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In this paper, a nonlinear population model for HIV-TB co-infection has been proposed. The model is incorporated with the effect of early and late initiation of HIV treatment in co-infectives already on TB treatment, on the occurrence of Immune Reconstitution Inflammatory syndrome (IRIS). A 15-dimensional (15D) mathematical model has been developed in this study. We begin with considering constant treatment rates and thereafter, proceed to time-dependent treatment rates for co-infectives as control parameters. The basic reproduction number, a threshold quantity, corresponding to each HIV and TB sub-model has been computed in case of constant controls. With constant values of control parameters, mathematical analysis shows the existence and local stability of the disease-free equilibrium point and the endemic equilibrium point for the model. Together with time-dependent parameters, an optimal control problem is introduced and solved using Pontryagin's maximum principle with an objective to minimize the number of infectives and disease induced deaths along with the cost of treatment. Numerical simulations are performed to examine the effect of reproduction numbers on control profiles and to identify, the ideal combination of treatment strategies which provides minimum burden on a society. Numerical results imply that if both HIV and TB are endemic in the population, then in order to bring in minimum burden from the co-infection, optimal control efforts must be enforced rather than constant treatment rate. [ABSTRACT FROM AUTHOR]

The Newton–Raphson basins of convergence, related to the equilibrium points, in the Sitnikov four-body problem with nonspherical primaries are numerically investigated. We monitor the parametric evolution of the positions of the roots, as a function of the oblateness coefficient. The classical Newton–Raphson optimal method is used for revealing the basins of convergence, by classifying dense grids of initial conditions in several types of two-dimensional planes. We perform a systematic and thorough analysis in an attempt to understand how the oblateness coefficient affects the geometry as well as the basin entropy of the convergence regions. The convergence areas are related with the required number of iterations and also with the corresponding probability distributions. [ABSTRACT FROM AUTHOR]

We examine the convergence properties of the generalized Hénon–Heiles system, by using the multivariate version of the Newton–Raphson iterative scheme. In particular, we numerically investigate how the perturbation parameter δ influences several aspects of the method, such as its speed and efficiency. Color-coded diagrams are used for revealing the basins of convergence on the configuration plane. Additionally, we compute the degree of fractality of the convergence basins on the configuration space, as a function of the perturbation parameter, by using different tools, such the uncertainty dimension and the (boundary) basin entropy. Our analysis suggests that the perturbation parameter strongly influences the number of the equilibrium points, as well as the geometry and the structure of the associated basins of convergence. Furthermore, the highest degree of fractality, along with the appearance of nonconverging points, occur near the critical values of the perturbation parameter. [ABSTRACT FROM AUTHOR]