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4. Fatigue in Covid-19 survivors: The potential impact of a nutritional supplement on muscle strength and function

Author

Steering Committee, Landi, Francesco, Gremese, Elisa, Coordination, Bernabei, Roberto, Fantoni, Massimo, Gasbarrini, Antonio, Field investigators, Gastroenterology team, Porcari, Serena, Settanni, Carlo Romano, Geriatric team, Benvenuto, Francesca, Bramato, Giulia, Brandi, Vincenzo, Carfì, Angelo, Ciciarello, Francesca, Fabrizi, Sofia, Galluzzo, Vincenzo, Lo Monaco, Maria Rita, Martone, Anna Maria, Marzetti, Emanuele, Napolitano, Carmen, Pagano, Francesco Cosimo, Pais, Cristina, Rocchi, Sara, Rota, Elisabetta, Salerno, Andrea, Tosato, Matteo, Tritto, Marcello, Zazzara, Maria Beatrice, Calvani, Riccardo, Catalano, Lucio, Picca, Anna, Savera, Giulia, Damiano, Francesco Paolo, Rocconi, Alessandra, Galliani, Alessandro, Spaziani, Giovanni, Tupputi, Salvatore, Cocchi, Camilla, Pirone, Flavia, D'Ignazio, Federica, Cacciatore, Stefano, Infectious disease team, Cauda, Roberto, Tamburrini, Enrica, Borghetti, A., Di Gianbenedetto, Simona, Murri, Rita, Cingolani, Antonella, Ventura, Giulio, Taddei, E., Moschese, D., Ciccullo, A., Dusina, A., Internal Medicine team, Stella, Leonardo, Addolorato, Giovanni, Franceschi, Francesco, Mingrone, Gertrude, Zocco, M.A., Microbiology team, Sanguinetti, Maurizio, Cattani, Paola, Marchetti, Simona, Posteraro, Brunella, Sali, M., Neurology team, Bizzarro, Alessandra, Lauria, Alessandra, Ophthalmology team, Rizzo, Stanislao, Savastano, Maria Cristina, Gambini, G., Cozzupoli, G.M., Culiersi, C., Otolaryngology team, Passali, Giulio Cesare, Paludetti, Gaetano, Galli, Jacopo, Crudo, F., Di Cintio, G., Longobardi, Y., Tricarico, L., Santantonio, M., Pediatric team, Buonsenso, Danilo, Valentini, P., Pata, D., Sinatti, D., De Rose, C., Pneumology team, Richeldi, Luca, Lombardi, Francesco, Calabrese, A., Leone, Paolo Maria, Calvello, Maria Rosaria, Intini, Enrica, Montemurro, Giuliano, Psychiatric team, Sani, Gabriele, Janiri, Delfina, Simonetti, Alessio, Giuseppin, G., Molinaro, M., odica, M., Radiology team, Natale, Luigi, Larici, Anna Rita, Marano, Riccardo, Rheumatology team, Paglionico, Annamaria, Petricca, Luca, Gigante, Luca, Natalello, G., Fedele, A.L., Lizzio, M.M., Tolusso, B., Di Mario, Clara, Alivernini, S., Vascular team, Santoliquido, Angelo, Santoro, Luca, Di Giorgio, Angela, Nesci, Antonio, and Popolla, V.

Published
2022
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5. A real-time integrated framework to support clinical decision making for covid-19 patients

Author

Murri, Rita, Masciocchi, Carlotta, Lenkowicz, Jacopo, Fantoni, Massimo, Damiani, Andrea, Marchetti, Antonio, Sergi, Paolo Domenico Angelo, Arcuri, Giovanni, Cesario, Alfredo, Patarnello, Stefano, Antonelli, Massimo, Bellantone, Rocco, Bernabei, Roberto, Boccia, Stefania, Calabresi, Paolo, Cambieri, Andrea, Cauda, Roberto, Colosimo, Cesare, Crea, Filippo, De Maria, Ruggero, De Stefano, Valerio, Franceschi, Francesco, Gasbarrini, Antonio, Landolfi, Raffaele, Parolini, Ornella, Richeldi, Luca, Sanguinetti, Maurizio, Urbani, Andrea, Zega, Maurizio, Scambia, Giovanni, and Valentini, Vincenzo

