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288 results on '"Hulst, Hanneke E."'

1. Don’t be late! Postponing cognitive decline and preventing early unemployment in people with multiple sclerosis: a study protocol

Author

Aarts, Jip, Saddal, Shalina R. D., Bosmans, Judith E., de Groot, Vincent, de Jong, Brigit A., Klein, Martin, Ruitenberg, Marit F. L., Schaafsma, Frederieke G., Schippers, Esther C. F., Schoonheim, Menno M., Uitdehaag, Bernard M. J., van der Veen, Sabina, Waskowiak, Pauline T., Widdershoven, Guy A. M., van der Hiele, Karin, and Hulst, Hanneke E.

Published
2024
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2. Don’t be late! Timely identification of cognitive impairment in people with multiple sclerosis: a study protocol

Author

Waskowiak, Pauline T., de Jong, Brigit A., Uitdehaag, Bernard M. J., Saddal, Shalina R. D., Aarts, Jip, Roovers, Aïda A. M., van Oirschot, Pim, de Groot, Vincent, Schaafsma, Frederieke G., van der Hiele, Karin, Ruitenberg, Marit F. L., Schoonheim, Menno M., Widdershoven, Guy A. M., van der Veen, Sabina, Schippers, Esther C. F., Klein, Martin, and Hulst, Hanneke E.

Published
2024
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8. Reconstructing unseen modalities and pathology with an efficient Recurrent Inference Machine

Author

Karkalousos, Dimitrios, Lønning, Kai, Hulst, Hanneke E., Dumoulin, Serge O., Sonke, Jan-Jakob, Vos, Frans M., and Caan, Matthan W. A.

Subjects
Electrical Engineering and Systems Science - Image and Video Processing
Abstract

Objective: To allow efficient learning using the Recurrent Inference Machine (RIM) for image reconstruction whereas not being strictly dependent on the training data distribution so that unseen modalities and pathologies are still accurately recovered. Methods: Theoretically, the RIM learns to solve the inverse problem of accelerated-MRI reconstruction whereas being robust to variable imaging conditions. The efficiency and generalization capabilities with different training datasets were studied, as well as recurrent network units with decreasing complexity: the Gated Recurrent Unit (GRU), the Minimal Gated Unit (MGU), and the Independently Recurrent Neural Network (IndRNN), to reduce inference times. Validation was performed against Compressed Sensing (CS) and further assessed based on data unseen during training. A pathology study was conducted by reconstructing simulated white matter lesions and prospectively undersampled data of a Multiple Sclerosis patient. Results: Training on a single modality of 3T $T_1$-weighted brain data appeared sufficient to also reconstruct 7T $T_{2}^*$-weighted brain and 3T $T_2$-weighted knee data. The IndRNN is an efficient recurrent unit, reducing inference time by 68\% compared to CS, whereas maintaining performance. The RIM was able to reconstruct lesions unseen during training more accurately than CS when trained on $T_2$-weighted knee data. Training on $T_1$-weighted brain data and on combined data slightly enhanced the signal compared to CS. Conclusion: The RIM is efficient when decreasing its complexity, which reduces the inference time, whereas still being able to reconstruct data and pathology that was unseen during training., Comment: 20 pages, 8 figures

Published
2020

13. Cognitive phenotypes predict response to restorative cognitive rehabilitation in multiple sclerosis.

Author

Ziccardi, Stefano, Fuchs, Tom, Dwyer, Michael G, Zivadinov, Robert, Hulst, Hanneke E, Calabrese, Massimiliano, and Benedict, Ralph HB

Subjects
COGNITIVE rehabilitation, MULTIPLE sclerosis, NEUROPSYCHOLOGICAL rehabilitation, COGNITION, EXECUTIVE function, PHENOTYPES
Abstract

Background: Cognitive phenotyping may be useful for predicting rehabilitation response in multiple sclerosis. Objective: To evaluate the association between cognitive phenotype(s) and response to restorative cognitive rehabilitation (RRCR). Methods: In a post hoc retrospective analysis of the RRCR study including 51 multiple sclerosis patients, we evaluated both impairment within specific cognitive domains as well as overall global impairment severity to investigate their relationship to improvement following rehabilitation. Results: Greater improvement in executive function was predicted by impairment within this domain as well as by having fewer impaired cognitive domains overall. Similar results were observed for visuospatial memory. Conclusions: Patients most likely to benefit from restorative cognitive rehabilitation may exhibit impairment within the domain of interest yet lower cognitive burden overall. [ABSTRACT FROM AUTHOR]

