13 results on '"Farrokhpour, Mohsen"'
Search Results
2. Variable Levels of Oxytocin During Sepsis: The Role of Oxytocin in Sepsis Pathophysiology.
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Yadollahzadeh, Mahdi, Rezaie, Nader, Eskandari, Mohana, Farrokhpour, Mohsen, Azimi, Mehdi, and Farasatinasab, Maryam
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OXYTOCIN ,SEPSIS ,PATHOLOGICAL physiology ,NEUROLOGY ,RADIOIMMUNOASSAY - Abstract
Background: Although the role of oxytocin in the pathophysiology of sepsis is still unknown, rising preclinical evidence suggests that oxytocin is possibly involved. However, no direct clinical studies have measured the levels of oxytocin during sepsis. In this preliminary study, the serum oxytocin levels were evaluated throughout the duration of sepsis. Method: Twenty-two male patients over 18 years of age with a SOFA score of 2 points or more who were admitted to the ICU were included. Patients with a history of neuroendocrine, psychiatric, and neurologic disorders, cancer, an infection caused by COVID-19, shock due to reasons other than sepsis, a history of psychiatric or neurologic medication use, and those who died during the study were excluded. The main endpoint included the measurement of serum oxytocin levels using radioimmunoassay at 6, 24, and 48 h of the ICU admission. Results: Mean serum oxytocin level was higher at 6 h of ICU admission (41.27 ± 13.14 ng/L) than after 24 and 48 h of ICU admission (22.63 ± 5.75 and 20.97 ± 7.61 ng/L respectively) (P -value <.001). Conclusion: Our study, while reporting increased serum oxytocin levels in the initial phase of sepsis and decline afterward, supports the possible contribution of oxytocin in the pathophysiology of sepsis. Given that oxytocin seems to modulate the innate immune system, future investigations are necessary to assess the potential role of oxytocin in the pathophysiology of sepsis. [ABSTRACT FROM AUTHOR]
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- 2023
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3. Investigating the Efficacy of an Herbal Medicine Package (Anti-Flu Pulmo-Health) Along with Common Medications in Alleviating COVID-19 Symptoms in Outpatients: A Double-Blinded Randomized Controlled Trial.
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Hasanzadeh, Reza, Sharifi Olounabadi, Ahmad Reza, Farrokhpour, Mohsen, Aghaei, Khodakaram, Fesharaki, Mohammad Gholami, Zarrabi, Mahboobeh, Tash, Fariba Abolhasan, and Dolatkhah, Shahaboddin
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COUGH ,HERBAL medicine ,COVID-19 pandemic ,DIASTOLIC blood pressure ,SYMPTOMS ,DRUGS - Abstract
Background: To date, no specific medication has been shown to be effective in treating COVID-19. Objectives: Due to the role of medicinal plants in reducing the symptoms of viral diseases, the present study aimed to assess the efficacy of an herbal medicine package (anti-flu Pulmo-Health), prepared based on Persian traditional medicine instructions and bioinformatics studies, in reducing the symptoms of COVID-19 in outpatients. Methods: This double-blinded randomized controlled trial was conducted on 60 COVID-19 outpatients referred to the Emergency Department of Baqiyatallah Hospital in Tehran (Iran) in July-Sep. 2020. The patients were randomly assigned into two groups, the control group (receiving routine treatment and a placebo) and the intervention group (receiving routine treatment plus anti-flu Pulmo-Health syrup and supplementary drops). The intervention continued for 10 days. The primary outcomes were oxygen saturation level, respiratory rate, heart rate, frequency of coughs during day and night times, shortness of breath score (based on the SOBDA questionnaire), expectoration, as well as the frequency of dry and productive coughs. Secondary outcomes were systolic and diastolic blood pressure, body temperature, headache, nausea, and chills. Results: In this study, 55 COVID-19 patients (27 cases in the control group and 28 subjects in the intervention group) were analyzed. The mean age of the patients was 46.25 ± 12.84 years, and 65% of them were female. The two groups of patients were homogenous in terms of demographic characteristics. The results showed that COVID-19 patients who received routine treatment plus the herbal syrup and supplementary drops revealed significantly better therapeutic responses in terms of respiratory rate, oxygen saturation, expectoration (P < 0.001), frequency of dry and productive coughs (P < 0.001), frequency of coughs, and shortness of breath (P < 0.001). Conclusions: As evidenced by the results of this study, the higher therapeutic response of COVID-19 outpatients to the anti-flu herbal syrup, this medicine is recommended as a supplement to improve respiratory symptoms in COVID-19 patients. [ABSTRACT FROM AUTHOR]
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- 2023
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4. Atorvastatin versus Placebo in ICU Patients with COVID-19: Ninety-day Results of the INSPIRATION-S Trial.
