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1. Evaluation of an institutional series of low-grade oncocytic tumor (LOT) of the kidney and review of the mutational landscape of LOT

Author

Ricci, Costantino, Ambrosi, Francesca, Franceschini, Tania, Giunchi, Francesca, Grillini, Alessia, Franchini, Eugenia, Grillini, Marco, Schiavina, Riccardo, Massari, Francesco, Mollica, Veronica, Tateo, Valentina, Bianchi, Federico Mineo, Bianchi, Lorenzo, Droghetti, Matteo, Maloberti, Thais, Tallini, Giovanni, Colecchia, Maurizio, Acosta, Andres Martin, Lobo, João, Trpkov, Kiril, Fiorentino, Michelangelo, and de Biase, Dario

Published
2023
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5. Site-specific concordance of targeted and systematic biopsy cores at the index lesion on multiparametric magnetic resonance: can we spare the double-tap?

Author

Droghetti, Matteo, Bianchi, Lorenzo, Beretta, Carlo, Balestrazzi, Eleonora, Costa, Francesco, Feruzzi, Alberto, Piazza, Pietro, Roveroni, Carlo, Gaudiano, Caterina, Corcioni, Beniamino, Giunchi, Francesca, Fiorentino, Michelangelo, Golfieri, Rita, Schiavina, Riccardo, and Brunocilla, Eugenio

Published
2023
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7. TAMs PD-L1(+) in the reprogramming of germ cell tumors of the testis

Author

Melotti, Sofia, Ambrosi, Francesca, Franceschini, Tania, Giunchi, Francesca, Filippo, Giorgia Di, Franchini, Eugenia, Massari, Francesco, Mollica, Veronica, Tateo, Valentina, Bianchi, Federico Mineo, Colecchia, Maurizio, Acosta, Andres Martin, Lobo, João, Fiorentino, Michelangelo, and Ricci, Costantino

Published
2023
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14. The autocrine loop of ALK receptor and ALKAL2 ligand is an actionable target in consensus molecular subtype 1 colon cancer

Author

Mazzeschi, Martina, Sgarzi, Michela, Romaniello, Donatella, Gelfo, Valerio, Cavallo, Carola, Ambrosi, Francesca, Morselli, Alessandra, Miano, Carmen, Laprovitera, Noemi, Girone, Cinzia, Ferracin, Manuela, Santi, Spartaco, Rihawi, Karim, Ardizzoni, Andrea, Fiorentino, Michelangelo, D’Uva, Gabriele, Győrffy, Balázs, Palmer, Ruth, and Lauriola, Mattia

Published
2022
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15. Antitissue transglutaminase antibodies’ normalization after starting a gluten-free diet in a large population of celiac children-a real-life experience

Author

Sbravati, Francesca, Cosentino, Anita, Lenzi, Jacopo, Fiorentino, Michelangelo, Ambrosi, Francesca, Salerno, Angela, Di Biase, Annarita, Righi, Beatrice, Brusa, Sandra, Valin, Paola Sogno, Bruni, Laura, Battistini, Barbara, Pagano, Sara, Grondona, Ana Gabriela, Labriola, Flavio, and Alvisi, Patrizia

Published
2022
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17. β‐Catenin alterations in testicular Leydig cell tumour: a immunohistochemical and molecular analysis.

Author

Kitagawa, Yukiko, De Biase, Dario, Ricci, Costantino, Cornejo, Kristine M, Fiorentino, Michelangelo, Collins, Katrina, Idrees, Muhammad T, Colecchia, Maurizio, Ulbright, Thomas M, and Acosta, Andres Martin

Subjects
LEYDIG cells, IMMUNOHISTOCHEMISTRY, TESTIS tumors, CATENINS, SERTOLI cells, TERATOCARCINOMA, GENOMICS
Abstract

