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5. Subsequent female breast cancer risk associated with anthracycline chemotherapy for childhood cancer

Author

Wang, Yuehan, Ronckers, Cécile M., van Leeuwen, Flora E., Moskowitz, Chaya S., Leisenring, Wendy, Armstrong, Gregory T., de Vathaire, Florent, Hudson, Melissa M., Kuehni, Claudia E., Arnold, Michael A., Demoor-Goldschmidt, Charlotte, Green, Daniel M., Henderson, Tara O., Howell, Rebecca M., Ehrhardt, Matthew J., Neglia, Joseph P., Oeffinger, Kevin C., van der Pal, Helena J. H., Robison, Leslie L., Schaapveld, Michael, Turcotte, Lucie M., Waespe, Nicolas, Kremer, Leontien C. M., and Teepen, Jop C.

Published
2023
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6. The burden of cardiovascular disease and risk for subsequent major adverse cardiovascular events in survivors of childhood cancer: a prospective, longitudinal analysis from the St Jude Lifetime Cohort Study

Author

Hammoud, Rawan A, Liu, Qi, Dixon, Stephanie B, Onerup, Aron, Mulrooney, Daniel A, Huang, I-Chan, Jefferies, John L, Rhea, Isaac B, Ness, Kirsten K, Ehrhardt, Matthew J, Hudson, Melissa M, Ky, Bonnie, Bhakta, Nickhill, Sapkota, Yadav, Yasui, Yutaka, and Armstrong, Gregory T

Published
2024
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10. Pediatric Normal Tissue Effects in the Clinic (PENTEC): An International Collaboration to Assess Normal Tissue Radiation Dose-Volume-Response Relationships for Children With Cancer

Author

Constine, Louis S., Olch, Arthur J., Jackson, Andrew, Hua, Chia-Ho, Ronckers, Cecile M., Milano, Michael T., Marcus, Karen J., Yorke, Ellen, Hodgson, David C., Howell, Rebecca M., Hudson, Melissa M., Williams, Jacqueline P., Marples, Brian, C.M. Kremer, Leontien, Marks, Lawrence B., and Bentzen, Søren M.

Published
2024
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11. Identification of novel hypermethylated or hypomethylated CpG sites and genes associated with anthracycline-induced cardiomyopathy

Author

Singh, Purnima, Zhou, Liting, Shah, Disheet A., Cejas, Romina B., Crossman, David K., Jouni, Mariam, Magdy, Tarek, Wang, Xuexia, Sharafeldin, Noha, Hageman, Lindsey, McKenna, Donald E., Horvath, Steve, Armenian, Saro H., Balis, Frank M., Hawkins, Douglas S., Keller, Frank G., Hudson, Melissa M., Neglia, Joseph P., Ritchey, A. Kim, Ginsberg, Jill P., Landier, Wendy, Burridge, Paul W., and Bhatia, Smita

Published
2023
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14. Distinct DNA methylation signatures associated with blood lipids as exposures or outcomes among survivors of childhood cancer: a report from the St. Jude lifetime cohort

Author

Dong, Qian, Chen, Cheng, Song, Nan, Qin, Na, Plonski, Noel-Marie, Finch, Emily R., Shelton, Kyla, Easton, John, Mulder, Heather, Plyer, Emily, Neale, Geoffrey, Walker, Emily, Li, Qian, Huang, I-Chan, Zhang, Jinghui, Wang, Hui, Hudson, Melissa M., Robison, Leslie L., Ness, Kirsten K., and Wang, Zhaoming

Published
2023
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15. Recommendations for surveillance of pulmonary dysfunction among childhood, adolescent, and young adult cancer survivors: a report from the International Late Effects of Childhood Cancer Guideline Harmonization Group

Author

Otth, Maria, Kasteler, Rahel, Mulder, Renée L., Agrusa, Jennifer, Armenian, Saro H., Barnea, Dana, Bergeron, Anne, Bhatt, Neel S., Bourke, Stephen J., Constine, Louis S., Goutaki, Myrofora, Green, Daniel M., Hennewig, Ulrike, Houdouin, Veronique, Hudson, Melissa M., Kremer, Leontien, Latzin, Philipp, Ng, Antony, Oeffinger, Kevin C., Schindera, Christina, Skinner, Roderick, Sommer, Grit, Srinivasan, Saumini, Stokes, Dennis C., Versluys, Birgitta, Waespe, Nicolas, Weiner, Daniel J., Dietz, Andrew C., and Kuehni, Claudia E.

