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Pharmaceutical analysis simply means analysis of pharmaceuticals. Webster’ dictionary defines a pharmaceutical is a medical drug. A more appropriate term for a pharmaceutical is active pharmaceutical ingredient (API) or active ingredient to distinguish it from a formulated product or drug product is prepared by formulating a drug substance with inert ingredient (excipient) to prepare a drug product that is suitable for administration to patients. Research and development (R&D) play a very comprehensive role in new drug development and follow up activities to ensure that a new drug product meets the established standards is stable and continue to approved by regulatory authorities, assuring that all batches of drug product are made to the specific standards utilization of approved ingredients and production method becomes the responsibility of pharmaceutical analysts in the quality control (QC) or quality assurance department. The methods are generally developed in an analytical R&D department and transferred to QC or other departments as needed. At times they are transferred to other divisions. Key Words: API, quality control, Research and development (R&D), excipient

The present study was undertaken to investigate and validate the traditional claims ofClerodendrum paniculatum Linnfor its anti-anxiety activity.C. paniculatum linnbelongs to Verbenacae family. Ethnomedical importance of various species ofClerodendrumgenus has been reported in various indigenous systems of medicines and folk medicines. It is used as a medicine for the treatment of sore eyes, gonorrhoea, urinary tract infection and kidney problems. Till date there are no reports available regarding its pharmacological properties of hence, it is therefore worthwhile to study the unrevealed properties of this plant. The shade dried aerial parts of plant were extracted by extracted using ethyl acetate, petroleum ether and aqueous as a solvent. Obtained extracts were subjected for phytochemical screening and antianxiety activity was studied using elevated plus maze and light and dark models. Results of the phytochemical screening revealed the presence of flavonoids, tannins, glycosides, saponins, and terpenoid like compounds. In addition, among the extracts studied for anti-anxiety activity of ethyl acetate extract shown significant activity comparable with standard drug, diazepam. Petroleum ether and aqueous extracts shown least anti-anxiety activity in comparison with the standard.

Sustainable development of any country depends upon the type and quantum of road transportation infrastructure provided. In India, the large networks of existing roads, which are built at huge expenses, have started showing signs of distress failure before design period. The pavement maintenance management system (PMMS) is a technique utilized for examination and deciding the asphalt circumstance rating in the investigation zone. In this study, a preliminary survey is conducted from Thanakankulam to Thiruparankundram. HDM-4 is a product instrument created by World Bank for worldwide applications can be adequately used for distinguishing ideal support methodology for roadway asphalts. Further analysis process will be carried out by HDM-4 tool to determine the pavement condition index and its strategies. Executed to help the Highway Agencies for building up reasonable degrees of subsidizing, and to set levels and Priorities to expand the viability of use on asphalt support exercises. Subsequently, HDM-4 framework has been chosen and utilized in this examination because of the more extensive International Acceptance., {"references":["Amritpal Singh, Annu, \"The role of HDM-4 in developing pavement maintenance management systems (PMMS) for the patiala city road network\", International Journal of Emerging Technology and Innovative Engineering Volume I, Issue 7, July yy62015.","Bandara and M. Gunaratne, current and future pavement maintenance prioritization based on rapid visual condition evaluation, journal of transportation engineering / March/April 2001; 127:116-123.","Chalise DN. Roads Board, Nepal: A Sustainable Approach to Road Maintenance Management, Transport and Communication Bulletin for Asia and the Pacific, No. 75, 2005.","Fareed M. A. Karim, Dr Khaled Abdul Haleem Rubasi, and Dr Ali Abdo Saleh. The Road Pavement Condition Index (PCI) Evaluation and Maintenance: A Case Study of Yemen, Organization, Technology and Management in Construction 2016; 8: 1446–1455","Hamad Al-Ajami , \"Pavement maintenance management systems\", Civil and Environmental Research, ISSN 2224-5790,Vol.7, No.5, 2015.","Jendia S, Al Hallaq M. Development of Pavement Maintenance Management System (PMMS) for Gaza City, J Islamic University of Gaza (Series of Natural Studies & Engineering), 2005; 13(1): 119–138p.","Milaa Murshan, Monicaba Vala, A review on GIS-based pavement maintenance management system for urban corridors, International Journal of Advance Engineering and Research Development Volume 4, Issue 3, March -2017.","Mounesh R T, Rohit V A, Prakash R H, Shivaprasad C N, Pavement Maintenance and Management of Urban Roads Using HDM 4, International Journal of Engineering Technology, Management and Applied Sciences, May 2015, Volume 3, Issue 5, ISSN 2349-4476.","Sarsam S. Visual Evaluation of Asphalt Concrete Surface Condition using an Expert System VEACPSC, Indian Highways IRC. 38(9), 2010.","Sarsam SI, Mohammed IA, Burhan AM. Using Pavement Automated Monitoring System in Prioritization of Maintenance Decisions, Int J Constr Eng Plann. IJCE J Pub. 2015; 1(1): 1–13p.","Shashi Bhushan Girimath, Dr. Venkat Chilukuri, Prof. T. G. Sitharam, Dr. Krishnamurthy, \"Pavement Management System for Urban Roads\", IJSRD - International Journal for Scientific Research & Development Vol. 2, Issue 03, 2014.","Sudhakar. R, Pavement Maintenance Management System for Urban Roads Using HDM-4, Indian geotechnical society Chennai chapter (2009).","Raid R. A. Almuhanna, \"Using PAVER 6.5.7 and GIS program for pavement maintenance management for selected roads in Kerbala city\". Case Studies in Construction Materials 8 (2018) 323–332.","Tanuj Chopra, Manoranjan Parida, Naveen Kwatra, Jyoti Mandhani, \"Development of Pavement Maintenance Management System (PMMS) of Urban Road Network Using HDM-4 Model\" , International Journal of Engineering & Applied Sciences (IJEAS) ,Vol.9, Issue 1(2017) 14-31.","Vinod Mashyal, \"Pavement Maintenance and Management of urban roads by using HDM-4\", International Research Journal of Engineering and Technology (IRJET), 2018."]}