Background: Testicular Leydig cell tumours (LCTs) are the most common type of sex cord–stromal tumour in men, representing 1%–3% of all testicular neoplasms. Among testicular sex cord–stromal tumours, CTNNB1 mutations and nuclear expression of β‐catenin have been typically associated with Sertoli cell tumour. Recent genomic analyses have shown that CTNNB1 variants are also identified in a subset of LCTs; however, the frequency and clinicopathologic associations of β‐catenin alterations remain incompletely understood in this tumour type. Methods: In this study, we evaluated 32 LCTs (five malignant/metastasizing, 27 nonmetastasizing) using β‐catenin immunohistochemistry and DNA sequencing. Results: Immunohistochemistry revealed focal or multifocal nuclear β‐catenin expression in 47% of the tumours. Diffuse nuclear β‐catenin expression (in >50% of the tumour cells) was not detected in any of the cases analysed herein. Comparison of β‐catenin‐positive and β‐catenin‐negative cases did not show significant differences in the frequency of adverse histopathologic findings or malignant clinical behaviour. DNA sequencing performed de novo on a subset of seven cases revealed the presence of exon 3 CTNNB1 variants in four of them (4/7, 57%), with variant allele frequencies (VAF) ranging from 7 to 33%. Two additional β‐catenin‐positive cases that had been sequenced as part of a previous study harboured exon 3 CTNNB1 variants at VAF of 28% and 7%, respectively. Conclusion: These results demonstrate that β‐catenin alterations are relatively common in LCT, most likely occurring as subclonal events that are not enriched in cases with aggressive features. Further studies are needed to clarify the oncogenic role of β‐catenin in this tumour type. [ABSTRACT FROM AUTHOR]

Published
2024
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19. Real-time Augmented Reality Three-dimensional Guided Robotic Radical Prostatectomy: Preliminary Experience and Evaluation of the Impact on Surgical Planning

Author

Schiavina, Riccardo, Bianchi, Lorenzo, Lodi, Simone, Cercenelli, Laura, Chessa, Francesco, Bortolani, Barbara, Gaudiano, Caterina, Casablanca, Carlo, Droghetti, Matteo, Porreca, Angelo, Romagnoli, Daniele, Golfieri, Rita, Giunchi, Francesca, Fiorentino, Michelangelo, Marcelli, Emanuela, Diciotti, Stefano, and Brunocilla, Eugenio

Published
2021
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20. PD-L1 Expression in Circulating Tumor Cells as a Promising Prognostic Biomarker in Advanced Non–small-cell Lung Cancer Treated with Immune Checkpoint Inhibitors

Author

Dall'Olio, Filippo G., Gelsomino, Francesco, Conci, Nicole, Marcolin, Laura, De Giglio, Andrea, Grilli, Giada, Sperandi, Francesca, Fontana, Francesca, Terracciano, Mario, Fragomeno, Benedetta, Tober, Nastassja, Manferrari, Giulia, Brocchi, Stefano, Golfieri, Rita, Fiorentino, Michelangelo, and Ardizzoni, Andrea

Published
2021
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21. Analysis of GATA3 and FOXA2 expression suggests that downregulation of genes involved in the maintenance of a mature yolk sac tumor phenotype may underlie sarcomatoid transformation.

Author

Ricci, Costantino, Ambrosi, Francesca, Grillini, Alessia, Massari, Francesco, Fiorentino, Michelangelo, Colecchia, Maurizio, Ulbright, Thomas M., and Acosta, Andres Martin

Abstract

In the post-chemotherapy setting, germ cell tumors of the testis (GCTT) that resemble non-specific sarcomas and co-express cytokeratins and glypican-3 (GPC3) are diagnosed as "sarcomatoid yolk sac tumor postpubertal-type (YSTpt)". The diagnosis of sarcomatoid YSTpt is clinically relevant but challenging due to its rarity, non-specific histology, and negative α-fetoprotein (AFP) staining. Recently, FOXA2 has emerged as a key-gene in the reprogramming of GCTT (activating the transcription of several genes, among which GATA3), and immunohistochemical studies showed that GATA3 and FOXA2 have a higher sensitivity for non-sarcomatoid YSTpt than GPC3 and AFP. We found that sarcomatoid YSTpt did not express FOXA2 [0: 14/14 (100%)] and showed focal expression of GATA3 [0: 12/14 (85.7%), 1 + : 2/14 (14.3%)], thus suggesting that these markers are not useful in diagnosing this tumor. Furthermore, we proposed a potential mechanism of sarcomatoid transformation in the post-chemotherapy setting of GCTT, mediated by the downregulation of FOXA2 and GATA3. [ABSTRACT FROM AUTHOR]

