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1. Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches.

Author

Welsh, Joshua, Goberdhan, Deborah, ODriscoll, Lorraine, Buzas, Edit, Blenkiron, Cherie, Bussolati, Benedetta, Cai, Houjian, Di Vizio, Dolores, Driedonks, Tom, Erdbrügger, Uta, Falcon-Perez, Juan, Fu, Qing-Ling, Hill, Andrew, Lenassi, Metka, Lim, Sai, Mahoney, Mỹ, Mohanty, Sujata, Möller, Andreas, Nieuwland, Rienk, Ochiya, Takahiro, Sahoo, Susmita, Torrecilhas, Ana, Zheng, Lei, Zijlstra, Andries, Abuelreich, Sarah, Bagabas, Reem, Bergese, Paolo, Bridges, Esther, Brucale, Marco, Burger, Dylan, Carney, Randy, Cocucci, Emanuele, Colombo, Federico, Crescitelli, Rossella, Hanser, Edveena, Harris, Adrian, Haughey, Norman, Hendrix, An, Ivanov, Alexander, Jovanovic-Talisman, Tijana, Kruh-Garcia, Nicole, Kuulei-Lyn Faustino, Vroniqa, Kyburz, Diego, Lässer, Cecilia, Lennon, Kathleen, Lötvall, Jan, Maddox, Adam, Martens-Uzunova, Elena, Mizenko, Rachel, Newman, Lauren, Ridolfi, Andrea, Rohde, Eva, Rojalin, Tatu, Rowland, Andrew, Saftics, Andras, Sandau, Ursula, Saugstad, Julie, Shekari, Faezeh, Swift, Simon, Ter-Ovanesyan, Dmitry, Tosar, Juan, Useckaite, Zivile, Valle, Francesco, Varga, Zoltan, van der Pol, Edwin, van Herwijnen, Martijn, Wauben, Marca, Wehman, Ann, Williams, Sarah, Zendrini, Andrea, Zimmerman, Alan, Théry, Clotilde, and Witwer, Kenneth

Subjects
MISEV, ectosomes, exosomes, extracellular particles, extracellular vesicles, guidelines, microparticles, microvesicles, minimal information requirements, reproducibility, rigor, standardisation, Extracellular Vesicles, Exosomes, Biological Transport, Biomarkers, Phenotype
Abstract

Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of origin and change the functions and phenotypes of other cells. These features indicate strong biomarker and therapeutic potential and have generated broad interest, as evidenced by the steady year-on-year increase in the numbers of scientific publications about EVs. Important advances have been made in EV metrology and in understanding and applying EV biology. However, hurdles remain to realising the potential of EVs in domains ranging from basic biology to clinical applications due to challenges in EV nomenclature, separation from non-vesicular extracellular particles, characterisation and functional studies. To address the challenges and opportunities in this rapidly evolving field, the International Society for Extracellular Vesicles (ISEV) updates its Minimal Information for Studies of Extracellular Vesicles, which was first published in 2014 and then in 2018 as MISEV2014 and MISEV2018, respectively. The goal of the current document, MISEV2023, is to provide researchers with an updated snapshot of available approaches and their advantages and limitations for production, separation and characterisation of EVs from multiple sources, including cell culture, body fluids and solid tissues. In addition to presenting the latest state of the art in basic principles of EV research, this document also covers advanced techniques and approaches that are currently expanding the boundaries of the field. MISEV2023 also includes new sections on EV release and uptake and a brief discussion of in vivo approaches to study EVs. Compiling feedback from ISEV expert task forces and more than 1000 researchers, this document conveys the current state of EV research to facilitate robust scientific discoveries and move the field forward even more rapidly.

Published
2024

12. Corrigendum to “Small extracellular vesicles derived from human mesenchymal stem cells prevent Th17-dominant neutrophilic airway inflammation via immunoregulation on Th17 cells” [Int. Immunopharmacol. 133 (2024) 112126]

Author

He, Bi-Xin, primary, Fang, Shu-Bin, additional, Xie, Ying-Chun, additional, Lou, Dong-Xiao, additional, Wu, Zi-Cong, additional, Li, Chan-Gu, additional, Liu, Xiao-Qing, additional, Zhou, Zhi-Rou, additional, Huang, Long-Xin, additional, Tian, Tian, additional, Chen, De-Hua, additional, and Fu, Qing-Ling, additional

Published
2024
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13. Intranasal delivery of small extracellular vesicles reduces the progress of amyotrophic lateral sclerosis and the overactivation of complement-coagulation cascade and NF-ĸB signaling in SOD1G93A mice.