Published
2024
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19. Interindividual variation in ovarian reserve after gonadotoxic treatment in female childhood cancer survivors – a genome-wide association study: results from PanCareLIFE

Author

van der Perk, M.E. Madeleine, Broer, Linda, Yasui, Yutaka, Laven, Joop S.E., Robison, Leslie L., Tissing, Wim J.E., Versluys, Birgitta, Bresters, Dorine, Kaspers, Gertjan J.L., Lambalk, Cornelis B., Overbeek, Annelies, Loonen, Jacqueline J., Beerendonk, Catharina C.M., Byrne, Julianne, Berger, Claire, Clemens, Eva, van Dulmen-den Broeder, Eline, Dirksen, Uta, van der Pal, Helena J., de Vries, Andrica C.H., Winther, Jeanette Falck, Ranft, Andreas, Fosså, Sophie D., Grabow, Desiree, Muraca, Monica, Kaiser, Melanie, Kepák, Tomáš, Kruseova, Jarmila, Modan-Moses, Dalit, Spix, Claudia, Zolk, Oliver, Kaatsch, Peter, Kremer, Leontien C.M., Brooke, Russell J., Wang, Fan, Baedke, Jessica L., Uitterlinden, André G., Bos, Annelies M.E., van Leeuwen, Flora E., Ness, Kirsten K., Hudson, Melissa M., van der Kooi, Anne-Lotte L.F., and van den Heuvel-Eibrink, Marry M.

Published
2024
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21. Gene-Level Analysis of Anthracycline-Induced Cardiomyopathy in Cancer Survivors: A Report From COG-ALTE03N1, BMTSS, and CCSS

Author

Sharafeldin, Noha, Zhou, Liting, Singh, Purnima, Crossman, David K., Wang, Xuexia, Hageman, Lindsey, Landier, Wendy, Blanco, Javier G., Burridge, Paul W., Sapkota, Yadav, Yasui, Yutaka, Armstrong, Gregory T., Robison, Leslie L., Hudson, Melissa M., Oeffinger, Kevin, Chow, Eric J., Armenian, Saro H., Weisdorf, Daniel J., and Bhatia, Smita

Published
2023
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22. Development and validation of age-specific risk prediction models for primary ovarian insufficiency in long-term survivors of childhood cancer: a report from the Childhood Cancer Survivor Study and St Jude Lifetime Cohort

Author

Im, Cindy, Lu, Zhe, Mostoufi-Moab, Sogol, Delaney, Angela, Yu, Lin, Baedke, Jessica L, Han, Yutong, Sapkota, Yadav, Yasui, Yutaka, Chow, Eric J, Howell, Rebecca M, Bhatia, Smita, Hudson, Melissa M, Ness, Kirsten K, Armstrong, Gregory T, Nathan, Paul C, and Yuan, Yan

Published
2023
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25. Cancer germline predisposing variants and late mortality from subsequent malignant neoplasms among long-term childhood cancer survivors: a report from the St Jude Lifetime Cohort and the Childhood Cancer Survivor Study

Author

Chen, Cheng, Qin, Na, Wang, Mingjuan, Dong, Qian, Tithi, Saima Sultana, Hui, Yawei, Chen, Wenan, Wu, Gang, Kennetz, Dennis, Edmonson, Michael N, Rusch, Michael C, Thrasher, Andrew, Easton, John, Mulder, Heather L, Song, Nan, Plonski, Noel-Marie, Shelton, Kyla, Im, Cindy, Ehrhardt, Matthew J, Nichols, Kim E, Leisenring, Wendy M, Stratton, Kayla L, Howell, Rebecca, Yasui, Yutaka, Bhatia, Smita, Armstrong, Gregory T, Ness, Kirsten K, Hudson, Melissa M, Zhang, Jinghui, Wang, Hui, Srivastava, Deo Kumar, Robison, Leslie L, and Wang, Zhaoming

Published
2023
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26. Childhood cancer survivorship care during the COVID-19 pandemic: an international report of practice implications and provider concerns