Published
2022
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11. Sarilumab use in severe SARS-CoV-2 pneumonia

Author

Gremese, Elisa, Cingolani, Antonella, Bosello, Silvia Laura, Alivernini, Stefano, Tolusso, Barbara, Perniola, Simone, Landi, Francesco, Pompili, Maurizio, Murri, Rita, Santoliquido, Angelo, Garcovich, Matteo, Sali, Michela, De Pascale, Gennaro, Gabrielli, Maurizio, Biscetti, Federico, Montalto, Massimo, Tosoni, Alberto, Gambassi, Giovanni, Rapaccini, Gian Ludovico, Iaconelli, Amerigo, Zileri Del Verme, Lorenzo, Petricca, Luca, Fedele, Anna Laura, Lizzio, Marco Maria, Tamburrini, Enrica, Natalello, Gerlando, Gigante, Laura, Bruno, Dario, Verardi, Lucrezia, Taddei, Eleonora, Calabrese, Angelo, Lombardi, Francesco, Bernabei, Roberto, Cauda, Roberto, Franceschi, Francesco, Landolfi, Raffaele, Richeldi, Luca, Sanguinetti, Maurizio, Fantoni, Massimo, Antonelli, Massimo, and Gasbarrini, Antonio

Published
2020
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13. A novel multi-marker discovery approach identifies new serum biomarkers for Parkinson’s disease in older people: an EXosomes in PArkiNson Disease (EXPAND) ancillary study

Author

Calvani, Riccardo, Picca, Anna, Landi, Giovanni, Marini, Federico, Biancolillo, Alessandra, Coelho-Junior, Hélio José, Gervasoni, Jacopo, Persichilli, Silvia, Primiano, Aniello, Arcidiacono, Annalaura, Urbani, Andrea, Bossola, Maurizio, Bentivoglio, Anna Rita, Cesari, Matteo, Bernabei, Roberto, Monaco, Maria Rita Lo, and Marzetti, Emanuele

Published
2020
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25. Audiologic Assessment in Adults with Down Syndrome

Author

Picciotti, Pasqualina M., Carfì, Angelo, Anzivino, Roberta, Paludetti, Gaetano, Conti, Guido, Brandi, Vincenzo, Bernabei, Roberto, and Onder, Graziano

Abstract

Increased life expectancy in persons with Down syndrome (DS) is associated with premature age-related changes. The aim of this study was to assess auditory function in adults with DS and to evaluate the prevalence of hearing loss in this population. Audiometric tests were performed in 72 adults with DS (mean age 37.3 ± 10.1 years, 51.4% females). Air conduction pure tone average (PTA) thresholds at frequencies 0.5-1-2-4 kHz were calculated to assess hearing function. Hearing loss was present if the PTA threshold was > 20 dB hearing level. Higher frequencies of 4 and 8 kHz were also assessed. Hearing loss was shown in 47 (65.3%) participants. The prevalence of hearing loss increased with age, ranging from 42.86% in the 20-29 years group to 90.91% in the 50-59 years group. High frequencies (4 and 8 kHz) were more often impaired than other frequencies used to measure PTA. Thus, the study concluded hearing loss is common in adults with DS and shows a pattern compatible with precocious aging of the hearing system. Auditory evaluation is strongly recommended in adults with DS.

Published
2017
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27. Association of polypharmacy and hyperpolypharmacy with frailty states: a systematic review and meta-analysis

Author

Palmer, Katie, Villani, Emanuele R., Vetrano, Davide L., Cherubini, Antonio, Cruz-Jentoft, Alfonso J., Curtin, Denis, Denkinger, Michael, Gutiérrez-Valencia, Marta, Guðmundsson, Adalsteinn, Knol, Wilma, Mak, Diane V., O’Mahony, Denis, Pazan, Farhad, Petrovic, Mirko, Rajkumar, Chakravarthi, Topinkova, Eva, Trevisan, Catarina, van der Cammen, Tischa J. M., van Marum, Rob J., Wehling, Martin, Ziere, Gijsbertus, Bernabei, Roberto, Onder, Graziano, and On behalf of the European Geriatric Medicine Society Pharmacology special interest group

Published
2019
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30. Informal caregiver's socio demographic profile for community-dwelling women and men with mild to moderate Alzheimer's disease, compliance, and satisfaction to treatment: A post-hoc analysis of the AXEPT study.

