Search

Your search keyword '"Campbell, Thomas L."' showing total 320 results
Start Over Author "Campbell, Thomas L." Search Limiters Academic (Peer-Reviewed) Journals
320 results on '"Campbell, Thomas L."'

3. Family Issues in Health Care

Author

Campbell, Thomas L., McDaniel, Susan H., Cole-Kelly, Kathy, Paulman, Paul M., editor, Taylor, Robert B., editor, Paulman, Audrey A., editor, and Nasir, Laeth S., editor

Published
2022
Full Text
View/download PDF

4. Cell-type specific methylation changes in the newborn child associated to obstetric pain relief.

Author

Tran, Charles J., Campbell, Thomas L., Johnson, Ralen H., Xie, Lin Y., Hultman, Christina M., van den Oord, Edwin J. C. G., and Aberg, Karolina A.

Subjects
*ANESTHESIA in obstetrics, *GENE ontology, *ANALGESIA, *CELL differentiation, *ODDS ratio
Abstract

Although it is widely known that various pharmaceuticals affect the methylome, the knowledge of the effects from anesthesia is limited, and nearly nonexistent regarding the effects of obstetric anesthesia on the newborn child. Using sequencing based-methylation data and a reference-based statistical deconvolution approach we performed methylome-wide association studies (MWAS) of neonatal whole blood, and for each cell-type specifically, to detect methylation variations that are associated with the pain relief administered to the mother during delivery. Significant findings were replicated in a different dataset and followed-up with gene ontology analysis to pinpoint biological functions of potential relevance to these neonatal methylation alterations. The MWAS analyses detected methylome-wide significant (q<0.1) alterations in the newborn for laughing gas in granulocytes (two CpGs, p<5.50x10-9, q = 0.067), and for pudendal block in monocytes (five CpGs across three loci, p<1.51 x10-8, q = 0.073). Suggestively significant findings (p<1.00x10-6) were detected for both treatments for bulk and all cell-types, and replication analyses showed consistent significant enrichment (odds ratios ranging 3.47–39.02; p<4.00×10−4) for each treatment, suggesting our results are robust. In contrast, we did not observe any overlap across treatments, suggesting that the treatments are associated with different alterations of the neonatal blood methylome. Gene ontology analyses of the replicating suggestively significant results indicated functions related to, for example, cell differentiation, intracellular membrane-bound organelles and calcium transport. In conclusion, for the first time, we investigated and detected effect of obstetric pain-relief on the blood methylome in the newborn child. The observed differences suggest that anesthetic treatment, such as laughing gas or pudendal block, may alter the neonatal methylome in a cell-type specific manner. Some of the observed alterations are part of gene ontology terms that previously have been suggested in relation to anesthetic treatment, supporting its potential role also in obstetric anesthesia. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

6. Family Issues in Health Care

Author

Campbell, Thomas L., McDaniel, Susan H., Cole-Kelly, Kathy, Paulman, Paul M., editor, Taylor, Robert B., editor, Paulman, Audrey A., editor, and Nasir, Laeth S., editor

Published
2017
Full Text
View/download PDF

7. Family Issues in Health Care

Author

Campbell, Thomas L., McDaniel, Susan H., Cole-Kelly, Kathy, Taylor, Robert B., editor, David, Alan K., editor, Fields, Scott A., editor, Phillips, D. Melessa, editor, and Scherger, Joseph E., editor

Published
2005
Full Text
View/download PDF

8. The Family System

Author

Campbell, Thomas L., McDaniel, Susan H., Seaburn, David B., Mengel, Mark B., editor, Holleman, Warren L., editor, and Fields, Scott A., editor

Published
2002
Full Text
View/download PDF

34. Family Stress and Counseling

Author

Campbell, Thomas L., Seaburn, David, McDaniel, Susan H., Taylor, Robert B., editor, David, Alan K., editor, Johnson, Thomas A., Jr., editor, Phillips, D. Melessa, editor, and Scherger, Joseph E., editor

Published
1998
Full Text
View/download PDF

35. Conducting a Family Interview

Author

Campbell, Thomas L., McDaniel, Susan H., Lipkin, Mack, Jr., editor, Putnam, Samuel M., editor, Lazare, Aaron, editor, Carroll, J. Gregory, Jr., editor, and Frankel, Richard M., editor

Published
1995
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results