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【目的】研究鼻咽癌中浸润的淋巴类细胞与癌细胞凋亡间的相关性。【方法】收集中山医科大学病理学教研室 38 例未经治疗的鼻咽癌活检标本。应用 TUNEL ( TdT-mediated dUTP Nick End Labeling)方法定量检测凋亡癌细胞计数(每 5 000 个 鼻咽癌细胞中的凋亡细胞数)。以免疫组化法分别检测T 细胞,单核/巨噬细胞,B 细胞和树突状细胞。【结果】① 在未经治疗 的鼻咽癌活检标本各例间癌细胞凋亡计数差异很大,平均为( 12. 9±13. 9) /5 000;② 凋亡癌细胞计数与T 细胞指数( I, 即平均 每个高倍视野浸润的 T 淋巴细胞数)和单核/巨噬细胞指数( moncyte macro phage index,MMI, 即平均每个高倍视野浸润的单核/ 巨噬细胞数)均呈正相关, P 0. 05。【结论】① 代表细胞介导免疫的浸润性 T 淋巴细胞可 以诱导鼻咽癌细胞凋亡;② 浸润的单核/巨噬细胞可能主要是癌细胞凋亡的诱导者也可能部分是凋亡的后果;③ 代表体液免疫的浸润性 B淋巴细胞和递呈抗原的树突状细胞与鼻咽癌细胞的凋亡无直接相关性。

目的: 研究鼻咽癌细胞株 CNE-1、CNE-2 裸鼠移植瘤中癌细胞增生、凋亡及其与肿瘤生长速度的关系, 探讨移植 瘤中肿瘤细胞凋亡的机理。方法: 将鼻咽癌细胞株 CNE-1、CNE-2 分别接种于裸鼠皮下, 并连续在体内传 9 代。对每一代肿 瘤组织进行 HE染色, TUNEL 法(原位细胞死亡末端标记法)检测原位细胞凋亡及免疫组化法检测 PCNA、bcl-2、bax 和 p53 的 表达。结果 : CNE-2移植瘤生长速度快于 CNE-1移植瘤;CNE-2移植瘤内肿瘤细胞分裂指数和细胞增生指数明显高于 CNE1 移植瘤, 而细胞凋亡却相对较少; 移植瘤组织中的凋亡主要表现为“皱缩性坏死”和“凋亡小体”的形成; 所有移植瘤组织中都 有 p53 蛋白积聚和 bax 过表达,但却未见 bcl-2的表达。结论: CNE-1和 CNE-2 细胞株移植于裸鼠皮下后, 生长速度的差异是 由于肿瘤细胞增生-凋亡比例不同所致; 裸鼠移植瘤组织中瘤细胞的死亡主要表现为凋亡,凋亡的途径可能是不依赖于野生型 p53,而由 bax 所介导的。

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Taking 2-year-old Camellia oleifera seedlings from the state-owned Bobai Forest Farm in Guangxi as the research object, different concentrations of nitrogen, phosphorus, potassium, and trace elements were used to determine the growth indicators and nutrient content of root, stem, and leaf parts during the grafting seedling stage. The characteristics of different leaf fertilizers on the growth and nutrient absorption of Camellia oleifera seedlings were studied. The results showed that different foliar fertilizer treatments had a significant impact on the nutritional growth of Camellia oleifera seedlings, and foliar fertilizer had a significant fertilizer effect on Camellia oleifera seedlings. Treatment ⑦ had the highest increase in net leaf growth compared to the control, reaching 47. 16%. Treatment ⑧ had the highest nitrogen content, which increased by 170. 89% compared to the control. In terms of trace elements, treatment ⑧ showed the highest increase in magnesium content compared to the control, with an increase of 101. 47%. The demand pattern for nutrients during the seedling stage of Camellia oleifera was N>K> P. Research had shown that when the ratio of nitrogen, phosphorus, and potassium was 10 :15 : 6 and the spraying concentration was 2. 5%, it can significantly promote the growth of seedlings compared to the control. [ABSTRACT FROM AUTHOR]