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Talasaz, Azita H., Sadeghipour, Parham, Bakhshandeh, Hooman, Sharif-Kashani, Babak, Rashidi, Farid, Beigmohammadi, Mohammad Taghi, Moghadam, Keivan Gohari, Rezaian, Somaye, Dabbagh, Ali, Sezavar, Seyed Hashem, Farrokhpour, Mohsen, Abedini, Atefeh, Aliannejad, Rasoul, Riahi, Taghi, Yadollahzadeh, Mahdi, Lookzadeh, Somayeh, Rezaeifar, Parisa, Matin, Samira, Tahamtan, Ouria, and Mohammadi, Keyhan
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- 2023
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5. Intermediate-Dose versus Standard-Dose Prophylactic Anticoagulation in Patients with COVID-19 Admitted to the Intensive Care Unit: 90-Day Results from the INSPIRATION Randomized Trial.
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Bikdeli, Behnood, Talasaz, Azita H., Rashidi, Farid, Bakhshandeh, Hooman, Rafiee, Farnaz, Rezaeifar, Parisa, Baghizadeh, Elahe, Matin, Samira, Jamalkhani, Sepehr, Tahamtan, Ouria, Sharif-Kashani, Babak, Beigmohammadi, Mohammad Taghi, Farrokhpour, Mohsen, Sezavar, Seyed Hashem, Payandemehr, Pooya, Dabbagh, Ali, Moghadam, Keivan Gohari, Khalili, Hossein, Yadollahzadeh, Mahdi, and Riahi, Taghi
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- 2022
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6. Serum level of Vitamin D is associated with COVID-19 mortality rate in hospitalized patients.
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Ranjbar, Mitra, Karbalaie Niya, Mohammad Hadi, Roham, Maryam, Rezaie, Nader, Yadollahzadeh, Mahdi, Farrokhpour, Mohsen, Azimi, Mehdi, Motamed, Nima, Perumal, Dhayaneethie, Tameshkel, Fahimeh Safarnezhad, Dadras, Farahnaz, Madani, Nahid Hashemi, Ghanbari, Behrooz, Faraji, Amirhossein, Nikkhah, Mehdi, Rahmani, Shahrzad, Golgiri, Fatemah, Emadi, Seyed Yadollah, Abbasi, Rowshanak, and Mohseni, Iman
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COVID-19 ,HOSPITAL patients ,CONFIDENCE intervals ,RESPIRATORY infections ,VITAMIN D ,RISK assessment ,MALNUTRITION ,DESCRIPTIVE statistics ,DATA analysis software ,ODDS ratio ,COVID-19 pandemic - Abstract
Background: Due to widespread of coronavirus disease 2019 (COVID-19) infection, identification of its risk factors and clinical characteristics are important. The aim of the present study was to assess Vitamin D levels in individuals with severe acute respiratory syndrome coronavirus-19 infection and to report on its potential as a predictive marker. Materials and Methods: All patients, diagnosed with COVID-19 infection from February 16 to March 21, 2020, and referred to Firoozgar Hospital, Tehran, Iran, were enrolled in this study. Vitamin D analysis was undertaken on patient serum samples using a commercial kit (Pars Azmoon Co., Tehran, Iran). SPSS v. 22 was used for statistical analysis. Results: Vitamin D serum concentration was analyzed in a total of 317 patients whose mean age ± standard deviation was 62.05 ± 15 years and with 62.5% being male. A significant association of Vitamin D level and death was observed. Higher levels of serum Vitamin D had protection against death (odds ratio = 0.955 [95% confidence interval = 0.923--0.988], P = 0.008). Conclusion: As a preliminary study in the Iranian population who suffered COVID-19 disease, we identified that Vitamin D deficiency was associated with a higher death rate and intensive care unit admission. [ABSTRACT FROM AUTHOR]
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- 2021
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7. The predictive power of serum vitamin D for poor outcomes in COVID‐19 patients.