The term ‘liquisolid systems’ (LS) is a powdered form of liquid drug formulated by converting liquid or solid lipophilic drug in suitable non-volatile solvent systems into dry looking, non-adherent, free-flowing, and readily compressible powdered mixtures by blending with selected carrier and coating materials. The aim of the present study is to improve the solubility of poorly water soluble drug, dabigatran etexilate mesylate a BCS class II drug. Dabigatran Etexilate Mesylate is an inactive pro-drug that is converted to dabigatran, the active form used as an anti-coagulant. Various non-volatile solvents (PEG 600, PEG 400, Castor oil, Span 80, Tween 80, Glycerine, Transcutol, Olive oil, Liquid Paraffin) were used and maximum solubility was observed in combination of span80 and castor oil (400.96ug/ml). Selection of carrier materials like Maize starch, MCC, Avicel pH 101 and 102 and Prosolv SMCC 50 with a loading factor of 0.72, 0.75, 0.77, 0.87 and 1.75 respectively were optimized. To this admixture, coating material Aerosil 200 in different ratios (R=5, 10, 15, 20, 25) was added to enhance the flow property. Finally the powdered material is compressed to tablets by direct compression using 11.9mm. The tablets were evaluated for physicochemical properties, and dissolution studies. Among all formulations, dabigatran etexilate mesylate liquisolid compacts containing Prosolv SMCC 50 (LSP) showed higher dissolution rate (99.8% in 30 min) than the pure drug (11.15% in 45 min). FTIR studies and DSC studies revealed that there is no significant interaction between the drug and excipients. The XRD analysis confirmed formation of a solid solution inside the compact matrix. Formulations were stable. From this study it can be concluded that the liquisolid technique is a promising alternative for improvement of dissolution property of waterinsoluble drugs. Hence Span80+Castor oil (non-volatile solvent) and Prosolv SMCC 50 were optimized in enhancing the dissolution rate of dabigatran etexilate mesylate. Keywords: Dabigatran Etexilate Mesylate, Non- Volatile solvents, Liquisolid compacts, Liquid load factor