Background/Aims: Pediatric oral and maxillofacial surgeons have faced severe challenges in ward management due to their high risk of exposure during the COVID‐19 epidemic. The aim of this study was to analyze and summarize the treatment methods and infection prevention and control measures applied in emergency cases in the Department of Pediatric Oral and Maxillofacial Surgery, Children's Hospital of Chongqing Medical University, during the COVID‐19 epidemic. Methods: In this retrospective study, information was collected from 256 pediatric emergency patients who were treated from January 23, 2020 to August 9, 2021. The patients' data were statistically analyzed according to age, gender, disease and pathogenesis, operation time, and the main treatment applied in pediatric oral and maxillofacial emergency cases during the COVID‐19 epidemic. Results: During the epidemic period, 256 pediatric emergency patients were successfully treated. Among them, there were 170 boys and 86 girls. In all, 182 patients were diagnosed with oral or facial lacerations; 43 had jaw fractures; 26 had maxillofacial infections; and five had dento‐alveolar fractures. A total of 246 patients underwent surgery under negative pressure with level 3 protection standards. No doctors or patients infected with COVID‐19 were found throughout the stury period. Conclusions: Pediatric oral and maxillofacial emergency in‐patients mainly experienced maxillofacial trauma during the COVID‐19 epidemic, followed by infection. Effective diagnosis and treatment, and avoidance of COVID‐19 infection can be achieved by strictly following epidemic prevention and treatment procedures. [ABSTRACT FROM AUTHOR]