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249 results on '"Hurt, Aeron C"'

5. Immune cellular networks underlying recovery from influenza virus infection in acute hospitalized patients

Author

Nguyen, Thi H. O., Koutsakos, Marios, van de Sandt, Carolien E., Crawford, Jeremy Chase, Loh, Liyen, Sant, Sneha, Grzelak, Ludivine, Allen, Emma K., Brahm, Tim, Clemens, E. Bridie, Auladell, Maria, Hensen, Luca, Wang, Zhongfang, Nüssing, Simone, Jia, Xiaoxiao, Günther, Patrick, Wheatley, Adam K., Kent, Stephen J., Aban, Malet, Deng, Yi-Mo, Laurie, Karen L., Hurt, Aeron C., Gras, Stephanie, Rossjohn, Jamie, Crowe, Jane, Xu, Jianqing, Jackson, David, Brown, Lorena E., La Gruta, Nicole, Chen, Weisan, Doherty, Peter C., Turner, Stephen J., Kotsimbos, Tom C., Thomas, Paul G., Cheng, Allen C., and Kedzierska, Katherine

Published
2021
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6. Serologic Evidence of Exposure to Highly Pathogenic Avian Influenza H5 Viruses in Migratory Shorebirds, Australia

Author

Wille, Michelle, Lisovski, Simeon, Risely, Alice, Ferenczi, Marta, Roshier, David, Wong, Frank Y.K., Breed, Andrew C., Klaassen, Marcel, and Hurt, Aeron C.

Subjects
Immunologic factors -- Analysis, Avian influenza -- Analysis, Ducks -- Analysis, Avian influenza viruses -- Analysis, Antigens, Antibodies, Influenza, Lectins, Health, World Health Organization
Abstract

Highly pathogenic avian influenza (HPAI) A(H5N1) viruses of the goose/Guangdong (gs/GD) lineage emerged in domestic birds in China in 1996, causing high morbidity and mortality rates in poultry; subsequent zoonotic [...]

Published
2019
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9. Subdominance and poor intrinsic immunogenicity limit humoral immunity targeting influenza HA stem

Author

Tan, Hyon-Xhi, Jegaskanda, Sinthujan, Juno, Jennifer A., Esterbauer, Robyn, Wong, Julius, Kelly, Hannah G., Liu, Yi, Tilmanis, Danielle, Hurt, Aeron C., Yewdell, Jonathan W., Kent, Stephen J., and Wheatley, Adam K.

Subjects
Immunogenetics -- Research, Stem cells -- Research, B cells -- Research, Influenza vaccines, Vaccines, Antigens, Immunotherapy, Immune response, Antigenic determinants, Infection, Influenza, Vaccination, Antibodies, Organic acids, Lectins, Health care industry
Abstract

Both natural influenza infection and current seasonal influenza vaccines primarily induce neutralizing antibody responses against highly diverse epitopes within the 'head' of the viral hemagglutinin (HA) protein. There is increasing interest in redirecting immunity toward the more conserved HA stem or stalk as a means of broadening protective antibody responses. Here we examined HA stem-specific B cell and T follicular helper (Tfh) cell responses in the context of influenza infection and immunization in mouse and monkey models. We found that during infection, the stem domain was immunologically subdominant to the head in terms of serum antibody production and antigen-specific B and Tfh cell responses. Similarly, we found that HA stem immunogens were poorly immunogenic compared with the full-length HA with abolished sialic acid binding activity, with limiting Tfh cell elicitation a potential constraint to the induction or boosting of anti-stem immunity by vaccination. Finally, we confirm that currently licensed seasonal influenza vaccines can boost preexisting memory responses against the HA stem in humans. An increased understanding of the immune dynamics surrounding the HA stem is essential to inform the design of next-generation influenza vaccines for broad and durable protection., Introduction Influenza viruses cause significant global morbidity and mortality through seasonal epidemics and periodic pandemics. The effectiveness of influenza vaccination is limited by the focusing of humoral immunity on a [...]

