7 results on '"Farhang-Sardroodi, Suzan"'
Search Results
2. A machine learning approach to differentiate between COVID-19 and influenza infection using synthetic infection and immune response data.
- Author
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Farhang-Sardroodi, Suzan, Ghaemi, Mohammad Sajjad, Craig, Morgan, Hsu Kiang Ooi, and Heffernan, Jane M.
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- 2022
- Full Text
- View/download PDF
3. Chemotherapy-induced cachexia and model-informed dosing to preserve lean mass in cancer treatment.
- Author
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Farhang-Sardroodi, Suzan, La Croix, Michael A., and Wilkie, Kathleen P.
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LEAN body mass , *CANCER treatment , *CACHEXIA , *CHEMOTHERAPY complications , *CANCER chemotherapy , *MUSCLE mass - Abstract
Although chemotherapy is a standard treatment for cancer, it comes with significant side effects. In particular, certain agents can induce severe muscle loss, known as cachexia, worsening patient quality of life and treatment outcomes. 5-fluorouracil, an anti-cancer agent used to treat several cancers, has been shown to cause muscle loss. Experimental data indicates a non-linear dose-dependence for muscle loss in mice treated with daily or week-day schedules. We present a mathematical model of chemotherapy-induced muscle wasting that captures this non-linear dose-dependence. Area-under-the-curve metrics are proposed to quantify the treatment's effects on lean mass and tumour control. Model simulations are used to explore alternate dosing schedules, aging effects, and morphine use in chemotherapy treatment with the aim of better protecting lean mass while actively targeting the tumour, ultimately leading to improved personalization of treatment planning and improved patient quality of life. Author summary: In this paper we present a novel mathematical model for muscle loss due to cancer chemotherapy treatment. Loss of muscle mass relates to increased drug toxicity and side-effects, and to decreased patient quality of life and survival rates. With our model, we examine the therapeutic efficacy of various dosing schedules with the aim of controlling a growing tumour while also preserving lean mass. Preservation of body composition, in addition to consideration of inflammation and immune interactions, the gut microbiome, and other systemic health measures, may lead to improved patient-specific treatment plans that improve patient quality of life. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
4. Success probability for selectively neutral invading species in the line model with a random fitness landscape.
- Author
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Farhang‐Sardroodi, Suzan, Komarova, Natalia L., Michelen, Marcus, and Pemantle, Robin
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PROBABILITY theory , *SUCCESS , *SPECIES , *SIZE - Abstract
We consider a spatial (line) model for invasion of a population by a single mutant with a stochastically selectively neutral fitness landscape, independent from the fitness landscape for nonmutants. This model is similar to those considered earlier. We show that the probability of mutant fixation in a population of size N, starting from a single mutant, is greater than 1/N, which would be the case if there were no variation in fitness whatsoever. In the small variation regime, we recover precise asymptotics for the success probability of the mutant. This demonstrates that the introduction of randomness provides an advantage to minority mutations in this model, and shows that the advantage increases with the system size. We further demonstrate that the mutants have an advantage in this setting only because they are better at exploiting unusually favorable environments when they arise, and not because they are any better at exploiting pockets of favorability in an environment that is selectively neutral overall. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
5. The effect of spatial randomness on the average fixation time of mutants.
- Author
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Farhang-Sardroodi, Suzan, Darooneh, Amirhossein H., Nikbakht, Moladad, Komarova, Natalia L., and Kohandel, Mohammad
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POPULATION dynamics , *CELLS , *STOCHASTIC convergence , *GENETIC mutation , *COMPUTER simulation - Abstract
The mean conditional fixation time of a mutant is an important measure of stochastic population dynamics, widely studied in ecology and evolution. Here, we investigate the effect of spatial randomness on the mean conditional fixation time of mutants in a constant population of cells, N. Specifically, we assume that fitness values of wild type cells and mutants at different locations come from given probability distributions and do not change in time. We study spatial arrangements of cells on regular graphs with different degrees, from the circle to the complete graph, and vary assumptions on the fitness probability distributions. Some examples include: identical probability distributions for wild types and mutants; cases when only one of the cell types has random fitness values while the other has deterministic fitness; and cases where the mutants are advantaged or disadvantaged. Using analytical calculations and stochastic numerical simulations, we find that randomness has a strong impact on fixation time. In the case of complete graphs, randomness accelerates mutant fixation for all population sizes, and in the case of circular graphs, randomness delays mutant fixation for N larger than a threshold value (for small values of N, different behaviors are observed depending on the fitness distribution functions). These results emphasize fundamental differences in population dynamics under different assumptions on cell connectedness. They are explained by the existence of randomly occurring “dead zones” that can significantly delay fixation on networks with low connectivity; and by the existence of randomly occurring “lucky zones” that can facilitate fixation on networks of high connectivity. Results for death-birth and birth-death formulations of the Moran process, as well as for the (haploid) Wright Fisher model are presented. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF
