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254 results on '"Kim, Nam‐Joong"'

1. Blood culture-free ultra-rapid antimicrobial susceptibility testing

Author

Kim, Tae Hyun, Kang, Junwon, Jang, Haewook, Joo, Hyelyn, Lee, Gi Yoon, Kim, Hamin, Cho, Untack, Bang, Hyeeun, Jang, Jisung, Han, Sangkwon, Kim, Dong Young, Lee, Chan Mi, Kang, Chang Kyung, Choe, Pyoeng Gyun, Kim, Nam Joong, Oh, Myoung-don, Kim, Taek Soo, Kim, Inho, Park, Wan Beom, and Kwon, Sunghoon

Published
2024
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4. Limited impact of bacterial virulence on early mortality risk factors in Acinetobacter baumannii bacteremia observed in a Galleria mellonella model

Author

Ham, Sin Young, Chun, June Young, Song, Kyoung-Ho, Kang, Chang Kyung, Park, Jeong Su, Jo, Hee Bum, Ryu, Choong-Min, Choi, Yunsang, Choi, Seong Jin, Lee, Eunyoung, Choe, Pyoeng Gyun, Moon, Song Mi, Park, Wan Beom, Bang, Jihwan, Park, Sang-Won, Park, Kyoung Un, Kim, Nam Joong, Oh, Myoung-don, Kim, Eu Suk, and Kim, Hong Bin

Published
2024
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8. Clinical and economic burden of bacteremia due to multidrug-resistant organisms in Korea: a prospective case control study

Author

Song, Kyoung-Ho, Kim, Chung-Jong, Choi, Nam-Kyong, Ahn, Jeonghoon, Choe, Pyoeng Gyun, Park, Wan Beom, Kim, Nam Joong, Choi, Hee Jung, Bae, Ji Yun, Kim, Eu Suk, Lee, Hyunju, Park, Jeong Su, Jung, Younghee, Lee, Seung Soon, Park, Kyung-Hwa, Jung, Sook-In, Kim, Yeon-Sook, Bang, Ji-Hwan, Lee, Shinwon, Kang, Yu Min, Kwak, Yee Gyung, and Kim, Hong Bin

Published
2022
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12. Clinicomicrobiological risk factors for infective endocarditis in viridans group streptococci bacteraemia.

Author

Bae, Jiyeon, Park, Jae Hyeon, Lee, Minkyeong, Jo, Hyeon Jae, Lee, Chan Mi, Kang, Chang Kyung, Choe, Pyoeng Gyun, Park, Wan Beom, Kim, Nam Joong, Kim, Inho, and Oh, Myoung-don

Subjects
HEART valve diseases, HEMATOLOGIC malignancies, DISEASE risk factors, BLOOD diseases, LOGISTIC regression analysis
Abstract

Background When to perform echocardiography to rule out infective endocarditis (IE) in patients with viridans group streptococci (VGS) bloodstream infections (BSIs) is unclear. Objectives We aimed to identify independent risk factors for IE in patients with VGS BSI. Methods This retrospective study conducted at Seoul National University Hospital from January 2013 to December 2022 involved patients with VGS and nutritionally variant streptococcal BSI, excluding single positive blood cultures and polymicrobial BSI cases. Independent risk factors were identified by multivariate logistic regression and sensitivity analyses according to echocardiography results, VGS species or the inclusion of possible IE cases. Results Of 845 VGS BSI cases, 349 were analysed and 86 IE cases were identified (24.6%). In the multivariate analysis, heart valve disease [adjusted odds ratio (aOR), 14.14, 95% CI, 6.14–32.58; P  < 0.001], persistent bacteraemia (aOR, 5.12, 95% CI, 2.03–12.94; P  = 0.001), age (per year, aOR, 0.98; 95% CI, 0.96–1.00; P =  0.015), solid cancer (aOR, 0.26; 95% CI, 0.13–0.53; P <  0.001) and haematologic malignancy (aOR, 0.04; 95% CI, 0.01–0.41; P =  0.006) were independently associated with IE. Sensitivity analyses yielded consistent results; also, infection by a member of the mitis group was independent risk factor for IE (aOR, 6.50; 95% CI, 2.87–14.68; P  < 0.001). Conclusions Younger age, heart valve disease, persistent bacteraemia, absence of underlying malignancy and BSI by a member of the mitis group were independent risk factors for IE in patients with VGS BSI. Echocardiographic evaluation could be prudently considered based on these clinicomicrobiological risk factors. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Surface-Aerosol Stability and Pathogenicity of Diverse Middle East Respiratory Syndrome Coronavirus Strains, 2012-2018