Published
2019
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10. Human CD8+ T cell cross-reactivity across influenza A, B and C viruses

Author

Koutsakos, Marios, Illing, Patricia T., Nguyen, Thi H. O., Mifsud, Nicole A., Crawford, Jeremy Chase, Rizzetto, Simone, Eltahla, Auda A., Clemens, E. Bridie, Sant, Sneha, Chua, Brendon Y., Wong, Chinn Yi, Allen, E. Kaitlynn, Teng, Don, Dash, Pradyot, Boyd, David F., Grzelak, Ludivine, Zeng, Weiguang, Hurt, Aeron C., Barr, Ian, Rockman, Steve, Jackson, David C., Kotsimbos, Tom C., Cheng, Allen C., Richards, Michael, Westall, Glen P., Loudovaris, Thomas, Mannering, Stuart I., Elliott, Michael, Tangye, Stuart G., Wakim, Linda M., Rossjohn, Jamie, Vijaykrishna, Dhanasekaran, Luciani, Fabio, Thomas, Paul G., Gras, Stephanie, Purcell, Anthony W., and Kedzierska, Katherine

Published
2019
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14. Circulating TFH cells, serological memory, and tissue compartmentalization shape human influenza-specific B cell immunity

Author

Koutsakos, Marios, Wheatley, Adam K., Loh, Liyen, Clemens, E. Bridie, Sant, Sneha, Nüssing, Simone, Fox, Annette, Chung, Amy W., Laurie, Karen L., Hurt, Aeron C., Rockman, Steve, Lappas, Martha, Loudovaris, Thomas, Mannering, Stuart I., Westall, Glen P., Elliot, Michael, Tangye, Stuart G., Wakim, Linda M., Kent, Stephen J., Nguyen, Thi H. O., and Kedzierska, Katherine

Published
2018
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17. Robust immunity to influenza vaccination in haematopoietic stem cell transplant recipients following reconstitution of humoral and adaptive immunity.

Author

Zhang, Wuji, Rowntree, Louise C, Muttucumaru, Ramona, Damelang, Timon, Aban, Malet, Hurt, Aeron C, Auladell, Maria, Esterbauer, Robyn, Wines, Bruce, Hogarth, Mark, Turner, Stephen J, Wheatley, Adam K, Kent, Stephen J, Patil, Sushrut, Avery, Sharon, Morrissey, Orla, Chung, Amy W, Koutsakos, Marios, Nguyen, Thi HO, and Cheng, Allen C

Subjects
HEMATOPOIETIC stem cells, STEM cell transplantation, INFLUENZA vaccines, HUMORAL immunity, IMMUNOLOGIC memory, IMMUNE reconstitution inflammatory syndrome
Abstract

Objectives: Influenza causes significant morbidity and mortality, especially in high‐risk populations. Although current vaccination regimens are the best method to combat annual influenza disease, vaccine efficacy can be low in high‐risk groups, such as haematopoietic stem cell transplant (HSCT) recipients. Methods: We comprehensively assessed humoral immunity, antibody landscapes, systems serology and influenza‐specific B‐cell responses, together with their phenotypes and isotypes, to the inactivated influenza vaccine (IIV) in HSCT recipients in comparison to healthy controls. Results: Inactivated influenza vaccine significantly increased haemagglutination inhibition (HAI) titres in HSCT recipients, similar to healthy controls. Systems serology revealed increased IgG1 and IgG3 antibody levels towards the haemagglutinin (HA) head, but not to neuraminidase, nucleoprotein or HA stem. IIV also increased frequencies of total, IgG class‐switched and CD21loCD27+ influenza‐specific B cells, determined by HA probes and flow cytometry. Strikingly, 40% of HSCT recipients had markedly higher antibody responses towards A/H3N2 vaccine strain than healthy controls and showed cross‐reactivity to antigenically drifted A/H3N2 strains by antibody landscape analysis. These superior humoral responses were associated with a greater time interval after HSCT, while multivariant analyses revealed the importance of pre‐existing immune memory. Conversely, in HSCT recipients who did not respond to the first dose, the second IIV dose did not greatly improve their humoral response, although 50% of second‐dose patients reached a seroprotective HAI titre for at least one of vaccine strains. Conclusions: Our study demonstrates efficient, although time‐dependent, immune responses to IIV in HSCT recipients, and provides insights into influenza vaccination strategies targeted to immunocompromised high‐risk groups. [ABSTRACT FROM AUTHOR]

