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Generally, reactivation of hepatitis B virus (HBV) infection is induced by the administration of immunosuppressants or anticancer agents, but reactivation without such drugs has rarely been reported. Here we report an elder case with spontaneous reactivation of HBV replication accompanied by hepatitis B surface antigen (HBsAg) mutations. A 69-year-old man with a history of diabetes mellitus and chronic kidney disease (CKD) was found to be positive for HBsAg (0.072 IU/ml) in June 2018. In May 2019, marked hepatic dysfunction and increased HBsAg (2533.2 IU/ml) were observed when he visited the hospital due to diarrhea and worsening of CKD. At that time, hepatitis B surface antibody (HBsAb) was positive (268.9 mIU/ml) and HBV DNA was 6.0 log IU/ml. After treatment with entecavir, HBV DNA and HBsAg rapidly decreased. Full-genome HBV sequence analysis revealed that the patient was infected with HBV of subgenotype B1 and it had an "a" determinant mutation M133L in the S gene coding HBsAg. Notably, both HBsAg and HBsAb were positive at the time of HBV reactivation, suggesting that the HBV with these mutations escaped from neutralization by HBsAb. This case suggests that immune escape mutations could play an important role in spontaneous HBV reactivation.

Sialoglyco particulates carrying an N-glycolylneuraminyl-α-(2 → 3)-N-acetyllactosamine (Neu5Gcα2,3LacNAc) residue that displays a high level of affinity for the equine influenza virus (EIV) were generated using sialoglycopolypeptide and hexyl-containing hybrid silica particulates. The particulates were spherical with a diameter of approximately 950 nm and found to have good dispersibility in aqueous solution. Interaction between the sialoglyco particulates and the EIV was investigated by real-time reverse transcriptase polymerase chain reaction (rRT-PCR) of the EIV genome captured on the particulates. The number of EIV-specific genes detected by rRT-PCR on a nasal swab obtained from infected horses clearly increased when the sample was treated with sialoglyco particulates. Our results show these novel sialoglyco particulates can be used as a highly sensitive tool for detecting low levels of EIV that were previously undetectable in the early or late stage of infection.

Satellite laser communication is a promising solution to satisfy the increasing demand for high-capacity wireless communications. Satellite laser communication has several advantages over its radio frequency counterparts, such as a higher capacity with a broader bandwidth and transmission security provided by highly directional laser beams. However, the received optical power fluctuations induced by atmospheric scintillation cause burst errors, requiring the employment of high-performance error correction codes, such as turbo or low-density parity check (LDPC) codes. Recently, polar code has been attracting significant attention, primarily because of its lower encoding and decoding computational complexity and its high performance, reaching the Shannon limit. We have reported a long-distance experiment using 7.8-km terrestrial free-space optical (FSO) communication links and compared the performance of polar and LDPC codes. Our experimental results revealed the advantage of polar codes over LDPC codes when channel state information (CSI) was not available. In FSO communications suffering from atmospheric fading, it is known that we can enhance the error-correction performance of these codes by utilizing a channel equalization technique based on the estimated CSI. In this study, we present the results of long-distance transmission experiments using polar codes with channel equalization. As a result, equalization improves the error-correction performance. Moreover, even with channel equalization, the block error rate of polar codes is better than that of LDPC codes, as in our previous report.

Quantum key distribution (QKD) is a technology to securely share keys against any attack physically permitted, with the principle of quantum mechanics. In recent years, the satellite QKD, which employs artificial satellites as trusted mobile nodes, has been attracting attention in order to overcome the bottleneck of transmission distance. However, in the satellite QKD, quality degradation due to atmospheric effects is expected, as in ordinary satellite laser communications. Therefore, it is desirable to apply an error-correcting code (ECC) that has high error-correcting performance even under the atmospheric-induced effects to the error-correcting process of the satellite QKD. Therefore, in this paper, we examined the application of polar codes, which is known as an ECC with high error correction capability. First, in order to optimize the error correction efficiency, we propose a method to adaptively obtain an appropriate code rate for the received signal strength that changes momentarily due to atmospheric effects. Then, we compare the throughput performances with polar codes to it with low-density parity-check (LDPC) codes, with the numerical simulation assuming Bennett-Brassard 1984 protocol (BB84).