Author

van Doremalen, Neeltje, Letko, Michael, Fischer, Robert J., Bushmaker, Trenton, Schulz, Jonathan, Yinda, Claude K., Seifert, Stephanie N., Kim, Nam Joong, Hemida, Maged G., Kayali, Ghazi, Park, Wan Beom, Perera, Ranawaka A.P.M., Tamin, Azaibi, Thornburg, Natalie J., Tong, Suxiang, Queen, Krista, van Kerkhove, Maria D., Choi, Young Ki, Oh, Myoung-don, Assiri, Abdullah M., Peiris, Malik, Gerber, Susan I., and Munster, Vincent J.

Subjects
Bioaerosols -- Health aspects -- Environmental aspects -- Chemical properties, Coronaviruses -- Physiological aspects -- Environmental aspects, Health
Abstract

Middle East respiratory syndrome coronavirus (MERS-CoV) was detected during 2012 and continues to cause outbreaks as a result of frequent spillover from dromedary camels to humans. Human infection with MERS-CoV [...]

Published
2021
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16. Antibody Responses 8 Months after Asymptomatic or Mild SARS-CoV-2 Infection

Author

Choe, Pyoeng Gyun, Kim, Kye-Hyung, Kang, Chang Kyung, Suh, Hyeon Jeong, Kang, EunKyo, Lee, Sun Young, Kim, Nam Joong, Yi, Jongyoun, Park, Wan Beom, and Oh, Myoung-don

Subjects
Immune response -- Health aspects, Viral antibodies -- Physiological aspects -- Health aspects, Antibodies -- Physiological aspects -- Health aspects, Health
Abstract

Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) leads to an antibody response, even in those who are completely asymptomatic. However, the initial immune response is not as strong [...]

Published
2021
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19. Antibody Responses to SARS-CoV-2 at 8 Weeks Postinfection in Asymptomatic Patients

Author

Choe, Pyoeng Gyun, Kang, Chang Kyung, Suh, Hyeon Jeong, Jung, Jongtak, Kang, EunKyo, Lee, Sun Young, Song, Kyoung-Ho, Kim, Hong Bin, Kim, Nam Joong, Park, Wan Beom, Kim, Eu Suk, and Oh, Myoung-Don

Subjects
Severe acute respiratory syndrome -- Development and progression, Coronaviruses -- Health aspects, Antibodies -- Health aspects, COVID-19 -- Development and progression, Health
Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a new strain of betacoronavirus that causes coronavirus disease (COVID-19), quickly spread worldwide; the World Health Organization declared COVID-19 a pandemic on March [...]

Published
2020
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20. Clonal hematopoiesis is associated with risk of severe Covid-19

