1. Synthesis and evaluation of new bis-1,3,4,2-triazaphospholinoalkane derivatives as in vitro α-amylase and lipase inhibitors.
- Author
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Hamzaoui S, Ben Salah B, Hamden K, Rekik A, and Kossentini M
- Subjects
- Drug Design, Lipase metabolism, Molecular Structure, Structure-Activity Relationship, alpha-Amylases metabolism, Alkanes chemical synthesis, Alkanes pharmacology, Anti-Obesity Agents chemical synthesis, Anti-Obesity Agents pharmacology, Enzyme Inhibitors chemical synthesis, Enzyme Inhibitors pharmacology, Hypoglycemic Agents chemical synthesis, Hypoglycemic Agents pharmacology, Lipase antagonists & inhibitors, alpha-Amylases antagonists & inhibitors
- Abstract
A series of new 1,ω-bis-(5-alkyl-2-oxide-3-tosyl-1,3,4,2-triazaphospholino)alkanes 2 and 3 were prepared in good yields by the treatment of 1,ω-bis-(1-tosylamidrazone)alkanes 1 with two molar equivalents of phosphoryl trichloride and phenylphosphonic dichloride, respectively. All the newly synthesized compounds were characterized by IR, (1) H NMR, (13) C NMR, (31) P NMR, and elemental analysis. All the new compounds were screened for their inhibitory effect on the key enzymes related to diabetes and obesity, as α-amylase and lipase. The in vitro study revealed that these alkane derivatives exert an inhibitory action against these key enzymes, especially 2b with an IC50 of 16 μg/mL against α-amylase and lipase. Overall, the findings of the current study indicate that 2d exhibits attractive properties and can therefore be considered for future application in the development of antidiabetic and hypolipidemic drugs., (© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
- Published
- 2015
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