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435 results on '"Clark, Anna"'

4. Human SARS-CoV-2 challenge uncovers local and systemic response dynamics

Author

Lindeboom, Rik G. H., Worlock, Kaylee B., Dratva, Lisa M., Yoshida, Masahiro, Scobie, David, Wagstaffe, Helen R., Richardson, Laura, Wilbrey-Clark, Anna, Barnes, Josephine L., Kretschmer, Lorenz, Polanski, Krzysztof, Allen-Hyttinen, Jessica, Mehta, Puja, Sumanaweera, Dinithi, Boccacino, Jacqueline M., Sungnak, Waradon, Elmentaite, Rasa, Huang, Ni, Mamanova, Lira, Kapuge, Rakesh, Bolt, Liam, Prigmore, Elena, Killingley, Ben, Kalinova, Mariya, Mayer, Maria, Boyers, Alison, Mann, Alex, Swadling, Leo, Woodall, Maximillian N. J., Ellis, Samuel, Smith, Claire M., Teixeira, Vitor H., Janes, Sam M., Chambers, Rachel C., Haniffa, Muzlifah, Catchpole, Andrew, Heyderman, Robert, Noursadeghi, Mahdad, Chain, Benny, Mayer, Andreas, Meyer, Kerstin B., Chiu, Christopher, Nikolić, Marko Z., and Teichmann, Sarah A.

Published
2024
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26. Spatially resolved multiomics of human cardiac niches

Author

Kanemaru, Kazumasa, Cranley, James, Muraro, Daniele, Miranda, Antonio M. A., Ho, Siew Yen, Wilbrey-Clark, Anna, Patrick Pett, Jan, Polanski, Krzysztof, Richardson, Laura, Litvinukova, Monika, Kumasaka, Natsuhiko, Qin, Yue, Jablonska, Zuzanna, Semprich, Claudia I., Mach, Lukas, Dabrowska, Monika, Richoz, Nathan, Bolt, Liam, Mamanova, Lira, Kapuge, Rakeshlal, Barnett, Sam N., Perera, Shani, Talavera-López, Carlos, Mulas, Ilaria, Mahbubani, Krishnaa T., Tuck, Liz, Wang, Lu, Huang, Margaret M., Prete, Martin, Pritchard, Sophie, Dark, John, Saeb-Parsy, Kourosh, Patel, Minal, Clatworthy, Menna R., Hübner, Norbert, Chowdhury, Rasheda A., Noseda, Michela, and Teichmann, Sarah A.

Published
2023
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29. An integrated cell atlas of the lung in health and disease

Author

Sikkema, Lisa, Ramírez-Suástegui, Ciro, Strobl, Daniel C., Gillett, Tessa E., Zappia, Luke, Madissoon, Elo, Markov, Nikolay S., Zaragosi, Laure-Emmanuelle, Ji, Yuge, Ansari, Meshal, Arguel, Marie-Jeanne, Apperloo, Leonie, Banchero, Martin, Bécavin, Christophe, Berg, Marijn, Chichelnitskiy, Evgeny, Chung, Mei-i, Collin, Antoine, Gay, Aurore C. A., Gote-Schniering, Janine, Hooshiar Kashani, Baharak, Inecik, Kemal, Jain, Manu, Kapellos, Theodore S., Kole, Tessa M., Leroy, Sylvie, Mayr, Christoph H., Oliver, Amanda J., von Papen, Michael, Peter, Lance, Taylor, Chase J., Walzthoeni, Thomas, Xu, Chuan, Bui, Linh T., De Donno, Carlo, Dony, Leander, Faiz, Alen, Guo, Minzhe, Gutierrez, Austin J., Heumos, Lukas, Huang, Ni, Ibarra, Ignacio L., Jackson, Nathan D., Kadur Lakshminarasimha Murthy, Preetish, Lotfollahi, Mohammad, Tabib, Tracy, Talavera-López, Carlos, Travaglini, Kyle J., Wilbrey-Clark, Anna, Worlock, Kaylee B., Yoshida, Masahiro, van den Berge, Maarten, Bossé, Yohan, Desai, Tushar J., Eickelberg, Oliver, Kaminski, Naftali, Krasnow, Mark A., Lafyatis, Robert, Nikolic, Marko Z., Powell, Joseph E., Rajagopal, Jayaraj, Rojas, Mauricio, Rozenblatt-Rosen, Orit, Seibold, Max A., Sheppard, Dean, Shepherd, Douglas P., Sin, Don D., Timens, Wim, Tsankov, Alexander M., Whitsett, Jeffrey, Xu, Yan, Banovich, Nicholas E., Barbry, Pascal, Duong, Thu Elizabeth, Falk, Christine S., Meyer, Kerstin B., Kropski, Jonathan A., Pe’er, Dana, Schiller, Herbert B., Tata, Purushothama Rao, Schultze, Joachim L., Teichmann, Sara A., Misharin, Alexander V., Nawijn, Martijn C., Luecken, Malte D., and Theis, Fabian J.