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Derakhshanian, Hoda, Rastad, Hadith, Ghosh, Sanjoy, Zeinali, Marjan, Ziaee, Mahsa, Khoeini, Tara, Farrokhpour, Mohsen, Qorbani, Mostafa, Ramezani Ghamsari, Mona, Hasani, Hossein, and Mirzaasgari, Zahra
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COVID-19 ,VITAMIN D ,TREATMENT effectiveness ,VITAMIN D deficiency ,VITAMIN D receptors ,PHYSICIANS ,BLOOD sedimentation - Abstract
Considering the high prevalence of vitamin D deficiency worldwide and its relationship with immune response to viral infections, this study attempted to identify the predictive power of serum vitamin D for poor outcomes among the COVID‐19 patients. This retrospective cohort study included all patients with confirmed COVID‐19 hospitalized between February 20, 2020, and April 20, 2020, at a designated COVID‐19 hospital, located in Tehran province, Iran. General characteristics, medical history and clinical symptoms were recorded by trained physicians. Blood parameters including complete blood count, creatinine, lactate dehydrogenase, creatine phosphokinase, erythrocyte sedimentation rate, C‐reactive protein and vitamin D were tested. This study included 290 hospitalized patients with COVID‐19 (the mean age [SD]: 61.6 [16.9], 56.6% males), of whom 142 had vitamin D concentrations less than 20 ng/ml, defined as vitamin D deficiency. COVID‐19 patients with vitamin D deficiency were more likely to die (Crude OR [95% CI]: 2.30 [1.25–4.26]), require ICU (2.06 [1.22–3.46]) and invasive mechanical ventilation (2.03 [1.04–3.93]) based on univariate logistic regression results. Although, after adjusting for potentials confounders such as gender and age, the association between vitamin D and need to invasive mechanical ventilation lost its significance, adjusted values for the risk of death and ICU requirement were still statistically significant. Vitamin D deficiency can be considered as a predictor of poor outcomes and mortality in COVID‐19 patients. Therefore, checking serum 25 (OH) D on admission and taking vitamin D supplements according to the prophylactic or treatment protocols is recommended for all COVID‐19 patients. [ABSTRACT FROM AUTHOR]
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- 2021
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8. Effect of Intermediate-Dose vs Standard-Dose Prophylactic Anticoagulation on Thrombotic Events, Extracorporeal Membrane Oxygenation Treatment, or Mortality Among Patients With COVID-19 Admitted to the Intensive Care Unit: The INSPIRATION Randomized Clinical Trial.
