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BACKGROUND: Studies have shown that insulin-like growth factor 1/platelet-derived growth factor has an inhibitory effect on fibroblast apoptosis. miR-141- 3p in bone marrow stromal cells increases with age and has a relationship with the activation of inflammatory signaling pathways, suggesting that it may be a therapeutic target for lumbar disc herniation. OBJECTIVE: To explore the effects of miR-141-3p on dorsal root ganglion inflammation and lower limb pain in rats with lumbar disc herniation by regulating insulin-like growth factor 1/platelet-derived growth factor. METHODS: Fifty male Sprague-Dawley rats, SPF level, were randomly divided into normal group, model group, miR-NC group, miR-141-3p inhibitor group and miR-141-3p mimics group, with 10 rats in each group. Except for the normal group, animal models of lumbar disc herniation were established in rats by autologous nucleus pulposus transplantation. After successful modeling, rats in the miR-NC, miR-141-3p inhibitor and miR-141-3p mimics groups were injected intrathecally with 10 μL of 20 μmol/L miR-NC, miR-141-3p inhibitor, miR-141-3p mimics, once a day for 28 days, respectively, while those in the normal and model groups were injected with the same volume of saline at the same location at the same time. Paw withdrawal thermal latency threshold was used to evaluate lower limb pain in rats. The mRNA expression of miR-141-3p in dorsal root ganglion tissue was detected by real-time fluorescence quantitative PCR, the levels of inflammatory factors in dorsal root ganglion tissue were detected by ELISA, and the expression of insulin-like growth factor 1/platelet-derived growth factor in dorsal root ganglion tissue was detected by western blot. The correlation between miR-141-3p and insulin-like growth factor 1/platelet-derived growth factor was analyzed. RESULTS AND CONCLUSION: There were no significant differences in all indexes between the miR-NC group and the model group. Paw withdrawal thermal latency threshold was significantly lower in the model group than in the normal group (P < 0.05), significantly lower in the miR-141-3p inhibitor group than the miR-NC group (P < 0.05), and significantly higher in the miR-141-3p mimics group than in the miR-141-3p inhibitor group (P < 0.05). The mRNA expression of miR-141-3p in dorsal root ganglion tissue was significantly lower in the model group than in the normal group (P < 0.05), significantly lower in the miR-141- 3p inhibitor group than in the miR-NC group (P < 0.05), and significantly higher in the miR-141-3p mimics group than in the miR-141-3p inhibitor group (P < 0.05). The levels of tumor necrosis factor α, interleukin 1β, and interleukin 1 in dorsal root ganglion tissue were significantly higher in the model group than in the normal group (P < 0.05), significantly higher in the miR-141-3p inhibitor group than in the miR-NC group (P < 0.05), and significantly lower in the miR-141- 3p mimics group than in the miR-141-3p inhibitor group (P < 0.05). The protein expressions of insulin-like growth factor 1 and platelet-derived growth factor in dorsal root ganglion tissue were significantly lower in the model group than in the normal group (P < 0.05), significantly lower in the miR-141-3p inhibitor group than in the miR-NC group (P < 0.05), and significantly higher in the miR-141-3p mimics group than in the miR-141-3p inhibitor group (P < 0.05). The expressions of insulin-like growth factor 1 and platelet-derived growth factor showed a positive correlation with miR-141-3p (r=0.904, P < 0.001; r=0.879, P < 0.001). To conclude, miR-141-3p can significantly improve lower limb pain and inhibit inflammation in dorsal root ganglia in rats with lumbar disc herniation, and its mechanism may be related to the promotion of insulin-like growth factor 1/platelet-derived growth factor expression. [ABSTRACT FROM AUTHOR]

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Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Coal Science & Technology (0253-2336) is the property of Coal Science & Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Remote Sensing is the property of Editorial Office of Journal of Remote Sensing & Science Publishing Co. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

经内镜逆行胰胆管造影术(ERCP)是目前诊治胆胰疾病的重要手段之一。但其作为一项侵入 性操作,无法完全避免并发症的发生。其中,胆管感染是ERCP术后常见并发症之一,如不进行有效防治,可导 致严重后果,甚至危及生命。作者通过阅读国内外相关文献,对ERCP术后胆管感染的防治研究进展进行综 述,主要包括了术前、术中、术后的相关防治措施。 [ABSTRACT FROM AUTHOR]

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Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Coal Science & Technology (0253-2336) is the property of Coal Science & Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Geomatics & Information Science of Wuhan University is the property of Geomatics & Information Science of Wuhan University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Copyright of Journal of Clinical Hepatology / Linchuang Gandanbing Zazhi is the property of Journal of Clinical Hepatology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Coal Science & Technology (0253-2336) is the property of Coal Science & Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Generally, for the limited regulating gear restricts the existing transformer voltage regulation method, and the criterion of voltage regulation is the voltage curve determined by dispatching department, it is difficult to achieve a flexible, efficient, and high precision constant voltage modulation. To better solve the problem of transformer output voltage deviation, this paper proposed a method to dynamically adjust the voltage quality based on cyber physical system. Firstly, it respectively established transformer physical model and information model with MATLAB simulink and enterprise architect(EA). Then according to the mutual mapping between physical parameters and information attributes, with the help of an intermediary platform: Visual Studio, it used the dynamic link library to integrate the physical model and information model on a unified simulation platform. Therefor at last it established the transformer cyber physical system model on the MATLAB platform. Through information real-time feedback mechanism on quantities, it could control the automatic adjustment of inductor winding ratio, and stabilized the transformer output voltage. The simulation results show the effectiveness of cyber physical system on transformer voltage control. [ABSTRACT FROM AUTHOR]

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Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Coal Science & Technology (0253-2336) is the property of Coal Science & Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Application Research of Computers / Jisuanji Yingyong Yanjiu is the property of Application Research of Computers Edition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Since the traditional QR code recognition methods fail to fulfill the recognition task on multi-structural deformation deformed QR code cases, this paper presented a novel QR code recognition algorithm based on extreme learning machine. This method calculated Euclidean distance of feature points as deformation characteristics. And employed extreme learning machine to classify the deformation type. It determined the transform coefficients of each type, which were used for coordinates mapping. Then obtained real coordinates by perspective mapping with different transform coefficients, thus the code were reconstructed. Experimental results demonstrate that this method holds a satisfactory performance on both of recognition rate and time consuming. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Xi'an Jiaotong University (Medical Sciences) is the property of Xian Jiaotong University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)