Published
2023
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32. A spatially resolved atlas of the human lung characterizes a gland-associated immune niche

Author

Madissoon, Elo, Oliver, Amanda J., Kleshchevnikov, Vitalii, Wilbrey-Clark, Anna, Polanski, Krzysztof, Richoz, Nathan, Ribeiro Orsi, Ana, Mamanova, Lira, Bolt, Liam, Elmentaite, Rasa, Pett, J. Patrick, Huang, Ni, Xu, Chuan, He, Peng, Dabrowska, Monika, Pritchard, Sophie, Tuck, Liz, Prigmore, Elena, Perera, Shani, Knights, Andrew, Oszlanczi, Agnes, Hunter, Adam, Vieira, Sara F., Patel, Minal, Lindeboom, Rik G. H., Campos, Lia S., Matsuo, Kazuhiko, Nakayama, Takashi, Yoshida, Masahiro, Worlock, Kaylee B., Nikolić, Marko Z., Georgakopoulos, Nikitas, Mahbubani, Krishnaa T., Saeb-Parsy, Kourosh, Bayraktar, Omer Ali, Clatworthy, Menna R., Stegle, Oliver, Kumasaka, Natsuhiko, Teichmann, Sarah A., and Meyer, Kerstin B.

Published
2023
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34. Alternative Histories of the Self

Author

Clark, Anna

Subjects
Edith Ellis, Chevalier d'Eon, transgender, history of sexuality, lesbian history, LGBTQIA+ history, Anne Lister, James Hinton, Richard Johnson, gender history, polygamy, unique self, sexual transgression, social conventions, social history, empire, coded diaries, diplomat, individual, non conformity, queer history, ethics, social justice, political traditions, relationships, secrets, privacy, same-sex desire, men, women, thema EDItEUR::D Biography, Literature and Literary studies::DN Biography and non-fiction prose::DNC Memoirs, thema EDItEUR::N History and Archaeology::NH History::NHD European history, thema EDItEUR::N History and Archaeology, thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day, thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBS Social groups, communities and identities::JBSF Gender studies, gender groups
Abstract

This open access book investigates how people re-imagined the idea of the unique self in the period from 1762 to 1917. Some used the notion of the unique self to justify their gender and sexual transgression, but others rejected the notion of the unique self and instead demanded the sacrifice of the self for the good of society. The substantial introductory chapter places these themes in the cultural context of the long nineteenth century, but the book as a whole represents an alternative method for studying the self. Instead of focusing on the thoughts of great thinkers, this book explores how five unusual individuals twisted conventional ideas of the self as they interpreted their own lives. These subjects include: * The Chevalièr/e d’Eon, a renegade diplomat who was outed as a woman * Anne Lister, who wrote coded diaries about her attraction to women * Richard Johnson, who secretly criticized the empire that he served * James Hinton, a Victorian doctor who publicly advocated philanthropy and privately supported polygamy * Edith Ellis, a socialist lesbian who celebrated the ‘abnormal’ These five case studies are skilfully used to explore how the notion of the unique individual was used to make sense of sexual or gender non-conformity. Yet this queer reading will go beyond same-sex desire to analyse the issue of secrets and privacy; for instance, what stigma did men who practiced or advocated unconventional relationships with women incur? Finally, Clark ties these unusual lives to the wider questions of ethics and social justice: did those who questioned sexual conventions challenge political traditions as well? This is a highly innovative study that will be of interest to intellectual historians of modern Britain and Europe, as well as historians of gender and sexuality. The ebook editions of this book are available open access under a CC BY-NC-ND 4.0 licence on bloomsburycollections.com. Open access was funded by Knowledge Unlatched.