Published
2024
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16. The hippocampus in multiple sclerosis

Author

Barkhof, Frederik, Ciccarelli, Olga, De Stefano, Nicola, Enzinger, Christian, Filippi, Massimo, Frederiksen, Jette L., Gasperini, Claudio, Kappos, Ludwig, Palace, Jacqueline, Rocca, Maria A., Rovira, Alex, Sastre-Garriga, Jaume, Vrenken, Hugo, Yousry, Tarek A., Rocca, Maria A, De Luca, John, Frisén, Jonas, Geurts, Jeroen J G, and Hulst, Hanneke E

Published
2018
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17. Neurobiological basis and risk factors of persistent fatigue and concentration problems after COVID-19: study protocol for a prospective case–control study (VeCosCO)

Author

Verveen, Anouk, primary, Verfaillie, Sander C J, additional, Visser, Denise, additional, Csorba, Irene, additional, Coomans, Emma M, additional, Koch, Dook W, additional, Appelman, Brent, additional, Barkhof, Frederik, additional, Boellaard, Ronald, additional, de Bree, Godelieve, additional, van de Giessen, Elsmarieke M, additional, Golla, Sandeep, additional, van Heugten, Caroline M, additional, Horn, Janneke, additional, Hulst, Hanneke E, additional, de Jong, Menno D, additional, Kuut, Tanja A, additional, van der Maaden, Tessa, additional, van Os, Yvonne M G, additional, Prins, Maria, additional, Slooter, Arjen J C, additional, Visser-Meily, Johanna M A, additional, van Vugt, Michele, additional, van den Wijngaard, Cees C, additional, Nieuwkerk, P T, additional, Knoop, H, additional, Tolboom, Nelleke, additional, and van Berckel, Bart N M, additional

Published
2023
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19. Cognitive performance in multiple sclerosis: what is the role of the GABAergic system?

Author

Huiskamp, Marijn, primary, Yaqub, Maqsood, additional, van Lingen, Marike R, additional, Pouwels, Petra J W, additional, de Ruiter, Lodewijk R J, additional, Killestein, Joep, additional, Schwarte, Lothar A, additional, Golla, Sandeep S V, additional, van Berckel, Bart N M, additional, Boellaard, Ronald, additional, Geurts, Jeroen J G, additional, and Hulst, Hanneke E, additional

Published
2023
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20. Neurobiological basis and risk factors of persistent fatigue and concentration problems after COVID-19: study protocol for a prospective case-control study (VeCosCO)

Author

AIOS Psychiatrie, Brain, RF&S Revalidatie, Fysiotherapie & Sport, Revalidatie Medisch Volwassenen, Circulatory Health, MS Radiologie, Cancer, Onderzoek, Verveen, Anouk, Verfaillie, Sander C J, Visser, Denise, Csorba, Irene, Coomans, Emma M, Koch, Dook W, Appelman, Brent, Barkhof, Frederik, Boellaard, Ronald, de Bree, Godelieve, van de Giessen, Elsmarieke M, Golla, Sandeep, van Heugten, Caroline M, Horn, Janneke, Hulst, Hanneke E, de Jong, Menno D, Kuut, Tanja A, van der Maaden, Tessa, van Os, Yvonne M G, Prins, Maria, Slooter, Arjen J C, Visser-Meily, Johanna M A, van Vugt, Michele, van den Wijngaard, Cees C, Nieuwkerk, P T, Knoop, H, Tolboom, Nelleke, van Berckel, Bart N M, AIOS Psychiatrie, Brain, RF&S Revalidatie, Fysiotherapie & Sport, Revalidatie Medisch Volwassenen, Circulatory Health, MS Radiologie, Cancer, Onderzoek, Verveen, Anouk, Verfaillie, Sander C J, Visser, Denise, Csorba, Irene, Coomans, Emma M, Koch, Dook W, Appelman, Brent, Barkhof, Frederik, Boellaard, Ronald, de Bree, Godelieve, van de Giessen, Elsmarieke M, Golla, Sandeep, van Heugten, Caroline M, Horn, Janneke, Hulst, Hanneke E, de Jong, Menno D, Kuut, Tanja A, van der Maaden, Tessa, van Os, Yvonne M G, Prins, Maria, Slooter, Arjen J C, Visser-Meily, Johanna M A, van Vugt, Michele, van den Wijngaard, Cees C, Nieuwkerk, P T, Knoop, H, Tolboom, Nelleke, and van Berckel, Bart N M

