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The immunological (lymphocyte blast transformation with PHA, determination of IgA, IgM, IgG), cytochemical (the mean cytochemical index of neutrophil lipids, glycogen, peroxidase content), hematological (the leukocyte, lymphocyte and neutrophil counts), and biochemical tests were employed to study immune responsiveness in 108 patients with chronic non-calculous cholecystitis running a refractory relapsing course. The patients showed the signs of immune deficiency. Some of the above described tests turned out informative for detecting such deficiency. It has been demonstrated that conventional therapy does not provide any stable clinical effect, aggravating the manifestations of immune deficiency. The introduction into the complex of treatment measures of diphenhydramine, saparal and levamisole, in particular, favoured more rapid elimination of the clinical symptoms of a relapse, of allergic reactions, psychoemotional disorders and reduced the signs of a decrease in immune responsiveness in patients with chronic non calculous cholecystitis running a refractory relapsing course.