Published
2017

37. Local and systemic responses to SARS-CoV-2 infection in children and adults

Author

Yoshida, Masahiro, Worlock, Kaylee B., Huang, Ni, Lindeboom, Rik G. H., Butler, Colin R., Kumasaka, Natsuhiko, Dominguez Conde, Cecilia, Mamanova, Lira, Bolt, Liam, Richardson, Laura, Polanski, Krzysztof, Madissoon, Elo, Barnes, Josephine L., Allen-Hyttinen, Jessica, Kilich, Eliz, Jones, Brendan C., de Wilton, Angus, Wilbrey-Clark, Anna, Sungnak, Waradon, Pett, J. Patrick, Weller, Juliane, Prigmore, Elena, Yung, Henry, Mehta, Puja, Saleh, Aarash, Saigal, Anita, Chu, Vivian, Cohen, Jonathan M., Cane, Clare, Iordanidou, Aikaterini, Shibuya, Soichi, Reuschl, Ann-Kathrin, Herczeg, Iván T., Argento, A. Christine, Wunderink, Richard G., Smith, Sean B., Poor, Taylor A., Gao, Catherine A., Dematte, Jane E., Reynolds, Gary, Haniffa, Muzlifah, Bowyer, Georgina S., Coates, Matthew, Clatworthy, Menna R., Calero-Nieto, Fernando J., Göttgens, Berthold, O’Callaghan, Christopher, Sebire, Neil J., Jolly, Clare, De Coppi, Paolo, Smith, Claire M., Misharin, Alexander V., Janes, Sam M., Teichmann, Sarah A., Nikolić, Marko Z., and Meyer, Kerstin B.

Published
2022
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39. The impact of 7-hour and 11-hour rest breaks between shifts on heavy vehicle truck drivers’ sleep, alertness and naturalistic driving performance

Author

Cori, Jennifer M., Downey, Luke A., Sletten, Tracey L., Beatty, Caroline J., Shiferaw, Brook A., Soleimanloo, Shamsi Shekari, Turner, Sophie, Naqvi, Aqsa, Barnes, Maree, Kuo, Jonny, Lenné, Michael G., Anderson, Clare, Tucker, Andrew J., Wolkow, Alexander P., Clark, Anna, Rajaratnam, Shantha M.W., and Howard, Mark E.

Published
2021
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40. The climate change mitigation effects of daily active travel in cities

Author

Brand, Christian, Dons, Evi, Anaya-Boig, Esther, Avila-Palencia, Ione, Clark, Anna, de Nazelle, Audrey, Gascon, Mireia, Gaupp-Berghausen, Mailin, Gerike, Regine, Götschi, Thomas, Iacorossi, Francesco, Kahlmeier, Sonja, Laeremans, Michelle, Nieuwenhuijsen, Mark J, Pablo Orjuela, Juan, Racioppi, Francesca, Raser, Elisabeth, Rojas-Rueda, David, Standaert, Arnout, Stigell, Erik, Sulikova, Simona, Wegener, Sandra, and Int Panis, Luc

Published
2021
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41. Dosimetric impact of contour editing on CT and MRI deep‐learning autosegmentation for brain OARs.

Author

Alzahrani, Nouf M., Henry, Ann M., Clark, Anna K., Al‐Qaisieh, Bashar M., Murray, Louise J., and Nix, Michael G.

Subjects
MEDICAL dosimetry, PEARSON correlation (Statistics), ACROMIOCLAVICULAR joint, MAGNETIC resonance imaging
Abstract

Purpose: To establish the clinical applicability of deep‐learning organ‐at‐risk autocontouring models (DL‐AC) for brain radiotherapy. The dosimetric impact of contour editing, prior to model training, on performance was evaluated for both CT and MRI‐based models. The correlation between geometric and dosimetric measures was also investigated to establish whether dosimetric assessment is required for clinical validation. Method: CT and MRI‐based deep learning autosegmentation models were trained using edited and unedited clinical contours. Autosegmentations were dosimetrically compared to gold standard contours for a test cohort. D1%, D5%, D50%, and maximum dose were used as clinically relevant dosimetric measures. The statistical significance of dosimetric differences between the gold standard and autocontours was established using paired Student's t‐tests. Clinically significant cases were identified via dosimetric headroom to the OAR tolerance. Pearson's Correlations were used to investigate the relationship between geometric measures and absolute percentage dose changes for each autosegmentation model. Results: Except for the right orbit, when delineated using MRI models, the dosimetric statistical analysis revealed no superior model in terms of the dosimetric accuracy between the CT DL‐AC models or between the MRI DL‐AC for any investigated brain OARs. The number of patients where the clinical significance threshold was exceeded was higher for the optic chiasm D1% than other OARs, for all autosegmentation models. A weak correlation was consistently observed between the outcomes of dosimetric and geometric evaluations. Conclusions: Editing contours before training the DL‐AC model had no significant impact on dosimetry. The geometric test metrics were inadequate to estimate the impact of contour inaccuracies on dose. Accordingly, dosimetric analysis is needed to evaluate the clinical applicability of DL‐AC models in the brain. [ABSTRACT FROM AUTHOR]

Published
2024
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42. Single cell derived mRNA signals across human kidney tumors