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Sadeghipour, Parham, Talasaz, Azita H., Rashidi, Farid, Sharif-Kashani, Babak, Beigmohammadi, Mohammad Taghi, Farrokhpour, Mohsen, Sezavar, Seyed Hashem, Payandemehr, Pooya, Dabbagh, Ali, Moghadam, Keivan Gohari, Jamalkhani, Sepehr, Khalili, Hossein, Yadollahzadeh, Mahdi, Riahi, Taghi, Rezaeifar, Parisa, Tahamtan, Ouria, Matin, Samira, Abedini, Atefeh, Lookzadeh, Somayeh, and Rahmani, Hamid
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ANTICOAGULANTS ,COVID-19 ,INTENSIVE care patients ,THROMBOSIS ,FIBRINOLYTIC agents ,STATINS (Cardiovascular agents) ,EXTRACORPOREAL membrane oxygenation ,THROMBOCYTOPENIA - Abstract
Importance: Thrombotic events are commonly reported in critically ill patients with COVID-19. Limited data exist to guide the intensity of antithrombotic prophylaxis.Objective: To evaluate the effects of intermediate-dose vs standard-dose prophylactic anticoagulation among patients with COVID-19 admitted to the intensive care unit (ICU).Design, Setting, and Participants: Multicenter randomized trial with a 2 × 2 factorial design performed in 10 academic centers in Iran comparing intermediate-dose vs standard-dose prophylactic anticoagulation (first hypothesis) and statin therapy vs matching placebo (second hypothesis; not reported in this article) among adult patients admitted to the ICU with COVID-19. Patients were recruited between July 29, 2020, and November 19, 2020. The final follow-up date for the 30-day primary outcome was December 19, 2020.Interventions: Intermediate-dose (enoxaparin, 1 mg/kg daily) (n = 276) vs standard prophylactic anticoagulation (enoxaparin, 40 mg daily) (n = 286), with modification according to body weight and creatinine clearance. The assigned treatments were planned to be continued until completion of 30-day follow-up.Main Outcomes and Measures: The primary efficacy outcome was a composite of venous or arterial thrombosis, treatment with extracorporeal membrane oxygenation, or mortality within 30 days, assessed in randomized patients who met the eligibility criteria and received at least 1 dose of the assigned treatment. Prespecified safety outcomes included major bleeding according to the Bleeding Academic Research Consortium (type 3 or 5 definition), powered for noninferiority (a noninferiority margin of 1.8 based on odds ratio), and severe thrombocytopenia (platelet count <20 ×103/µL). All outcomes were blindly adjudicated.Results: Among 600 randomized patients, 562 (93.7%) were included in the primary analysis (median [interquartile range] age, 62 [50-71] years; 237 [42.2%] women). The primary efficacy outcome occurred in 126 patients (45.7%) in the intermediate-dose group and 126 patients (44.1%) in the standard-dose prophylaxis group (absolute risk difference, 1.5% [95% CI, -6.6% to 9.8%]; odds ratio, 1.06 [95% CI, 0.76-1.48]; P = .70). Major bleeding occurred in 7 patients (2.5%) in the intermediate-dose group and 4 patients (1.4%) in the standard-dose prophylaxis group (risk difference, 1.1% [1-sided 97.5% CI, -∞ to 3.4%]; odds ratio, 1.83 [1-sided 97.5% CI, 0.00-5.93]), not meeting the noninferiority criteria (P for noninferiority >.99). Severe thrombocytopenia occurred only in patients assigned to the intermediate-dose group (6 vs 0 patients; risk difference, 2.2% [95% CI, 0.4%-3.8%]; P = .01).Conclusions and Relevance: Among patients admitted to the ICU with COVID-19, intermediate-dose prophylactic anticoagulation, compared with standard-dose prophylactic anticoagulation, did not result in a significant difference in the primary outcome of a composite of adjudicated venous or arterial thrombosis, treatment with extracorporeal membrane oxygenation, or mortality within 30 days. These results do not support the routine empirical use of intermediate-dose prophylactic anticoagulation in unselected patients admitted to the ICU with COVID-19.Trial Registration: ClinicalTrials.gov Identifier: NCT04486508. [ABSTRACT FROM AUTHOR]- Published
- 2021
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9. Infliximab and Intravenous Gammaglobulin in Hospitalized Severe COVID-19 Patients in Intensive Care Unit.