Author

Bolton, Kelly L., Koh, Youngil, Foote, Michael B., Im, Hogune, Jee, Justin, Sun, Choong Hyun, Safonov, Anton, Ptashkin, Ryan, Moon, Joon Ho, Lee, Ji Yeon, Jung, Jongtak, Kang, Chang Kyung, Song, Kyoung-Ho, Choe, Pyoeng Gyun, Park, Wan Beom, Kim, Hong Bin, Oh, Myoung-don, Song, Han, Kim, Sugyeong, Patel, Minal, Derkach, Andriy, Gedvilaite, Erika, Tkachuk, Kaitlyn A., Wiley, Brian J., Chan, Ireaneus C., Braunstein, Lior Z., Gao, Teng, Papaemmanuil, Elli, Esther Babady, N., Pessin, Melissa S., Kamboj, Mini, Diaz, Jr, Luis A., Ladanyi, Marc, Rauh, Michael J., Natarajan, Pradeep, Machiela, Mitchell J., Awadalla, Philip, Joseph, Vijai, Offit, Kenneth, Norton, Larry, Berger, Michael F., Levine, Ross L., Kim, Eu Suk, Kim, Nam Joong, and Zehir, Ahmet

Published
2021
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25. Sensitive and Specific Detection of Low-Level Antibody Responses in Mild Middle East Respiratory Syndrome Coronavirus Infections

Author

Okba, Nisreen M.A., Raj, V. Stalin, Widjaja, Ivy, GeurtsvanKessel, Corine H., Bruin, Erwin de, Chandler, Felicity D., Park, Wan Beom, Kim, Nam-Joong, Farag, Elmoubasher A.B.A., Hajri, Mohammed Al-, Bosch, Berend-Jan, Oh, Myoung-don, Koopmans, Marion P.G., Reusken, Chantal B.E.M., and Haagmans, Bart L.

Subjects
Enzyme-linked immunosorbent assay -- Health aspects, Diseases -- Research -- Health aspects -- Netherlands -- Middle East -- South Korea -- Qatar, Middle East respiratory syndrome -- Research -- Health aspects, Antibodies -- Health aspects, Disease transmission, Coronavirus infections, Intelligence gathering, Lung diseases, Infection, Respiratory tract diseases, Health
Abstract

Middle East respiratory syndrome coronavirus (MERS-CoV) poses a public health threat; ongoing outbreaks have been reported since its detection in 2012 (1). MERS-CoV infection may be asymptomatic or may cause [...]

Published
2019
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26. Clinical outcomes and immunological features of COVID-19 patients receiving B-cell depletion therapy during the Omicron era.

Author

Lee, Chan Mi, Kim, Minji, Park, Seong-wook, Kang, Chang Kyung, Choe, Pyoeng Gyun, Kim, Nam Joong, Jo, Hyeon Jae, Shin, Hyun Mu, Lee, Chang-Han, Kim, Hang-Rae, Park, Wan Beom, and Oh, Myoung-don

Subjects
COVID-19, SARS-CoV-2 Omicron variant, COVID-19 pandemic, HUMORAL immunity, TREATMENT effectiveness
Abstract

Background: The clinical outcomes and immunological features of coronavirus disease 2019 (COVID-19) patients receiving B-cell depletion therapy (BCDT), especially in Omicron variant era, have not been fully elucidated. We aimed to investigate the outcomes and immune responses of COVID-19 patients receiving BCDT during the Omicron period. Methods: We retrospectively compared clinical outcomes between COVID-19 patients treated with BCDT (the BCDT group) and those with the same underlying diseases not treated with BCDT (the non-BCDT group). For immunological analyses, we prospectively enrolled COVID-19 patients receiving BCDT and immunocompetent COVID-19 patients as controls. We measured humoral and cellular immune responses using the enzyme-linked immunosorbent assay and flow cytometry. Results: Severe to critical COVID-19 was more frequent in the BCDT group than in the non-BCDT group (41.9% vs. 28.3%, p =.030). BCDT was an independent risk factor for severe to critical COVID-19 (adjusted odds ratio [aOR] 2.21, 95% confidence interval [CI] 1.21–4.04, p =.010) as well as for COVID-19-related mortality (aOR 4.03, 95% CI 1.17–13.86, p =.027). Immunological analyses revealed that patients receiving BCDT had lower anti-S1 IgG titres and a tendency to higher proportions of activated CD4+ T-cells than the controls. Conclusions: BCDT was associated with worse COVID-19 outcomes in the Omicron period. Humoral immune response impairment and T-cell hyperactivation were the main immunological features of COVID-19 patients treated with BCDT, which may have contributed to the worse outcomes of COVID-19 in this population. [ABSTRACT FROM AUTHOR]

