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674 results on '"Chen, Weihong"'

23. Expert consensus on One Health for establishing an enhanced and integrated surveillance system for key infectious diseases

Author

Cheng, Yanpeng, Zhang, Zhen, Shu, Yuelong, Ren, Lili, Kang, Min, Kong, Dongfeng, Shi, Xiaolu, Lv, Qiuying, Chen, Zhigao, Li, Yinghui, Zhang, Renli, Lu, Puxuan, Lu, Yan, Liu, Tingting, Chen, Nixuan, Xiong, Huawei, Du, Chen, Yuan, Jun, Wang, Liang, Liu, Rongqi, Chen, Weihong, Li, Xueyun, Lin, Qihui, Li, Gang, Zhang, Xindong, Yuan, Jianhui, Wang, Tieqiang, Guo, Yongchao, Lu, Jianhua, Zou, Xuan, and Feng, Tiejian

Published
2024
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47. Malignant Transformation Rate in Chinese Patients with Oral Leukoplakia: a Meta-analysis

Author

YANG Ling, HOU Lili, CHEN Weihong, WENG Ximei, LUO Shasha, XIA Jialin

Subjects
oral leukoplakia, malignant transformation rate, meta-analysis, cohort study, china, Medicine
Abstract

Background Oral cancer is highly prevalent, which is often caused by oral potentially malignant disorders, and oral leukoplakia is the most common. The malignant transformation of oral leukoplakia not only affects the physical and mental health of patients, but also imposesa heavy economic burden on the patient's families and society. Due to limited sample size, regional differences and other factors, the epidemiological characteristics of malignant transformation in Chinese patients with oral leukoplakia in China are various. Objective To perform a systematic review of the malignant transformation rate of oral leukoplakia in Chinese patients. Methods Databases of CNKI, SinoMed, CQVIP, Wanfang Data, PubMed, Web of Science, Embase and Cochrane Library were searched to identify cohort studies about malignant transformation rate of oral leukoplakia in Chinese patients included from inception to February 2022. Two researchers separately screened the cohort studies, evaluated the qualities and extracted data. Meta-analysis was conducted using Stata 15.0. Results Thirty cohort studies including 109 047 patients were finally included. Meta-analysis revealed that the malignant transformation rate of oral leukoplakia in Chinese patients was 9.0%〔95%CI (7.0%, 11.3%) 〕. The results of subgroup analysis revealed that the malignant transformation rate was 7.6% in male patients〔95%CI (5.1%, 10.6%) 〕, and was 13.2% in female patients〔95%CI (9.5%, 17.4%) 〕. The malignant transformation rate of oral leukoplakia in patients aged

Published
2023
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48. A meta-analysis of prevalence of mouth opening restriction in patients with oral cancer

Author

YANG Ling, HOU Lili, ZHAO Yan, CHEN Weihong, ZHANG Jinfeng, and MAO Yan

Subjects
oral neoplasm, mouth opening restriction, prevalence, meta-analysis, Medicine
Abstract

Objective·To study the prevalence of mouth opening restriction in oral cancer patients by meta-analysis.Methods·China National Knowledge Infrastructure (CNKI), Chinese Science and Technology Journal Database (VIP), Wanfang Data (Wanfang), Chinese BioMedical Literature Database (CBM), PubMed, Ovid, EMbase, Cochrane Library, Web of Science/SciSearch, and ClinicalTrials.gov were searched for observational studies about the prevalence rate of restricted mouth opening in oral cancer patients (including prospective, retrospective, and cross-sectional studies). The time limit for retrieval was from the database establishment to April 30th, 2022. The obtained documents were independently screened and extracted according to the inclusion and exclusion criteria, and the literature quality evaluation was performed by using methodological index for non-randomized studies (MINORS). The data were combined with the mouth-opening-restricted prevalence rate as the outcome indicator, the meta-analysis was performed by using Stata 15.0 software, and the subgroup analysis was performed based on the detection time, tumor site, and tumor stage. The evidence quality of outcome indicators was evaluated by using GRADE profiler 3.6 software according to GRADE (Grading of Recommendations Assessment, Development, and Evaluation) system.Results·A total of 3 719 documents were obtained during the initial examination, and 18 documents were finally included, including 2 701 objects. The meta-analysis results showed that the total prevalence rate of mouth opening restriction in oral cancer patients was 42.7% (95%CI 27.0%‒59.1%). The results of subgroup analysis showed that the prevalence rates of mouth opening restriction in patients with oral cancer before surgery, and 3 months, 6 months and 1 year or more after surgery were 29.6% (95%CI 9.0%‒55.8%), 75.2% (95%CI 68.3%‒81.5%), 59.1% (95%CI 38.8%‒77.9%) and 22.3% (95%CI 2.0%‒54.3%), respectively. The prevalence rates of mouth opening restriction in patients with oral cancer at T1‒T2 stage and T3‒T4 stage were 38.6% (95%CI 26.0%‒52.0%) and 99.6% (95%CI 93.9%‒100.0%) respectively. The prevalence rates of mouth opening restriction in patients with oral cancer in the retromolar triangle, the gingiva, the tongue, the salivary gland, the floor of mouth and the lip were 93.1% (95%CI 68.5%‒100.0%), 68.1% (95%CI 52.9%‒81.7%), 46.1% (95%CI 11.6%‒82.7%), 26.1% (95%CI 15.9%‒37.5%), 21.9% (95%CI 0.7%‒54.0%), and 3.1% (95%CI 0‒9.3%), respectively. The GRADE system for evidence quality grading indicated that the quality of evidence for outcome indicator was extremely low.Conclusion·The total prevalence rate of mouth opening restriction in patients with oral cancer is high, nearly 50%; the patients at 3 months after surgery, at 6 months after surgery, at T3‒T4 stage or whose tumor located in the retromolar triangle have higher prevalence rates.

Published
2023
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