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186 results on '"Conlon, Peter J"'

1. Donor genetic burden for cerebrovascular risk and kidney transplant outcome

Author

Collins, Kane E., Gilbert, Edmund, Mauduit, Vincent, Benson, Katherine A., Elhassan, Elhussein A. E., O’Seaghdha, Conall, Hill, Claire, McKnight, Amy Jayne, Maxwell, Alexander P., van der Most, Peter J., de Borst, Martin H., Guan, Weihua, Jacobson, Pamala A., Israni, Ajay K., Keating, Brendan J., Lord, Graham M., Markkinen, Salla, Helanterä, Ilkka, Hyvärinen, Kati, Partanen, Jukka, Madden, Stephen F., Limou, Sophie, Cavalleri, Gianpiero L., and Conlon, Peter J.

Published
2024
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3. A Novel Monoallelic ALG5 Variant Causing Late-Onset ADPKD and Tubulointerstitial Fibrosis

Author

Elhassan, Elhussein A.E., Kmochová, Tereza, Benson, Katherine A., Fennelly, Neil K., Barešová, Veronika, Kidd, Kendrah, Doyle, Brendan, Dorman, Anthony, Morrin, Martina M., Kyne, Niamh C., Vyleťal, Petr, Hartmannová, Hana, Hodaňová, Kateřina, Sovová, Jana, Mušálková, Dita, Vrbacká, Alena, Přistoupilová, Anna, Živný, Jan, Svojšová, Klára, Radina, Martin, Stránecký, Viktor, Loginov, Dmitry, Pompach, Petr, Novák, Petr, Vaníčková, Zdislava, Hansíková, Hana, Rajnochová-Bloudíčková, Silvie, Viklický, Ondřej, Hůlková, Helena, Cavalleri, Gianpiero L., Hnízda, Aleš, Bleyer, Anthony J., Kmoch, Stanislav, Conlon, Peter J., and Živná, Martina

Published
2024
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5. High frequency and mortality of head and neck malignancy in organ transplant recipients in Ireland – A national cohort study

Author

Conlon, Eoin, Fitzgerald, Conall, Hintze, Justin, Elhassan, Elhussein A.E., Sexton, Donal J., O'Leary, Eamonn, O'Kelly, Patrick, O'Neill, Jim O., Egan, Jim, Houlihan, Diarmaid D., Murray, Deirdre, McCormick, P. Aiden, Morris, Patrick G., Raghallaigh, Siona Ni, Little, Dilly, Conlon, Peter J., Moloney, Fergal J., and O'Neill, James Paul

Published
2023
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6. The utility of a genetic kidney disease clinic employing a broad range of genomic testing platforms: experience of the Irish Kidney Gene Project

Author

Elhassan, Elhussein A. E., Murray, Susan L., Connaughton, Dervla M., Kennedy, Claire, Cormican, Sarah, Cowhig, Cliona, Stapleton, Caragh, Little, Mark A., Kidd, Kendrah, Bleyer, Anthony J., Živná, Martina, Kmoch, Stanislav, Fennelly, Neil K., Doyle, Brendan, Dorman, Anthony, Griffin, Matthew D., Casserly, Liam, Harris, Peter C., Hildebrandt, Friedhelm, Cavalleri, Gianpiero L., Benson, Katherine A., and Conlon, Peter J.

Published
2022
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8. Epigenome-wide meta-analysis identifies DNA methylation biomarkers associated with diabetic kidney disease

Author

Smyth, Laura J., Dahlström, Emma H., Syreeni, Anna, Kerr, Katie, Kilner, Jill, Doyle, Ross, Brennan, Eoin, Nair, Viji, Fermin, Damian, Nelson, Robert G., Looker, Helen C., Wooster, Christopher, Andrews, Darrell, Anderson, Kerry, McKay, Gareth J., Cole, Joanne B., Salem, Rany M., Conlon, Peter J., Kretzler, Matthias, Hirschhorn, Joel N., Sadlier, Denise, Godson, Catherine, Florez, Jose C., Forsblom, Carol, Maxwell, Alexander P., Groop, Per-Henrik, Sandholm, Niina, and McKnight, Amy Jayne