Published
2024
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27. Waning Antibody Responses in Asymptomatic and Symptomatic SARS-CoV-2 Infection

Author

Choe, Pyoeng Gyun, Kang, Chang Kyung, Suh, Hyeon Jeong, Jung, Jongtak, Song, Kyoung-Ho, Bang, Ji Hwan, Kim, Eu Suk, Kim, Hong Bin, Park, Sang Won, Kim, Nam Joong, Park, Wan Beom, and Oh, Myoung-don

Subjects
Epidemics -- Physiological aspects -- South Korea, Immune response -- Observations, Viral antibodies -- Identification and classification, Antibodies -- Identification and classification, Health
Abstract

Neutralizing antibodies develop in asymptomatic persons with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection; however, the initial immune response is not as strong as in patients with more severe [...]

Published
2021
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28. Antimicrobial consumption and resistance in adult hospital inpatients in 53 countries: results of an internet-based global point prevalence survey

Author

Koraqi, Andi, Hoxha, Iris, Tafaj, Silva, Lacej, Denada, Hojman, Martin, Quiros, Rodolfo Ernesto, Ghazaryan, Lilit, Cairns, Kelly A, Cheng, Allen, Horne, Kylie C, Doukas, Fiona F, Gottlieb, Thomas, Alsalman, Jameela, Magerman, Koen, Marielle, Gounongbe YT, Ljubovic, Amela Dedeic, Coelho, André Afonso Machado, Gales, Ana Cristina, Keuleyan, Emma, Sabuda, Deana, Boswell, Jennifer Lee, Conly, John M, Rojas, Alvaro, Carvajal, Camila, Labarca, Jaime, Solano, Antonio, Valverde, Carlos Ramírez, Villalobos-Vindas, Juan M, Pristas, Irina, Plecko, Vanda, Paphitou, Niki, Shaqiri, Erjona, Rummukainen, Maija-Liisa, Pagava, Karaman, Korinteli, Irma, Brandt, Tobias, Messler, Sabine, Enimil, Anthony, Iosifidis, Elias, Roilides, Emmanuel, Sow, Mamadou Saliou, Sengupta, Sharmila, George, Joby V, Poojary, Aruna, Patil, Priyanka, Soltani, Jafar, Jafarpour, Zahra, Ameen, Hadi, Fitzgerald, David, Maor, Yasmin, Chowers, Michal, Temkin, Elizabeth, Esposito, Susanna, Arnoldo, Luca, Brusaferro, Silvio, Gu, Yoshiaki, El-Hajji, Feras Darwish, Kim, Nam Joong, Kambaralieva, Baktygul, Pavare, Jana, Zarakauska, Lelde, Usonis, Vytautas, Burokiene, Sigita, Ivaskeviciene, Inga, Mijovic, Gordana, Duborija-Kovacevic, Natasa, Bondesio, Kristen, Iregbu, Kenneth, Oduyebo, Oyinlola, Raka, Denis, Raka, Lul, Rachina, Svetlana, Enani, Mushira Abdulaziz, Al Shehri, Mohamed, Carevic, Biljana, Dragovac, Gorana, Obradovic, Dusanka, Stojadinovic, Aleksandra, Radulovic, Lili, Wu, Jia EN, Wei Teng Chung, Gladys, Chen, Hui Hiong, Tambyah, Paul Anantharajah, Lye, David, Tan, Sock Hoon, Ng, Tat Ming, Tay, Hui Lin, Ling, Moi Lin, Chlebicki, Maciej Piotr, Kwa, Andrea L, Lee, Winnie, Beović, Bojana, Dramowski, Angela, Finlayson, Heather, Taljaard, Jantjie, Ojeda-Burgos, Guillermo, Retamar, Pilar, Lucas, Johan, Pot, Wolter, Verduin, Cees, Kluytmans, Jan, Scott, Michael, Aldeyab, Mamoon A, McCullagh, Bernadette, Gormley, Cairine, Sharpe, David, Gilchrist, Mark, Whitney, Laura, Laundy, Matthew, Lockwood, Debbie, Drysdale, Simon B, Boudreaux, Jennifer, Septimus, Edward J, Greer, Nickie, Gawrys, Gerard, Rios, Edgar, May, Suzanne, Versporten, Ann, Zarb, Peter, Caniaux, Isabelle, Gros, Marie-Françoise, Drapier, Nico, Miller, Mark, Jarlier, Vincent, Nathwani, Dilip, and Goossens, Herman