Published
2024
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22. Detection of EGFR-Activating and T790M Mutations Using Liquid Biopsy in Patients With EGFR-Mutated Non–Small-Cell Lung Cancer Whose Disease Has Progressed During Treatment With First- and Second-Generation Tyrosine Kinase Inhibitors: A Multicenter Real-Life Retrospective Study

Author

Minari, Roberta, Mazzaschi, Giulia, Bordi, Paola, Gnetti, Letizia, Alberti, Giorgia, Altimari, Annalisa, Gruppioni, Elisa, Sperandi, Francesca, Parisi, Claudia, Guaitoli, Giorgia, Bettelli, Stefania, Longo, Lucia, Bertolini, Federica, Pagano, Maria, Bonelli, Candida, Tagliavini, Elena, Nicoli, Davide, Ubiali, Alessandro, Zangrandi, Adriano, Trubini, Serena, Proietto, Manuela, Fiorentino, Michelangelo, and Tiseo, Marcello

Published
2020
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25. Comprehensive analysis of 34 MiT family translocation renal cell carcinomas and review of the literature: investigating prognostic markers and therapy targets

Author

Caliò, Anna, Brunelli, Matteo, Segala, Diego, Pedron, Serena, Remo, Andrea, Ammendola, Serena, Munari, Enrico, Pierconti, Francesco, Mosca, Alessandra, Bollito, Enrico, Sidoni, Angelo, Fisogni, Simona, Sacco, Cosimo, Canu, Luisa, Sentinelli, Steno, Fraccon, Anna Paola, Fiorentino, Michelangelo, Scott, Cathryn, Milella, Michele, Porta, Camillo, Argani, Pedram, and Martignoni, Guido

Published
2020
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36. Cohort profile: the Turin prostate cancer prognostication (TPCP) cohort.

Author

Destefanis, Nicolas, Fiano, Valentina, Milani, Lorenzo, Vasapolli, Paolo, Fiorentino, Michelangelo, Giunchi, Francesca, Lianas, Luca, Del Rio, Mauro, Frexia, Francesca, Pireddu, Luca, Molinaro, Luca, Cassoni, Paola, Giulio Papotti, Mauro, Gontero, Paolo, Calleris, Giorgio, Oderda, Marco, Ricardi, Umberto, Iorio, Giuseppe Carlo, Fariselli, Piero, and Isaevska, Elena

Subjects
PROSTATE cancer, ARTIFICIAL neural networks, DNA methylation, PROGNOSTIC models, GLEASON grading system, PROGNOSIS
Abstract