Author

van den Oever, Selina R., Pluijm, Saskia M. F., Skinner, Rod, Glaser, Adam, Mulder, Renée L., Armenian, Saro, Bardi, Edit, Berger, Claire, Ehrhardt, Matthew J., Gilleland Marchak, Jordan, Haeusler, Gabrielle M., Hartogh, Jaap den, Hjorth, Lars, Kepak, Tomas, Kriviene, Izolda, Langer, Thorsten, Maeda, Miho, Márquez-Vega, Catalina, Michel, Gisela, Muraca, Monica, Najib, Mohamed, Nathan, Paul C., Panasiuk, Anna, Prasad, Maya, Roganovic, Jelena, Uyttebroeck, Anne, Winther, Jeanette F., Zadravec Zaletel, Lorna, van Dalen, Elvira C., van der Pal, Helena J. H., Hudson, Melissa M., and Kremer, Leontien C. M.

Published
2022
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30. Specific causes of excess late mortality and association with modifiable risk factors among survivors of childhood cancer: a report from the Childhood Cancer Survivor Study cohort

Author

Dixon, Stephanie B, Liu, Qi, Chow, Eric J, Oeffinger, Kevin C, Nathan, Paul C, Howell, Rebecca M, Leisenring, Wendy M, Ehrhardt, Matthew J, Ness, Kirsten K, Krull, Kevin R, Mertens, Ann C, Hudson, Melissa M, Robison, Leslie L, Yasui, Yutaka, and Armstrong, Gregory T

Published
2023
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37. Recommendations for the surveillance of mental health problems in childhood, adolescent, and young adult cancer survivors: a report from the International Late Effects of Childhood Cancer Guideline Harmonization Group

Author

Marchak, Jordan Gilleland, Christen, Salome, Mulder, Renée L, Baust, Katja, Blom, Johanna M C, Brinkman, Tara M, Elens, Iris, Harju, Erika, Kadan-Lottick, Nina S, Khor, Joel W T, Lemiere, Jurgen, Recklitis, Christopher J, Wakefield, Claire E, Wiener, Lori, Constine, Louis S, Hudson, Melissa M, Kremer, Leontien C M, Skinner, Roderick, Vetsch, Janine, Lee, Jennifer L, and Michel, Gisela

Published
2022
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40. Genome-wide association study of posttraumatic stress disorder among childhood cancer survivors: results from the Childhood Cancer Survivor Study and the St. Jude Lifetime Cohort

Author

Lu, Donghao, Sapkota, Yadav, Valdimarsdóttir, Unnur A., Koenen, Karestan C., Li, Nan, Leisenring, Wendy M., Gibson, Todd, Wilson, Carmen L., Robison, Leslie L., Hudson, Melissa M., Armstrong, Gregory T., Krull, Kevin R., Yasui, Yutaka, Bhatia, Smita, and Recklitis, Christopher J.

Published
2022
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41. Estimating transition intensity rate on interval-censored data using semi-parametric with EM algorithm approach.

Author

Qian, Chen, Srivastava, Deo Kumar, Pan, Jianmin, Hudson, Melissa M., and Rai, Shesh N.

Subjects
EXPECTATION-maximization algorithms, CENSORING (Statistics), PARAMETRIC modeling, CHILDHOOD cancer, CARDIOTOXICITY, PARAMETER estimation
Abstract

Phase IV clinical trials are designed to monitor long-term side effects of medical treatment. For instance, childhood cancer survivors treated with chest radiation and/or anthracycline are often at risk of developing cardiotoxicity during their adulthood. Often the primary focus of a study could be on estimating the cumulative incidence of a particular outcome of interest such as cardiotoxicity. However, it is challenging to evaluate patients continuously and usually, this information is collected through cross-sectional surveys by following patients longitudinally. This leads to interval-censored data since the exact time of the onset of the toxicity is unknown. Rai et al. computed the transition intensity rate using a parametric model and estimated parameters using maximum likelihood approach in an illness-death model. However, such approach may not be suitable if the underlying parametric assumptions do not hold. This manuscript proposes a semi-parametric model, with a logit relationship for the treatment intensities in two groups, to estimate the transition intensity rates within the context of an illness-death model. The estimation of the parameters is done using an EM algorithm with profile likelihood. Results from the simulation studies suggest that the proposed approach is easy to implement and yields comparable results to the parametric model. [ABSTRACT FROM AUTHOR]

Published
2024
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42. Post‐diagnosis dietary factors, supplement use and colorectal cancer prognosis: A Global Cancer Update Programme (CUP Global) systematic literature review and meta‐analysis.