Author

Colombo, Delia, Zagni, Emanuela, Rossini, Paolo Maria, Di Cioccio, Luigi, Gragnaniello, Daniela, Luda Di Cortemiglia, Emilio, Attar, Mahmood, Simoni, Lucia, Haggiag, Shalom, and Bernabei, Roberto

Subjects
ALZHEIMER'S disease treatment, RESEARCH, STATISTICS, PSYCHOLOGY of men, SCIENTIFIC observation, CROSS-sectional method, PATIENT satisfaction, SATISFACTION, FISHER exact test, T-test (Statistics), PSYCHOLOGY of caregivers, INDEPENDENT living, PSYCHOLOGY of women, CHI-squared test, DESCRIPTIVE statistics, RESEARCH funding, SOCIODEMOGRAPHIC factors, PATIENT compliance, DATA analysis, LOGISTIC regression analysis, DATA analysis software
Abstract

In this post-hoc analysis of the AXEPT study, 855 patients were analyzed, 544 (63.6%) females. The mean (± SD) MMSE score in women vs men was 20.8 ± 2.6 vs. 21.2 ± 2.5; p = 0.0087, and women were more likely affected by psychiatric disorders (n = 76, 14.0% women vs. n = 21, 6.8% men; p = 0.0015). Men were mainly assisted by their wives (n = 207, 66.6%), women mainly by their daughters (n = 243, 44.7%) and only in a minority of cases by their husbands (n = 92, 16.9%). Women less frequently cohabited with their caregivers than men (n = 233, 43.1% vs. n = 240, 77.9%, p < 0.0001), and received less daily time of caregiving (mean (± SD): 10.0 ± 7.2 vs. 15.2 ± 8.2; p < 0.0001). No gender differences were highlighted in compliance to treatment and caregiver satisfaction, while gender differences in caregiving were found at disadvantage of women affected by more severe cognitive and psychiatric conditions. [ABSTRACT FROM AUTHOR]

Published
2023
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31. Malnutrition in COVID-19 survivors: prevalence and risk factors.

Author

Tosato, Matteo, Calvani, Riccardo, Ciciarello, Francesca, Galluzzo, Vincenzo, Martone, Anna Maria, Zazzara, Maria Beatrice, Pais, Cristina, Savera, Giulia, Robles, Maria Camprubi, Ramirez, Maria, Landi, Francesco, Gemelli Against COVID-19 Post-Acute Care Team, Gremese, Elisa, Bernabei, Roberto, Fantoni, Massimo, Gasbarrini, Antonio, Settanni, Carlo Romano, Porcari, Serena, Benvenuto, Francesca, and Bramato, Giulia

Abstract

Background : Nutritional status is a critical factor throughout COVID-19 disease course. Malnutrition is associated with poor outcomes in hospitalized COVID-19 patients. Aim : To assess the prevalence of malnutrition and identify its associated factors in COVID-19 survivors. Methods: Study cohort included 1230 COVID-19 survivors aged 18–86 attending a post-COVID-19 outpatient service. Data on clinical parameters, anthropometry, acute COVID-19 symptoms, lifestyle habits were collected through a comprehensive medical assessment. Malnutrition was assessed according to Global Leadership Initiative on Malnutrition (GLIM) criteria. Results : Prevalence of malnutrition was 22% at 4–5 months after acute disease. Participants who were not hospitalized during acute COVID-19 showed a higher frequency of malnutrition compared to those who needed hospitalization (26% versus 19%, p < 0.01). Malnutrition was found in 25% COVID-19 survivors over 65 years of age compared to 21% younger participants (p < 0.01). After multivariable adjustment, the likelihood of being malnourished increased progressively and independently with advancing age (Odds ratio [OR] 1.02; 95% CI 1.01–1.03) and in male participants (OR 5.56; 95% CI 3.53–8.74). Malnutrition was associated with loss of appetite (OR 2.50; 95% CI 1.73–3.62), and dysgeusia (OR 4.05; 95% CI 2.30–7.21) during acute COVID-19. Discussion : In the present investigation we showed that malnutrition was highly prevalent in a large cohort of COVID-19 survivors at 4–5 months from acute illness. Conclusions : Our findings highlight the need to implement comprehensive nutritional assessment and therapy as an integral part of care for COVID-19 patients. [ABSTRACT FROM AUTHOR]