Introduction: Prostate cancer (PCa) is the most frequent tumor among men in Europe and has both indolent and aggressive forms. There are several treatment options, the choice of which depends on multiple factors. To further improve current prognostication models, we established the Turin Prostate Cancer Prognostication (TPCP) cohort, an Italian retrospective biopsy cohort of patients with PCa and long-term follow-up. This work presents this new cohort with its main characteristics and the distributions of some of its core variables, along with its potential contributions to PCa research. Methods: The TPCP cohort includes consecutive non-metastatic patients with first positive biopsy for PCa performed between 2008 and 2013 at the main hospital in Turin, Italy. The follow-up ended on December 31st 2021. The primary outcome is the occurrence of metastasis; death from PCa and overall mortality are the secondary outcomes. In addition to numerous clinical variables, the study's prognostic variables include histopathologic information assigned by a centralized uropathology review using a digital pathology software system specialized for the study of PCa, tumor DNA methylation in candidate genes, and features extracted from digitized slide images via Deep Neural Networks. Results: The cohort includes 891 patients followed-up for a median time of 10 years. During this period, 97 patients had progression to metastatic disease and 301 died; of these, 56 died from PCa. In total, 65.3% of the cohort has a Gleason score less than or equal to 3 + 4, and 44.5% has a clinical stage cT1. Consistent with previous studies, age and clinical stage at diagnosis are important prognostic factors: the crude cumulative incidence of metastatic disease during the 14-years of follow-up increases from 9.1% among patients younger than 64 to 16.2% for patients in the age group of 75-84, and from 6.1% for cT1 stage to 27.9% in cT3 stage. Discussion: This study stands to be an important resource for updating existing prognostic models for PCa on an Italian cohort. In addition, the integrated collection of multi-modal data will allow development and/or validation of new models including new histopathological, digital, and molecular markers, with the goal of better directing clinical decisions to manage patients with PCa. [ABSTRACT FROM AUTHOR]

Published
2023
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42. Influence of Neighborhood Social and Natural Environment on Prostate Tumor Histology in a Cohort of Male Health Professionals.

Author

Iyer, Hari S, Vaselkiv, Jane B, Stopsack, Konrad H, Roscoe, Charlotte, DeVille, Nicole V, Zhang, Yiwen, Penney, Kathryn L, Balk, Steven P, Fiorentino, Michelangelo, Hart, Jaime E, James, Peter, Vivo, Immaculata De, Mucci, Lorelei A, Laden, Francine, and Rebbeck, Timothy R

Subjects
CONFIDENCE intervals, CENSUS, INFLAMMATION, MEN, OCCUPATIONAL exposure, RACE, SOCIAL context, RISK assessment, ATROPHY, INCOME, SOCIAL classes, DESCRIPTIVE statistics, RESEARCH funding, NATURE, HISTOLOGY, ODDS ratio, LOGISTIC regression analysis, PROSTATE tumors, NEIGHBORHOOD characteristics, SECONDARY analysis, ENVIRONMENTAL exposure, DISEASE risk factors
Abstract

Adverse neighborhood social and natural (green space) environments may contribute to the etiology of prostate cancer (CaP), but mechanisms are unclear. We examined associations between neighborhood environment and prostate intratumoral inflammation in 967 men diagnosed with CaP with available tissue samples from 1986–2009 in the Health Professionals Follow-up Study. Exposures were linked to work or residential addresses in 1988. We estimated indices of neighborhood socioeconomic status (nSES) and segregation (Index of Concentration at the Extremes (ICE)) using US Census tract–level data. Surrounding greenness was estimated using seasonal averaged Normalized Difference Vegetation Index (NDVI) data. Surgical tissue underwent pathological review for acute and chronic inflammation, corpora amylacea, and focal atrophic lesions. Adjusted odds ratios (aORs) for inflammation (ordinal) and focal atrophy (binary) were estimated using logistic regression. No associations were observed for acute or chronic inflammation. Each interquartile-range increase in NDVI within 1,230 m of the participant's work or home address (aOR = 0.74, 95% confidence interval (CI): 0.59, 0.93), in ICE-income (aOR = 0.79, 95% CI: 0.61, 1.04), and in ICE-race/income (aOR = 0.79, 95% CI: 0.63, 0.99) was associated with lower odds of postatrophic hyperplasia. Interquartile-range increases in nSES (aOR = 0.76, 95% CI: 0.57, 1.02) and ICE-race/income (aOR = 0.73, 95% CI: 0.54, 0.99) were associated with lower odds of tumor corpora amylacea. Histopathological inflammatory features of prostate tumors may be influenced by neighborhood. [ABSTRACT FROM AUTHOR]

Published
2023
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43. FoxA2 is a reliable marker for the diagnosis of yolk sac tumour postpubertal‐type.

