1. Screening of anti-inflammatory and antipyretic activity of Vitex leucoxylon Linn.
- Author
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Shukla, Padmini, Shukla, P., Mishra, S. B., and Gopalakrishna, B.
- Subjects
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ACETATES , *VITEX , *INFLAMMATION prevention , *FEVER , *LABORATORY rats , *EDEMA prevention , *PREVENTION - Abstract
Objective: This study was designed to evaluate the anti-inflammatory and antipyretic activity of ethyl acetate extract of Vitex leucoxylon Linn. in various animal experimental models. Materials and Methods: Ethyl acetate extract of V. leucoxylon Linn. evaluated for antiinflammatory activity in carrageenan, mediator-induced rat paw edema, and cotton pellet-induced granuloma model. The antipyretic activity was evaluated by yeast-induced pyrexia model. Results: Single administration of the ethyl acetate extract of V. leucoxylon Linn. at dose of 500 mg/kg p.o. showed significant (P < 0.001) inhibition of rat paw edema. The ethyl acetate extract showed significant antipyretic activity in brewer yeast-induced pyrexia in rats throughout the observation period of 4 h. Conclusion: This study shows that ethyl acetate extract of V. leucoxylon Linn. has significant anti-inflammatory and antipyretic activity. [ABSTRACT FROM AUTHOR]
- Published
- 2010
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