1. Quantitative analysis of structural alterations in the choroid of patients with active Behçet uveitis
- Author
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Önal, Sumru (ORCID 0000-0002-4036-922X & YÖK ID 52359); Uludağ, Günay (ORCID & YÖK ID 175586); Mengi, Emre (ORCID 0000-0003-0788-0066 & YÖK ID 113760); Metin, Mustafa M.; Akbay, Aylin Koç, Oray, Merih; Herbort, Carl P.; Akman, Mehmet; Tuğal Tutkun, İlknur, Koç University Hospital, School of Medicine; College of Sciences, Department of Department of Mathematics; Department of Ophthalmology, Önal, Sumru (ORCID 0000-0002-4036-922X & YÖK ID 52359); Uludağ, Günay (ORCID & YÖK ID 175586); Mengi, Emre (ORCID 0000-0003-0788-0066 & YÖK ID 113760); Metin, Mustafa M.; Akbay, Aylin Koç, Oray, Merih; Herbort, Carl P.; Akman, Mehmet; Tuğal Tutkun, İlknur, Koç University Hospital, School of Medicine; College of Sciences, and Department of Department of Mathematics; Department of Ophthalmology
- Abstract
Purpose: To quantitatively analyze in vivo morphology of subfoveal choroid during an acute attack of Behçet uveitis. Methods: In this prospective study, 28 patients with Behçet uveitis of <= 4-year duration, and 28 control subjects underwent enhanced depth imaging optical coherence tomography. A novel custom software was used to calculate choroidal stroma-to-choroidal vessel lumen ratio. Subfoveal choroidal thickness was measured at fovea and 750 mu m nasal, temporal, superior, and inferior to fovea. Patients underwent fluorescein angiography and indocyanine green angiography. Receiver operating characteristic curve and area under the curve were computed for central foveal thickness. The eye with a higher Behçet disease ocular attack score 24 was studied. The main outcome measures were choroidal stromato-choroidal vessel lumen ratio and choroidal thickness. Results: The mean total Behçet disease ocular attack score 24, fluorescein angiography, and indocyanine green angiography scores were 7.42 +/- 4.10, 17.42 +/- 6.03, and 0.66 +/- 0.73, respectively. Choroidal stroma-to-choroidal vessel lumen ratio was significantly higher in patients (0.413 +/- 0.056 vs. 0.351 +/- 0.063, P = 0.003). There were no significant differences in subfoveal choroidal thickness between patients and control subjects. Choroidal stroma-tochoroidal vessel lumen ratio correlated with retinal vascular staining and leakage score of fluorescein angiography (r = 0.300, P = 0.036). Central foveal thickness was significantly increased in patients (352.750 +/- 107.134 mu m vs. 263.500 +/- 20.819 p.m, P < 0.001). Central foveal thickness showed significant correlations with logarithm of minimum angle of resolution vision, Behçet disease ocular attack score 24, total fluorescein angiography score, retinal vascular staining and/or leakage and capillary leakage scores of fluorescein angiography, and total indocyanine green angiography score. At 275 mu m cutoff, diagnostic sensitivity and specificity of ce, Istanbul University
- Published
- 2018