Author

Young, Matthew D., Mitchell, Thomas J., Custers, Lars, Margaritis, Thanasis, Morales-Rodriguez, Francisco, Kwakwa, Kwasi, Khabirova, Eleonora, Kildisiute, Gerda, Oliver, Thomas R. W., de Krijger, Ronald R., van den Heuvel-Eibrink, Marry M., Comitani, Federico, Piapi, Alice, Bugallo-Blanco, Eva, Thevanesan, Christine, Burke, Christina, Prigmore, Elena, Ambridge, Kirsty, Roberts, Kenny, Braga, Felipe A. Vieira, Coorens, Tim H. H., Del Valle, Ignacio, Wilbrey-Clark, Anna, Mamanova, Lira, Stewart, Grant D., Gnanapragasam, Vincent J., Rampling, Dyanne, Sebire, Neil, Coleman, Nicholas, Hook, Liz, Warren, Anne, Haniffa, Muzlifah, Kool, Marcel, Pfister, Stefan M., Achermann, John C., He, Xiaoling, Barker, Roger A., Shlien, Adam, Bayraktar, Omer A., Teichmann, Sarah A., Holstege, Frank C., Meyer, Kerstin B., Drost, Jarno, Straathof, Karin, and Behjati, Sam

Published
2021
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44. Physical activity of electric bicycle users compared to conventional bicycle users and non-cyclists: Insights based on health and transport data from an online survey in seven European cities

Author

Castro, Alberto, Gaupp-Berghausen, Mailin, Dons, Evi, Standaert, Arnout, Laeremans, Michelle, Clark, Anna, Anaya-Boig, Esther, Cole-Hunter, Tom, Avila-Palencia, Ione, Rojas-Rueda, David, Nieuwenhuijsen, Mark, Gerike, Regine, Panis, Luc Int, de Nazelle, Audrey, Brand, Christian, Raser, Elisabeth, Kahlmeier, Sonja, and Götschi, Thomas

Published
2019
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46. It's Not Remedial: Re-envisioning Pre-First-Year College Writing

Author

Huse, Heidi, Wright, Jenna, Clark, Anna, and Hacker, Tim

Abstract

Responding to mandates from the Tennessee Higher Education Commission to eliminate "remedial" or "developmental" courses from state-funded, four-year institutions, the University of Tennessee at Martin (UTM) Department of English developed a college-level pre-first-year writing program for entering students identified as underprepared for college-level writing expectations. In this article, we describe the design and implementation of our new two-course program of college-level writing courses for underprepared students and reflect on the program's status after one year. We offer a general context for UTM's developmental courses into which we place our specific courses as they began and later evolved into our current English 100 and 110 program. Our goals in writing this article are to help other institutions with limited resources that face situations similar to those we've encountered over the past few years--institutions that, like UTM, have difficult decisions to make while still seeking to enhance all their students' academic success.

Published
2005

47. Just a matter of time: reviewing temporality in Australian historiography.

Author

Clark, Anna

Subjects
*HISTORIOGRAPHY, *PHILOSOPHY of time, *HISTORICITY, *HISTORICAL research, AUSTRALIAN history
Abstract

Time is a foundational concept in historical studies. The past is located 'in time', of course, such that time guides and bounds 'what happened' to a 'when'. There have also been increasing theorisations that understand 'time' itself as temporally and culturally bound. As well as historicising, then, time itself must be historicised. Using Australian historiography as a case study, this paper explores the changing concept of 'time' over time. It sets out a provisional timeline of Australian history's understanding and deployment of historical time, contributing a much-needed historicisation of time to a growing field of historical theory. In charting a history of time in Australian historiography, it demonstrates the historicity of 'time'. This paper shows how the concept of time not only reflects, but in turn shapes and defines, historical practice and research. [ABSTRACT FROM AUTHOR]

Published
2024
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49. A framework for identifying fertility gene targets for mammalian pest control.

Author

Clark, Anna C., Edison, Rey, Esvelt, Kevin, Kamau, Sebastian, Dutoit, Ludovic, Champer, Jackson, Champer, Samuel E., Messer, Philipp W., Alexander, Alana, and Gemmell, Neil J.

Subjects
*PEST control, *GENE targeting, *FERTILITY, *GENE expression, *COMPARATIVE genomics, *CATTLE fertility, *KNOCKOUT mice
Abstract

Fertility‐targeted gene drives have been proposed as an ethical genetic approach for managing wild populations of vertebrate pests for public health and conservation benefit. This manuscript introduces a framework to identify and evaluate target gene suitability based on biological gene function, gene expression and results from mouse knockout models. This framework identified 16 genes essential for male fertility and 12 genes important for female fertility that may be feasible targets for mammalian gene drives and other non‐drive genetic pest control technology. Further, a comparative genomics analysis demonstrates the conservation of the identified genes across several globally significant invasive mammals. In addition to providing important considerations for identifying candidate genes, our framework and the genes identified in this study may have utility in developing additional pest control tools such as wildlife contraceptives. [ABSTRACT FROM AUTHOR]

Published
2024
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