Published
2022
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10. Pilot Randomized Controlled Trial of a Standard Versus a Modified Low-Phosphorus Diet in Hemodialysis Patients

Author

Byrne, Fiona N., Gillman, Barbara A., Kiely, Mairead, Palmer, Brendan, Shiely, Frances, Kearney, Patricia M., Earlie, Joyce, Bowles, Maria B., Keohane, Fiona M., Connolly, Pauline P., Wade, Sarah, Rennick, Theresa A., Moore, Bernice L., Smith, Oonagh N., Sands, Celene M., Slevin, Orla, McCarthy, Denise C., Brennan, Karina M., Mellett, Halóg, Dahly, Darren, Bergin, Eoin, Casserly, Liam F., Conlon, Peter J., Hannan, Kieran, Holian, John, Lappin, David W., O'Meara, Yvonne M., Mellotte, George J., Reddan, Donal, Watson, Alan, and Eustace, Joseph

Published
2020
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11. Genetic and Clinical Predictors of Age of ESKD in Individuals With Autosomal Dominant Tubulointerstitial Kidney Disease Due to UMOD Mutations

Author

Kidd, Kendrah, Vylet’al, Petr, Schaeffer, Céline, Olinger, Eric, Živná, Martina, Hodaňová, Kateřina, Robins, Victoria, Johnson, Emily, Taylor, Abbigail, Martin, Lauren, Izzi, Claudia, Jorge, Sofia C., Calado, Joaquim, Torres, Rosa J., Lhotta, Karl, Steubl, Dominik, Gale, Daniel P., Gast, Christine, Gombos, Eva, Ainsworth, Hannah C., Chen, Ying Maggie, Almeida, Jorge Reis, de Souza, Cintia Fernandes, Silveira, Catarina, Raposeiro, Rita, Weller, Nelson, Conlon, Peter J., Murray, Susan L., Benson, Katherine A., Cavalleri, Gianpiero L., Votruba, Miroslav, Vrbacká, Alena, Amoroso, Antonio, Gianchino, Daniela, Caridi, Gianluca, Ghiggeri, Gian Marco, Divers, Jasmin, Scolari, Francesco, Devuyst, Olivier, Rampoldi, Luca, Kmoch, Stanislav, and Bleyer, Anthony J.

Published
2020
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13. The impact of donor and recipient common clinical and genetic variation on estimated glomerular filtration rate in a European renal transplant population

Author

Stapleton, Caragh P., Heinzel, Andreas, Guan, Weihua, van der Most, Peter J., van Setten, Jessica, Lord, Graham M., Keating, Brendan J., Israni, Ajay K., de Borst, Martin H., Bakker, Stephan J.L., Snieder, Harold, Weale, Michael E., Delaney, Florence, Hernandez-Fuentes, Maria P., Reindl-Schwaighofer, Roman, Oberbauer, Rainer, Jacobson, Pamala A., Mark, Patrick B., Chapman, Fiona A., Phelan, Paul J., Kennedy, Claire, Sexton, Donal, Murray, Susan, Jardine, Alan, Traynor, Jamie P., McKnight, Amy Jayne, Maxwell, Alexander P., Smyth, Laura J., Oetting, William S., Matas, Arthur J., Mannon, Roslyn B., Schladt, David P., Iklé, David N., Cavalleri, Gianpiero L., and Conlon, Peter J.

Published
2019
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25. An intermediate-effect size variant in UMOD confers risk for chronic kidney disease.

Author

Olinger, Eric, Schaeffer, Céline, Kidd, Kendrah, Elhassan, Elhussein A. E., Yurong Cheng, Dufour, Inés, Schiano, Guglielmo, Mabillard, Holly, Pasqualetto, Elena, Hofmann, Patrick, Fuster, Daniel G., Kistler, Andreas D., Wilson, Ian J., Kmoch, Stanislav, Raymond, Laure, Robert, Thomas, Eckardt, Kai-Uwe, Bleyer Sr., Anthony J., Köttgen, Anna, and Conlon, Peter J.

