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10 results on '"Gauler, Georg"'

1. A Real-World Rheumatology Registry and Research Consortium: The German RheumaDatenRhePort (RHADAR) Registry

Author

Kleinert, Stefan, Bartz-Bazzanella, Peter, von der Decken, Cay, Knitza, Johannes, Witte, Torsten, Fekete, Sándor P, Konitzny, Matthias, Zink, Alexander, Gauler, Georg, Wurth, Patrick, Aries, Peer, Karberg, Kirsten, Kuhn, Christoph, Schuch, Florian, Späthling-Mestekemper, Susanna, Vorbrüggen, Wolfgang, Englbrecht, Matthias, and Welcker, Martin

Subjects
Computer applications to medicine. Medical informatics, R858-859.7, Public aspects of medicine, RA1-1270
Abstract

Real-world data are crucial to continuously improve the management of patients with rheumatic and musculoskeletal diseases (RMDs). The German RheumaDatenRhePort (RHADAR) registry encompasses a network of rheumatologists and researchers in Germany providing pseudonymized real-world patient data and allowing timely and continuous improvement in the care of RMD patients. The RHADAR modules allow automated anamnesis and adaptive coordination of appointments regarding individual urgency levels. Further modules focus on the collection and integration of electronic patient-reported outcomes in between consultations. The digital RHADAR modules ultimately allow a patient-centered adaptive approach to integrated medical care starting as early as possible in the disease course. Such a closed-loop system consisting of various modules along the whole patient pathway enables comprehensive and timely patient management in an unprecedented manner.

Published
2021
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2. Analysis of the shorter drug survival times for Janus kinase inhibitors and interleukin-17 inhibitors compared with tumor necrosis factor inhibitors in a real-world cohort of axial spondyloarthritis patients - a retrospective analysis from the RHADAR network

Author

Strunz, Patrick-Pascal, Englbrecht, Matthias, Risser, Linus Maximilian, Witte, Torsten, Froehlich, Matthias, Schmalzing, Marc, Gernert, Michael, Schmieder, Astrid, Bartz-Bazzanella, Peter, von der Decken, Cay, Karberg, Kirsten, Gauler, Georg, Wurth, Patrick, Späthling-Mestekemper, Susanna, Kuhn, Christoph, Vorbrüggen, Wolfgang, Heck, Johannes, Welcker, Martin, and Kleinert, Stefan

Published
2024
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4. Radiographic and non-radiographic axial spondyloarthritis are not routinely distinguished in everyday clinical care: an analysis of real-world data from rheumatology practices

Author

Kleinert, Stefan, Schuch, Florian, Rapp, Praxedis, Ronneberger, Monika, Wendler, Joerg, Sternad, Patrizia, Popp, Florian, Bartz-Bazzanella, Peter, von der Decken, Cay, Karberg, Kirsten, Gauler, Georg, Wurth, Patrick, Späthling-Mestekemper, Susanna, Kuhn, Christoph, Vorbrüggen, Wolfgang, and Welcker, Martin

Published
2024
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7. Drug survival superiority of tumor necrosis factor inhibitors and interleukin-17 inhibitors over Janus kinase inhibitors and interleukin-12/23 inhibitors in German psoriatic arthritis outpatients: retrospective analysis of the RHADAR database.

Author

Strunz, Patrick-Pascal, Englbrecht, Matthias, Risser, Linus Maximilian, Witte, Torsten, Froehlich, Matthias, Schmalzing, Marc, Gernert, Michael, Schmieder, Astrid, Bartz-Bazzanella, Peter, von der Decken, Cay, Karberg, Kirsten, Gauler, Georg, Wurth, Patrick, Späthling-Mestekemper, Susanna, Kuhn, Christoph, Vorbrüggen, Wolfgang, Heck, Johannes, Welcker, Martin, and Kleinert, Stefan

Subjects
TUMOR necrosis factors, PSORIATIC arthritis, KINASE inhibitors, DATABASES, INTERLEUKIN-17, ANTIRHEUMATIC agents
Abstract

Objective: Treatment options with disease-modifying antirheumatic drugs (DMARDs) for psoriatic arthritis (PsA) have evolved over recent years. In addition to Janus kinase inhibitors (JAKi), four classes of biologic DMARDs (bDMARDs; interleukin [IL]-23 inhibitors [IL-23i], IL-12/23 inhibitors [IL-12/23i], tumor necrosis factor inhibitors [TNFi], and IL-17 inhibitors [IL-17i]) are currently approved for moderate to severe PsA treatment. There is minimal evidence of the persistence of these drugs among PsA outpatients in a real-world scenario during the period following the approval of JAKi. Therefore, we aimed to analyze the drug survival rates of biologic and JAKi therapies among German PsA outpatients during routine clinical care. Methods: We retrospectively analyzed PsA patients with a new prescription for a biologic or JAKi in the RHADAR database between January 2015 and October Results: 1352 new prescriptions with bDMARDs (IL-12/23i [n=50], IL-23i [n=31], TNFi [n=774], IL-17i [n=360]) or JAKi (n=137) were identified. The 5-year drug survival rate was 67.8% for IL-17i, 62.3% for TNFi, 53.3% for JAKi, and 46.0% for IL-12/23i. Discontinuation probabilities for JAKi and IL-12/23i were significantly higher compared with TNFi (JAKi hazard ratio [HR] 1.66, [95% CI 1.23-2.24], p=0.001; IL-12/23i HR 1.54, [95% CI 1.02-2.33], p=0.042) and IL-17i (JAKi HR 1.77, [95% CI 1.27-2.47], p=0.001; IL-12/23i HR 1.64, [95% CI 1.06-2.55], p=0.027). JAKi-treated patients had more severe disease and more osteoarthritis (OA) compared to TNFi and more OA compared to IL-17i. Conclusion: German PsA outpatients might persist longer with TNFi and IL-17i compared with IL-12/23i or JAKi. For TNFi, differences in subgroup characteristics and comorbidities (OA) may have affected drug survival rates. For IL-17i, the longer drug survival might not only be related to less OA compared to JAKi and, therefore, might be affected by other factors. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Eine Applikation für die rheumatologische Versorgung: RheCORD.

Author

Welcker, Martin, Klennert, Michael, Aries, Peer, Bartz-Bazzanella, Peter, Von der Decken, Cay, Engelbrecht, Matthias, Gauler, Georg, Hornig, Johannes, Karberg, Kirsten, Kuhn, Christoph, Schuch, Florian, Späthling-Mestekemper, Susanna, Vorbrüggen, Wolfgang, Wurth, Patrick, Muth, Theresia, Froschauer-Häfele, Sonja, Mühlensiepen, Felix, Popp, Florian, Burigk, Kristin, and Kladny, Heike

Published
2023
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