6. Analysis of Host Immunological Response of Adenovirus-Based COVID-19 Vaccines.
- Author
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Farhang-Sardroodi, Suzan, Korosec, Chapin S., Gholami, Samaneh, Craig, Morgan, Moyles, Iain R., Ghaemi, Mohammad Sajjad, Ooi, Hsu Kiang, and Heffernan, Jane M.
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COVID-19 vaccines ,COVID-19 ,COVID-19 pandemic ,GENETIC vectors ,ORDINARY differential equations - Abstract
During the SARS-CoV-2 global pandemic, several vaccines, including mRNA and adenovirus vector approaches, have received emergency or full approval. However, supply chain logistics have hampered global vaccine delivery, which is impacting mass vaccination strategies. Recent studies have identified different strategies for vaccine dose administration so that supply constraints issues are diminished. These include increasing the time between consecutive doses in a two-dose vaccine regimen and reducing the dosage of the second dose. We consider both of these strategies in a mathematical modeling study of a non-replicating viral vector adenovirus vaccine in this work. We investigate the impact of different prime-boost strategies by quantifying their effects on immunological outcomes based on simple system of ordinary differential equations. The boost dose is administered either at a standard dose (SD) of 1000 or at a low dose (LD) of 500 or 250 vaccine particles. Results show dose-dependent immune response activity. Our model predictions show that by stretching the prime-boost interval to 18 or 20, in an SD/SD or SD/LD regimen, the minimum promoted antibody (Nab) response will be comparable with the neutralizing antibody level measured in COVID-19 recovered patients. Results also show that the minimum stimulated antibody in SD/SD regimen is identical with the high level observed in clinical trial data. We conclude that an SD/LD regimen may provide protective capacity, which will allow for conservation of vaccine doses. [ABSTRACT FROM AUTHOR]
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- 2021
- Full Text
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7. Mathematical Model of Muscle Wasting in Cancer Cachexia.
- Author
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Farhang-Sardroodi, Suzan and Wilkie, Kathleen P.
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CACHEXIA , *MUSCLES , *UBIQUITIN ligases , *MATHEMATICAL models , *SATELLITE cells , *MYOFIBROBLASTS - Abstract
Cancer cachexia is a debilitating condition characterized by an extreme loss of skeletal muscle mass, which negatively impacts patients' quality of life, reduces their ability to sustain anti-cancer therapies, and increases the risk of mortality. Recent discoveries have identified the myostatin/activin A/ActRIIB pathway as critical to muscle wasting by inducing satellite cell quiescence and increasing muscle-specific ubiquitin ligases responsible for atrophy. Remarkably, pharmacological blockade of the ActRIIB pathway has been shown to reverse muscle wasting and prolong the survival time of tumor-bearing animals. To explore the implications of this signaling pathway and potential therapeutic targets in cachexia, we construct a novel mathematical model of muscle tissue subjected to tumor-derived cachectic factors. The model formulation tracks the intercellular interactions between cancer cell, satellite cell, and muscle cell populations. The model is parameterized by fitting to colon-26 mouse model data, and the analysis provides insight into tissue growth in healthy, cancerous, and post-cachexia treatment conditions. Model predictions suggest that cachexia fundamentally alters muscle tissue health, as measured by the stem cell ratio, and this is only partially recovered by anti-cachexia treatment. Our mathematical findings suggest that after blocking the myostatin/activin A pathway, partial recovery of cancer-induced muscle loss requires the activation and proliferation of the satellite cell compartment with a functional differentiation program. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
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