Author

Chan, Doris S. M., Cariolou, Margarita, Markozannes, Georgios, Balducci, Katia, Vieira, Rita, Kiss, Sonia, Becerra‐Tomás, Nerea, Aune, Dagfinn, Greenwood, Darren C., González‐Gil, Esther M., Copson, Ellen, Renehan, Andrew G., Bours, Martijn, Demark‐Wahnefried, Wendy, Hudson, Melissa M., May, Anne M., Odedina, Folakemi T., Skinner, Roderick, Steindorf, Karen, and Tjønneland, Anne

Subjects
COLORECTAL cancer, CANCER prognosis, DIETARY patterns, PEANUT allergy, CANCER of unknown primary origin, OMEGA-3 fatty acids, UNSATURATED fatty acids
Abstract

The role of diet in colorectal cancer prognosis is not well understood and specific lifestyle recommendations are lacking. We searched for randomised controlled trials (RCTs) and longitudinal observational studies on post‐diagnosis dietary factors, supplement use and colorectal cancer survival outcomes in PubMed and Embase from inception until 28th February 2022. Random‐effects dose–response meta‐analyses were conducted when at least three studies had sufficient information. The evidence was interpreted and graded by the CUP Global independent Expert Committee on Cancer Survivorship and Expert Panel. Five RCTs and 35 observational studies were included (30,242 cases, over 8700 all‐cause and 2100 colorectal cancer deaths, 3700 progression, recurrence, or disease‐free events). Meta‐analyses, including 3–10 observational studies each, were conducted for: whole grains, nuts/peanuts, red and processed meat, dairy products, sugary drinks, artificially sweetened beverages, coffee, alcohol, dietary glycaemic load/index, insulin load/index, marine omega‐3 polyunsaturated fatty acids, supplemental calcium, circulating 25‐hydroxyvitamin D (25[OH]D) and all‐cause mortality; for alcohol, supplemental calcium, circulating 25(OH)D and colorectal cancer‐specific mortality; and for circulating 25(OH)D and recurrence/disease‐free survival. The overall evidence was graded as 'limited'. The inverse associations between healthy dietary and/or lifestyle patterns (including diets that comprised plant‐based foods), whole grains, total, caffeinated, or decaffeinated coffee and all‐cause mortality and the positive associations between unhealthy dietary patterns, sugary drinks and all‐cause mortality provided 'limited—suggestive' evidence. All other exposure‐outcome associations provided 'limited—no conclusion' evidence. Additional, well‐conducted cohort studies and carefully designed RCTs are needed to develop specific lifestyle recommendations for colorectal cancer survivors. [ABSTRACT FROM AUTHOR]

Published
2024
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43. Post‐diagnosis adiposity and colorectal cancer prognosis: A Global Cancer Update Programme (CUP Global) systematic literature review and meta‐analysis.

Author

Becerra‐Tomás, Nerea, Markozannes, Georgios, Cariolou, Margarita, Balducci, Katia, Vieira, Rita, Kiss, Sonia, Aune, Dagfinn, Greenwood, Darren C., Dossus, Laure, Copson, Ellen, Renehan, Andrew G., Bours, Martijn, Demark‐Wahnefried, Wendy, Hudson, Melissa M., May, Anne M., Odedina, Folakemi T., Skinner, Roderick, Steindorf, Karen, Tjønneland, Anne, and Velikova, Galina

Subjects
COLORECTAL cancer, CANCER prognosis, CANCER of unknown primary origin, OBESITY, WAIST-hip ratio, CANCER relapse, CLINICAL trials
Abstract

