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Start Over Author "Uemura, Hirotsugu" Publisher wolters kluwer uk
21 results on '"Uemura, Hirotsugu"'

2. MP05-19 POLYGENETIC RISK SCORE FOR PROSTATE CANCER IS ASSOCIATED WITH LIPOPOLYSACCHARIDE PATHWAY IN GUT MICROBIOME.

Author

Hatano, Koji, Tomofuji, Yoshihiko, Matsushita, Makoto, Oka, Toshiki, Motooka, Daisuke, Fujimoto, Saizo, Hata, Junya, Tsujimura, Akira, Obara, Wataru, Nakamura, Shota, Uemura, Hirotsugu, Okada, Yukinori, Nonomura, Norio, and Fujita, Kazutoshi

Subjects
DISEASE risk factors, GUT microbiome, PROSTATE cancer, LIPOPOLYSACCHARIDES, EAST Asians, PROSTATE-specific antigen, KNOCKOUT mice
Published
2024
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3. Effect of Tamsulosin on Bladder Blood Flow and Bladder Function in a Rat Model of Bladder Over Distention/Emptying Induced Bladder Overactivity.

Author

Okutsu, Hiroko, Matsumoto, Seiji, Ohtake, Akiyoshi, Suzuki, Masanori, Sato, Shuichi, Sasamata, Masao, and Uemura, Hirotsugu

Subjects
BLOOD flow, BLADDER obstruction, ADRENERGIC alpha blockers, PATHOLOGICAL physiology, ADENOSINE triphosphate, BENIGN prostatic hyperplasia, URINARY tract infections, LABORATORY rats
Abstract

Purpose: Decreased bladder blood flow was the subject of a recent study as a pathophysiological cause of bladder overactivity. We developed a rat model of bladder over distention/emptying induced bladder overactivity and investigated the effect of the α1-adrenoceptor antagonist tamsulosin on bladder blood flow and bladder function in this model. Materials and Methods: The bladder was distended with 2 ml saline using anesthesia for 2 hours (over distention) and then emptied. Bladder blood flow was measured using a perfusion imager. Micturition behavior and parameters were observed using a metabolic cage and a cystometry method, respectively, from 2 hours after bladder emptying. After model establishment was confirmed we examined the participation of afferent C-fibers and the effects of tamsulosin in rats pretreated with capsaicin (Sigma-Aldrich®) (125 mg/kg) and tamsulosin (1 μg/kg per hour), respectively, using a metabolic cage. Results: Decreased bladder blood flow was observed upon over distention with partial recovery at emptying. Bladder over distention/emptying increased micturition frequency and decreased mean voided volume in the micturition recording study, and decreased the intercontraction interval and voided volume without affecting micturition pressure, threshold pressure or post-void residual volume in the cystometry study. Capsaicin pretreatment did not affect bladder overactivity. However, 1-week continuous treatment with tamsulosin increased bladder blood flow after bladder emptying, resulting in decreased micturition frequency and increased voided volume. Conclusions: Bladder over distention/emptying induced bladder blood flow decrease/partial recovery and caused bladder overactivity via a mechanism other than capsaicin sensitive C-fiber activation. Findings in tamsulosin treated rats confirmed the potency of tamsulosin to increase bladder blood flow and ameliorate bladder overactivity. [ABSTRACT FROM AUTHOR]

Published
2011
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12. 1251 PROSPECTIVE RANDOMIZED TRIAL OF ALPHA-BLOCKER COMBINED WITH IMIDAFENACIN IN THE TREATMENT OF NOCTURIA IN PATIENTS WITH BENIGN PROSTATIC HYPERPLASIA AND CONCOMITANT OVERACTIVE BLADDER SYNDROME: RESULTS OF GOOD-NIGHT STUDY.

Author

Inamoto, Teruo, Tsujimura, Akira, Nonomura, Norio, Azuma, Hauhito, Akino, Hironobu, Oguchi, Naoki, Kitagawa, Yasuhide, Segawa, Naoki, Tamada, Satoshi, Shimizu, Nobutaka, Watanabe, Akihiko, Urashima, Mitsuyoshi, Okuyama, Akihiko, Katsuoka, Yoji, Uemura, Hirotsugu, Nakatani, Tatsuya, Namiki, Mikio, Fuse, Hideki, Matsuda, Tadashi, and Osamu, Yokoyama

Published
2012
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