Published
2023
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21. Substitutions Near the Receptor Binding Site Determine Major Antigenic Change During Influenza Virus Evolution

Author

Koel, Björn F., Burke, David F., Bestebroer, Theo M., van der Vliet, Stefan, Zondag, Gerben C. M., Vervaet, Gaby, Skepner, Eugene, Lewis, Nicola S., Spronken, Monique I. J., Russell, Colin A., Eropkin, Mikhail Y., Hurt, Aeron C., Barr, Ian G., de Jong, Jan C., Rimmelzwaan, Guus F., Osterhaus, Albert D. M. E., Fouchier, Ron A. M., and Smith, Derek J.

Published
2013
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22. Debate regarding oseltamivir use for seasonal and pandemic influenza

Author

Hurt, Aeron C. and Kelly, Heath

Subjects
Epidemics -- Care and treatment -- Health aspects -- Japan -- Australia, Avian influenza -- Care and treatment -- Health aspects, Oseltamivir phosphate -- Health aspects, Avian influenza viruses -- Health aspects, Health, World Health Organization
Abstract

A lively, and sometimes heated, debate has recently been conducted in the popular press (1) and medical literature (2-4) about the effectiveness of oseltamivir, its usefulness in treating seasonal influenza, [...]

Published
2016
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25. Global circulation patterns of seasonal influenza viruses vary with antigenic drift

Author

Bedford, Trevor, Riley, Steven, Barr, Ian G., Broor, Shobha, Chadha, Mandeep, Cox, Nancy J., Daniels, Rodney S., Gunasekaran, C. Palani, Hurt, Aeron C., Kelso, Anne, Klimov, Alexander, Lewis, Nicola S., Li, Xiyan, McCauley, John W., Odagiri, Takato, Potdar, Varsha, Rambaut, Andrew, Shu, Yuelong, Skepner, Eugene, Smith, Derek J., Suchard, Marc A., Tashiro, Masato, Wang, Dayan, Xu, Xiyan, Lemey, Philippe, and Russell, Colin A.

Subjects
Medical research, Medicine, Experimental, Influenza -- Health aspects -- Analysis -- Distribution, Antigens -- Research, Company distribution practices, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Understanding the spatiotemporal patterns of emergence and circulation of new human seasonal influenza virus variants is a key scientific and public health challenge. The global circulation patterns of influenza A/H3N2 viruses are well characterized (1-7), but the patterns of A/H1N1 and B viruses have remained largely unexplored. Here we show that the global circulation patterns of A/H1N1 (up to 2009), B/Victoria, and B/Yamagata viruses differ substantially from those of A/H3N2 viruses, on the basis of analyses of 9,604 haemagglutinin sequences of human seasonal influenza viruses from 2000 to 2012. Whereas genetic variants of A/H3N2 viruses did not persist locally between epidemics and were reseeded from East and Southeast Asia, genetic variants of A/H1N1 and B viruses persisted across several seasons and exhibited complex global dynamics with East and Southeast Asia playing a limited role in disseminating new variants. The less frequent global movement of influenza A/H1N1 and B viruses coincided with slower rates of antigenic evolution, lower ages of infection, and smaller, less frequent epidemics compared to A/H3N2 viruses. Detailed epidemic models support differences in age of infection, combined with the less frequent travel of children, as probable drivers of the differences in the patterns of global circulation, suggesting a complex interaction between virus evolution, epidemiology, and human behaviour., Owing to the frequency and severity of human seasonal influenza A/H3N2 virus epidemics, recent work has focused on the global circulation dynamics of H3N2 viruses (1-7). Studies have shown that, [...]