The adiposity influence on colorectal cancer prognosis remains poorly characterised. We performed a systematic review and meta‐analysis on post‐diagnosis adiposity measures (body mass index [BMI], waist circumference, waist‐to‐hip ratio, weight) or their changes and colorectal cancer outcomes. PubMed and Embase were searched through 28 February 2022. Random‐effects meta‐analyses were conducted when at least three studies had sufficient information. The quality of evidence was interpreted and graded by the Global Cancer Update Programme (CUP Global) independent Expert Committee on Cancer Survivorship and Expert Panel. We reviewed 124 observational studies (85 publications). Meta‐analyses were possible for BMI and all‐cause mortality, colorectal cancer‐specific mortality, and cancer recurrence/disease‐free survival. Non‐linear meta‐analysis indicated a reverse J‐shaped association between BMI and colorectal cancer outcomes (nadir at BMI 28 kg/m2). The highest risk, relative to the nadir, was observed at both ends of the BMI distribution (18 and 38 kg/m2), namely 60% and 23% higher risk for all‐cause mortality; 95% and 26% for colorectal cancer‐specific mortality; and 37% and 24% for cancer recurrence/disease‐free survival, respectively. The higher risk with low BMI was attenuated in secondary analyses of RCTs (compared to cohort studies), among studies with longer follow‐up, and in women suggesting potential methodological limitations and/or altered physiological state. Descriptively synthesised studies on other adiposity‐outcome associations of interest were limited in number and methodological quality. All the associations were graded as limited (likelihood of causality: no conclusion) due to potential methodological limitations (reverse causation, confounding, selection bias). Additional well‐designed observational studies and interventional trials are needed to provide further clarification. [ABSTRACT FROM AUTHOR]

Published
2024
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44. Post‐diagnosis physical activity and sedentary behaviour and colorectal cancer prognosis: A Global Cancer Update Programme (CUP Global) systematic literature review and meta‐analysis.

Author

Markozannes, Georgios, Becerra‐Tomás, Nerea, Cariolou, Margarita, Balducci, Katia, Vieira, Rita, Kiss, Sonia, Aune, Dagfinn, Greenwood, Darren C., Gunter, Marc J., Copson, Ellen, Renehan, Andrew G., Bours, Martijn, Demark‐Wahnefried, Wendy, Hudson, Melissa M., May, Anne M., Odedina, Folakemi T., Skinner, Roderick, Steindorf, Karen, Tjønneland, Anne, and Velikova, Galina

Subjects
SEDENTARY behavior, PHYSICAL activity, COLORECTAL cancer, CANCER prognosis, CANCER relapse, CANCER of unknown primary origin
Abstract

Low physical activity and high sedentary behaviour have been clearly linked with colorectal cancer development, yet data on their potential role in colorectal cancer survival is limited. Better characterisation of these relationships is needed for the development of post‐diagnosis physical activity and sedentary behaviour guidance for colorectal cancer survivors. We searched PubMed and Embase through 28 February 2022 for studies assessing post‐diagnosis physical activity, and/or sedentary behaviour in relation to all‐cause and cause‐specific mortality and recurrence after colorectal cancer diagnosis. Total and recreational physical activity were assessed overall and by frequency, duration, intensity, and volume using categorical, linear, and non‐linear dose–response random‐effects meta‐analyses. The Global Cancer Update Programme (CUP Global) independent Expert Committee on Cancer Survivorship and Expert Panel interpreted and graded the likelihood of causality. We identified 16 observational studies on 82,220 non‐overlapping patients from six countries. Physical activity was consistently inversely associated with colorectal cancer morbidity and mortality outcomes, with 13%–60% estimated reductions in risk. Sedentary behaviour was positively associated with all‐cause mortality. The evidence had methodological limitations including potential confounding, selection bias and reverse causation, coupled with a limited number of studies for most associations. The CUP Global Expert panel concluded limited‐suggestive evidence for recreational physical activity with all‐cause mortality and cancer recurrence. Total physical activity and its specific domains and dimensions, and sedentary behaviour were all graded as limited‐no conclusion for all outcomes. Future research should focus on randomised trials, while observational studies should obtain objective and repeated physical activity measures and better adjustment for confounders. [ABSTRACT FROM AUTHOR]

Published
2024
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46. Motor and sensory impairment in survivors of childhood central nervous system (CNS) tumors in the St. Jude Lifetime Cohort (SJLIFE).

Author

Rodwin, Rozalyn L., Wang, Fang, Lu, Lu, Li, Zhenghong, Srivastava, Deo Kumar, Phillips, Nicholas S., Khan, Raja B., Brinkman, Tara M., Krull, Kevin R., Boop, Frederick A., Armstrong, Gregory T., Merchant, Thomas E., Gajjar, Amar, Robison, Leslie L., Hudson, Melissa M., Kadan‐Lottick, Nina S., and Ness, Kirsten K.

