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Railway transportation, as an important lifeline during earthquake relief and post-disaster reconstruction, has an extremely significant role. The study of track irregularity caused by earthquakes is the basis for ensuring traffic safety after their occurrence. In this paper, a finite element model of a five-span simply supported high-speed railway beam bridge with the China Railway Track System (CRTS) II was established and an experimental verification was performed. Eighty arbitrarily selected seismic waves were extracted from the Pacific Earthquake Engineering Research Center (PEER) strong ground motion database and a nonlinear time-history analysis was performed on the finite element model. The frequency–domain distribution law of earthquake-induced track irregularities was studied. A stable target earthquake-induced track irregularity spectrum model was constructed, and its expression was fitted. According to the results, in the case of transverse earthquakes, the rails experienced noticeable alignment irregularity and cross-level irregularity, while the amplitude of the gauge and vertical irregularity were relatively small. The target irregularity spectrum has a higher amplitude in the low-frequency components. When peak ground acceleration (PGA) was low, earthquake-induced track irregularity was not obvious, but the deteriorating effects of earthquakes on track irregularities increased significantly with increasing PGA. [ABSTRACT FROM AUTHOR]