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The article presents a case study of a 42-year-old man with multiple irregular plaques with ulcers on his left hand. Topics include caused by a wood stabbing, leading to chronic non-healing lesion, followed by the development of the secondary pulmonary tuberculosis; and patient reporting no systemic symptoms of fever, fatigue, having night sweats, and weight loss.

The article offers information that Atopic dermatitis is a common inflammatory skin disease which is characterized by chronic eczematous skin with inflammation and palindromia. It also discusses that the pathogenesis of Atopic dermatitis is defects in humoral immune responses involving selective deficits in B-cell activation by antigen receptors and T-cell costimulation by CD28 and gradual development of AD with hyper-IgE.

A 55-year-old Chinese man presented with a 17-month history of pustules, papules, nodules, plaques, and ulcers involving most of his body, including the scalp, face, neck, trunk, and extremities. Several superficial ulcers with vegetative exophytic margins and plaques were also present. Cribriform sinuses were on the plaque surfaces and ulcer bases. Pus discharged under pressure. C-reactive protein level was 120.07 mg/dL, with the erythrocyte sedimentation rate at 95 mm/h. Repeated smears and cultures were negative. Forearm incisional biopsy showed pseudoepitheliomatous hyperplasia and diffuse neutrophilic infiltration with microabscesses. Vegetative pyoderma gangrenosum was diagnosed. Lesions markedly abated after systemic corticosteroid therapy. [ABSTRACT FROM AUTHOR]