Published
2015

26. Strong host phylogenetic and ecological effects on host competency for avian influenza in Australian wild birds.

Author

Wille, Michelle, Lisovski, Simeon, Roshier, David, Ferenczi, Marta, Hoye, Bethany J., Leen, Trent, Warner, Simone, Fouchier, Ron A. M., Hurt, Aeron C., Holmes, Edward C., and Klaassen, Marcel

Subjects
AVIAN influenza A virus, EL Nino, AVIAN influenza, BIRD communities, AGE differences, COMMUNITIES
Abstract

Host susceptibility to parasites is mediated by intrinsic and external factors such as genetics, ecology, age and season. While waterfowl are considered central to the reservoir community for low pathogenic avian influenza A viruses (LPAIV), the role of host phylogeny has received limited formal attention. Herein, we analysed 12 339 oropharyngeal and cloacal swabs and 10 826 serum samples collected over 11 years from wild birds in Australia. As well as describing age and species-level differences in prevalence and seroprevalence, we reveal that host phylogeny is a key driver in host range. Seasonality effects appear less pronounced than in the Northern Hemisphere, while annual variations are potentially linked to El Niño–Southern Oscillation. Our study provides a uniquely detailed insight into the evolutionary ecology of LPAIV in its avian reservoir community, defining distinctive processes on the continent of Australia and expanding our understanding of LPAIV globally. [ABSTRACT FROM AUTHOR]

Published
2023
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27. Investigating the transmission of baloxavir‐resistant influenza viruses from treated index patients to untreated household contacts in the BLOCKSTONE study.

Author

Harding, Joanne, Bernasconi, Corrado, Williams, Sarah, Wildum, Steffen, Kinoshita, Masahiro, Uehara, Takeki, and Hurt, Aeron C.

Subjects
INFLUENZA viruses, HOUSEHOLDS, INFLUENZA, CLINICAL trials, TITERS, INFLUENZA A virus
Abstract

In a post‐hoc analysis of the phase 3 BLOCKSTONE study (JapicCTI‐184180), we investigated household transmission of baloxavir‐resistant (PA/I38X) influenza viruses. Using baloxavir resistance rates from prior clinical trials and the rate of influenza transmission observed in the study, the predicted number of PA/I38X transmission events was 4.8, assuming wild type and PA/I38X viruses were equally transmissible. However, no PA/I38X viruses were observed. These results suggest a low potential for baloxavir‐resistant influenza virus transmission from treated to untreated individuals, potentially due to reduced viral/transmission fitness for PA/I38X viruses and/or low viral titres at the time when resistant viruses arise. [ABSTRACT FROM AUTHOR]

Published
2023
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28. Retinoic Acid–Inducible Gene I Activation Inhibits Human Respiratory Syncytial Virus Replication in Mammalian Cells and in Mouse and Ferret Models of Infection.

Author

Schwab, Lara S U, Farrukee, Rubaiyea, Eléouët, Jean-François, Rameix-Welti, Marie-Anne, Londrigan, Sarah L, Brooks, Andrew G, Hurt, Aeron C, Coch, Christoph, Zillinger, Thomas, Hartmann, Gunther, and Reading, Patrick C

Subjects
RESPIRATORY syncytial virus, GENETIC regulation, VIRAL replication, PATTERN perception receptors, LABORATORY mice, TRETINOIN
Abstract

Infections caused by human respiratory syncytial virus (RSV) are associated with substantial rates of morbidity and mortality. Treatment options are limited, and there is urgent need for the development of efficient antivirals. Pattern recognition receptors such as the cytoplasmic helicase retinoic acid–inducible gene (RIG) I can be activated by viral nucleic acids, leading to activation of interferon-stimulated genes and generation of an "antiviral state." In the current study, we activated RIG-I with synthetic RNA agonists (3pRNA) to induce resistance to RSV infection in vitro and in vivo. In vitro, pretreatment of human, mouse, and ferret airway cell lines with RIG-I agonist before RSV exposure inhibited virus infection and replication. Moreover, a single intravenous injection of 3pRNA 1 day before RSV infection resulted in potent inhibition of virus replication in the lungs of mice and ferrets, but not in nasal tissues. These studies provide evidence that RIG-I agonists represent a promising antiviral drug for RSV prophylaxis. [ABSTRACT FROM AUTHOR]

Published
2022
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31. The Global Circulation of Seasonal Influenza a (H3N2) Viruses

Author

Russell, Colin A., Jones, Terry C., Barr, Ian G., Cox, Nancy J., Garten, Rebecca J., Gregory, Vicky, Gust, Ian D., Hampson, Alan W., Hay, Alan J., Hurt, Aeron C., de Jong, Jan C., Kelso, Anne, Klimov, Alexander I., Kageyama, Tsutomu, Komadina, Naomi, Lapedes, Alan S., Lin, Yi P., Mosterin, Ana, Obuchi, Masatsugu, Odagiri, Takato, Osterhaus, Albert D. M. E., Rimmelzwaan, Guus F., Shaw, Michael W., Skepner, Eugene, Stohr, Klaus, Tashiro, Masato, Fouchier, Ron A. M., and Smith, Derek J.

