. b. rhodesiense, Chemistry, QD1-999
Abstract

Abstract This study identified the isoindolone ring as a scaffold for novel agents against Trypanosoma brucei rhodesiense and explored the structure‐activity relationships of various aromatic ring substitutions. The compounds were evaluated in an integrated in vitro screen. Eight compounds exhibited selective activity against T. b. rhodesiense (IC50

Published
2021
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