Published
2023

22. sj-pdf-5-msj-10.1177_13524585231159817 – Supplemental material for Neurophysiological MEG markers of cognitive impairment and performance validity in multiple sclerosis

Author

Simon, Shira, Nauta, Ilse M, Hillebrand, Arjan, Schoonheim, Menno M, Uitdehaag, Bernard MJ, van Dam, Maureen, Hulst, Hanneke E, Klein, Martin, Stam, Cornelis J, de Jong, Brigit A, and Strijbis, Eva MM

Subjects
FOS: Clinical medicine, 111702 Aged Health Care, FOS: Health sciences, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, sj-pdf-5-msj-10.1177_13524585231159817 for Neurophysiological MEG markers of cognitive impairment and performance validity in multiple sclerosis by Shira Simon, Ilse M Nauta, Arjan Hillebrand, Menno M Schoonheim, Bernard MJ Uitdehaag, Maureen van Dam, Hanneke E Hulst, Martin Klein, Cornelis J Stam, Brigit A de Jong and Eva MM Strijbis in Multiple Sclerosis Journal

Published
2023
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23. sj-docx-3-msj-10.1177_13524585231159817 – Supplemental material for Neurophysiological MEG markers of cognitive impairment and performance validity in multiple sclerosis

Author

Simon, Shira, Nauta, Ilse M, Hillebrand, Arjan, Schoonheim, Menno M, Uitdehaag, Bernard MJ, van Dam, Maureen, Hulst, Hanneke E, Klein, Martin, Stam, Cornelis J, de Jong, Brigit A, and Strijbis, Eva MM

Subjects
FOS: Clinical medicine, 111702 Aged Health Care, FOS: Health sciences, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, sj-docx-3-msj-10.1177_13524585231159817 for Neurophysiological MEG markers of cognitive impairment and performance validity in multiple sclerosis by Shira Simon, Ilse M Nauta, Arjan Hillebrand, Menno M Schoonheim, Bernard MJ Uitdehaag, Maureen van Dam, Hanneke E Hulst, Martin Klein, Cornelis J Stam, Brigit A de Jong and Eva MM Strijbis in Multiple Sclerosis Journal

Published
2023
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24. sj-docx-1-msj-10.1177_13524585231159817 – Supplemental material for Neurophysiological MEG markers of cognitive impairment and performance validity in multiple sclerosis

Author

Simon, Shira, Nauta, Ilse M, Hillebrand, Arjan, Schoonheim, Menno M, Uitdehaag, Bernard MJ, van Dam, Maureen, Hulst, Hanneke E, Klein, Martin, Stam, Cornelis J, de Jong, Brigit A, and Strijbis, Eva MM

Subjects
FOS: Clinical medicine, 111702 Aged Health Care, FOS: Health sciences, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, sj-docx-1-msj-10.1177_13524585231159817 for Neurophysiological MEG markers of cognitive impairment and performance validity in multiple sclerosis by Shira Simon, Ilse M Nauta, Arjan Hillebrand, Menno M Schoonheim, Bernard MJ Uitdehaag, Maureen van Dam, Hanneke E Hulst, Martin Klein, Cornelis J Stam, Brigit A de Jong and Eva MM Strijbis in Multiple Sclerosis Journal

Published
2023
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25. sj-pdf-6-msj-10.1177_13524585231159817 – Supplemental material for Neurophysiological MEG markers of cognitive impairment and performance validity in multiple sclerosis

Author

Simon, Shira, Nauta, Ilse M, Hillebrand, Arjan, Schoonheim, Menno M, Uitdehaag, Bernard MJ, van Dam, Maureen, Hulst, Hanneke E, Klein, Martin, Stam, Cornelis J, de Jong, Brigit A, and Strijbis, Eva MM