Introduction Under the current pandemic situation of the coronavirus disease 2019 (COVID-19), we have newly developed a commercially available device named Endomask to prevent the diffusion of droplets from subjects undergoing esophagogastroduodenoscopy (EGD). Herein, we evaluate the efficacy and safety of the device, and also evaluate the stress of the device on the operators and the subjects of EGD. Methods The efficacy of the device was evaluated using an experimental model that simulated the environment of EGD. The safety of the device was evaluated clinically by means of measuring the oxygen saturation and the expiratory carbonic dioxide partial pressure of subjects with our device during EGD. The stress of the device on the operability of the endoscopists and the respiration of the subjects were evaluated using questionnaires. Results In the experiments with Endomask, the percentage of the area with simulated droplets was significantly reduced compared to that without our device (median, 0.24% vs. 6.96%, p = 0.009). The saturation of oxygen and the expiratory carbonic dioxide partial pressure of subjects with the device did not show significant change at any recording times. Neither the operators nor the subjects felt serious stress from examination with the device. Conclusions Endomask could remarkably and safely prevent the diffusion of droplets without serious stress. Endomask is expected to contribute to a reduction of the infectious risk of SARS-CoV-2 in endoscopy units during COVID-19 pandemic.

Free-space optical (FSO) communications offer high-capacity wireless transmission due to their plentiful properties originated from higher carrier frequency. These properties also yield a greater security advantage: the high directionality of the laser beam and the line-of-sight configuration can reasonably restrict an attack model launched by an eavesdropper (Eve). Secret key agreement over FSO links (FSO-SKA) employs this security advantage for key establishment between two distant parties, which is secure against Eve even with unbounded computer resources. In this chapter, we numerically evaluate the performance of FSO-SKA for satellite laser communications under the given power constraint. We also compare the performance of FSOSKA and quantum key distribution (QKD). Our result shows that FSO-SKA can generate a key even for the distance between geostationary orbit satellite and ground station. We anticipate that FSO-SKA has a potential to extend the secure satellite networks to global scale, which is hard only with QKD.

Appropriate management of constipation in hemodialysis patients has not been established, although constipation is the most frequent gastrointestinal complication in dialysis patients. We herein report the efficacy and safety of polyethylene glycol in constipated hemodialysis patients assessed prospectively. Seven patients using stimulant laxatives participated in this study. Polyethylene glycol was administered to reduce stimulant laxatives during the six-week intervention period. The amount of stimulant laxatives decreased and spontaneous bowel movements with ideal stool consistency increased significantly after the intervention. No serious adverse effects were observed throughout this study. In conclusion, polyethylene glycol can be a useful tool for managing constipated hemodialysis patients.

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The lead author has in this decade been studying the processes of creating and transferring multinational IT service knowledge among the headquarters of a global IT Service firm in Japan and the firm’s local subsidiaries in China and APAC regions. Key findings of the preceding studies are, (1) the average of Project Managers’ skill level in China and APAC regions has already reached to the global average determined in the standardized PM skill assessment within the global firm. (2) IT service project managers’ value systems are highly influenced by those of organization the PMs belong to, and the value systems vary not only by nations but also by industries. (3) To transfer knowledge from HQ to overseas subsidiaries in China and APAC regions, especially in the case that the knowledge to be transferred is extremely new and unfamiliar to the knowledge transferees (i.e., local PMs), it is better for the knowledge transferrers from HQs to consider the differences between the value systems of the transferrer and the transferee.