Author

Zhou, Jinrui, Li, Fuxiang, Jia, Bin, Wu, Zicong, Huang, Zhonghai, He, Meiting, Weng, Huandi, So, Kwok-Fai, Qu, Wenrui, Fu, Qing-Ling, and Zhou, Libing

Abstract

Amyotrophic lateral sclerosis (ALS) is a fatal disease characterized by progressive motoneuron degeneration, and effective clinical treatments are lacking. In this study, we evaluated whether intranasal delivery of mesenchymal stem cell–derived small extracellular vesicles (sEVs) is a strategy for ALS therapy using SOD1G93A mice. In vivo tracing showed that intranasally-delivered sEVs entered the central nervous system and were extensively taken up by spinal neurons and some microglia. SOD1G93A mice that intranasally received sEV administration showed significant improvements in motor performances and survival time. After sEV administration, pathological changes, including spinal motoneuron death and synaptic denervation, axon demyelination, neuromuscular junction degeneration and electrophysiological defects, and mitochondrial vacuolization were remarkably alleviated. sEV administration attenuated the elevation of proinflammatory cytokines and glial responses. Proteomics and transcriptomics analysis revealed upregulation of the complement and coagulation cascade and NF-ĸB signaling pathway in SOD1G93A mouse spinal cords, which was significantly inhibited by sEV administration. The changes were further confirmed by detecting C1q and NF-ĸB expression using Western blots. In conclusion, intranasal administration of sEVs effectively delays the progression of ALS by inhibiting neuroinflammation and overactivation of the complement and coagulation cascades and NF-ĸB signaling pathway and is a potential option for ALS therapy. [ABSTRACT FROM AUTHOR]

Published
2024
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15. MiRNA-148a-containing GMSC-derived EVs modulate Treg/Th17 balance via IKKB/NF-κB pathway and treat a rheumatoid arthritis model

Author

Chen, Jingrong, primary, Shi, Xiaoyi, additional, Deng, Yanan, additional, Dang, Junlong, additional, Liu, Yan, additional, Zhao, Jun, additional, Rongzhen, Liang, additional, Zeng, Donglan, additional, Wu, Wenbin, additional, Xiong, Yiding, additional, Yuan, Jia, additional, Chen, Ye, additional, Wang, Julie, additional, Lin, Weidong, additional, Chen, Xiangfang, additional, Huang, Weishan, additional, Olsen, Nancy, additional, Pan, Yunfeng, additional, Fu, Qing-Ling, additional, and Zheng, Song Guo, additional

Published
2024
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16. Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches

