1. Clinical and biochemical factors for response to aspirin desensitization in aspirin-induced asthma patients – pilot study.
- Author
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Tyrak KE, Mejza F, Buczek M, Cholewa A, Wolny A, Pędzik I, Ignacak M, Konduracka E, Kupryś-Lipińska I, Majda A, Oleś K, Sładek K, Kuna P, and Mastalerz L
- Subjects
- Adult, Aged, Aspirin immunology, Asthma, Aspirin-Induced immunology, Asthma, Aspirin-Induced pathology, Cell Count, Eosinophils, Female, Humans, Macrophages, Male, Middle Aged, Nasal Lavage Fluid immunology, Pilot Projects, Quality of Life, Sputum immunology, Treatment Outcome, Asthma, Aspirin-Induced therapy, Desensitization, Immunologic, Nasal Lavage Fluid cytology, Sputum cytology
- Abstract
Aspirin desensitization is considered to be an effective and well-tolerated therapy for patients with Non-steroidal anti-inflammatory(NSAIDs)-Exacerbated Respiratory Disease (NERD). The aim of the present study was to investigate the influence of aspirin desensitization on inflammatory cell count in induced sputum and nasal lavage in fifteen NERD individuals subjected to one-year aspirin therapy. The decrease in induced sputum count of eosinophils and macrophages was observed. Clinical efficacy of aspirin therapy in improving nasal symptoms and quality of life in NERD patients was also confirmed.
- Published
- 2016