1. Immunostaining Patterns of CD10 in Fibroadenomas and Phyllodes Tumours of Breast
- Author
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Farah Muhammad Ali, Saba Hassan Shamim, Farheen Danish, Lubna Avesi, Uzma Bukhari, and Sana Tahir
- Subjects
Biochemistry ,QD415-436 ,Dentistry ,RK1-715 ,Therapeutics. Pharmacology ,RM1-950 ,Medicine (General) ,R5-920 - Abstract
Background: Accurate differentiation between fibroadenomas and phyllodes tumours (PTs) is challenging due to overlapping morphological features. CD10, an immunohistochemistry (IHC) marker, has shown promise in distinguishing these breast lesions. This study aimed to evaluate CD10 expression patterns in fibroepithelial lesions (FELs) of the breast. Methodology: This cross-sectional study was conducted in the Histopathology Department, at Dow University of Health Sciences over 1 year (01st Jan 2023 to 15th Dec 2023). Through the purposive sampling technique, the female patients having FELs were diagnosed by Consultant Pathologists as fibroadenomas or PT and were included in the study by employing specific histological parameters on H & E slides. Immunohistochemistry with CD10 antibody was conducted on a total of 120 samples with an equal split of fibroadenomas, benign PT, borderline PT, and malignant PT (30 cases each), assessing stromal cell staining and categorizing expression as negative (30% positivity). Data was statistically analyzed by using SPSS version 26 including reporting mean ± S.D for continuous data and utilizing the Chi-square test to assess associations, with significance set at p
- Published
- 2024
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