Author

Celbiologie, Cell Biology, Metabolism & Cancer - Cellbiology, Welsh, Joshua A, Goberdhan, Deborah C I, O'Driscoll, Lorraine, Buzas, Edit I, Blenkiron, Cherie, Bussolati, Benedetta, Cai, Houjian, Di Vizio, Dolores, Driedonks, Tom A P, Erdbrügger, Uta, Falcon-Perez, Juan M, Fu, Qing-Ling, Hill, Andrew F, Lenassi, Metka, Lim, Sai Kiang, Mahoney, Mỹ G, Mohanty, Sujata, Möller, Andreas, Nieuwland, Rienk, Ochiya, Takahiro, Sahoo, Susmita, Torrecilhas, Ana C, Zheng, Lei, Zijlstra, Andries, Abuelreich, Sarah, Bagabas, Reem, Bergese, Paolo, Bridges, Esther M, Brucale, Marco, Burger, Dylan, Carney, Randy P, Cocucci, Emanuele, Colombo, Federico, Crescitelli, Rossella, Hanser, Edveena, Harris, Adrian L, Haughey, Norman J, Hendrix, An, Ivanov, Alexander R, Jovanovic-Talisman, Tijana, Kruh-Garcia, Nicole A, Ku'ulei-Lyn Faustino, Vroniqa, Kyburz, Diego, Lässer, Cecilia, Lennon, Kathleen M, Lötvall, Jan, Maddox, Adam L, Martens-Uzunova, Elena S, Mizenko, Rachel R, Newman, Lauren A, Ridolfi, Andrea, Rohde, Eva, Rojalin, Tatu, Rowland, Andrew, Saftics, Andras, Sandau, Ursula S, Saugstad, Julie A, Shekari, Faezeh, Swift, Simon, Ter-Ovanesyan, Dmitry, Tosar, Juan P, Useckaite, Zivile, Valle, Francesco, Varga, Zoltan, van der Pol, Edwin, van Herwijnen, Martijn J C, Wauben, Marca H M, Wehman, Ann M, Williams, Sarah, Zendrini, Andrea, Zimmerman, Alan J, Misev Consortium, Théry, Clotilde, Witwer, Kenneth W, Stoorvogel, Willem, Celbiologie, Cell Biology, Metabolism & Cancer - Cellbiology, Welsh, Joshua A, Goberdhan, Deborah C I, O'Driscoll, Lorraine, Buzas, Edit I, Blenkiron, Cherie, Bussolati, Benedetta, Cai, Houjian, Di Vizio, Dolores, Driedonks, Tom A P, Erdbrügger, Uta, Falcon-Perez, Juan M, Fu, Qing-Ling, Hill, Andrew F, Lenassi, Metka, Lim, Sai Kiang, Mahoney, Mỹ G, Mohanty, Sujata, Möller, Andreas, Nieuwland, Rienk, Ochiya, Takahiro, Sahoo, Susmita, Torrecilhas, Ana C, Zheng, Lei, Zijlstra, Andries, Abuelreich, Sarah, Bagabas, Reem, Bergese, Paolo, Bridges, Esther M, Brucale, Marco, Burger, Dylan, Carney, Randy P, Cocucci, Emanuele, Colombo, Federico, Crescitelli, Rossella, Hanser, Edveena, Harris, Adrian L, Haughey, Norman J, Hendrix, An, Ivanov, Alexander R, Jovanovic-Talisman, Tijana, Kruh-Garcia, Nicole A, Ku'ulei-Lyn Faustino, Vroniqa, Kyburz, Diego, Lässer, Cecilia, Lennon, Kathleen M, Lötvall, Jan, Maddox, Adam L, Martens-Uzunova, Elena S, Mizenko, Rachel R, Newman, Lauren A, Ridolfi, Andrea, Rohde, Eva, Rojalin, Tatu, Rowland, Andrew, Saftics, Andras, Sandau, Ursula S, Saugstad, Julie A, Shekari, Faezeh, Swift, Simon, Ter-Ovanesyan, Dmitry, Tosar, Juan P, Useckaite, Zivile, Valle, Francesco, Varga, Zoltan, van der Pol, Edwin, van Herwijnen, Martijn J C, Wauben, Marca H M, Wehman, Ann M, Williams, Sarah, Zendrini, Andrea, Zimmerman, Alan J, Misev Consortium, Théry, Clotilde, Witwer, Kenneth W, and Stoorvogel, Willem