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Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Cotton is an important cash crop in Xinjiang, accounting for 90.2% of China's total production in 2022. However, natural factors such as drought, high soil salinity, and the constraints of perennial shallow tillage soil management practices limit the yield and efficiency of cotton production and sustainable agricultural development. Deep vertical rotary tillage facilitates the breaking up of soil solidification and promotes the salt leached by irrigation water. In order to investigate the improvement effect of deep vertical rotary tillage on heavily saline cotton fields in Southern Xinjiang of China, this study conducted a 2 a (2021-2022) field experiment with three deep vertical rotary tillage depths (DT20: deep vertical rotary tillage 20 cm, DT40: deep vertical rotary tillage 40 cm, DT60: deep vertical rotary tillage 60 cm), and alternate with conventional tillage (five-share plowing 20 cm CT20), and CT20 was set to be the two consecutive years of conventional tillage. Original soil samples from 0-60 cm were collected to determine the water-stable aggregates. Soil moisture, salinity, organic carbon, total nitrogen, total phosphorus and total potassium were defermined by samples under the drip irrigation tapes, wide rows and narrow rows of each treatment on the 3rd day after each irrigation. Cotton root samples were collected at 105 days after sowing in 2021 and at 103 days in 2022. The effects of different depths of deep vertical rotary tillage on soil physical properties, soil nutrient content, cotton root length density, boll weight, dry matter mass accumulation and seed cotton yield were investigated, and the effect of crop yield was quantified by structural equation modeling. The results showed that: 1) deep vertical rotary tillage was able to loosen the soil in the tillage layer to optimize the soil structure. DT60 treatment was able to significantly reduce the soil bulk density, the content of coarse aggregates (>2 mm), and silt and clay particle (<0.053 mm) in the tillage depth layer compared with DT20 and CT20 treatment, which led to a significant reduction in mean weight diameter and mean geometric diameter, and increased total soil porosity and the content of micro-aggregates (<0.25～ 0.053 mm), while DT60 treatment was unable to further improve the soil structure in the deep soil layer compared with DT40 treatment. 2) DT40 and DT60 treatments were able to significantly increase soil moisture from 0-40 cm soil layer and reduce soil salinity and pH value, whereas DT20 treatment was only able to reduce soil salinity from 0-20 cm soil layer, whereas DT60 treatment was able to significantly reduce soil salinity and pH value from 0-60 cm soil layer compared with DT40 treatment. The reduction of soil salinity promoted the accumulation of soil organic carbon in the 0-40 cm soil layer and soil total nitrogen in the 0-60 cm soil layer, but DT60 treatment was unable to significantly increase soil organic carbon and soil total nitrogen in the 0-20 cm soil layer compared with the DT40 treatment. 3) The analysis of the structural equation modeling showed that soil salinity was an indirect factor affecting the seed cotton yield, and the accumulation of cotton’s dry matter and the weight of cotton bolls were the direct factored. The reduction of soil salinity favors soil nutrient accumulation and cotton root growth, promoted nutrient transport and accumulation to the plant organ, and increased cotton dry matter accumulation and seed cotton yield. Therefore, DT60 treatment had the best effect of soil salinity reduction, and thus the effect of yield increase. Comprehensive analysis showed that the depth of 60 cm on deep vertical rotary tillage with conventional tillage alternating can realize the synergy of improving and increasing the yield and efficiency of the severe saline cotton fields in the Southern Xinjiang of China. [ABSTRACT FROM AUTHOR]

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Copyright of Journal of South China Agricultural University is the property of Gai Kan Bian Wei Hui and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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In order to investigate the effects of jumping loads on structural vibrations. Firstly, an improved semi-sine model was proposed, and characteristic parameters for the crowd jumping load model were suggested. Next, an analytical solution for the dynamic response of a simply supported beam under a single person's jumping load was derived. Finally, using a pedestrian footbridge in Jingzhou City as an example, the experimental and numerical results of the structural acceleration response under jumping loads were compared to validate the applicability of the improved semi-sine model. The results show the improved semi-sine model exhibits a maximum error of 2. 8% when compared to experimental measurements. In contrast, the semi-sine and semi-sine squared models exhibit corresponding maximum errors of 23. 4% and 7. 1%, respectively. At a jumping frequency of 2. 3 Hz, the jumping load frequency closely approximates the first-order natural frequency of the structure, resulting in resonance within the structure. In the mid to high-frequency range, the response results of the improved semi-sine model closely align with experimental measurements. These results hold valuable insights for accurately simulating jumping loads. [ABSTRACT FROM AUTHOR]

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Copyright of Asian Journals of Ecotoxicology is the property of Gai Kan Bian Wei Hui and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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BACKGROUND: Anterior subtotal corpectomy, decompression and fusion is a conventional method to treat cervical degenerative diseases. A titanium cage is an important implant to maintain the stability of the cervical spine after subtotal corpectomy. In recent years, many patients have complications such as titanium cage sinking, which are highly controversial. OBJECTIVE: To investigate the internal biomechanical relationship between the tilt angle of the titanium cage and postoperative titanium cage subsidence after anterior subtotal cervical corpectomy, decompression and fusion. METHODS: A three-dimensional finite element model of the C4-C6 segment was established by CT images of a normal human cervical spine, in which the anterior subtotal resection, decompression and fusion of the C5 vertebral body were simulated, and titanium cages with different tilt angles (-6° to -1° negative angle, that is, the front edge of titanium cage is shorter than the rear edge of titanium cage; 1° to 6° positive angle, that is, the front edge of titanium cage is longer than the rear edge of titanium cage) were placed. After setting the boundary conditions, preloads of 50, 100 and 150 N were applied respectively on the C4 vertebral body. The stress value of each contact point between the titanium cage and C4 lower-end plate and C6 lower-end plate (seven stress contact points on the contact surface of titanium mesh) was recorded and statistical analysis was conducted. RESULTS AND CONCLUSION: (1) The tilt angles of the titanium cage of the positive angle group and negative angle group under 50, 100 and 150 N stress respectively were found by Mann Whitn test, with P < 0.05, which was statistically significant. The dispersion coefficients of the positive angle group were smaller than those of the negative angle group under 50, 100 and 150 N stress conditions. (2) Under 50, 100 and 150 N stress conditions, the Wilcoxon sign rank test in the positive angle group of titanium cage tilt angle found that when the angle was set to 1° to 5°, the difference was not statistically significant (P > 0.05). However, when the tilt angle of the titanium cage was set to 6°, the difference was statistically significant (P < 0.05). (3) Under 50, 100 and 150 N stress conditions, the Wilcoxon sign rank test in the negative angle group of titanium cage tilt angle found that when the tilt angle was set to -1° to-6°, the difference was not statistically significant (P > 0.05). (4) It is concluded that in the sagittal position, the titanium cage with a positive tilt angle is more stable than with a negative tilt angle, which is more suitable for clinical use. The tilt angle of the titanium cage is relatively stable in the range of 1° to 5°. When the tilt angle is 6°, the stability starts to decline, which is easy to cause complications of titanium cage sinking after surgery. It is more suitable to select the titanium cage with a tilt angle of 1° to 5° according to the clinical situation during surgery to improve the efficacy. [ABSTRACT FROM AUTHOR]