Search

Your search keyword '"Braunschweiger, Paul"' showing total 25 results
Start Over Author "Braunschweiger, Paul" Search Limiters Academic (Peer-Reviewed) Journals
25 results on '"Braunschweiger, Paul"'

2. Consensus standards for introductory e-learning courses in human participants research ethics

Author

Williams, John R, Sprumont, Dominique, Hirtle, Marie, Adebamowo, Clement, Braunschweiger, Paul, Bull, Susan, Burri, Christian, Czarkowski, Marek, Fan, Chien Te, Franck, Caroline, Gefenas, Eugenjius, Geissbuhler, Antoine, Klingmann, Ingrid, Kouyaté, Bocar, Kraehenbhul, Jean-Pierre, Kruger, Mariana, Moodley, Keymanthri, Ntoumi, Francine, Nyirenda, Thomas, Pym, Alexander, Silverman, Henry, and Tenorio, Sara

Published
2014

10. NEW NSF AND NIH RESPONSIBLE CONDUCT OF RESEARCH (RCR) GUIDELINES: A THREE-PHASE PLAN.

Author

McCafferty, Jennifer, Cushman, Reid, Goodman, Kenneth W., Braunschweiger, Paul, and Fiore, Robin N.

Subjects
RESEARCH ethics, UNITED States education system
Abstract

The article reports on the introduction of new guidelines on the Responsible Conduct of Research (RCR) from the U.S. National Institutes of Health (NIH) and the U.S National Science Foundation (NSF). It is said that the federal mandates for RCR education and training represent another unfunded mandate that must be implemented throughout the organization.

Published
2012

12. Acute Hemorrhagic Necrosis of Tumors Induced by Interleukin-1α Effects Independent of Tumor Necrosis Factor.

Author

Johnson, Candance S., Chang, Ming-jei, Braunschweiger, Paul G., and Furmanski, Philip

Abstract

Tumor necrosis factor (TNF), a protein synthesized in response to the endotoxin bacterial lipopolysaccharide (LPS), is the classical mediator of acute hemorrhagic necrosis of tumors. We have demonstrated that interleukin-la (IL-lα), with a spectrum of activities very similar to those of TNF, also causes acute hemorrhagic necrosis of tumors. Both TNF and IL-1 induce a cascade of events including the synthesis or release of each other. The present studies were thus undertaken to determine whether the hemorrhagic necrosis induced in tumors by IL-lα is due to TNF. Kinetic parameters of IL-lα-induced hemorrhage were similar to those observed with recombinant murine TNF-α (TNF-α) or LPS in RIF-1 fibrosarcomas in C3H/HeN (endotoxin-sensitive) mice. However, the amount of TNF found in the sera or tumors of animals treated with LPS was more than 20-fold higher than in mice treated with IL-lα, and LPS induced similar degrees of hemorrhagic necrosis, which was measured by determining the packed volume of red blood cells by Fe labeling. A low but significantly hemorrhagic dose of IL-lα induced no detectable TNF in tumors. Pretreatment with 250 μg of neutralizing antibody to TNF had no effect on IL-lα-induced hemorrhage, whereas TNF-α- and LPS-induced hemorrhagic effects were significantly reduced. These results demonstrate an important antitumor activity of IL-αa that appears to be independent of TNF. [J Natl Cancer Inst 83:842–848,1991] [ABSTRACT FROM PUBLISHER]

Published
1991

Catalog

Books, media, physical & digital resources
See catalog results