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Your search keyword '"Ansari, M.S."' showing total 193 results
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193 results on '"Ansari, M.S."'

15. Genotypic Analysis of COL4A1 Gene in Diabetic Nephropathy and Type 2 Diabetes Mellitus Patients: A Comparative Genetic Study.

Author

Shukla, Neha, Kumari, Shivani, Verma, Poornima, Kushwah, Atar Singh, Banarjee, Monisha, Sankhwar, S.N., Srivastava, Aneesh, Ansari, M.S., and Gautam, Naveen Kumar

Subjects
TYPE 2 diabetes, DIABETIC nephropathies, POLYCYSTIC kidney disease, PEOPLE with diabetes, GENOTYPES, RESTRICTION fragment length polymorphisms, RENAL fibrosis
Abstract

Diabetic nephropathy (DN) is specified by microalbuminuria, glomerular lesions, and renal fibrosis leading to end-stage renal disease. The pathophysiology of DN is multifactorial as a result of gene–environment interaction. Clinical studies suggested that gene mutations affect various pathways involved in DN, including extracellular matrix (ECM). During chronic hyperglycemia, collagen type-4-mediated ECM overproduction occurs, leading to renal fibrosis and DN development. In this study, COL4A1 gene variant rs605143 (G/A) was analyzed in diabetes and DN patients from the study population. We genotyped 386 study subjects, comprising 120 type 2 diabetes mellitus (T2DM) patients, 120 DN, and 146 healthy controls. All study subjects were analyzed for biochemical assays by commercially available kits and genotypic analysis by polymerase chain reaction–restriction fragment length polymorphism and confirmed by Sanger sequencing. Statistical analyses were done using SPSS and GraphPad. Anthroclinicopathological parameters showed a significant association between T2DM and DN. Genotype AA of COL4A1 gene variant rs605143 (G/A) showed a significant association with T2DM and DN compared with controls with 5.87- and 8.01-folds risk, respectively. Mutant allele A also significantly associated with T2DM and DN independently compared with healthy controls with 2.29- and 2.81-time risk in the study population. This study's findings suggested that COL4A1 gene variant rs605143 (G/A) can be used as predictive biomarkers for T2DM and DN independently. However, this gene variant needs to be analyzed in a large sample to explore the shared genetic association between T2DM and DN. [ABSTRACT FROM AUTHOR]

Published
2023
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38. Chronic progressive penile strangulation with urethrocutaneous fistula-report of a case

Author

Singh, Iqbal, Nabi, G., Ansari, M.S., and Panesar, Gulshant

Subjects
Gangrene -- Care and treatment -- Complications and side effects, Ischemia -- Management -- Complications and side effects -- Care and treatment, Penis -- Injuries, Company business management, Health
Abstract

Code Number: is03037 ABSTRACT We report a case of a self-inflicted chronic progressive penile strangulation leading to the formation of urethrocutaneous fistula in a mentally deranged 12-year-old boy. The literature [...]

Published
2003

44. Massive pleural effusion without bony involvement: an unusual presentation of advanced carcinoma prostate

Author

Ansari, M.S., Nabi, Gholam, and Seth, Amlesh

Subjects
Pleural effusions -- Diagnosis, Pleural effusions -- Care and treatment, Prostate cancer -- Complications
Abstract

Code Number: cn02008 ABSTRACT As noted under the natural history, the bone of axial skeleton and the ileopelvic lymphnodes specially the obturator groups are the commonest sites of metastasis spread [...]

Published
2002

45. Development of a two arm, high energy, high power laser for plasma research in India

Author

Joshi A.S., Kamath M.P., Sharma A.K., Raghuramaiah M.R., Patidar R.K., Ansari M.S., Sreedhar N., Chandra R., Navathe C.P., Naik P.A., and Gupta P.D.

Subjects
Physics, QC1-999
Abstract

We report here work done towards development of a two arm, high energy, high power Nd:phosphate glass laser system. One arm of the laser is proposed to be operated in a long pulse (∼1.5ns pulse duration) with an energy of ∼400 J. Presently, this arm of the laser is operating at energy of ∼100 J after a disc amplifier that amplifies the laser beam of diameter ∼94 mm. After the addition of two more disc amplifiers which are nearing completion, the laser beam will have energy of ∼400 J, with a beam diameter 140 mm, at an intensity of ∼2 GW/cm2. This beam will be converted to its second harmonic using a 2 × 2 array KDP crystals. The second arm, under development, will operate with a hybrid amplification scheme using optical parametric chirped pulse amplification (OPCPA) and conventional amplification using the existing Nd:glass amplifiers to produce 50 TW, 25 J, 500 fs pulse. A tiled triangular pulse compressor is under development for compressing the stretched pulse.

Published
2013
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