The coding problem for wiretap channels with causal state information available at the encoder is studied. In particular, we address the wiretap channel only with one-time state information (instead of the usual causal state information up to present) in the sense that the one-time encoder uses only the current state information $S_{k}$ at each time $k$ to establish the secrecy capacity formula under the $\delta $ -strong secrecy criterion. The coding problem for wiretap channels with one-time channel state information available at the encoder under cost constraints is also studied and lower bounds on the “ $\delta $ -strong” secrecy capacity given cost are also demonstrated.

The effect of plasticizer content on the vibration absorbing properties for polyurethane elastomers was investigated. A natural frequency appeared on the frequency spectra at around 100 Hz. The natural frequency linearly decreased, and the transmissibility also decreased with the plasticizer content. Magnetic elastomers containing carbonyl iron particles with a dimeter of 7.0 mm also showed a natural frequency at ~260 Hz, and the natural frequency significantly decreased with the plasticizer content. The decrease in the transmissibility with the plasticizer content was larger than that for polyurethane elastomers. The natural frequency for magnetic elastomers increased by several ten Hz by a magnetic field of 60 mT although the transmissibility was independently of the plasticizer content. The effect of load on the natural frequency for these elastomers was also investigated, and it was found that the natural frequency is proportional to the storage modulus, G, with different two slopes depending on the mass of the system, m. The linear relation between the natural frequency and (G’/m)1/2 revealed that the observed vibration can be basically described by a simple harmonic oscillation.

We studied the size effect of disk-shaped magnetic elastomers, which were placed on a permanent magnet, on their magnetomechanical response for the permanent magnet. The diameter of the magnetic elastomers varied from 14 to 40 mm, whereas the diameter of the permanent magnet was constant at 30 or 35 mm. The smallest magnetic elastomer did not exhibit magnetomechanical response for both 30- and 35-mm-diameter permanent magnets; however, a clear response was observed when the diameter of the magnetic elastomer equaled that of the permanent magnet. Magnetic field distribution revealed a steep gradient of magnetic fields at the fringe of permanent magnets. Image analyses indicated that the bottom of magnetic elastomers was restricted to deform along the horizontal direction under compression. In the vertical direction, the magnetostriction due to the magnetic attractive force from permanent magnets was negligibly small. Therefore, the size-dependent behavior of magnetomechanical response is considered a pinning effect wherein the bottom of magnetic elastomers was restricted by the magnetic field gradient in the horizontal direction. We also analyzed the magnetomechanical response of magnetic elastomers when magnetic fields were applied by square- or ring-shaped permanent magnets.

Free-space optical (FSO) communications are becoming promising schemes for high-capacity wireless links due to their plentiful characteristics originated from higher carrier frequency. These characteristics also yield a greater security advantage over radio frequency counterparts: the physical ability of a wiretapper is reasonably restricted due to the high directionality of communication beam and the line-of-sight configuration of the link. Secret key agreement over FSO links (FSO-SKA) employs this security advantage as well as the post-processing over an authenticated public channel to establish an information-theoretic secure key which cannot be broken even with unbounded computer resources. In the previous works, the authors demonstrated the full-field implementations of FSO-SKA with a 7.8-km FSO link testbed including a probing station to estimate the possible wiretapping risks from the sidelobe of the communication beam. In the demonstration, however, there is still room to improve the secret key rate by exploiting the optical fading which contains additional information about random states of the FSO links. We here propose a novel protocol for FSO-SKA employing such channel state information. In the protocol, the legitimate receiver decides whether to discard the received symbols or not according to the received optical power at the time. Based on the experimental data from the FSO link testbed, we demonstrate that the proposed protocol improves the secret key rate compared with our previous result. To our best knowledge, this is the first demonstration that exploits the effect of atmospheric turbulences to improve the security performance of communication systems. We anticipate that this idea will be applicable on the broader areas of FSO communications and opens a way toward practical wireless network spanned by FSO links.