Published
2024

17. Minimal information for studies of extracellular vesicles (MISEV2023) : from basic to advanced approaches

Author

Welsh, Joshua A., Goberdhan, Deborah C. I., O'Driscoll, Lorraine, Buzas, Edit I., Blenkiron, Cherie, Bussolati, Benedetta, Cai, Houjian, Di Vizio, Dolores, Driedonks, Tom A. P., Erdbrügger, Uta, Falcon-Perez, Juan M., Fu, Qing-Ling, Hill, Andrew F., Lenassi, Metka, Lim, Sai Kiang, Mahoney, Mỹ G., Mohanty, Sujata, Möller, Andreas, Nieuwland, Rienk, Ochiya, Takahiro, Sahoo, Susmita, Torrecilhas, Ana C., Zheng, Lei, Zijlstra, Andries, Abuelreich, Sarah, Bagabas, Reem, Bergese, Paolo, Bridges, Esther M., Brucale, Marco, Burger, Dylan, Carney, Randy P., Cocucci, Emanuele, Colombo, Federico, Crescitelli, Rossella, Eichenberger, Ramon, Hanser, Edveena, Harris, Adrian L., Haughey, Norman J., Hendrix, An, Ivanov, Alexander R., Jovanovic-Talisman, Tijana, Kruh-Garcia, Nicole A., Ku'ulei-Lyn Faustino, Vroniqa, Kyburz, Diego, Lässer, Cecilia, Lennon, Kathleen M., Lötvall, Jan, Maddox, Adam L., Martens-Uzunova, Elena S., Mizenko, Rachel R., Newman, Lauren A., Ridolfi, Andrea, Rohde, Eva, Rojalin, Tatu, Rowland, Andrew, Saftics, Andras, Sandau, Ursula S., Saugstad, Julie A., Shekari, Faezeh, Swift, Simon, Ter-Ovanesyan, Dmitry, Tosar, Juan P., Useckaite, Zivile, Valle, Francesco, Varga, Zoltan, van der Pol, Edwin, van Herwijnen, Martijn J. C., Wauben, Marca H. M., Wehman, Ann M., Williams, Sarah, Zendrini, Andrea, Zimmerman, Alan J, Misev Consortium, Théry, Clotilde, Witwer, Kenneth W., Welsh, Joshua A., Goberdhan, Deborah C. I., O'Driscoll, Lorraine, Buzas, Edit I., Blenkiron, Cherie, Bussolati, Benedetta, Cai, Houjian, Di Vizio, Dolores, Driedonks, Tom A. P., Erdbrügger, Uta, Falcon-Perez, Juan M., Fu, Qing-Ling, Hill, Andrew F., Lenassi, Metka, Lim, Sai Kiang, Mahoney, Mỹ G., Mohanty, Sujata, Möller, Andreas, Nieuwland, Rienk, Ochiya, Takahiro, Sahoo, Susmita, Torrecilhas, Ana C., Zheng, Lei, Zijlstra, Andries, Abuelreich, Sarah, Bagabas, Reem, Bergese, Paolo, Bridges, Esther M., Brucale, Marco, Burger, Dylan, Carney, Randy P., Cocucci, Emanuele, Colombo, Federico, Crescitelli, Rossella, Eichenberger, Ramon, Hanser, Edveena, Harris, Adrian L., Haughey, Norman J., Hendrix, An, Ivanov, Alexander R., Jovanovic-Talisman, Tijana, Kruh-Garcia, Nicole A., Ku'ulei-Lyn Faustino, Vroniqa, Kyburz, Diego, Lässer, Cecilia, Lennon, Kathleen M., Lötvall, Jan, Maddox, Adam L., Martens-Uzunova, Elena S., Mizenko, Rachel R., Newman, Lauren A., Ridolfi, Andrea, Rohde, Eva, Rojalin, Tatu, Rowland, Andrew, Saftics, Andras, Sandau, Ursula S., Saugstad, Julie A., Shekari, Faezeh, Swift, Simon, Ter-Ovanesyan, Dmitry, Tosar, Juan P., Useckaite, Zivile, Valle, Francesco, Varga, Zoltan, van der Pol, Edwin, van Herwijnen, Martijn J. C., Wauben, Marca H. M., Wehman, Ann M., Williams, Sarah, Zendrini, Andrea, Zimmerman, Alan J, Misev Consortium, Théry, Clotilde, and Witwer, Kenneth W.

Abstract

Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of origin and change the functions and phenotypes of other cells. These features indicate strong biomarker and therapeutic potential and have generated broad interest, as evidenced by the steady year-on-year increase in the numbers of scientific publications about EVs. Important advances have been made in EV metrology and in understanding and applying EV biology. However, hurdles remain to realising the potential of EVs in domains ranging from basic biology to clinical applications due to challenges in EV nomenclature, separation from non-vesicular extracellular particles, characterisation and functional studies. To address the challenges and opportunities in this rapidly evolving field, the International Society for Extracellular Vesicles (ISEV) updates its 'Minimal Information for Studies of Extracellular Vesicles', which was first published in 2014 and then in 2018 as MISEV2014 and MISEV2018, respectively. The goal of the current document, MISEV2023, is to provide researchers with an updated snapshot of available approaches and their advantages and limitations for production, separation and characterisation of EVs from multiple sources, including cell culture, body fluids and solid tissues. In addition to presenting the latest state of the art in basic principles of EV research, this document also covers advanced techniques and approaches that are currently expanding the boundaries of the field. MISEV2023 also includes new sections on EV release and uptake and a brief discussion of in vivo approaches to study EVs. Compiling feedback from ISEV expert task forces and more than 1000 researchers, this document conveys the current state of EV research to facilitate robust scientific discoveries and move the field forward even more rapidly.