Author

Ricci, Costantino, Ambrosi, Francesca, Franceschini, Tania, Giunchi, Francesca, Di Filippo, Giorgia, Franchini, Eugenia, Massari, Francesco, Mollica, Veronica, Tateo, Valentina, Bianchi, Federico Mineo, Colecchia, Maurizio, Acosta, Andres Martin, and Fiorentino, Michelangelo

Subjects
FORKHEAD transcription factors, GERM cells
Abstract

Aims: Yolk sac tumour postpubertal‐type (YSTpt) shows a wide range of histological patterns and is challenging to diagnose. Recently, forkhead box transcription factor A2 (FoxA2) emerged as a driver of YSTpt formation and a promising marker for diagnosing YSTpt. However, FoxA2 has not been tested in the different patterns of YSTpt. This study aimed to assess the staining pattern of FoxA2 in te different patterns of YSTpt and other germ cell tumours of the testis (GCTT), comparing it with glypican‐3 (GPC3) and α‐fetoprotein (AFP). Methods and results: FOXA2, GPC3 and AFP immunohistochemistry was performed on 24 YSTpt (24 microcystic/reticular, 10 myxoid, two macrocystic, five glandular/alveolar, two endodermal sinus/perivascular, four solid, two polyembryoma/embryoid body and two polyvesicular vitelline) and 81 other GCTT. The percentage of positive cells (0, 1+, 2+, 3+) and the intensity (0, 1, 2, 3) were evaluated regardless of and within each YSTpt pattern. FoxA2 was positive in all YSTpt (24 of 24) and all but one (23 of 24) exhibited 2+/3+ stain, with higher intensity [median value (mv): 2.6] than AFP (1.8) and GPC3 (2.5). Both FoxA2 and GPC3 were positive in all microcystic/reticular (24 of 24), myxoid (10 of 10), macrocystic (two of two), endodermal sinus/perivascular (four of four) and polyembryoma/embryoid body (two of two) patterns. Nevertheless, only FoxA2 was positive in all glandular/alveolar (five of five), solid (four of four) and polyvesicular vitelline (two of two) patterns. The intensity of FoxA2 was higher than AFP and GPC3 in almost all YST patterns. In the other GCTT, FoxA2 was positive only in teratoma postpubertal‐type (Tpt) [13 of 20 (65%)], with staining almost exclusively confined to the mature gastrointestinal/respiratory tract epithelium. Conclusions: FoxA2 is a highly sensitive and specific biomarker that supports the diagnosis of YSTpt. FoxA2 is superior to GPC3 and AFP, especially in rare and difficult‐to‐diagnose histological patterns of YSTpt, but mature glands of Tpt could represent a potential diagnostic pitfall. [ABSTRACT FROM AUTHOR]

Published
2023
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44. An Apparent Diffusion Coefficient-Based Machine Learning Model Can Improve Prostate Cancer Detection in the Grey Area of the Prostate Imaging Reporting and Data System Category 3: A Single-Centre Experience.

Author

Gaudiano, Caterina, Mottola, Margherita, Bianchi, Lorenzo, Corcioni, Beniamino, Braccischi, Lorenzo, Tomassoni, Makoto Taninokuchi, Cattabriga, Arrigo, Cocozza, Maria Adriana, Giunchi, Francesca, Schiavina, Riccardo, Fanti, Stefano, Fiorentino, Michelangelo, Brunocilla, Eugenio, Mosconi, Cristina, and Bevilacqua, Alessandro

Subjects
DIGITAL image processing, PREDICTIVE tests, MEN'S health, MACHINE learning, EARLY detection of cancer, MAGNETIC resonance imaging, MANN Whitney U Test, DESCRIPTIVE statistics, RESEARCH funding, RECEIVER operating characteristic curves, SENSITIVITY & specificity (Statistics), PROSTATE tumors, LONGITUDINAL method, NEEDLE biopsy
Abstract