Published
2018
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36. Tracking antigen‐specific TCR clonotypes in SARS‐CoV‐2 infection reveals distinct severity trajectories.

Author

Kim, Ik Soo, Kang, Chang Kyung, Lee, Seung Jae, Lee, Chang‐Han, Kim, Minji, Seo, Chaehwa, Kim, Gwanghun, Lee, Soojin, Park, Kyoung Sun, Chang, Euijin, Jung, Jongtak, Song, Kyoung‐Ho, Choe, Pyoeng Gyun, Park, Wan Beom, Kim, Eu Suk, Bin Kim, Hong, Kim, Nam Joong, Oh, Myoung‐don, Lee, Jong‐Eun, and Shin, Hyun Mu

Subjects
CYTOTOXIC T cells, SARS-CoV-2, T cells, B cells, COMMUNICABLE diseases
Abstract

Despite the importance of antigen‐specific T cells in infectious disease, characterizing and tracking clonally amplified T cells during the progression of a patient's symptoms remain unclear. Here, we performed a longitudinal, in‐depth single‐cell multiomics analysis of samples from asymptomatic, mild, usual severe, and delayed severe patients of SARS‐CoV‐2 infection. Our in‐depth analysis revealed that hyperactive or improper T‐cell responses were more aggressive in delayed severe patients. Interestingly, tracking of antigen‐specific T‐cell receptor (TCR) clonotypes along the developmental trajectory indicated an attenuation in functional T cells upon severity. In addition, increased glycolysis and interleukin‐6 signaling in the cytotoxic T cells were markedly distinct in delayed severe patients compared to usual severe patients, particularly in the middle and late stages of infection. Tracking B‐cell receptor clonotypes also revealed distinct transitions and somatic hypermutations within B cells across different levels of disease severity. Our results suggest that single‐cell TCR clonotype tracking can distinguish the severity of patients through immunological hallmarks, leading to a better understanding of the severity differences in and improving the management of infectious diseases by analyzing the dynamics of immune responses over time. [ABSTRACT FROM AUTHOR]

Published
2023
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37. Gender affects prognosis of methicillin-resistant Staphylococcus aureus bacteremia differently depending on the severity of underlying disease

Author

Kang, Chang Kyung, Kwak, Yee Gyung, Park, Youngmi, Song, Kyoung-Ho, Kim, Eu Suk, Jung, Sook-In, Park, Kyung-Hwa, Park, Wan Beom, Kim, Nam Joong, Kim, Young Keun, Jang, Hee-Chang, Lee, Shinwon, Jeon, Jae Hyun, Kwon, Ki Tae, Kim, Chung-Jong, Kim, Yeon-Sook, Kim, Hong Bin, and the Korea INfectious Diseases (KIND) study group

Published
2018
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39. Impact of area under the concentration–time curve to minimum inhibitory concentration ratio on vancomycin treatment outcomes in methicillin-resistant Staphylococcus aureus bacteraemia

Author

Song, Kyoung-Ho, Kim, Hong Bin, Kim, Hyung-sook, Lee, Myung Jin, Jung, Younghee, Kim, Gayeon, Hwang, Jeong-Hwan, Kim, Nak-Hyun, Kim, Moonsuk, Kim, Chung-Jong, Choe, Pyoeng Gyun, Chung, Jae-Yong, Park, Wan Beom, Kim, Eu Suk, Park, Kyoung Un, Kim, Nam Joong, Kim, Eui-Chong, and Oh, Myoung-don