Published
2023
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36. The Geriatrician: The Frontline Specialist in the Treatment of COVID-19 Patients

Author

Landi, Francesco, Barillaro, Christian, Bellieni, Andrea, Brandi, Vincenzo, Carfi, Angelo, Cipriani, Maria Camilla, D'Angelo, Emanuela, Falsiroli, Cinzia, Fusco, Domenico, Landi, Giovanni, Liperoti, Rosa, Lo Monaco, Maria Rita, Martone, Anna Maria, Marzetti, Emanuele, Pagano, Francesco Cosimo, Pais, Cristina, Russo, Andrea, Salini, Sara, Tosasto, Matteo, Tummolo, Anna Maria, Benvenuto, Francesca, Bramato, Giulia, Catalano, Lucia, Ciciarello, Francesca, Martis, Ilaria, Rocchi, Sara, Rota, Elisabetta, Salerno, Andrea, Tritto, Marcello, Sgadari, Antonio, Zuccàla, Giuseppe, and Bernabei, Roberto

Published
2020
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37. Association of Delirium and Depression with Respiratory and Outcome Measures in COVID-19 Inpatients.

Author

Simonetti, Alessio, Pais, Cristina, Savoia, Vezio, Cipriani, Maria Camilla, Tosato, Matteo, Janiri, Delfina, Bernardi, Evelina, Ferrara, Ottavia Marianna, Margoni, Stella, Kotzalidis, Georgios D., Chieffo, Daniela, Fantoni, Massimo, Liperoti, Rosa, Landi, Francesco, Bernabei, Roberto, and Sani, Gabriele

Subjects
DELIRIUM, RESPIRATORY insufficiency, HAMILTON Depression Inventory, PSYCHIATRIC rating scales, OXYGEN in the blood, COVID-19
Abstract

Delirium (DEL) and depression (DEP) may impair the course and severity of acute respiratory illness. The impact of such syndromes on respiratory and outcome parameters in inpatients with COVID-19 needs clarification. To clarify the relationship between DEL and DEP and respiratory outcome measures, we enrolled 100 inpatients from COVID-19 units of the Fondazione Policlinico Universitario Agostino Gemelli IRCCS of Rome. Participants were divided into those with DEL, DEP, or absence of either delirium or depression (CONT). Delirium severity was assessed with the Neelson and Champagne Confusion Scale (NEECHAM). Psychopathology was assessed with the Hamilton Rating Scale for Depression (HAM-D), the Hamilton Rating Scale for Anxiety (HAM-A), and the Brief Psychiatric Rating Scale (BPRS). Dependent variables include: (a) respiratory parameters, i.e., partial pressure of oxygen in arterial blood (PaO2), oxygen saturation (SpO2), ratio between arterial partial pressure of oxygen (PaO2), and fraction of inspired oxygen (PaO2/FiO2); (b) outcome parameters, i.e., duration of hospitalization and number of pharmacological treatments used during the hospitalization. We investigated between-group differences and the relationships between severity of delirium/depression and the dependent variables. Duration of hospitalization was longer for DEL than for either DEP or CONT and for DEP compared to CONT. NEECHAM and HAM-D scores predicted lower PaO2 and PaO2/FiO2 levels in the DEL and DEP groups, respectively. In DEP, BPRS scores positively correlated with duration of hospitalization. Delirium impacted the course of COVID-19 more severely than depression. The mechanisms by which delirium and depression worsen respiratory parameters differ. [ABSTRACT FROM AUTHOR]

Published
2023
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38. Neuropsychological measures of post-COVID-19 cognitive status.