Published
2024

18. Minimal information for studies of extracellular vesicles (MISEV2023):From basic to advanced approaches

Author

Welsh, Joshua A., Goberdhan, Deborah C.I., O’Driscoll, Lorraine, Buzas, Edit I., Blenkiron, Cherie, Bussolati, Benedetta, Cai, Houjian, Di Vizio, Dolores, Driedonks, Tom A.P., Erdbrügger, Uta, Falcon-Perez, Juan M., Fu, Qing Ling, Hill, Andrew F., Lenassi, Metka, Lim, Sai Kiang, Mahoney, M. ỹ.G., Mohanty, Sujata, Möller, Andreas, Nieuwland, Rienk, Ochiya, Takahiro, Sahoo, Susmita, Torrecilhas, Ana C., Zheng, Lei, Zijlstra, Andries, Abuelreich, Sarah, Bagabas, Reem, Bergese, Paolo, Bridges, Esther M., Brucale, Marco, Burger, Dylan, Carney, Randy P., Cocucci, Emanuele, Crescitelli, Rossella, Hanser, Edveena, Harris, Adrian L., Haughey, Norman J., Benediktsdóttir, Berglind E., Gargiulo, Ernesto, Gori, Alessandro, Guo, Wei, Hufnagel, Antonia, Di Ianni, Emilio, Jacobsen, Soren, Li, Bo, Mellergaard, Maiken, Nejsum, Peter, Nolan, John P., Østergaard, Ole, Yarani, Reza, Yin, Hang, Welsh, Joshua A., Goberdhan, Deborah C.I., O’Driscoll, Lorraine, Buzas, Edit I., Blenkiron, Cherie, Bussolati, Benedetta, Cai, Houjian, Di Vizio, Dolores, Driedonks, Tom A.P., Erdbrügger, Uta, Falcon-Perez, Juan M., Fu, Qing Ling, Hill, Andrew F., Lenassi, Metka, Lim, Sai Kiang, Mahoney, M. ỹ.G., Mohanty, Sujata, Möller, Andreas, Nieuwland, Rienk, Ochiya, Takahiro, Sahoo, Susmita, Torrecilhas, Ana C., Zheng, Lei, Zijlstra, Andries, Abuelreich, Sarah, Bagabas, Reem, Bergese, Paolo, Bridges, Esther M., Brucale, Marco, Burger, Dylan, Carney, Randy P., Cocucci, Emanuele, Crescitelli, Rossella, Hanser, Edveena, Harris, Adrian L., Haughey, Norman J., Benediktsdóttir, Berglind E., Gargiulo, Ernesto, Gori, Alessandro, Guo, Wei, Hufnagel, Antonia, Di Ianni, Emilio, Jacobsen, Soren, Li, Bo, Mellergaard, Maiken, Nejsum, Peter, Nolan, John P., Østergaard, Ole, Yarani, Reza, and Yin, Hang

Abstract

Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of origin and change the functions and phenotypes of other cells. These features indicate strong biomarker and therapeutic potential and have generated broad interest, as evidenced by the steady year-on-year increase in the numbers of scientific publications about EVs. Important advances have been made in EV metrology and in understanding and applying EV biology. However, hurdles remain to realising the potential of EVs in domains ranging from basic biology to clinical applications due to challenges in EV nomenclature, separation from non-vesicular extracellular particles, characterisation and functional studies. To address the challenges and opportunities in this rapidly evolving field, the International Society for Extracellular Vesicles (ISEV) updates its ‘Minimal Information for Studies of Extracellular Vesicles’, which was first published in 2014 and then in 2018 as MISEV2014 and MISEV2018, respectively. The goal of the current document, MISEV2023, is to provide researchers with an updated snapshot of available approaches and their advantages and limitations for production, separation and characterisation of EVs from multiple sources, including cell culture, body fluids and solid tissues. In addition to presenting the latest state of the art in basic principles of EV research, this document also covers advanced techniques and approaches that are currently expanding the boundaries of the field. MISEV2023 also includes new sections on EV release and uptake and a brief discussion of in vivo approaches to study EVs. Compiling feedback from ISEV expert task forces and more than 1000 researchers, this document conveys the current state of EV research to facilitate robust scientific discoveries and move the field forward even more rapidly., Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of origin and change the functions and phenotypes of other cells. These features indicate strong biomarker and therapeutic potential and have generated broad interest, as evidenced by the steady year-on-year increase in the numbers of scientific publications about EVs. Important advances have been made in EV metrology and in understanding and applying EV biology. However, hurdles remain to realising the potential of EVs in domains ranging from basic biology to clinical applications due to challenges in EV nomenclature, separation from non-vesicular extracellular particles, characterisation and functional studies. To address the challenges and opportunities in this rapidly evolving field, the International Society for Extracellular Vesicles (ISEV) updates its ‘Minimal Information for Studies of Extracellular Vesicles’, which was first published in 2014 and then in 2018 as MISEV2014 and MISEV2018, respectively. The goal of the current document, MISEV2023, is to provide researchers with an updated snapshot of available approaches and their advantages and limitations for production, separation and characterisation of EVs from multiple sources, including cell culture, body fluids and solid tissues. In addition to presenting the latest state of the art in basic principles of EV research, this document also covers advanced techniques and approaches that are currently expanding the boundaries of the field. MISEV2023 also includes new sections on EV release and uptake and a brief discussion of in vivo approaches to study EVs. Compiling feedback from ISEV expert task forces and more than 1000 researchers, this document conveys the current state of EV research to facilitate robust scientific discoveries and move the field forward even more rapidly.