Published
2015
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42. MERS-CoV antibody responses 1 year after symptom onset, South Korea, 2015

Author

Choe, Pyoeng Gyun, Perera, R.A.P.M., Park, Wan Beom, Song, Kyoung-Ho, Bang, Ji Hwan, Kim, Eu Suk, Kim, Hong Bin, Ko, Long Wei Ronald, Park, Sang Won, Kim, Nam-Joong, Lau, Eric H.Y., Poon, Leo L.M., Peiris, Malik, and Oh, Myoung-don

Subjects
Enzyme-linked immunosorbent assay -- Health aspects, Middle East respiratory syndrome -- Health aspects, Antibodies -- Health aspects, Health
Abstract

Middle East respiratory syndrome (MERS) remains a disease of global public health concern for which no proven specific countermeasures are available. As of December 5, 2016, [approximately equal to] 1,800 [...]

Published
2017
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48. Kinetics of serologic responses to MERS coronavirus infection in humans, south Korea

Author

Park, Wan Beom, Perera, Ranawaka A.P.M., Choe, Pyoeng Gyun, Lau, Eric H.Y., Choi, Seong Jin, Chun, June Young, Oh, Hong Sang, Song, Kyoung-Ho, Bang, Ji Hwan, Kim, Eu Suk, Kim, Hong Bin, Park, Sang Won, Kim, Nam Joong, Poon, Leo Lit Man, Peiris, Malik, and Oh, Myoung-don

Subjects
Enzyme-linked immunosorbent assay -- Health aspects, Health
Abstract

We investigated the kinetics of serologic responses to Middle East respiratory syndrome coronavirus (MERS-CoV) infection by using virus neutralization and MERS-CoV S1 IgG ELISA tests. In most patients, robust antibody [...]

Published
2015
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50. Comparable humoral and cellular immunity against Omicron variant BA.4/5 of once‐boosted BA.1/2 convalescents and twice‐boosted COVID‐19‐naïve individuals.

Author

Kang, Chang Kyung, Kim, Min‐Gang, Park, Seong‐wook, Kim, Yong‐Woo, Lee, Chan Mi, Choe, Pyoeng Gyun, Park, Wan Beom, Kim, Nam Joong, Kim, Minji, Lee, Soojin, Kim, Ik Soo, Lee, Chang‐Han, Shin, Hyun Mu, Kim, Hang‐Rae, and Oh, Myoung‐don

Subjects
SARS-CoV-2, SARS-CoV-2 Omicron variant, CELLULAR immunity, COVID-19, PSYCHONEUROIMMUNOLOGY
Abstract

The fourth vaccination dose confers additional protective immunity against severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection in individuals with no prior coronavirus disease‐19 (COVID‐19). However, its immunological benefit against currently circulating BA.4/5 is unclear in individuals who have received a booster shot and been infected with Omicron variant BA.1/2. We analyzed immune responses in whom had been boosted once and did not have COVID‐19 (n = 16), boosted once and had COVID‐19 when BA.1/2 was dominant in Korea (Hybrid‐6M group, n = 27), and boosted twice and did not have COVID‐19 (Vx4 group, n = 15). Antibody binding activities against RBDo BA.1 and RBDo BA.4/5, antigen‐specific memory CD4+ and CD8+ T‐cell responses against BA.4/5, and B‐cell responses against SARS‐CoV‐2 wild‐type did not differ statistically between the Hybrid‐6M and Vx4 groups. The humoral and cellular immune responses of the Hybrid‐6M group against BA.4/5 were comparable to those of the Vx4 group. Individuals who had been boosted and had an Omicron infection in early 2022 may not have high priority for an additional vaccination. [ABSTRACT FROM AUTHOR]

Published
2023
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