Subjects
DISEASE risk factors, CHRONIC kidney failure, GENETIC load, KIDNEY failure, KIDNEY diseases, ORGAN donors, INTERNISTS
Abstract

The kidney-specific gene UMOD encodes for uromodulin, the most abundant protein excreted in normal urine. Rare large-effect variants in UMOD cause autosomal dominant tubulointerstitial kidney disease (ADTKD), while common low-impact variants strongly associate with kidney function and the risk of chronic kidney disease (CKD) in the general population. It is unknown whether intermediate-effect variants in UMOD contribute to CKD. Here, candidate intermediate-effect UMOD variants were identified using large-population and ADTKD cohorts. Biological and phenotypical effects were investigated using cell models, in silico simulations, patient samples, and international databases and biobanks. Eight UMOD missense variants reported in ADTKD are present in the Genome Aggregation Database (gnomAD), with minor allele frequency (MAF) ranging from 10-5 to 10-3. Among them, the missense variant p.Thr62Pro is detected in ~1/1,000 individuals of European ancestry, shows incomplete penetrance but a high genetic load in familial clusters of CKD, and is associated with kidney failure in the 100,000 Genomes Project (odds ratio [OR] = 3.99 [1.84 to 8.98]) and the UK Biobank (OR = 4.12 [1.32 to 12.85). Compared with canonical ADTKD mutations, the p. Thr62Pro carriers displayed reduced disease severity, with slower progression of CKD and an intermediate reduction of urinary uromodulin levels, in line with an intermediate trafficking defect in vitro and modest induction of endoplasmic reticulum (ER) stress. Identification of an intermediate-effect UMOD variant completes the spectrum of UMOD-associated kidney diseases and provides insights into the mechanisms of ADTKD and the genetic architecture of CKD. [ABSTRACT FROM AUTHOR]

Published
2022
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41. Is Bigger Better? Living Donor Kidney Volume as Measured by the Donor CT Angiogram in Predicting Donor and Recipient eGFR after Living Donor Kidney Transplantation.

Author

Ebad, Chaudhry Adeel, Brennan, David, Chevarria, Julio, Hussein, Mohammad Bin, Sexton, Donal, Mulholland, Douglas, Doyle, Ciaran, O'Kelly, Patrick, Williams, Yvonne, Dunne, Ruth, O'Seaghdha, Conall, Little, Dilly, Morrin, Martina, and Conlon, Peter J.

Subjects
EPIDERMAL growth factor receptors, KIDNEY transplantation, KIDNEYS, BODY surface area
Abstract

Background. The role of kidney volume measurement in predicting the donor and recipient kidney function is not clear. Methods. We measured kidney volume bilaterally in living kidney donors using CT angiography and assessed the association with the donor remaining kidney and recipient kidney (donated kidney) function at 1 year after kidney transplantation. Donor volume was categorized into tertiles based on lowest, middle, and highest volume. Results. There were 166 living donor and recipient pairs. The mean donor age was 44.8 years (SD ± 10.8), and donor mean BMI was 25.5 (SD ± 2.9). The recipients of living donor kidneys were 64% male and had a mean age of 43.5 years (SD ± 13.3). Six percent of patients experienced an episode of cellular rejection and were maintained on dialysis for a mean of 18 months (13–32) prior to transplant. Kidney volume was divided into tertiles based on lowest, middle, and highest volume. Kidney volume median (range) in tertiles 1, 2, and 3 was 124 (89–135 ml), 155 (136–164 ml), and 184 (165–240 ml) with donor eGFR ml/min (adjusted for body surface area expressed as ml/min/1.73 m2) at the time of donation in each tertile, 109 (93–129), 110 (92–132), and 101 ml/min (84–117). The median (IQR) eGFR in tertiles 1 to 3 in kidney recipients at 1 year after donation was 54 (44–67), 62 (50–75), and 63 ml/min (58–79), respectively. The median (IQR) eGFR in tertiles 1 to 3 in the remaining kidney of donors at 1 year after donation was 59 (53–66), 65 (57–72), and 65 ml/min (56–73), respectively. Conclusion. Bigger kidney volume was associated with better eGFR at 1 year after transplant in the recipient and marginally in the donor remaining kidney. [ABSTRACT FROM AUTHOR]

Published
2021
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45. Calcium and phosphate levels after kidney transplantation and long-term patient and allograft survival.

