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Objective: To explore Rasayana herbs ascribed in Ayurveda classics and their contemporary appraisal for Rasayana potential. Data Source: Classical Ayurvedic review of Rasayana herbs were done from three distinguished Ayurveda classics (Charaka Samhita, Sushruta Samhita and Ashtang Hridaya) known as Brithattrayi. The contemporary review of those classical herbs was done from PubMed and other reputed databases. Review Methods: The classical Ayurveda review was done manually from Charaka Samhita, Sushruta Samhita and Ashtanga Hridaya. The single herbs mentioned in specifically dedicated Rasayana chapters of these classics (Charaka Chikitsa 1, Sushruta Chikitsa 27, 28, Ashtanga Hridaya Uttarsthana 39) were gathered. The botanical identity of the herbs were taken from “The plant list.org”. The contemporary review of those classical herbs mentioned as Rasayana in Ayurveda classics were done from PubMed and other databases. The searching key was Latin name of drug/herb+Rasayana activity. Results: Total 39 herbs were enumerated in Brihattrayi, among them 21 are in Charaka Samhita, 12 in Sushruta Samhita and 21 are from Ashtanga Hridaya, few of them are Bhallataka, Mandukaparni, Guduchi, Varahikanda, Soma, Tuvaraka, Vacha and Bhringaraja. Most of the herbs mentioned as Rasayana are evaluated scientifically for their antioxidant, immunomodulatory and nootropic potential. These reported activities of herbs support their Rasayana property. Conclusion: These studies indicate that daily damage of cells leads to early ageing and occurrence of many diseases. Rasayana herbs through their anti-oxidant, immunomodulatory and nootropic potential protect the damage which contribute towards health and longevity.

Diabetes is one among the various lifestyle disorders and was reported to be 7th leading cause of death by the WHO in 2016. To manage blood glucose levels and combat associated medical conditions, polypharmacy is becoming the choice of treatment by diabetics. Due to the unawareness of diabetics regarding the polypharmacy, it was thought to gather the scientific published literature at a place which will guide both the physicians as well as patients to choose a right herb along with conventional medicine. The scientific online portals were reviewed, and data reporting synergistic or antagonistic effects were searched for their clinical as well as preclinical evidence. There are several herbs mentioned in classical texts, which have antidiabetic potential and other beneficial effects on one's body. These drugs do exhibit synergistic as well as antagonistic effects when used along with conventional medicines. One should opt for polypharmacy cautiously and judiciously under medical supervision only.

Introduction: COVID-19, caused by SARS-CoV-2 or novel corona virus is declared as a global emergency. Researchers are working hard to develop effective remedy and vaccine, but still the challenge to manage the spread and disease progression is existing. In Ayurveda, a good number of herbs are ascribed for health promotion and longevity; many of them are scientifically proven to boost immunity. Jeevaneeya mahakashaya of Charaka Samhita is such group of ten herbs enumerated for longevity and rejuvenation. However, few of the herbs of Jeevaneeya mahakashaya are endangered and not available easily. Thus, in the present article, the herbs of Jeevaneeya mahakashaya having Pratinidhi (substitutes) suggested in Bhavaprakasha Nighantu were reviewed. Objective: The objective of this study is to analyze the rationality and applicability of Jeevaneeya mahakashaya in the prevention and management of COVID-19. Data Source: The data was collected from Charaka Samhita and Bhavaprakasha Nighantu and PubMed database. Review Methods: Jeevaneeya mahakashaya and its Pratinidhi herbs were reviewed from Charaka Samhita and Bhavaprakasha Nighantu, respectively. Herbs of Jeevaneeya mahakashaya were also reviewed from PubMed data base for reported pharmacological activities beneficial in the management of COVID-19 by their botanical name. Results: The literature search revealed that the herbs enumerated in the Jeevaneeya mahakashaya were scientifically evaluated in various preclinical and clinical studies and showed anti-viral, anti-bacterial, immunomodulatory, anti-inflammatory, anti-oxidant, anti-tussive, cardio-protective, neuroprotective, nephroprotective, and hepatoprotective activity. These potential of herbs may help in CD4+ and CD8+ cell proliferation, interleukin 6, tumour necrosis factor alpha, inflammatory markers inhibition. It also protects various organs from damage, and improves respiration. Conclusion: The rational use of plants of Jeevaneeya mahakashaya may help in the prevention and management of SARS-CoV 2.