Published
2024

23. Association between daily 1‐km resolution levels of ambient air pollution and hospital visits for allergic diseases

Author

He, Bi‐Xin, primary, Ma, Jia‐Jun, additional, Lai, He, additional, Li, Chan‐Gu, additional, Huang, Long‐Xin, additional, Huang, Hao‐Neng, additional, Liu, Xiao‐Qing, additional, Zhou, Zhi‐Rou, additional, Xie, Ying‐Chun, additional, Kuang, Peng‐Peng, additional, Ou, Chun‐Quan, additional, and Fu, Qing‐Ling, additional

Published
2023
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25. Early Diagnosis of Mild Cognitive Impairment due to Alzheimer’s Disease Using a Composite of MemTrax and Blood Biomarkers

Author

Chen, Weineng, primary, Lin, Cha, additional, Su, Fengjuan, additional, Fang, Yingying, additional, Liu, Ganqiang, additional, Chen, Yu-Chian, additional, Zhou, Xianbo, additional, Yao, Xiaoli, additional, Ashford, Curtis B., additional, Li, Feng, additional, Ashford, J. Wesson, additional, Fu, Qing-Ling, additional, and Pei, Zhong, additional

Published
2023
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27. Association between daily 1‐km resolution levels of ambient air pollution and hospital visits for allergic diseases.

Author

He, Bi‐Xin, Ma, Jia‐Jun, Lai, He, Li, Chan‐Gu, Huang, Long‐Xin, Huang, Hao‐Neng, Liu, Xiao‐Qing, Zhou, Zhi‐Rou, Xie, Ying‐Chun, Kuang, Peng‐Peng, Ou, Chun‐Quan, and Fu, Qing‐Ling

Subjects
ALLERGIES, AIR pollution, AIR pollution monitoring, AIR pollutants
Abstract

This article examines the association between daily levels of ambient air pollution and hospital visits for allergic diseases. Previous studies have typically used population-average exposure data, which may lead to biased effect estimates. In this study, individual exposure data was used to assess the effects of ambient air pollution on outpatient visits for allergic diseases. The results showed that increases in fine particulate matter (PM2.5) and ozone (O3) were associated with an increased risk of allergic diseases. Additionally, population-average exposure to PM2.5, particulate matter (PM10), O3, and sulphur dioxide (SO2) were also associated with an increased risk of allergic diseases. The study highlights the adverse effects of air pollution on allergic diseases and supports efforts to mitigate pollution and protect vulnerable individuals. [Extracted from the article]

Published
2024
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30. Mesenchymal stromal cells‐derived small extracellular vesicles modulate DC function to suppress Th2 responses via IL‐10 in patients with allergic rhinitis

Author

Peng, Ya‐Qi, Wu, Zi‐Cong, Xu, Zhi‐Bin, Fang, Shu‐Bin, Chen, De‐Hua, Zhang, Hong‐Yu, Liu, Xiao‐Qing, He, Bi‐Xin, Chen, Dong, Akdis, Cezmi A, Fu, Qing‐Ling, University of Zurich, and Fu, Qing‐Ling