Subjects
FOS: Clinical medicine, 111702 Aged Health Care, FOS: Health sciences, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, sj-pdf-6-msj-10.1177_13524585231159817 for Neurophysiological MEG markers of cognitive impairment and performance validity in multiple sclerosis by Shira Simon, Ilse M Nauta, Arjan Hillebrand, Menno M Schoonheim, Bernard MJ Uitdehaag, Maureen van Dam, Hanneke E Hulst, Martin Klein, Cornelis J Stam, Brigit A de Jong and Eva MM Strijbis in Multiple Sclerosis Journal

Published
2023
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26. sj-docx-4-msj-10.1177_13524585231159817 – Supplemental material for Neurophysiological MEG markers of cognitive impairment and performance validity in multiple sclerosis

Author

Simon, Shira, Nauta, Ilse M, Hillebrand, Arjan, Schoonheim, Menno M, Uitdehaag, Bernard MJ, van Dam, Maureen, Hulst, Hanneke E, Klein, Martin, Stam, Cornelis J, de Jong, Brigit A, and Strijbis, Eva MM

Subjects
FOS: Clinical medicine, 111702 Aged Health Care, FOS: Health sciences, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, sj-docx-4-msj-10.1177_13524585231159817 for Neurophysiological MEG markers of cognitive impairment and performance validity in multiple sclerosis by Shira Simon, Ilse M Nauta, Arjan Hillebrand, Menno M Schoonheim, Bernard MJ Uitdehaag, Maureen van Dam, Hanneke E Hulst, Martin Klein, Cornelis J Stam, Brigit A de Jong and Eva MM Strijbis in Multiple Sclerosis Journal

Published
2023
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28. Neurophysiological MEG markers of cognitive impairment and performance validity in multiple sclerosis.

Author

Simon, Shira, Nauta, Ilse M, Hillebrand, Arjan, Schoonheim, Menno M, Uitdehaag, Bernard MJ, van Dam, Maureen, Hulst, Hanneke E, Klein, Martin, Stam, Cornelis J, de Jong, Brigit A, and Strijbis, Eva MM

Subjects
TEST validity, COGNITION disorders, MULTIPLE sclerosis, COGNITIVE ability, NEUROPSYCHOLOGICAL tests, COGNITIVE testing, NEUROPSYCHOLOGICAL rehabilitation
Abstract

Background: Suboptimal performance during neuropsychological testing frequently occurs in multiple sclerosis (MS), leading to unreliable cognitive outcomes. Neurophysiological alterations correlate with MS-related cognitive impairment, but studies have not yet considered performance validity. Objectives: To investigate neurophysiological markers of cognitive impairment in MS, while explicitly addressing performance validity. Methods: Magnetoencephalography recordings, neuropsychological assessments, and performance validity testing were obtained from 90 MS outpatients with cognitive complaints. Spectral and resting-state functional connectivity (rsFC) properties were compared between cognitively impaired (CI), cognitively preserved (CP), and suboptimally performing (SUB) patients using regression models and permutation testing. Results: CI had higher power in low-frequency bands and lower power in high bands compared to CP, indicating neuronal slowing. CI also showed lower beta power compared to SUB. Overall power spectra visually differed between CI and CP, and SUB showed overlap with both groups. CI had lower rsFC than CP and SUB patients. CP and SUB patients showed no differences. Conclusion: Neuronal slowing and altered rsFC can be considered cognitive markers in MS. Patients who performed suboptimally showed resemblance with patients with and without cognitive impairments, and although their overall neurophysiological profile was more similar to patients without impairments, it suggests heterogeneity regarding their pathophysiology. [ABSTRACT FROM AUTHOR]

Published
2023
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30. A randomized trial predicting response to cognitive rehabilitation in multiple sclerosis: Is there a window of opportunity?

Author

Prouskas, Stefanos E, Schoonheim, Menno M, Huiskamp, Marijn, Steenwijk, Martijn D, Gehring, Karin, Barkhof, Frederik, de Jong, Brigit A, Sitskoorn, Margriet M, Geurts, Jeroen J.G., Hulst, Hanneke E, Prouskas, Stefanos E, Schoonheim, Menno M, Huiskamp, Marijn, Steenwijk, Martijn D, Gehring, Karin, Barkhof, Frederik, de Jong, Brigit A, Sitskoorn, Margriet M, Geurts, Jeroen J.G., and Hulst, Hanneke E

