1. The nonalcoholic steatohepatitis extended hepatocyte ballooning score: histologic classification and clinical significance
- Author
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Ryan M. Gill, Daniela Allende, Patricia H. Belt, Cynthia A. Behling, Oscar W. Cummings, Cynthia D. Guy, Daniela Carpenter, Brent A. Neuschwander-Tetri, Arun J. Sanyal, James Tonascia, Mark L. Van Natta, Laura A. Wilson, Goro Yamada, Matthew Yeh, David E. Kleiner, and for the Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN)
- Subjects
Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Background and Aims:. The NAFLD activity score was developed to measure histologic changes in NAFLD during therapeutic trials. Hepatocyte ballooning (HB) is the most specific feature in steatohepatitis diagnosis, yet the impact of variations in HB has not been incorporated. Approach and Results:. Liver biopsies from patients enrolled in the NASH Clinical Research Network with an initial diagnosis of NASH or NAFL (n=1688) were evaluated to distinguish classic hepatocyte ballooning (cHB) from smaller, nonclassic hepatocyte ballooning (nHB), and also to designate severe ballooning and assign an extended hepatocyte ballooning (eB) score [0 points, no ballooning (NB); 1 point, few or many nHB; 2 points, few cHB; 3 points, many cHB; 4 points, severe cHB] to the biopsy assessment. The eB score was reproducible among NASH CRN liver pathologists (weighted kappa 0.76) and was significantly associated with older age (mean 52.1 y, cHB; 48.5 y, nHB, p
- Published
- 2023
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