Subjects
2403 Immunology, Immunology, Cell Differentiation, Mesenchymal Stem Cells, 610 Medicine & health, Dendritic Cells, Rhinitis, Allergic, Extracellular Vesicles, 10183 Swiss Institute of Allergy and Asthma Research, Leukocytes, Mononuclear, 2723 Immunology and Allergy, Humans, Immunology and Allergy, Cells, Cultured
Abstract

Mesenchymal stromal cells (MSCs) are well known for their immunoregulatory roles on allergic inflammation particularly by acting on T cells, B cells, and dendritic cells (DCs). MSC-derived small extracellular vesicles (MSC-sEV) are increasingly considered as one of the main factors for the effects of MSCs on immune responses. However, the effects of MSC-sEV on DCs in allergic diseases remain unclear. MSC-sEV were prepared from the induced pluripotent stem cells (iPSC)-MSCs by anion-exchange chromatography, and were characterized with the size, morphology, and specific markers. Human monocyte-derived DCs were generated and cultured in the presence of MSC-sEV to differentiate the so-called sEV-immature DCs (sEV-iDCs) and sEV-mature DCs (sEV-mDCs), respectively. The phenotypes and the phagocytic ability of sEV-iDCs were analyzed by flow cytometry. sEV-mDCs were co-cultured with isolated CD4

Published
2022

34. Requirements for human pluripotent stem cell derived small extracellular vesicles

Author

Li, Qing, primary, Li, Bo, additional, Chen, Zhengsheng, additional, Xu, Wenrong, additional, Yin, Hang, additional, Deng, Zhifeng, additional, Li, Haiyan, additional, Yan, Xiaomei, additional, Hao, Xiaoke, additional, Li, Li, additional, Tao, Zhihua, additional, Liu, Bicheng, additional, Ye, Teng, additional, Luo, Lei, additional, Qian, Hui, additional, Fu, Qing‐Ling, additional, Wang, Qian, additional, Zheng, Lei, additional, and Wang, Yang, additional

Published
2023
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35. Requirements for human mesenchymal stem cell‐derived small extracellular vesicles

Author

Li, Qing, primary, Li, Bo, additional, Ye, Teng, additional, Xu, Wenrong, additional, Yin, Hang, additional, Deng, Zhifeng, additional, Li, Haiyan, additional, Yan, Xiaomei, additional, Hao, Xiaoke, additional, Li, Li, additional, Tao, Zhihua, additional, Liu, Bicheng, additional, Chen, Zhengsheng, additional, Luo, Lei, additional, Qian, Hui, additional, Fu, Qing‐Ling, additional, Wang, Qian, additional, Zheng, Lei, additional, and Wang, Yang, additional

Published
2023
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41. Updating MISEV: Evolving the minimal requirements for studies of extracellular vesicles

Author

Witwer, Kenneth W, primary, Goberdhan, Deborah CI, additional, O'Driscoll, Lorraine, additional, Théry, Clotilde, additional, Welsh, Joshua A, additional, Blenkiron, Cherie, additional, Buzás, Edit I, additional, Di Vizio, Dolores, additional, Erdbrügger, Uta, additional, Falcón‐Pérez, Juan M, additional, Fu, Qing‐Ling, additional, Hill, Andrew F, additional, Lenassi, Metka, additional, Lötvall, Jan, additional, Nieuwland, Rienk, additional, Ochiya, Takahiro, additional, Rome, Sophie, additional, Sahoo, Susmita, additional, and Zheng, Lei, additional

Published
2021
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43. List of Contributors