Abstract

Background: Cognitive training elicits mild-to-moderate improvements in cognitive functioning in people with multiple sclerosis (PwMS), although response heterogeneity limits overall effectiveness.Objective: To identify patient characteristics associated with response and non-response to cognitive training.Methods: Eighty-two PwMS were randomized into a 7-week attention training ( n = 58, age = 48.4 ± 10.2 years) or a waiting-list control group ( n = 24, age = 48.5 ± 9.4 years). Structural and functional magnetic resonance imaging (MRI) was obtained at baseline and post-intervention. Twenty-one healthy controls (HCs, age = 50.27 ± 10.15 years) were included at baseline. Responders were defined with a reliable change index of 1.64 on at least 2/6 cognitive domains. General linear models and logistic regression were applied. Results: Responders ( n = 36) and non-responders ( n = 22) did not differ on demographics, clinical variables and baseline cognition and structural MRI. However, non-responders exhibited a higher baseline functional connectivity (FC) between the default-mode network (DMN) and the ventral attention network (VAN), compared with responders ( p = 0.018) and HCs ( p = 0.001). Conversely, responders exhibited no significant baseline differences in FC compared with HCs. Response to cognitive training was predicted by lower DMN-VAN FC ( p = 0.004) and DMN-frontoparietal FC ( p = 0.029) (Nagelkerke R 2 = 0.25). Conclusion: An intact pre-intervention FC is associated with cognitive training responsivity in pwMS, suggesting a window of opportunity for successful cognitive interventions.

Published
2022

32. miR-150-5p and let-7b-5p in Blood Myeloid Extracellular Vesicles Track Cognitive Symptoms in Patients with Multiple Sclerosis

Author

Scaroni, Federica, primary, Visconte, Caterina, additional, Serpente, Maria, additional, Golia, Maria Teresa, additional, Gabrielli, Martina, additional, Huiskamp, Marijn, additional, Hulst, Hanneke E., additional, Carandini, Tiziana, additional, De Riz, Milena, additional, Pietroboni, Anna, additional, Rotondo, Emanuela, additional, Scarpini, Elio, additional, Galimberti, Daniela, additional, Teunissen, Charlotte E., additional, van Dam, Maureen, additional, de Jong, Brigit A., additional, Fenoglio, Chiara, additional, and Verderio, Claudia, additional

Published
2022
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34. sj-docx-1-msj-10.1177_13524585221103134 – Supplemental material for A randomized trial predicting response to cognitive rehabilitation in multiple sclerosis: Is there a window of opportunity?

Author

Prouskas, Stefanos E, Schoonheim, Menno M, Huiskamp, Marijn, Steenwijk, Martijn D, Gehring, Karin, Barkhof, Frederik, de Jong, Brigit A, Sitskoorn, Margriet M, Geurts, Jeroen JG, and Hulst, Hanneke E

Subjects
FOS: Clinical medicine, 111702 Aged Health Care, FOS: Health sciences, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, sj-docx-1-msj-10.1177_13524585221103134 for A randomized trial predicting response to cognitive rehabilitation in multiple sclerosis: Is there a window of opportunity? by Stefanos E Prouskas, Menno M Schoonheim, Marijn Huiskamp, Martijn D Steenwijk, Karin Gehring, Frederik Barkhof, Brigit A de Jong, Margriet M Sitskoorn, Jeroen JG Geurts and Hanneke E Hulst in Multiple Sclerosis Journal

Published
2022
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35. sj-docx-1-msj-10.1177_13524585221125381 – Supplemental material for Inhibitory synaptic loss drives network changes in multiple sclerosis: An ex vivo to in silico translational study

Author

Huiskamp, Marijn, Kiljan, Svenja, Kulik, Shanna, Witte, Maarteen E, Jonkman, Laura E, GJM Bol, John, Schenk, Geert J, Hulst, Hanneke E, Tewarie, Prejaas, Schoonheim, Menno M, and Geurts, Jeroen JG

Subjects
FOS: Clinical medicine, 111702 Aged Health Care, FOS: Health sciences, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, sj-docx-1-msj-10.1177_13524585221125381 for Inhibitory synaptic loss drives network changes in multiple sclerosis: An ex vivo to in silico translational study by Marijn Huiskamp, Svenja Kiljan, Shanna Kulik, Maarteen E Witte, Laura E Jonkman, John GJM Bol, Geert J Schenk, Hanneke E Hulst, Prejaas Tewarie, Menno M Schoonheim and Jeroen JG Geurts in Multiple Sclerosis Journal