Subjects
CENTRAL nervous system, PERIPHERAL neuropathy, PRICE indexes, CHILDHOOD cancer, QUALITY of life, CENTRAL nervous system tumors
Abstract

Background: Survivors of childhood central nervous system (CNS) tumors can develop motor and sensory impairment from their cancer and treatment history. We estimated the prevalence of motor and sensory impairment in survivors compared with controls through clinical assessment and identified associated treatment exposures and functional, quality of life (QOL), and social outcomes. Methods: Survivors of childhood CNS tumors from the St. Jude Lifetime Cohort (n = 378, median [range] age 24.0 [18.0–53.0] years, 43.4% female) ≥5 years from diagnosis and controls (n = 445, median [range] age 34.0 [18.0–70.0] years, 55.7% female) completed in‐person evaluation for motor and sensory impairment using the modified Total Neuropathy Score. Impairment was graded by modified Common Terminology Criteria for Adverse Events. Multivariable models estimated associations between grade ≥2 motor/sensory impairment, individual/treatment characteristics, and secondary outcomes (function by Physical Performance Test, fitness by physiologic cost index, QOL by Medical Outcomes Survey Short Form‐36 physical/mental summary scores, social attainment). Results: Grade ≥2 motor or sensory impairment was more prevalent in survivors (24.1%, 95% Confidence Interval [CI] 19.8%–29.4%) than controls (2.9%, CI 1.4–4.5%). Among survivors, in multivariable models, motor impairment was associated with vinca exposure <15 mg/m2 versus none (OR 4.38, CI 1.06–18.08) and etoposide exposure >2036 mg/m2 versus none (OR 12.61, CI 2.19–72.72). Sensory impairment was associated with older age at diagnosis (OR 1.09, CI 1.01–1.16) and craniospinal irradiation versus none (OR 4.39, CI 1.68–11.50). There were lower odds of motor/sensory impairment in survivors treated in the year 2000 or later versus before 1990 (Motor: OR 0.29, CI 0.10–0.84, Sensory: OR 0.35, CI 0.13–0.96). Motor impairment was associated with impaired physical QOL (OR 2.64, CI 1.22–5.72). Conclusions: In survivors of childhood CNS tumors, motor and sensory impairment is prevalent by clinical assessment, especially after exposure to etoposide, vinca, or craniospinal radiation. Treating motor impairment may improve survivors' QOL. [ABSTRACT FROM AUTHOR]

Published
2024
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47. Trans-Ancestral Genetic Risk Factors for Treatment-Related Type 2 Diabetes Mellitus in Survivors of Childhood Cancer.

Author

Im, Cindy, Neupane, Achal, Baedke, Jessica L., Lenny, Brian, Delaney, Angela, Dixon, Stephanie B., Chow, Eric J., Mostoufi-Moab, Sogol, Yang, Tianzhong, Richard, Melissa A., Gramatges, M. Monica, Lupo, Philip J., Sharafeldin, Noha, Bhatia, Smita, Armstrong, Gregory T., Hudson, Melissa M., Ness, Kirsten K., Robison, Leslie L., Yasui, Yutaka, and Wilson, Carmen L.

Published
2024
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48. Estimation of Personal Symptom Networks Using the Ising Model for Adult Survivors of Childhood Cancer: A Simulation Study with Real-World Data Application.

Author

Zhou, Yiwang, Horan, Madeline R, Deshpande, Samira, Ness, Kirsten K, Hudson, Melissa M, Huang, I-Chan, and Srivastava, Deokumar

Subjects
ISING model, INCOME, CHILDHOOD cancer, FATIGUE (Physiology), CANCER survivors
Abstract