In recent years, the demand for high-speed communication has been increasing. Satellite laser communication is one of the infrastructures that can realize this demand. However, in free-space optics (FSO) that use satellite laser communications, a scintillation occurs when the light passes through the atmosphere, resulting in a burst error. To prevent this, a strong error correction code is required. The polar code, one of such channel coding schemes, has been recently proposed. We have considered applying polar codes into FSO channels and have evaluated its performances through computer simulations. However, the experiments of polar code transmission in an outdoor FSO channel has not been studied. Therefore, in this paper, we conduct an experiment in polar code transmission in a terrestrial FSO channel instead of a satellite FSO as the first step of study, and then analyze the performance from the transmission results.

Research and development of a novel method for a secure free-space optical communication system has been done in NICT since 2018, and demonstration experiments between an aircraft and a transportable optical ground station are planned in near future. In order to establish a stable and highly accurate optical communication link, the system must have a fine pointing mechanism in both the aircraft and the ground station. A compact and light-weight tracking system is required to be mounted on the aircraft, and there will be needed to have an adjustment function of the beam divergence control to allow stable communication under various altitude and atmospheric conditions. The transportable optical ground station should maintain vibration resistance when moving, and it must be easily deployed on each site where is the appropriate optical ground station site with respect to atmospheric turbulence condition.

Free-space optical (FSO) communications can offer secure connectivity thanks to the high directionality of the laser beam and the line-of-sight configuration. These security advantages are employed to realize high-speed key establishment between two distant parties, which is provably secure against an eavesdropper with unlimited computational resources. Besides, a well-maintained laser beam divergence allows group key agreement (GKA) among multiple parties. Here, we propose a novel method of GKA over FSO link—FSO-GKA. After numerically characterizing fundamental behaviors, we present a proof-of-concept demonstration of FSO-GKA using a 7.8-km terrestrial link. We achieve a group key rate of roughly 8 Mbps over a 58dB-loss channel based on 10-MHz on-off keying. We also investigate information leakage risks under several atmospheric conditions, which provides the basis for security certification of FSO-GKA. Our proposed scheme shows a new way to construct high-speed key exchange platforms.

We propose a self-validating scheme to calculate the unbiased responses of quantum many-body systems to external fields of arbibraty strength at any temperature. By switching on a specified field to a thermal pure quantum state of an isolated system, and tracking its time evolution, one can observe an intrinsic thermalization process driven solely by many-body effects. The transient behavior before thermalization contains rich information on excited states, giving the linear and nonlinear response functions at all frequencies. We uncover the necessary conditions to clarify the applicability of this formalism, supported by a proper definition of the nonlinear response function. The accuracy of the protocol is guaranteed by a rigorous upper bound of error exponentially decreasing with system size, and is well implemented in the simple ferromagnetic Heisenberg chain, whose response at high fields exhibits a nonlinear band deformation. We further extract the characteristic features of excitation of the spin-1/2 kagome antiferromagnet; the wavenumber-insensitive linear responses from the possible spin liquid ground state, and the significantly broad nonlinear peaks which should be generated from numerous collisions of quasi-particles, that are beyond the perturbative description., published version; 6 pages with 3 figures, and Supplemental Material

The effect of a weak magnetic field on vibration transmissibility was investigated for magnetic elastomers with various volume fractions of magnetic particles. Polyurethane elastomers without magnetic particles exhibited a natural frequency at 53 Hz and were insensitive to a magnetic field of 60 mT. The natural frequency for magnetic elastomers with a volume fraction of 0.23 was 115 Hz at 0 mT, and increased to 134 Hz at 60 mT. The vibration transmissibility was independent of the magnetic field. A linear relation between the natural frequency and (G/m)1/2 was observed (G: storage modulus, m: mass), indicating that the observed vibration is basically described by a simple harmonic oscillation.