Published
2022
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36. Structural MRI correlates of cognitive impairment in patients with multiple sclerosis: A Multicenter Study

Author

Preziosa, Paolo, Rocca, Maria A., Pagani, Elisabetta, Stromillo, Maria Laura, Enzinger, Christian, Gallo, Antonio, Hulst, Hanneke E., Atzori, Matteo, Pareto, Deborah, Riccitelli, Gianna C., Copetti, Massimiliano, De Stefano, Nicola, Fazekas, Franz, Bisecco, Alvino, Barkhof, Frederik, Yousry, Tarek A., Arévalo, Maria J., and Filippi, Massimo

Published
2016
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37. Functional network dynamics and decreased conscientiousness in multiple sclerosis

Author

Fuchs, Tom A., primary, Schoonheim, Menno M., additional, Broeders, Tommy A. A., additional, Hulst, Hanneke E., additional, Weinstock-Guttman, Bianca, additional, Jakimovski, Dejan, additional, Silver, Jacob, additional, Zivadinov, Robert, additional, Geurts, Jeroen J. G., additional, Dwyer, Michael G., additional, and Benedict, Ralph H. B., additional

Published
2021
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45. sj-docx-2-msj-10.1177_13524585211030212 – Supplemental material for Functional connectivity in multiple sclerosis modelled as connectome stability: A 5-year follow-up study

Author

Høgestøl, Einar August, Ghezzo, Samuele, Nygaard, Gro Owren, Espeseth, Thomas, Sowa, Piotr, Beyer, Mona K, Harbo, Hanne Flinstad, Westlye, Lars T, Hulst, Hanneke E, and Alnæs, Dag

Subjects
FOS: Clinical medicine, 111702 Aged Health Care, FOS: Health sciences, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, sj-docx-2-msj-10.1177_13524585211030212 for Functional connectivity in multiple sclerosis modelled as connectome stability: A 5-year follow-up study by Einar August Høgestøl, Samuele Ghezzo, Gro Owren Nygaard, Thomas Espeseth, Piotr Sowa, Mona K Beyer, Hanne Flinstad Harbo, Lars T Westlye, Hanneke E Hulst and Dag Alnæs in Multiple Sclerosis Journal

Published
2021
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46. sj-pdf-1-mso-10.1177_20552173211038027 - Supplemental material for Cognitive functioning in everyday life: The development of a questionnaire on instrumental activities of daily living in multiple sclerosis

Author

van Dam, Maureen, Sikkes, Sietske AM, Rammeloo, Emma, Reinders, Evy, Jelgerhuis, Julia R, Geurts, Jeroen JG, Uitdehaag, Bernhard MJ, and Hulst, Hanneke E

Subjects
FOS: Clinical medicine, 110904 Neurology and Neuromuscular Diseases, Neuroscience
Abstract

Supplemental material, sj-pdf-1-mso-10.1177_20552173211038027 for Cognitive functioning in everyday life: The development of a questionnaire on instrumental activities of daily living in multiple sclerosis by Maureen van Dam Sietske AM Sikkes Hanneke E Hulst in Multiple Sclerosis Journal – Experimental, Translational and Clinical

Published
2021
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47. sj-docx-1-mso-10.1177_20552173211064473 - Supplemental material for Feasibility of cognitive rehabilitation in patients with advanced multiple sclerosis: A pilot study

Author

Prouskas, Stefanos E, Chiaravalloti, Nancy D, Kant, Neeltje, Ball, Karlene K, de Groot, Vincent, Uitdehaag, Bernard MJ, Geurts, Jeroen JG, Kooij, Elizabeth A, and Hulst, Hanneke E

Subjects
FOS: Clinical medicine, 110904 Neurology and Neuromuscular Diseases, Neuroscience
Abstract

Supplemental material, sj-docx-1-mso-10.1177_20552173211064473 for Feasibility of cognitive rehabilitation in patients with advanced multiple sclerosis: A pilot study by Stefanos E Prouskas, Nancy D Chiaravalloti, Neeltje Kant, Karlene K Ball, Vincent de Groot, Bernard MJ Uitdehaag, Jeroen JG Geurts, Elizabeth A Kooij and Hanneke E Hulst in Multiple Sclerosis Journal ��� Experimental, Translational and Clinical