Purpose: Childhood cancer survivors experience interconnected symptoms, patterns of which can be elucidated by network analysis. However, current symptom networks are constructed based on the average survivors without considering individual heterogeneities. We propose to evaluate personal symptom network estimation using the Ising model with covariates through simulations and estimate personal symptom network for adult childhood cancer survivors. Patients and Methods: We adopted the Ising model with covariates to construct networks by employing logistic regressions for estimating associations between binary symptoms. Simulation experiments assessed the robustness of this method in constructing personal symptom network. Real-world data illustration included 1708 adult childhood cancer survivors from the St. Jude Lifetime Cohort Study (SJLIFE), a retrospective cohort study with prospective follow-up to characterize the etiology and late effects for childhood cancer survivors. Patients' baseline symptoms in 10 domains (cardiac, pulmonary, sensation, nausea, movement, pain, memory, fatigue, anxiety, depression) and individual characteristics (age, sex, race/ethnicity, attained education, personal income, and marital status) were self-reported using survey. Treatment variables (any chemo or radiation therapy) were obtained from medical records. Personal symptom network of 10 domains was estimated using the Ising model, incorporating individual characteristics and treatment data. Results: Simulations confirmed the robustness of the Ising model with covariates in constructing personal symptom networks. Real-world data analysis identified age, sex, race/ethnicity, education, marital status, and treatment (any chemo and radiation therapy) as major factors influencing symptom co-occurrence. Older childhood cancer survivors showed stronger cardiac-fatigue associations. Survivors of racial/ethnic minorities had stronger pain-fatigue associations. Female survivors with above-college education demonstrated stronger pain-anxiety associations. Unmarried survivors who received radiation had stronger association between movement and memory problems. Conclusion: The Ising model with covariates accurately estimates personal symptom networks. Individual heterogeneities exist in symptom co-occurrence patterns for childhood cancer survivors. The estimated personal symptom network offers insights into interconnected symptom experiences. [ABSTRACT FROM AUTHOR]

Published
2024
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49. Health-related quality of life and DNA methylation-based aging biomarkers among survivors of childhood cancer.

Author

Plonski, Noel-Marie, Pan, Yue, Chen, Cheng, Dong, Qian, Zhang, Xijun, Song, Nan, Shelton, Kyla, Easton, John, Mulder, Heather, Zhang, Jinghui, Neale, Geoffrey, Walker, Emily, Wang, Hui, Webster, Rachel, Brinkman, Tara, Krull, Kevin R, Armstrong, Gregory T, Ness, Kirsten K, Hudson, Melissa M, and Li, Qian

Subjects
QUALITY of life, CHILDHOOD cancer, CANCER survivors, BIOMARKERS, AGING
Abstract

Background Childhood cancer survivors are at high risk for morbidity and mortality and poor patient-reported outcomes, typically health-related quality of life (HRQOL). However, associations between DNA methylation–based aging biomarkers and HRQOL have not been evaluated. Methods DNA methylation was generated with Infinium EPIC BeadChip on blood-derived DNA (median for age at blood draw = 34.5 years, range = 18.5-66.6 years), and HRQOL was assessed with age at survey (mean = 32.3 years, range = 18.4-64.5 years) from 2206 survivors in the St Jude Lifetime Cohort. DNA methylation–based aging biomarkers, including epigenetic age using multiple clocks (eg, GrimAge) and others (eg, DNAmB2M: beta-2-microglobulin; DNAmADM: adrenomedullin), were derived from the DNAm Age Calculator (https://dnamage.genetics.ucla.edu). HRQOL was assessed using the Medical Outcomes Study 36-Item Short-Form Health Survey to capture 8 domains and physical and mental component summaries. General linear models evaluated associations between HRQOL and epigenetic age acceleration (EAA; eg, EAA_GrimAge) or other age-adjusted DNA methylation–based biomarkers (eg, ageadj_DNAmB2M) after adjusting for age at blood draw, sex, cancer treatments, and DNA methylation–based surrogate for smoking pack-years. All P values were 2-sided. Results Worse HRQOL was associated with greater EAA_GrimAge (physical component summaries: β = -0.18 years, 95% confidence interval [CI] = -0.251 to -0.11 years; P  = 1.85 × 10−5; and 4 individual HRQOL domains), followed by ageadj_DNAmB2M (physical component summaries: β = -0.08 years, 95% CI = -0.124 to -0.037 years; P  = .003; and 3 individual HRQOL domains) and ageadj_DNAmADM (physical component summaries: β = -0.082 years, 95% CI = -0.125 to -0.039 years; P  = .002; and 2 HRQOL domains). EAA_Hannum (Hannum clock) was not associated with any HRQOL. Conclusions Overall and domain-specific measures of HRQOL are associated with DNA methylation measures of biological aging. Future longitudinal studies should test biological aging as a potential mechanism underlying the association between poor HRQOL and increased risk of clinically assessed adverse health outcomes. [ABSTRACT FROM AUTHOR]

Published
2024
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