Author

Benowitz, Larry I., primary, Bixby, John L., additional, Brown, Todd J., additional, Cao, Qi Lin, additional, Chen, Dong Feng, additional, Chew, Justin, additional, Cho, Kin-Sang, additional, David, Samuel, additional, Deng, Lingxiao, additional, Ding, Fei, additional, Dunlop, Sarah A., additional, Dunlop, Sarah Alison, additional, Fargo, Keith N., additional, Ferguson, Toby A., additional, Foecking, Eileen M., additional, Fu, Qing-Ling, additional, Galea, Mary Pauline, additional, Geoffroy, Cédric C., additional, Ge, Shu-chao, additional, Guo, Chenying, additional, Guo, Jiasong, additional, Gu, Xiaosong, additional, Hagg, Theo, additional, He, Cheng, additional, He, Zhigang, additional, Houle, John D., additional, Huang, Yu-bin, additional, Hu, Bing, additional, Jakeman, Lyn B., additional, Jones, Kathryn J., additional, Koriyama, Yoshiki, additional, Kroner, Antje, additional, Lee, Daniel H.S., additional, Lemmon, Vance P., additional, Li, Shuxin, additional, Liu, Jie, additional, Moghieb, Ahmed, additional, Reier, Paul J., additional, Rodger, Jennifer, additional, Selzer, Michael E., additional, Sengelaub, Dale R., additional, Sharma, Kartavya, additional, Shifman, Michael I., additional, Smith, George M., additional, So, Kwok-Fai, additional, Su, Huanxing, additional, Su, Zhida, additional, Tian, Chen, additional, Tom, Veronica J., additional, Walker, Chandler, additional, Wang, Kevin K.W., additional, Wang, Xiaofei, additional, Wu, Wutian, additional, Xu, Xiao-Ming, additional, Yang, Yumin, additional, Yin, Wu, additional, Young, Wise, additional, Yuan, Juliet C., additional, Yuan, Qiuju, additional, Zhang, Guixin, additional, Zhang, Zhiqun, additional, Zheng, Binhai, additional, Zhou, Lihua, additional, Zhu, Ruilin, additional, Zou, Su-qi, additional, and Zou, Yimin, additional

Published
2015
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46. Mesenchymal stem cells regulate type 2 innate lymphoid cells via regulatory T cells through ICOS‐ICOSL interaction

Author

Fan, Xingliang, Xu, Zhi‐Bin, Li, Cheng‐Lin; https://orcid.org/0000-0002-8781-3789, Zhang, Hong‐Yu, Peng, Ya‐Qi, He, Bi‐Xin, Liu, Xiao‐Qing, Chen, De‐Hua, Chen, Dong, Akdis, Cezmi A, Fu, Qing‐Ling; https://orcid.org/0000-0002-5969-628X, Fan, Xingliang, Xu, Zhi‐Bin, Li, Cheng‐Lin; https://orcid.org/0000-0002-8781-3789, Zhang, Hong‐Yu, Peng, Ya‐Qi, He, Bi‐Xin, Liu, Xiao‐Qing, Chen, De‐Hua, Chen, Dong, Akdis, Cezmi A, and Fu, Qing‐Ling; https://orcid.org/0000-0002-5969-628X

Abstract

Group 2 innate lymphoid cells (ILC2s) are recognized as key controllers and effectors of type 2 inflammation. Mesenchymal stem cells (MSCs) have been shown to alleviate type 2 inflammation by modulating T lymphocyte subsets and decreasing TH 2 cytokine levels. However, the effects of MSCs on ILC2s have not been investigated. In this study, we investigated the potential immunomodulatory effects of MSCs on ILC2s in peripheral blood mononuclear cells (PBMCs) from allergic rhinitis patients and healthy subjects. We further investigated the mechanisms involved in the MSC modulation using isolated lineage negative (Lin- ) cells. PBMCs and Lin- cells were cocultured with induced pluripotent stem cell-derived MSCs (iPSC-MSCs) under the stimulation of epithelial cytokines IL-25 and IL-33. And the ILC2 levels and functions were examined and the possible mechanisms were investigated based on regulatory T (Treg) cells and ICOS-ICOSL pathway. iPSC-MSCs successfully decreased the high levels of IL-13, IL-9, and IL-5 in PBMCs in response to IL-25, IL-33, and the high percentages of IL-13+ ILC2s and IL-9+ ILC2s in response to epithelial cytokines were significantly reversed after the treatment of iPSC-MSCs. However, iPSC-MSCs were found directly to enhance ILC2 levels and functions via ICOS-ICOSL interaction in Lin- cells and pure ILC2s. iPSC-MSCs exerted their inhibitory effects on ILC2s via activating Treg cells through ICOS-ICOSL interaction. The MSC-induced Treg cells then suppressed ILC2s by secreting IL-10 in the coculture system. This study revealed that human MSCs suppressed ILC2s via Treg cells through ICOS-ICOSL interaction, which provides further insight to regulate ILC2s in inflammatory disorders. Keywords: ICOS-ICOSL interaction; IL-10; group 2 innate lymphoid cells; immunomodulation; mesenchymal stem cells; regulatory T cells.

Published
2021

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