Published
2021
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48. sj-docx-1-msj-10.1177_13524585211030212 – Supplemental material for Functional connectivity in multiple sclerosis modelled as connectome stability: A 5-year follow-up study

Author

Høgestøl, Einar August, Ghezzo, Samuele, Nygaard, Gro Owren, Espeseth, Thomas, Sowa, Piotr, Beyer, Mona K, Harbo, Hanne Flinstad, Westlye, Lars T, Hulst, Hanneke E, and Alnæs, Dag

Subjects
FOS: Clinical medicine, 111702 Aged Health Care, FOS: Health sciences, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, sj-docx-1-msj-10.1177_13524585211030212 for Functional connectivity in multiple sclerosis modelled as connectome stability: A 5-year follow-up study by Einar August Høgestøl, Samuele Ghezzo, Gro Owren Nygaard, Thomas Espeseth, Piotr Sowa, Mona K Beyer, Hanne Flinstad Harbo, Lars T Westlye, Hanneke E Hulst and Dag Alnæs in Multiple Sclerosis Journal

Published
2021
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49. Manual and automated tissue segmentation confirm the impact of thalamus atrophy on cognition in multiple sclerosis: A multicenter study

Author

Burggraaff, Jessica, Liu, Yao, Prieto, Juan C., Simoes, Jorge, de Sitter, Alexandra, Ruggieri, Serena, Brouwer, Iman, Lissenberg-Witte, Birgit I., Rocca, Mara A., Valsasina, Paola, Ropele, Stefan, Gasperini, Claudio, Gallo, Antonio, Pareto, Deborah, Sastre-Garriga, Jaume, Enzinger, Christian, Filippi, Massimo, De Stefano, Nicola, Ciccarelli, Olga, Hulst, Hanneke E., Wattjes, Mike P., Barkhof, Frederik, Uitdehaag, Bernard M. J., Vrenken, Hugo, Guttmann, Charles R. G., Universitat Autònoma de Barcelona, Neurology, Amsterdam Neuroscience - Neuroinfection & -inflammation, Radiology and nuclear medicine, Amsterdam Neuroscience - Brain Imaging, Epidemiology and Data Science, Anatomy and neurosciences, Other Research, APH - Methodology, UCL - (SLuc) Centre du cancer, UCL - (SLuc) Service de chirurgie et transplantation abdominale, UCL - SSS/IREC/CHEX - Pôle de chirgurgie expérimentale et transplantation, Institut Català de la Salut, [Burggraaff J, Simoes J] Department of Neurology, MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Location VUmc, De Boelelaan 1117, 1118, 1081 HV Amsterdam, The Netherlands. [Liu Y, de Sitter A] Department of Radiology and Nuclear Medicine, MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Location VUmc, De Boelelaan 1117, 1118, 1081 HV Amsterdam, The Netherlands. [Prieto JC] Center for Neurological Imaging, Department of Radiology, Brigham and Women’s Hospital, Harvard Medical School, 1249 Boylston Street, Boston, MA 02215, USA. [Ruggieri S] Department of Human Neurosciences, 'Sapienza' University of Rome, Piazzale Aldo Moro, 5, 00185 Roma RM, Italy. Department of Neurosciences, San Camillo Forlanini Hospital, Circonvallazione Gianicolense, 87, 00152 Roma RM, Italy. [Pareto D] Secció de Neuroradiologia, Unitat de Ressonància Magnètica, Departament de Radiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Sastre-Garriga J] Servei de Neurologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain, Vall d'Hebron Barcelona Hospital Campus, Burggraaff, J., Liu, Y., Prieto, J. C., Simoes, J., de Sitter, A., Ruggieri, S., Brouwer, I., Lissenberg-Witte, B. I., Rocca, M. A., Valsasina, P., Ropele, S., Gasperini, C., Gallo, A., Pareto, D., Sastre-Garriga, J., Enzinger, C., Filippi, M., De Stefano, N., Ciccarelli, O., Hulst, H. E., Wattjes, M. P., Barkhof, F., Uitdehaag, B. M. J., Vrenken, H., and Guttmann, C. R. G.