Author

Chevarria, Julio, Sexton, Donal J, Murray, Susan L, Adeel, Chaudhry E, O'Kelly, Patrick, Williams, Yvonne E, O'Seaghdha, Conall M, Little, Dilly M, and Conlon, Peter J

Subjects
CALCIUM phosphate, KIDNEY transplantation, CARDIOVASCULAR diseases risk factors, BODY mass index, SURVIVAL analysis (Biometry)
Abstract

Background Non-traditional cardiovascular risk factors, including calcium and phosphate derangement, may play a role in mortality in renal transplant. The data regarding this effect are conflicting. Our aim was to assess the impact of calcium and phosphate derangements in the first 90 days post-transplant on allograft and recipient outcomes. Methods We performed a retrospective cohort review of all-adult, first renal transplants in the Republic of Ireland between 1999 and 2015. We divided patients into tertiles based on serum phosphate and calcium levels post-transplant. We assessed their effect on death-censored graft survival and all-cause mortality. We used Stata for statistical analysis and did survival analysis and spline curves to assess the association. Results We included 1525 renal transplant recipients. Of the total, 86.3% had hypophosphataemia and 36.1% hypercalcaemia. Patients in the lowest phosphate tertile were younger, more likely female, had lower weight, more time on dialysis, received a kidney from a younger donor, had less delayed graft function and better transplant function compared with other tertiles. Patients in the highest calcium tertile were younger, more likely male, had higher body mass index, more time on dialysis and better transplant function. Adjusting for differences between groups, we were unable to show any difference in death-censored graft failure [phosphate = 1.14, 95% confidence interval (CI) 0.92–1.41; calcium = 0.98, 95% CI 0.80–1.20] or all-cause mortality (phosphate = 1.10, 95% CI 0.91–1.32; calcium = 0.96, 95% CI 0.81–1.13) based on tertiles of calcium or phosphate in the initial 90 days. Conclusions Hypophosphataemia and hypercalcaemia are common occurrences post-kidney transplant. We have identified different risk factors for these metabolic derangements. The calcium and phosphate levels exhibit no independent association with death-censored graft failure and mortality. [ABSTRACT FROM AUTHOR]

Published
2021
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48. A population-based comparison of organ transplant recipients in whom cutaneous squamous cell develops versus those in whom basal cell carcinoma develops.

Author

Menzies, Stephanie, O'Leary, Eamon, Callaghan, Grainne, Mansoor, Nazish, Deady, Sandra, Murad, Aizuri, Lenane, Patsy, O'Neill, Jim, Lally, Aoife, Houlihan, Diarmuid D., Murray, Susan, Sexton, Donal J., McCormick, P. Aiden, Egan, Jim J., O'Neill, James Paul, Conlon, Peter J., and Moloney, Fergal J.

Published
2022
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50. Variant renal artery anatomy in first degree relatives on MDCT angiography.

Author

Reid, Conor, Kelly, Dearbhla, Briody, Hayley, Lawless, Philip, Little, Dilly, Conlon, Peter J., and Morrin, Martina

Subjects
RENAL artery, ANATOMY, ANGIOGRAPHY, MULTIDETECTOR computed tomography, KIDNEY exchange
Abstract

Dear Editor, Since the widespread adoption of multidetector computed tomography (MDCT) angiography for pre-operative assessment of living kidney donors, significant variability in renal vascular anatomy has been identified. Given the frequency of living kidney donation at the Irish National Kidney Transplant Service, we recognized an opportunity to assess the incidence of variant renal anatomy in first degree relatives undergoing potential living donor workup. Complex living donor kidneys are used successfully at many centers and still outperform deceased donor kidneys in the long-term.[3] We wish to open up the discussion of the concordance of complex vascular anatomy among first degree relatives as we believe this will be of interest to your readership. [Extracted from the article]

Published
2023
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