Published
2008
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39. Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors, 2012–2013

Author

Meijer, Adam, Rebelo-de-Andrade, Helena, Correia, Vanessa, Besselaar, Terry, Drager-Dayal, Renu, Fry, Alicia, Gregory, Vicky, Gubareva, Larisa, Kageyama, Tsutomu, Lackenby, Angie, Lo, Janice, Odagiri, Takato, Pereyaslov, Dmitriy, Siqueira, Marilda M., Takashita, Emi, Tashiro, Masato, Wang, Dayan, Wong, Sun, Zhang, Wenqing, Daniels, Rod S., and Hurt, Aeron C.

Published
2014
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41. Mutations I117V and I117M and oseltamivir sensitivity of pandemic (H1N1) 2009 viruses

Author

Hurt, Aeron C., Leang, Sook Kwan, Speers, David J., Barr, Ian G., and Maurer-Stroh, Sebastian

Subjects
Oseltamivir phosphate -- Health aspects, Epidemics -- Genetic aspects -- Australia -- Health aspects, Influenza -- Genetic aspects -- Health aspects, Health
Abstract

The neuraminidase inhibitors (NAIs) oseltamivir and zanamivir have been widely used in many countries to treat infection with influenza A pandemic (H1N1) 2009 virus. Since the start of the pandemic, [...]

Published
2012
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42. Influenza vaccine strain selection and recent studies on the global migration of seasonal influenza viruses

Author

Russell, Colin A., Jones, Terry C., Barr, Ian G., Cox, Nancy J., Garten, Rebecca J., Gregory, Vicky, Gust, Ian D., Hampson, Alan W., Hay, Alan J., Hurt, Aeron C., de Jong, Jan C., Kelso, Anne, Klimov, Alexander I., Kageyama, Tsutomu, Komadina, Naomi, Lapedes, Alan S., Lin, Yi P., Mosterin, Ana, Obuchi, Masatsugu, Odagiri, Takato, Osterhaus, Albert D.M.E., Rimmelzwaan, Guus F., Shaw, Michael W., Skepner, Eugene, Stohr, Klaus, Tashiro, Masato, Fouchier, Ron A.M., and Smith, Derek J.

Published
2008
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43. Surveillance and analysis of avian influenza viruses, Australia

Author

Hansbro, Philip M., Warner, Simone, Tracey, John P., Arzey, K. Edla, Selleck, Paul, O'Riley, Kim, Beckett, Emma L., Bunn, Chris, Kirkland, Peter D., Vijaykrishna, Dhanasekaran, Olsen, Bjorn, and Hurt, Aeron C.

Subjects
Avian influenza -- Development and progression, Avian influenza viruses, Poultry industry, Health
Abstract

Shorebirds (Charadriiformes) and wild waterfowl (Anseriformes) represent the major natural reservoirs of avian influenza viruses (AIVs). These birds can carry all 16 hemagglutinin (HA) and 9 neuraminidase (NA) subtypes (1); [...]

Published
2010
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44. Influenza virus transmission from horses to dogs, Australia

Author

Kirkland, Peter D., Finlaison, Deborah S., Crispe, Ellie, and Hurt, Aeron C.

Subjects
Influenza viruses -- Health aspects, Dogs -- Health aspects, Influenza -- Health aspects, Disease transmission -- Health aspects, Horses -- Health aspects, Health
Abstract

Respiratory disease in dogs caused by type A influenza virus was first noted in racing greyhounds in Florida in January 2004 (1). This subtype H3N8 virus has a presumptive but [...]

Published
2010
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