Subjects
WLG, Word List Generation, SPM12, Statistical Parametric Mapping 12, Audiology, Tàlem - Imatgeria, Etiv, estimated total intracranial volume, lcsh:RC346-429, Otros calificadores::Otros calificadores::/complicaciones [Otros calificadores], GIF, Geodesic Information Flows, 0302 clinical medicine, Cognition, Segmentation, Thalamus, CP, cognitively preserved, NBV, Normalized brain volume, Multiple Sclerosi, Other subheadings::/diagnosis [Other subheadings], Neuropsychological assessment, Cognitive decline, Generalized estimating equation, WMV, white matter volume, ICC, intraclass correlation coefficient, medicine.diagnostic_test, 05 social sciences, Nervous System Diseases::Autoimmune Diseases of the Nervous System::Demyelinating Autoimmune Diseases, CNS::Multiple Sclerosis [DISEASES], sistema nervioso::sistema nervioso central::encéfalo::prosencéfalo::diencéfalo::tálamo [ANATOMÍA], Regular Article, Neuropsychological test, HC, healthy control, SDMT, Symbol Digit Modalities Test, Magnetic Resonance Imaging, Neurology, PASAT, Paced Auditory Serial Addition Test, enfermedades del sistema nervioso::enfermedades autoinmunitarias del sistema nervioso::enfermedades autoinmunes desmielinizantes del SNC::esclerosis múltiple [ENFERMEDADES], lcsh:R858-859.7, VolBrain, MRI Brain Volumetry System, SRT, Selective Reminding Test, Human, MRI, Esclerosi múltiple - Complicacions, medicine.medical_specialty, CNR, contrast-to-noise ratio, Multiple Sclerosis, Cognitive Neuroscience, RRMS, Relapsing-Remitting Multiple Sclerosis, Otros calificadores::/diagnóstico [Otros calificadores], Nervous System::Central Nervous System::Brain::Prosencephalon::Diencephalon::Thalamus [ANATOMY], 10/36 SRT, 10/36 Spatial Recall Test, lcsh:Computer applications to medicine. Medical informatics, NGMV, Normalized grey matter volume, 050105 experimental psychology, SD, standard deviations, CII, cognitive impairment index, EDSS, Expanded Disability Status Scale, WCST, Wisconsin Card Sorting Test, 03 medical and health sciences, Atrophy, medicine, Humans, 0501 psychology and cognitive sciences, Radiology, Nuclear Medicine and imaging, WM, white matter, lcsh:Neurology. Diseases of the nervous system, Thalamu, CI, cognitively impaired and preserved (CP), BRB-N, Brief Repeatable Battery of Neuropsychological Tests, business.industry, Multiple sclerosis, FSL-FIRST, FMRIB Integrated Registration and Segmentation Tool, eTIV, estimated total intracranial volume, CAT12, Computational Anatomy Toolbox for Statistical Parametric Mapping 12, GM, grey matter, medicine.disease, Deep grey matter, NWMV, Normalized white matter volume, MS, Multiple Sclerosis, GMV, grey matter volume, IPS, information processing speed, Neurology (clinical), business, 030217 neurology & neurosurgery, Other subheadings::Other subheadings::/complications [Other subheadings]
Abstract

Highlights • Thalamus atrophy is associated with cognitive impairment in multiple sclerosis. • This was confirmed by automated and manual segmentations, but effect sizes varied. • The algorithms work in a multi-center setting. • Automated techniques exhibit proportional bias with respect to thalamus size. • Differences between vendors can affect the robustness of these associations., Background and rationale Thalamus atrophy has been linked to cognitive decline in multiple sclerosis (MS) using various segmentation methods. We investigated the consistency of the association between thalamus volume and cognition in MS for two common automated segmentation approaches, as well as fully manual outlining. Methods Standardized neuropsychological assessment and 3-Tesla 3D-T1-weighted brain MRI were collected (multi-center) from 57 MS patients and 17 healthy controls. Thalamus segmentations were generated manually and using five automated methods. Agreement between the algorithms and manual outlines was assessed with Bland-Altman plots; linear regression assessed the presence of proportional bias. The effect of segmentation method on the separation of cognitively impaired (CI) and preserved (CP) patients was investigated through Generalized Estimating Equations; associations with cognitive measures were investigated using linear mixed models, for each method and vendor. Results In smaller thalami, automated methods systematically overestimated volumes compared to manual segmentations [ρ=(-0.42)-(-0.76); p-values

Published
2021

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