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Farrokhpour, Mohsen, Rezaie, Nader, Moradi, Najmeh, Rad, Fatemeh Ghaffari, Izadi, Shirin, Azimi, Mehdi, Zamani, Farhad, Izadi, Shahrokh, Ranjbar, Mitra, Makiani, Mahin Jamshidi, laali, Azadeh, Roham, Maryam, and Yadollahzadeh, Mahdi
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INTENSIVE care units , *HOSPITALS , *INTRAVENOUS therapy , *COMBINATION drug therapy , *COVID-19 , *SCIENTIFIC observation , *CONFIDENCE intervals , *INTUBATION , *INFLIXIMAB , *PATIENTS , *GAMMA globulins , *SEVERITY of illness index , *HOSPITAL admission & discharge , *DESCRIPTIVE statistics - Abstract
Background: Severe coronavirus disease 2019 (COVID-19) may lead to the cytokine storm syndrome which may cause acute respiratory failure syndrome and death. Our aim was to investigate the therapeutic effects of infliximab, intravenous gammaglobulin (IVIg) or combination therapy in patients with severe COVID-19 disease admitted to the intensive care unit (ICU). Methods: In this observational research, we studied 104 intubated adult patients with severe COVID-19 infection (based on clinical symptoms, and radiographic or CT scan parameters) who were admitted to the ICU of a multispecialty hospital during March 2020 in Tehran, Iran. All cases received standard treatment regimens as local protocol (Oseltamivir + hydroxychloroquine + lopinavir/ritonavir or sofosbuvir or atazanavir ± ribavirin). The cases were grouped as controls (n = 43), infliximab (n = 27), IVIg (n = 23) and combination (n = 11). Results: There was no significant difference between controls and treatment groups in terms of underlying diseases or the number of underlying diseases. The mean age (SD) of cases was 72.42 (16.06) in the control group, 64.52 (12.965) in IVIg, 63.40 (17.57) in infliximab and 64.00 (11.679) in combination therapy; (P = 0.047, 0.031 and 0.11, respectively). Also, 37% in the infliximab group, 26.1% in IVIg, 45.5% in combination therapy, and 62.8% in the control group expired (all P < 0.05). Hazard ratios were 0.31 in IVIg (95% CI: 0.12-0.76, P = 0.01), 0.30 in infliximab (95% CI: 0.13-0.67, P = 0.004), 0.39 in combination therapy (95% CI: 0.12-1.09, P = 0.071). Conclusion: According to the findings of this study, it seems that infliximab and IVIg, alone or together, in patients with severe COVID-19 disease can be considered an effective treatment. [ABSTRACT FROM AUTHOR]
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- 2021
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10. Troponin is a useful marker in clinical decision making in hospitalized patients with COVID-19 infections.
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Safarnezhad-Tameshkel, Fahimeh, Motamed, Nima, Karbalaie Niya, Mohammad Hadi, Perumal, Dhayaneethie, Rezaie, Nader, Izadi, Shirin, Ranjbar, Mitra, Yadollahzadeh, Mahdi, Behdad, Behnam, Hemmasi, Gholamreza, Kaveh, Vahid, Anoushirvani, Ali Arash, Malek, Mojtaba, Farahani, Behzad, Eskandari, Ramin, Panahi, Mahshid, Rahimi, Mandana, Emami, Sepideh, Zamani, Farhad, and Farrokhpour, Mohsen
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COVID-19 ,PATIENT decision making ,TROPONIN ,BIOMARKERS ,MULTIPLE regression analysis - Abstract
BACKGROUND: COVID-19 was introduced by the World Health Organization (WHO) as a global pandemic. The disease manifestations ranges from a mild common cold to severe disease and death. It has a higher mortality rate in people with a history of comorbidities, including cardiovascular disease (CVD) and can also contribute to cardiac injury. This study was conducted to evaluate the relationship between troponin levels as a cardiac marker and adverse outcomes in this disease. METHODS: The study sample included 438 patients hospitalized with COVID-19; however, the troponin data of 6 patients were not available. The need to be admitted to the intensive care unit (ICU), and death were considered the adverse outcome in patients with COVID-19. Troponin levels were checked in all patients on day 1 and day 3 of hospitalization. Multiple logistic regression analysis was performed to determine whether there was an independent association between the adverse outcomes and troponin enzyme in hospitalized patients with COVID-19. RESULTS: The mean age of patients was 61.29 ± 15.84 years. Among the 432 patients tested on day 1 of hospitalization, 24 patients (5.6%) tested positive (Troponin 1), and among the 303 patients tested on day 3, 13 patients (4.3%) tested positive (Troponin 2). Based on our results, Troponin 1 showed an independent association with both death (3.008 [95%CI = 1.091-8.290]; P = 0.033) and need for ICU admission (8.499 [95%CI = 3.316-21.788]; P < 0.001) in multiple logistic regression analysis. Moreover, the status of Troponin 2 had an independent significant association with both death (4.159 [95%CI = 1.156-14.961]; P = 0.029) and ICU admission (7.796 [95%CI = 1.954-31.097]; P = 0.004). CONCLUSION: Troponin showed a significant association with adverse outcomes in people who were hospitalized with COVID-19. The periodical assessment of this enzyme from the time of hospitalization may improve the clinical decision making of clinicians. [ABSTRACT FROM AUTHOR]
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- 2021
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11. Intermediate versus standard-dose prophylactic anticoagulation and statin therapy versus placebo in critically-ill patients with COVID-19: Rationale and design of the INSPIRATION/INSPIRATION-S studies.