We present practical GHz-clocked QKD systems, next generation entanglement QKD technologies, and QKD platform to manage the secure keys and to support a variety of applications. We then show the intrinsic limit of QKD, i.e., a key rate bound, and discuss how to realize the provable (information theoretic) security with a larger secrecy capacity over longer distances. In particular, we present a basic theory of physical layer cryptography, which characterizes the secrecy capacity, and engineers the tradeoff between the efficiency of reliable transmission and secrecy of communication. We introduce a concept to unify these schemes in photonic network, referred to as quantum photonic network. Future issues for realizing this new network paradigm are discussed.

Recently, the free space optical (FSO) communications have been widely studied as an alternative for large capacity communications and its possible implementation in satellite and terrestrial laser links. In satellite communications, clouds can strongly attenuate the laser signal that would lead to high bit-error rates or temporal unavailability of the link. To overcome the cloud coverage effects, often site diversity technique is implemented. When using multiple ground stations though, simplified optical system is required to allow the usage of more flexible approaches. In terrestrial laser communications, several methods for optical system simplification by using a multimode fiber (MMF) have been proposed.

Cholangiocarcinoma is an aggressive malignant tumor originating from intrahepatic or extrahepatic bile ducts. Its malignant phenotypes may be assumed by cancer stem cells (CSC). Here, we demonstrate that CD274 (PD-L1), known as an immunomodulatory ligand, has suppressive effects on CSC-related phenotypes of cholangiocarcinoma. Using two human cholangiocarcinoma cell lines, RBE and HuCCT1, we attempted to isolate the CD274(low) and CD274(high) cells from each cell line, and xenografted them into immunodeficient NOD⁄scid⁄γcnull (NOG) mice. We found that the CD274(low) cells isolated from both RBE and HuCCT1 are highly tumorigenic in NOG mice compared with CD274(high) cells. Furthermore, the CD274(low) cells possess several CSC-related characteristics, such as high aldehyde dehydrogenase (ALDH) activity, reduced reactive oxygen species production and a dormant state in the cell cycle. Furthermore, depletion of CD274 expression by shRNA in RBE cells enhances their tumorigenicity and increases ALDH activity. These findings are compatible with our observation that clinical cholangiocarcinoma specimens are classified into low and high groups for CD274 expression, and the CD274 low group shows poorer prognosis when compared with the CD274 high group. These results strongly suggest that CD274 has a novel function in the negative regulation of CSC-related phenotypes in human cholangiocarcinoma, which is distinct from its immunomodulatory actions.

Gastric acid measurement is useful in assessing the effectiveness of antisecretory drugs, however, the conventional tests involve invasive nasogastric intubation. Orally administered ¹³C-labeled calcium carbonate (Ca¹³CO₃) reacts with gastric acid to produce ¹³C-labeled carbon dioxide (¹³CO₂), which is then excreted in the breath. The objective of this study was to evaluate the suitability of Ca¹³CO3 breath test for estimating gastric acid secretion in human noninvasively. First, the Ca¹³CO₃ breath test and the measurement of pooled gastric acid under a fasting condition were performed in 6 healthy volunteers to evaluate the correlation between the two parameters. Next, endoscopic gastric acid collection and the Ca¹³CO₃ breath test were performed on different days after pentagastrin injection in 20 subjects to evaluate the correlation between the tests and the reproducibility. Finally, the same studies were repeated in 4 subjects before and after 1-week rabeprazole, a proton pump inhibitor, administration. The maximum CO₂ concentration (Cmax) correlated very well with the amount of pooled gastric acid (r = 0.95), suggesting that Ca¹³CO₃ breath test values well reflected the fasting intragastric acidity. The ¹³CO₂ concentration after pentagastrin injection correlated well with pentagastrin-stimulated maximal acid output (r = 0.79 at 20 min). The reproducibility of the Ca¹³CO₃ breath test under pentagastrin-stimulation was good (coefficient of variation = 0.11). Rabeprazole administration markedly reduced the values of the Ca¹³CO₃ breath test, suggesting that it can sensitively assess the efficacy of rabeprazole. The Ca¹³CO₃ breath test can potentially be a useful method for non-invasive estimation for gastric acid secretion in human.