Simple Summary: Multiparametric Magnetic Resonance Imaging (mpMRI) interpretation and reporting is based on the more recent version 2.1 of the Prostate Imaging-Reporting and Data System (PI-RADS), revised in 2019, indicating the probability of clinically significant Prostate Cancer (csPCa) on a 5-point scale, which should be confirmed through trans-rectal ultrasound (TRUS) fusion-targeted biopsy. Among PI-RADS categories, PI-RADS 3 lesions represent a highly "equivocal" result, with a non-negligible probability of PCa, or even csPCa. This study exploits machine learning methods in order to investigate the role of mpMRI as a stand-alone tool for early and non-invasive detection of PCa in a selected cohort of PI-RADS 3 lesions, by means of a radiomic analysis of Apparent Diffusion Coefficient sequences. Differently from what reported in the current literature, the methodology adopted has bounded the possibility of overoptimistic predictive performance, also improving the state-of-art by achieving a positive predictive value of 80%, with specificity = 76% and sensitivity = 78%. The Prostate Imaging and Reporting Data System (PI-RADS) has a key role in the management of prostate cancer (PCa). However, the clinical interpretation of PI-RADS 3 score lesions may be challenging and misleading, thus postponing PCa diagnosis to biopsy outcome. Multiparametric magnetic resonance imaging (mpMRI) radiomic analysis may represent a stand-alone noninvasive tool for PCa diagnosis. Hence, this study aims at developing a mpMRI-based radiomic PCa diagnostic model in a cohort of PI-RADS 3 lesions. We enrolled 133 patients with 155 PI-RADS 3 lesions, 84 of which had PCa confirmation by fusion biopsy. Local radiomic features were generated from apparent diffusion coefficient maps, and the four most informative were selected using LASSO, the Wilcoxon rank-sum test (p < 0.001), and support vector machines (SVMs). The selected features where augmented and used to train an SVM classifier, externally validated on a holdout subset. Linear and second-order polynomial kernels were exploited, and their predictive performance compared through receiver operating characteristics (ROC)-related metrics. On the test set, the highest performance, equally for both kernels, was specificity = 76%, sensitivity = 78%, positive predictive value = 80%, and negative predictive value = 74%. Our findings substantially improve radiologist interpretation of PI-RADS 3 lesions and let us advance towards an image-driven PCa diagnosis. [ABSTRACT FROM AUTHOR]

Published
2023
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47. Nodal Occult Metastases in Intermediate- and High-Risk Prostate Cancer Patients Detected Using Serial Section, Immunohistochemistry, and Real-Time Reverse Transcriptase Polymerase Chain Reaction: Prospective Evaluation With Matched-Pair Analysis

Author

Schiavina, Riccardo, Capizzi, Elisa, Borghesi, Marco, Vagnoni, Valerio, Romagnoli, Daniele, Rocca, Giovanni Christian, Giunchi, Francesca, D'Errico, Antonietta, De Giovanni, Alessia, Rizzi, Simona, Brunocilla, Eugenio, Martorana, Giuseppe, and Fiorentino, Michelangelo

Published
2015
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50. Influence of K-ras status and anti-tumour treatments on complications due to colorectal self-expandable metallic stents: A retrospective multicentre study

Author

Altimari, Annalisa, Cariani, Giulio, Caruso, Angelo, Conigliaro, Rita, Crosta, Cristiano, Delrio, Paolo, Di Marco, Maria Cristina, Fabbri, Carlo, Fiorentino, Michelangelo, Ghersi, Stefania, Gruppioni, Elisa, Hassan, Cesare, Laterza, Liboria, Nasti, Guglielmo, Pinto, Carmine, Rojas, Fabiola, Scaioli, Eleonora, Fuccio, Lorenzo, Correale, Loredana, Arezzo, Alberto, Repici, Alessandro, Manes, Gianpiero, Trovato, Cristina, Mangiavillano, Benedetto, Manno, Mauro, Cortelezzi, Claudio Camillo, Dinelli, Marco, Cennamo, Vincenzo, and de Bellis, Mario

Published
2014
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