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Bikdeli, Behnood, Talasaz, Azita H., Rashidi, Farid, Sharif-Kashani, Babak, Farrokhpour, Mohsen, Bakhshandeh, Hooman, Sezavar, Hashem, Dabbagh, Ali, Beigmohammadi, Mohammad Taghi, Payandemehr, Pooya, Yadollahzadeh, Mahdi, Riahi, Taghi, Khalili, Hossein, Jamalkhani, Sepehr, Rezaeifar, Parisa, Abedini, Atefeh, Lookzadeh, Somayeh, Shahmirzaei, Shaghayegh, Tahamtan, Ouria, and Matin, Samira
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COVID-19 , *STATINS (Cardiovascular agents) , *REVERSE transcriptase polymerase chain reaction , *ANTICOAGULANTS , *THROMBOEMBOLISM , *BLOOD platelet disorders - Abstract
Microvascular and macrovascular thrombotic events are among the hallmarks of coronavirus disease 2019 (COVID-19). Furthermore, the exuberant immune response is considered an important driver of pulmonary and extrapulmonary manifestations of COVID-19. The optimal management strategy to prevent thrombosis in critically-ill patients with COVID-19 remains unknown. The Intermediate versus Standard-dose Prophylactic anticoagulation In cRitically-ill pATIents with COVID-19: An opeN label randomized controlled trial (INSPIRATION) and INSPIRATION-statin (INSPIRATION-S) studies test two independent hypotheses within a randomized controlled trial with 2 × 2 factorial design. Hospitalized critically-ill patients with reverse transcription polymerase chain reaction confirmed COVID-19 will be randomized to intermediate-dose versus standard dose prophylactic anticoagulation. The 600 patients undergoing this randomization will be screened and if meeting the eligibility criteria, will undergo an additional double-blind stratified randomization to atorvastatin 20 mg daily versus matching placebo. The primary endpoint, for both hypotheses will be tested for superiority and includes a composite of adjudicated acute arterial thrombosis, venous thromboembolism (VTE), use of extracorporeal membrane oxygenation, or all-cause death within 30 days from enrollment. Key secondary endpoints include all-cause mortality, adjudicated VTE, and ventilator-free days. Key safety endpoints include major bleeding according to the Bleeding Academic Research Consortium definition and severe thrombocytopenia (platelet count <20,000/fL) for the anticoagulation hypothesis. In a prespecified secondary analysis for non-inferiority, the study will test for the non-inferiority of intermediate intensity versus standard dose anticoagulation for major bleeding, considering a non-inferiority margin of 1.8 based on odds ratio. Key safety endpoints for the statin hypothesis include rise in liver enzymes >3 times upper normal limit and clinically-diagnosed myopathy. The primary analyses will be performed in the modified intention-to-treat population. Results will be tested in exploratory analyses across key subgroups and in the intention-to-treat and per-protocol cohorts. INSPIRATION and INSPIRATON-S studies will help address clinically-relevant questions for antithrombotic therapy and thromboinflammatory therapy in critically-ill patients with COVID-19. • The optimal anticoagulant regimen for critically-ill patients with COVID-19 remains unknown. • It is unknown if pleiotropic effects of statins may reduce thromboinflammation in COVID-19. • This manuscript summarizes the rationale and methodology of the INSPIRATION and INSPIRATION-S studies. • The manuscript provides a summary about other anticoagulation trials and statin trials in COVID-19. [ABSTRACT FROM AUTHOR]
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- 2020
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12. Liver Enzymes and Inpatient Deaths in COVID-19 Hospitalized Patients.