Author

Lauria, Alessandra, Carfì, Angelo, Benvenuto, Francesca, Bramato, Giulia, Ciciarello, Francesca, Rocchi, Sara, Rota, Elisabetta, Salerno, Andrea, Stella, Leonardo, Tritto, Marcello, Di Paola, Antonella, Pais, Cristina, Tosato, Matteo, Janiri, Delfina, Sani, Gabriele, Monaco, Rita Lo, Pagano, Francesco C., Fantoni, Massimo, Bernabei, Roberto, and Landi, Francesco

Subjects
TRAIL Making Test, COVID-19 pandemic, NEUROPSYCHOLOGICAL tests, MEMORY span, PSYCHOLOGICAL stress, MINI-Mental State Examination
Abstract

Background: COVID-19 may result in persistent symptoms in the post-acute phase, including cognitive and neurological ones. The aim of this study is to investigate the cognitive and neurological features of patients with a confirmed diagnosis of COVID-19 evaluated in the post-acute phase through a direct neuropsychological evaluation. Methods: Individuals recovering from COVID-19 were assessed in an out-patient practice with a complete neurological evaluation and neuropsychological tests (Mini-Mental State Examination; Rey Auditory Verbal Test, Multiple Feature Target Cancellation Test, Trial Making Test, Digit Span Forward and Backward, and Frontal Assessment Battery). Pre- and post-COVID-19 global and mental health status was assessed along with the history of the acute phase of infection. Post-COVID-19 cognitive status was modeled by combining persistent self-reported COVID-related cognitive symptoms and pathologic neuropsychological tests. Results: A total of 406 individuals (average age 54.5 ± 15.1 years, 45.1% women) were assessed on average at 97.8 ± 48.0 days since symptom onset. Persistent self-reported neurological symptoms were found in the areas of sleep (32%), attention (31%), and memory (22%). The MMSE mean score was 28.6. In total, 84 subjects (20.7%) achieved pathologic neuropsychological test results. A high prevalence of failed tests was found in digit span backward (18.7%), trail making (26.6%), and frontal assessment battery (10.9%). Cognitive status was associated with a number of factors including cardiovascular disease history, persistent fatigue, female sex, age, anxiety, and mental health stress. Conclusion: COVID-19 is capable of eliciting persistent measurable neurocognitive alterations particularly relevant in the areas of attention and working memory. These neurocognitive disorders have been associated with some potentially treatable factors and others thatmay stratify risk at an early stage. [ABSTRACT FROM AUTHOR]

Published
2023
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42. The “Sarcopenia and Physical fRailty IN older people: multi-componenT Treatment strategies” (SPRINTT) randomized controlled trial: design and methods

Author

Landi, Francesco, Cesari, Matteo, Calvani, Riccardo, Cherubini, Antonio, Di Bari, Mauro, Bejuit, Raphael, Mshid, Jerome, Andrieu, Sandrine, Sinclair, Alan J., Sieber, Cornel C., Vellas, Bruno, Topinkova, Eva, Strandberg, Timo, Rodriguez-Manas, Leocadio, Lattanzio, Fabrizia, Pahor, Marco, Roubenoff, Ronenn, Cruz-Jentoft, Alfonso J., Bernabei, Roberto, Marzetti, Emanuele, and on behalf of the SPRINTT Consortium

Published
2017
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43. Sarcopenia: an overview

Author

Marzetti, Emanuele, Calvani, Riccardo, Tosato, Matteo, Cesari, Matteo, Di Bari, Mauro, Cherubini, Antonio, Collamati, Agnese, D’Angelo, Emanuela, Pahor, Marco, Bernabei, Roberto, Landi, Francesco, and on behalf of the SPRINTT Consortium

Published
2017
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44. Biomarkers for physical frailty and sarcopenia

Author

Calvani, Riccardo, Marini, Federico, Cesari, Matteo, Tosato, Matteo, Picca, Anna, Anker, Stefan D., von Haehling, Stephan, Miller, Ram R., Bernabei, Roberto, Landi, Francesco, Marzetti, Emanuele, and For the SPRINTT Consortium

Published
2017
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