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In animal models of experimental cerebral malaria (ECM), neuropathology is associated with an overwhelming inflammatory response and sequestration of leukocytes and parasite-infected RBCs in the brain. In this study, we explored the effect of vitamin D (VD; cholecalciferol) treatment on host immunity and outcome of ECM in C57BL/6 mice during Plasmodium berghei ANKA (PbA) infection. We observed that oral administration of VD both before and after PbA infection completely protected mice from ECM. VD administration significantly dampened the inducible systemic inflammatory responses with reduced circulating cytokines IFN-γ and TNF and decreased expression of these cytokines by the spleen cells. Meanwhile, VD also resulted in decreased expression of the chemokines CXCL9 and CXCL10 and cytoadhesion molecules (ICAM-1, VCAM-1, and CD36) in the brain, leading to reduced accumulation of pathogenic T cells in the brain and ultimately substantial improvement of the blood-brain barriers of PbA-infected mice. In addition, VD inhibited the differentiation, activation, and maturation of splenic dendritic cells. Meanwhile, regulatory T cells and IL-10 expression levels were upregulated upon VD treatment. These data collectively demonstrated the suppressive function of VD on host inflammatory responses, which provides significant survival benefits in the murine ECM model.

By designing an orthogonal experiment with four factors and three levels, (Na0.5Bi0.495Nd0.005)TiO3 (NBT‐Nd) nanopowders were prepared using a hydrothermal method under different conditions to determine the optimum hydrothermal synthesis conditions. The synthesized NBT‐Nd nanopowders were characterized using X‐ray diffraction measurement, ultraviolet–visible spectra, photoluminescence spectra, and transmission electron microscopy to evaluate the orthogonal experimental conditions. The results showed that NBT‐Nd powders with excellent crystalline and luminescence properties could be obtained at 160°C, with a 16 h reaction time, 8 mol·L−1 NaOH, and with 0.4489 g C19H42BrN. The optimized hydrothermal method‐prepared NBT‐Nd powder has a rather pure rhombohedral perovskite structure at room temperature, and exhibits an aggregated polycrystalline structure containing nanotubes and nano‐sized particles. Under excitation of 247 nm light, strong fluorescence emissions are excited at 423 nm and 441 nm in the NBT‐Nd powder that were generated by transitions of Nd3+ from 2D5/2 to 4I9/2 and from 4G11/2 to 4I9/2, respectively. Through CIE1931 chromaticity calculation of the emission peaks, the NBT‐Nd powder was shown to emit indigo blue fluorescent light. [ABSTRACT FROM AUTHOR]

By designing an orthogonal experiment with four factors and three levels, (Na 0.5 Bi 0.495 Nd 0.005 )TiO 3 (NBT-Nd) nanopowders were prepared using a hydrothermal method under different conditions to determine the optimum hydrothermal synthesis conditions. The synthesized NBT-Nd nanopowders were characterized using X-ray diffraction measurement, ultraviolet-visible spectra, photoluminescence spectra, and transmission electron microscopy to evaluate the orthogonal experimental conditions. The results showed that NBT-Nd powders with excellent crystalline and luminescence properties could be obtained at 160°C, with a 16 h reaction time, 8 mol·L -1 NaOH, and with 0.4489 g C 19 H 42 BrN. The optimized hydrothermal method-prepared NBT-Nd powder has a rather pure rhombohedral perovskite structure at room temperature, and exhibits an aggregated polycrystalline structure containing nanotubes and nano-sized particles. Under excitation of 247 nm light, strong fluorescence emissions are excited at 423 nm and 441 nm in the NBT-Nd powder that were generated by transitions of Nd 3+ from 2 D 5/2 to 4 I 9/2 and from 4 G 11/2 to 4 I 9/2 , respectively. Through CIE1931 chromaticity calculation of the emission peaks, the NBT-Nd powder was shown to emit indigo blue fluorescent light., (© 2021 John Wiley & Sons, Ltd.)