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Khoonsari, Mahmoodreza, Zamani, Farhad, Niya, Mohammad Hadi Karbalaie, Hemmasi, Gholamreza, Ajdarkosh, Hossein, Faraji, Amirhossein, Nikkhah, Mehdi, Pishgar, Elham, Makiani, Mahin Jamshidi, Ranjbar, Mitra, Tameshkel, Fahimeh Safarnezhad, Panahi, Mahshid, Ameli, Mitra, Yadollahzadeh, Mahdi, Farrokhpour, Mohsen, Maadi, Mansooreh, Ghafari, Abolfazl, Valuiyan, Marzieh, Pouladi, Masoume, and Motamed, Nima
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STATISTICAL correlation , *ENZYMES , *LIVER , *LIVER diseases , *MULTIPLE regression analysis , *DISEASE incidence , *DESCRIPTIVE statistics , *HOSPITAL mortality , *COVID-19 , *EVALUATION - Abstract
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) [COVID-19] quickly turned into a pandemic. Gastrointestinal involvement, especially liver diseases, is one of the main complications of COVID-19 patients. Objectives: The current study aimed to evaluate the high incidence of liver involvement in COVID-19 hospitalized patients and its association with mortality. Methods: A total of 560 hospitalized patients with a confirmed diagnosis of COVID-19 were included. Death was considered as the outcome. In addition to liver enzymes, demographic, clinical, and other laboratory data were also collected. Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels ≥ 40 were considered as abnormal. To investigate the association between abnormal levels of liver enzymes and death, multiple regression logistic was used. Results: According to the findings, 29.1% (95% CI = 25.3% - 32.9%) of patients had high levels (≥ 40 IU) of ALT, and 45.1% (95% CI = 40.9% - 49.3%) had high levels of AST (≥ 40 IU). The frequency (based on %) of high levels of AST (≥ 40 U/liter) was significantly higher in patients who died [67.3% (95% CI = 54.5% - 80.1%] of COVID-19 than those who survived [44.9% (95% CI = 39.7% - 50.0%)] (P-value < 0.001). No significant difference was detected in ALT between expired [29.1% (95% CI = 16.7% - 41.5%)] and survived patients [30.7% (95% CI = 25.9% - 35.5%] (P-value = 0.791). AST was found to have an independent association with death in multiple logistic regression (Wald = 4.429, OR (95% CI) = 1.014 (1.008 - 1.020), P-value = 0.035). Conclusions: Liver involvement is a common finding in COVID-19 hospitalized patients. Higher levels of AST were significantly associated with an increased mortality rate in COVID-19 patients. [ABSTRACT FROM AUTHOR]
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- 2020
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13. Successful Treatment of Chronic Myelogenic Leukemia (CML) with Imatinib after Renal Transplantation.
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Oskuei, Ali Eishei, Makhdoomi, Khadijeh, Abkhiz, Saeed, Vossoghian, Sara, and Farrokhpour, Mohsen
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Chronic Myelogenic Leukemia (CML) is a rare malignant disorder after solid organ transplantation, especially in renal transplant recipients. Imatinib Mesylate is currently approved as first line treatment of CML. Most reports on CML are from kidney recipients who received azathioprine in combination with cyclosporine and prednisolone as immunosuppressive therapy. We report a case with CML who was treated with Mycophenolate Mofetil. [ABSTRACT FROM AUTHOR]
- Published
- 2014
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