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Your search keyword '"Clauvel, Jean-Pierre"' showing total 37 results
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37 results on '"Clauvel, Jean-Pierre"'

6. Transient angiolymphoid hyperplasia and Kaposi's sarcoma after primary infection with human herpesvirus 8 in a patient with human immunodeficiency virus infection

Author

Oksenhendler, Eric, Cazals-Hatem, Dominique, Schulz, Thomas F., Barateau, Veronique, Grollet, Laurence, Sheldon, Julie, Clauvel, Jean-Pierre, Sigaux, Francois, and Agbalika, Felix

Subjects
Human herpesvirus 8 -- Health aspects, Virus diseases -- Causes of, HIV patients -- Diseases
Abstract

The case of a 43-year-old HIV patient illustrates that human herpesvirus 8 can cause an acute illness that may resolve completely without causing Kaposi's sarcoma. This virus has consistently been isolated from Kaposi's sarcoma tumor samples in HIV patients. This patient became ill with fever, joint pain and enlarged lymph nodes. Within 8 weeks, the lymph nodes returned to normal and he had no more symptoms. Analysis of blood samples taken before and after the illness revealed that he had seroconverted to HHV-8 during that time and the virus was detected in lymph node biopsy samples.

Published
1998

15. CD8 lymphocytosis and pseudotumoral splenomegaly in HIV infection

Author

Oksenhendler, Eric, Autran, Brigitte, Gorochov, Guy, D'Agay, Marie Francoise, Seligman, Maxime, and Clauvel, Jean-Pierre

Subjects
Splenomegaly -- Causes of, HIV infection -- Genetic aspects, CD8 lymphocytes -- Physiological aspects
Published
1992

18. Combination of HIV-1--Specific CD4 Th1 Cell Responses and IgG2 Antibodies Is the Best Predictor for Persistence of Long-Term Nonprogression.

Author

Martinez, Valerie, Costagliola, Dominique, Bonduelle, Olivia, N'go, Nicole, Schnuriger, Aurélie, Théodorou, Loannis, Clauvel, Jean-Pierre, Sicard, Didier, Agut, Henri, Debré, Patrice, Rouzioux, Christine, and Autran, Brigitte

Subjects
HIV, HIV infections, CELL growth, CELL proliferation, VIRUSES, ANTINEOPLASTIC agents
Abstract

Background. Strong T cell and antibody responses to human immunodeficiency virus (HIV), low virus production, and some genetic traits have been individually associated with nonprogression of HIV infection, but the best correlate with protection against disease progression remains unknown. Methods. We prospectively followed 66 untreated long-term nonprogressors and analyzed relationships between HIV-1-specific CD4 T helper (Th) 1 and CD8 T cell responses and HIV-1-specific antibodies, HIV-1 RNA and proviral DNA loads, host genes, and CD4 Thi cell counts at entry into the study and 4 years later. Results. HIV-1 p24-specific CD4 Thi cell proliferation, interferon (IFN)-γ production, and IFN-γ-producing cell frequencies at entry significantly and negatively correlated with HIV- 1 RNA and proviral DNA loads and were independent of CD4 Thi cell counts and host genes. HIV-1 Gag-specific IFN-γ-producing CD8 T cell frequencies correlated with HIV-1 proviral DNA loads but not with RNA loads. Only high frequencies of HIV-1 p24-specific CD4 Thi cells combined with HIV-1 gp41-specific IgG2 antibodies significantly predicted persistence of high CD4 Thi cell counts. Conclusion. HIV-1-specific CD4 Thi responses combined with IgG2 antibodies and IFN-γ-producing CD4 Thi cells are better predictors of long-term nonprogression than are virus parameters, host genes, or HIV-1-specific CD4 Thi or CD8 T cell proliferation. [ABSTRACT FROM AUTHOR]

Published
2005

23. Non-inflammatory herpes simplex hepatitis in an adult with chronic neutropenia.

Author

Bernuau, Jacques, Rueff, Bernard, Clauvel, Jean-Pierre, Degott, Claude, Perol, Yvonne, and Benhamou, Jean-Pierre

Abstract

ABSTRACT- We report the case of a young woman with chronic neutropenia, in whom hepatitis, extensive herpetic eruption and herpes simplex viremia developed after genital herpetic ulceration. Although severe liver necrosis was present, the patient's death did not result from hepatic failure. No inflammatory cell infiltration was found circumscribing the multiple necrotic foci in the liver. This absence of inflammatory cell infiltration reflects the host's inability to normally restrain herpes simplex virus dissemination and, in this patient, might be the consequence of chronic neutropenia. [ABSTRACT FROM AUTHOR]

Published
1981
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25. Zidovudine for thrombocytopenic purpura related to human immunodeficiency virus (HIV) infection.

Author

Oksenhendler, Eric, Bierling, Philippe, Ferchal, Francoise, Clauvel, Jean-Pierre, Seligmann, Maxime, Oksenhendler, E, Bierling, P, Ferchal, F, Clauvel, J P, and Seligmann, M

Subjects
AZIDOTHYMIDINE, THROMBOCYTOPENIA treatment, THERAPEUTICS, HIV infections, THROMBOPENIC purpura, PILOT projects, HIV seroconversion, PLATELET count
Abstract

Study Objective: To determine whether zidovudine is effective in increasing the platelet count in patients with thrombocytopenic purpura related to human immunodeficiency virus (HIV) infection.Design: Nonrandomized controlled trial with two consecutive regimens.Setting: Immunopathology and hematology clinics at two general hospitals.Patients: Consecutive sample of 34 patients infected with HIV who had thrombocytopenic purpura (platelets less than 50 x 10(9)/L) without visceral bleeding. Twenty-nine patients completed the study; one patient was removed because of drug toxicity.Interventions: Zidovudine for 12 weeks, 250 mg every 6 hours orally in 10 patients; and 500 mg every 8 hours orally in 24 patients.Measurements and Main Results: Three of ten patients receiving 250 mg every 6 hours and 12 of 24 patients receiving 500 mg every 8 hours had a persistent increase in their platelet counts. In both groups the mean value of the platelet count increased significantly by week 12; from 28 x 10(9)/L +/- 12 (SD) to 57 x 10(9)/L +/- 36 in the first group and from 20 x 10(9)/L +/- 13 to 77 x 10(9)/L +/- 42 in the second group (P less than 0.05 and P less than 0.01, respectively).Conclusions: Zidovudine is effective on platelet counts in some patients with HIV-related thrombocytopenia. These results suggest that HIV itself may play a direct or indirect role in the pathogenesis of this disorder. [ABSTRACT FROM AUTHOR]

Published
1989
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26. Antinuclear Autoantibodies Specific for Lamins.

Author

Lassaoued, Kaiss, Guilly, Marie-Noelle, Danon, Francoise, Andre, Chantal, Dhumeaux, Daniel, Clauvel, Jean-Pierre, Brouet, Jean-Claude, Seligmann, Maxime, and Courvalin, Jean-Claude

Subjects
ANTINUCLEAR factors, AUTOIMMUNE diseases, AUTOANTIBODIES, PATIENTS
Abstract

Presents information on a study which examined the antinuclear autoantibodies of several patients with chronic autoimmune disorder for lamins. Methodology of the study; Results and discussion.

Published
1988
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